Antimicrobial and anti‐inflammatory activity of five Taxandria fragrans oils in vitro
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ABSTRACT The antimicrobial activity of five samples of Taxandria fragrans essential oil was evaluated against a range of Gram‐positive (n= 26) and Gram‐negative bacteria (n= 39) and yeasts (n= 10). The majority of organisms were inhibited and/or killed at concentrations ranging from 0.06–4.0% v/v. Geometric means of MIC were lowest for oil Z (0.77% v/v), followed by oils X (0.86%), C (1.12%), A (1.23%) and B (1.24%). Despite differences in susceptibility data between oils, oils A and X did not differ when tested at 2% v/v in a time kill assay against Staphylococcus aureus. Cytotoxicity assays using peripheral blood mononuclear cells demonstrated that T. fragrans oil was cytotoxic at 0.004% v/v but not at 0.002%. Exposure to one or more of the oils at concentrations of ≤0.002% v/v resulted in a dose responsive reduction in the production of proinflammatory cytokines IL‐6 and TNF‐α, regulatory cytokine IL‐10, Th1 cytokine IFN‐γ and Th2 cytokines IL‐5 and IL‐13 by PHA stimulated mononuclear cells. Oil B inhibited the production of all cytokines except IL‐10, oil X inhibited TNF‐α, IL‐6 and IL‐10, oil A inhibited TNF‐α and IL‐6, oil C inhibited IL‐5 and IL‐6 and oil Z inhibited IL‐13 only. IL‐6 production was significantly inhibited by the most oils (A, B, C and X), followed by TNF‐α (oils A, B and X). In conclusion, T. fragrans oil showed both antimicrobial and anti‐inflammatory activity in vitro, however, the clinical relevance of this remains to be determined.
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Taxandria fragrans essential oils decrease production of TNF-α and IL-6 in PHA-stimulated mononuclear cells.
“Also using PHA from Phaseolus vulgaris for stimulating mononuclear cells, Hammer et al. (2000) [108] reported that the essential oils of Taxandria fragrans (J. R. Wheller & N. G. Marchant) J. R. Wheeler & N. G. Marchant, comb. nov., mainly constituted by 1,8-cineole, α-pinene and linalool, decreased the production of the cytokines TNF-α and IL-6.”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [108]
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Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review
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- Authors
- Hammer, K. A., Carson, C. F., Dunstan, J. A., Hale, J., Lehmann, H., Robinson, C. J., Prescott, S. L., & Riley, T. V.
- Affiliations
- The University of Western Australia (AU)
- Pathwest Laboratory Medicine (AU)
- Corresponding author
- Hammer, Katherine A.
- Venue
- Microbiology and Immunology
- Publisher
- Wiley
- Published
- 2008-10-19
- Volume
- 52
- Issue
- 11
- Pages
- 522-530
- ISSN
- 0385-5600 (ISSN-L)
- 1348-0421
- OpenAlex
- W2029021037
- Cited by
- 27
- References
- 33
- Citations by year
- 2026: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 1 · 2013: 1 · 2012: 3
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Microbiology and Immunology (publishedVersion)
- PubMed (publishedVersion)
- Murdoch University Research Portal (submittedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Funders
- Rural Industries Research and Development Corporation
- Medical Research Council
- National Health and Medical Research Council
- Great Southern Development Commission, Government of Western Australia
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- essential oils, antimicrobial activity, anti-inflammatory activity, minimum inhibitory concentration, Staphylococcus aureus, inflammatory cytokines, interleukin-6, TNF-α, IL-10, Th1/Th2 cytokines, cytotoxicity, peripheral blood mononuclear cells, plant-derived antimicrobials
- MeSH terms
- Anti-Inflammatory Agents, Anti-Bacterial Agents, Cells, Cultured, Humans, Leukocytes, Mononuclear, Microbial Sensitivity Tests, Plant Oils, Staphylococcus aureus, Cytokines, Myrtaceae
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