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Cited by 381

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Riluzole inhibits the persistent sodium current in mammalian CNS neurons

Urbani, Andrea, Belluzzi, Ottorino·2000·European Journal of Neuroscience
DOI 10.1046/j.1460-9568.2000.00242.x
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Abstract

The effects of 0.1–100 μ m riluzole, a neuroprotective agent with anticonvulsant properties, were studied on neurons from rat brain cortex. Patch‐clamp whole‐cell recordings in voltage‐clamp mode were performed on thin slices to examine the effects of the drug on a noninactivating (persistent) Na+ current (I Na,p). I Na,p was selected because it enhances neuronal excitability near firing threshold, which makes it a potential target for anticonvulsant drugs. When added to the external solution, riluzole dose‐dependently inhibited I Na,p up to a complete blocking of the current (EC 50 2 μ m), showing a significant effect at therapeutic drug concentrations. A comparative dose‐effect study was carried out in the same cells for the other main known action of riluzole, the inhibitory effect on the fast transient sodium current. This effect was confirmed in our experiments, but we found that it was achieved at levels much higher than putative therapeutic concentrations. Only the effect on I Na,p, and not that on fast sodium current, can account for the reduction in neuronal excitability observed in cortical neurons following riluzole treatment at therapeutic concentrations, and this might represent a novel mechanism accounting for the anticonvulsant and neuroprotective properties of riluzole.

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Metadata

Authors
Urbani, A., & Belluzzi, O.
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2000-10
Volume
12
Issue
10
Pages
3567-3574
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
DOI
10.1046/j.1460-9568.2000.00242.x
OpenAlex
W1983568884
Cited by
381
References
42
FWCI
1.69
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Riluzole inhibits the persistent sodium current in mammalian CNS neurons. https://app.cochat.ai/papers/10.1046/j.1460-9568.2000.00242.x
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Urbani, A., & Belluzzi, O. (2000). Riluzole inhibits the persistent sodium current in mammalian CNS neurons. European Journal of Neuroscience. https://doi.org/10.1046/j.1460-9568.2000.00242.x

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.