Impact of Time-Restricted Feeding and Dawn-to-Sunset Fasting on Circadian Rhythm, Obesity, Metabolic Syndrome, and Nonalcoholic Fatty Liver Disease
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Obesity now affects millions of people and places them at risk of developing metabolic syndrome, nonalcoholic fatty liver disease (NAFLD), and even hepatocellular carcinoma. This rapidly emerging epidemic has led to a search for cost-effective methods to prevent the metabolic syndrome and NAFLD as well as the progression of NAFLD to cirrhosis and hepatocellular carcinoma. In murine models, time-restricted feeding resets the hepatic circadian clock and enhances transcription of key metabolic regulators of glucose and lipid homeostasis. Studies of the effect of dawn-to-sunset Ramadan fasting, which is akin to time-restricted feeding model, have also identified significant improvement in body mass index, serum lipid profiles, and oxidative stress parameters. Based on the findings of studies conducted on human subjects, dawn-to-sunset fasting has the potential to be a cost-effective intervention for obesity, metabolic syndrome, and NAFLD.
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Time-restricted feeding is now being used to help treat and/or prevent obesity, as well as metabolic, cardiac and liver disorders.
“Time-restricted feeding is also now being used to help treat and/or prevent obesity, as well as metabolic, cardiac and liver disorders327,328.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [328]
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- Authors
- Mindikoglu, A. L., Opekun, A. R., Gagan, S. K., & Devaraj, S.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Mindikoglu, Ayse L.
- Venue
- Gastroenterology Research and Practice
- Publisher
- Wiley
- Published
- 2017
- Volume
- 2017
- Pages
- 1-13
- ISSN
- 1687-6121 (ISSN-L)
- 1687-630X
- PMC
- PMC5733887
- OpenAlex
- W2769045518
- Cited by
- 49
- References
- 109
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 15 · 2019: 7 · 2018: 2
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Gastroenterology Research and Practice (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (P30DK056338)
- Texas Medical Center Digestive Disease Center (P30DK056338)
- Topics
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- time-restricted feeding, Ramadan fasting, circadian rhythm, obesity, metabolic syndrome, non-alcoholic fatty liver disease, hepatocellular carcinoma, glucose homeostasis, lipid homeostasis, oxidative stress, serum lipids, body mass index
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