The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Antifungal activity of the components of Melaleuca alternifolia (tea tree) oil
Abstract
AIMS: To investigate the in vitro antifungal activity of the components of Melaleuca alternifolia (tea tree) oil. METHODS AND RESULTS: Activity was investigated by broth microdilution and macrodilution, and time kill methods. Components showing the most activity, with minimum inhibitory concentrations and minimum fungicidal concentrations of < or =0.25%, were terpinen-4-ol, alpha-terpineol, linalool, alpha-pinene and beta-pinene, followed by 1,8-cineole. The remaining components showed slightly less activity and had values ranging from 0.5 to 2%, with the exception of beta-myrcene which showed no detectable activity. Susceptibility data generated for several of the least water-soluble components were two or more dilutions lower by macrodilution, compared with microdilution. CONCLUSIONS: All tea tree oil components, except beta-myrcene, had antifungal activity. The lack of activity reported for some components by microdilution may be due to these components becoming absorbed into the polystyrene of the microtitre tray. This indicates that plastics are unsuitable as assay vessels for tests with these or similar components. SIGNIFICANCE AND IMPACT OF THE STUDY: This study has identified that most components of tea tree oil have activity against a range of fungi. However, the measurement of antifungal activity may be significantly influenced by the test method.
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Cites
Mechanisms of membrane toxicity of hydrocarbons
Sikkema, J., de Bont, J. A., & Poolman, B. (1995) · Microbiological Reviews · doi:10.1128/mr.59.2.201-222.1995 · Cited by 2,685 · cited 2×
“The solubility of terpenes is hypothesized as correlating with their antimicrobial activity (Sikkema et al. 1995).”
BackgroundCarson, C. F., Mee, B. J., & Riley, T. V. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.6.1914-1920.2002 · Cited by 975
Self-citationTea tree oil reduces histamine-induced skin inflammation
Koh, K. J., Pearce, A. L., Marshman, G., Finlay-Jones, J. J., & Hart, P. H. (2002) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2002.05034.x · Cited by 185
Treatment of dandruff with 5% tea tree oil shampoo
Satchell, A. C., Saurajen, A., Bell, C., & Barnetson, R. S. (2002) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2002.122734 · Cited by 152 · cited 2×
“…in the treatment of infections or conditions such as herpes labialis (Carson et al. 2001), acne (Bassett et al. 1990), tinea (Tong et al. 1992; Satchell et al. 2002a), onychomycosis (Buck et al. 1994), dandruff (Satchell et al. 2002b) and oral candidiasis (Vazquez and Zawawi 2002), and in the…”
Background
Cited by
Terpenes: substances useful in human healthcare
Paduch, R., Kandefer-Szerszeń, M., Trytek, M., & Fiedurek, J. (2007) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-007-0039-1 · Cited by 448
Li, Q., Ning, P., Zheng, L., Huang, J., Li, G., & Hsiang, T. (2010) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2010.06.003 · Cited by 178
Ameur, E., Sarra, M., Yosra, D., Mariem, K., Nabil, A., Lynen, F., & Larbi, K. M. (2021) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-021-03379-y · Cited by 36
Antimicrobial and anti‐inflammatory activity of five Taxandria fragrans oils in vitro
Hammer, K. A., Carson, C. F., Dunstan, J. A., Hale, J., Lehmann, H., Robinson, C. J., Prescott, S. L., & Riley, T. V. (2008) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2008.00070.x · Cited by 27
Self-citationEssential Oils as Potential Source of Anti‐Dandruff Agents: A Review
Arora, P., Nainwal, L. M., & Jain, S. (2022) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207324666210712094148 · Cited by 23
Metadata
- Authors
- Hammer, K. A., Carson, C. F., & Riley, T. V.
- Venue
- Journal of Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-10
- Volume
- 95
- Issue
- 4
- Pages
- 853-860
- ISSN
- 1364-5072 (ISSN-L)
- 1365-2672
- OpenAlex
- W2118222755
- Cited by
- 513
- References
- 4
- FWCI
- 15.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hammer, K. A., Carson, C. F., & Riley, T. V. (2003). Antifungal activity of the components of Melaleuca alternifolia (tea tree) oil. Journal of Applied Microbiology. https://doi.org/10.1046/j.1365-2672.2003.02059.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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