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Cited by 19

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Effects of short‐term administration of growth hormone in healthy young men, women, and women taking oral contraceptives

Edén Engström, B., Burman, P., Johansson, A. G., Wide, L., Karlsson, F. A.·2000·Journal of Internal Medicine
DOI 10.1046/j.1365-2796.2000.00672.x
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Abstract

Abstract. Edén Engström B, Burman P, Johansson AG, Wide L, Karlsson FA (University Hospital, Uppsala, Sweden). Effects of short‐term administration of growth hormone in healthy young men, women, and women taking oral contraceptives. J Intern Med 2000; 247: 570–578. Objective. Effects of short‐term administration of growth hormone (GH) with respect to gender and oral contraceptives (OCs) were investigated in healthy young adults. Design. Open, prospective 2‐week study. Setting. Clinical research centre, university hospital. Subjects. Three groups of healthy young adults were included: six men, six women with normal menstrual cycles, and six women taking OCs. Interventions. The subjects were given recombinant human GH subcutaneously for 2 weeks: 1 U m–2 body surface daily during the first week, and 3 U m–2 daily during the second week. Main outcome measures. Serum samples were drawn in the morning after overnight fasting on days 0, 3, 7, 10 and 14, and were analysed for GH, insulin‐like growth factor 1 (IGF‐1), insulin, testosterone, sex hormone‐binding globulin (SHBG), lipids and markers of bone metabolism. Second‐void morning urine was analysed for deoxypyridinoline (Dpyr). Results. During administration of GH, serum IGF‐1 increased in the men and in the women without OCs (86 and 52%, respectively). In the OC women, IGF‐1 did not change significantly. Serum insulin increased in all three groups, with the largest change (122%) in the men and the smallest (47%) in the OC women. Blood glucose was unchanged. Total cholesterol, low‐density lipoprotein (LDL) cholesterol and the LDL/high‐density lipoprotein cholesterol ratio were reduced in the men only. Biochemical markers of bone resorption (serum procollagen type I, urinary Dpyr) increased in the men, and markers of bone formation (serum osteocalcin and telopeptide of collagen type I) increased in the men as well as in the women not taking OCs. The testosterone/SHBG ratio increased in the men on account of a reduction in SHBG. Conclusion. The response to short‐term administration of GH differed in the three groups, with the largest effect in the men and the smallest in the OC women. The inhibitory influence of contraceptives underlines the role of sex steroids in modulating the susceptibility to GH.

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Metadata

Authors
Edén Engström, B., Burman, P., Johansson, A. G., Wide, L., & Karlsson, F. A.
Venue
Journal of Internal Medicine
Publisher
Wiley
Published
2000-05
Volume
247
Issue
5
Pages
570-578
ISSN
  • 0954-6820
  • 1365-2796
DOI
10.1046/j.1365-2796.2000.00672.x
Cited by
19
References
5
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 603 d)

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CoChat. (2026). Citation check: Effects of short‐term administration of growth hormone in healthy young men, women, and women taking oral contraceptives. https://app.cochat.ai/papers/10.1046/j.1365-2796.2000.00672.x
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Edén Engström, B., Burman, P., Johansson, A. G., Wide, L., & Karlsson, F. A. (2000). Effects of short‐term administration of growth hormone in healthy young men, women, and women taking oral contraceptives. Journal of Internal Medicine. https://doi.org/10.1046/j.1365-2796.2000.00672.x

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