The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Effect of the overexpression of wild‐type or mutant α‐synuclein on cell susceptibility to insult
Open accessAbstract
Mutations in α‐synuclein (A30P and A53T) are involved in some cases of familial Parkinson's disease (FPD), but it is not known how they result in nigral cell death. We examined the effect of α‐synuclein overexpression on the response of cells to various insults. Wild‐type α‐synuclein and α‐synuclein mutations associated with FPD were overexpressed in NT‐2/D1 and SK‐N‐MC cells. Overexpression of wild‐type α‐synuclein delayed cell death induced by serum withdrawal or H 2 O 2, but did not delay cell death induced by 1‐methyl‐4‐phenylpyridinium ion (MPP+). By contrast, wild‐type α‐synuclein transfectants were sensitive to viability loss induced by staurosporine, lactacystin or 4‐hydroxy‐2‐trans‐nonenal (HNE). Decreases in glutathione (GSH) levels were attenuated by wild‐type α‐synuclein after serum deprivation, but were aggravated following lactacystin or staurosporine treatment. Mutant α‐synucleins increased levels of 8‐hydroxyguanine, protein carbonyls, lipid peroxidation and 3‐nitrotyrosine, and markedly accelerated cell death in response to all the insults examined. The decrease in GSH levels was enhanced in mutant α‐synuclein transfectants. The loss of viability induced by toxic insults was by apoptosic mechanism. The presence of abnormal α‐synucleins in substantia nigra in PD may increase neuronal vulnerability to a range of toxic agents.
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Cites
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240
AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease
Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998) · Nature Genetics · doi:10.1038/ng0298-106 · Cited by 3,836
Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.
Yoritaka, A., Hattori, N., Uchida, K., Tanaka, M., Stadtman, E. R., & Mizuno, Y. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.2696 · Cited by 981
Alam, Z. I., Jenner, A., Daniel, S. E., Lees, A. J., Cairns, N., Marsden, C. D., Jenner, P., & Halliwell, B. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69031196.x · Cited by 845
Self-citationLyras, L., Cairns, N. J., Jenner, A., Jenner, P., & Halliwell, B. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68052061.x · Cited by 531 · cited 1×
“DNA extraction and assessment of purity were carried out as described by Lyras et al. (1997).”
MethodSelf-citationWhat nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo?
Halliwell, B. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00469-9 · Cited by 472
Self-citationDegradation of α-Synuclein by Proteasome
Bennett, M. C., Bishop, J. F., Leng, Y., Chock, P. B., Chase, T. N., & Mouradian, M. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.33855 · Cited by 417
Cited by
Oxidative stress in Parkinson's disease
Jenner, P. (2003) · Annals of Neurology · doi:10.1002/ana.10483 · Cited by 2,053
Self-citationThe Ubiquitin Proteasome System in Neurodegenerative Diseases
Ciechanover, A., & Brundin, P. (2003) · Neuron · doi:10.1016/s0896-6273(03)00606-8 · Cited by 982
Oxidative Stress and Neurotoxicity
Sayre, L. M., Perry, G., & Smith, M. A. (2008) · Chemical Research in Toxicology · doi:10.1021/tx700210j · Cited by 867
Failure of the ubiquitin-proteasome system in Parkinson’s disease
McNaught, K. S. P., Olanow, C. W., Halliwell, B., Isacson, O., & Jenner, P. (2001) · Nature Reviews Neuroscience · doi:10.1038/35086067 · Cited by 519
Self-citationAsanuma, M., Miyazaki, I., & Ogawa, N. (2003) · Neurotoxicity Research · doi:10.1007/bf03033137 · Cited by 516
Metadata
- Authors
- Lee, M., Hyun, D., Halliwell, B., & Jenner, P.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2001-02
- Volume
- 76
- Issue
- 4
- Pages
- 998-1009
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1557235501
- Cited by
- 232
- References
- 7
- FWCI
- 19.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lee, M., Hyun, D., Halliwell, B., & Jenner, P. (2001). Effect of the overexpression of wild‐type or mutant α‐synuclein on cell susceptibility to insult. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.2001.00149.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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