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Cited by 402Iron Metabolism and DisordersNeurological diseases and metabolismParkinson's Disease Mechanisms and Treatments

The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.

Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

Zecca, Luigi, Gallorini, Mario, Schünemann, Volker, Trautwein, Alfred X., Gerlach, Manfred, Riederer, Peter, Vezzoni, Paolo, Tampellini, Davide·2001·Journal of Neurochemistry
DOI 10.1046/j.1471-4159.2001.00186.x
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Abstract

Information on the molecular distribution and ageing trend of brain iron in post-mortem material from normal subjects is scarce. Because it is known that neuromelanin and ferritin form stable complexes with iron(III), in this study we measured the concentration of iron, ferritin and neuromelanin in substantia nigra from normal subjects, aged between 1 and 90 years, dissected post mortem. Iron levels in substantia nigra were 20 ng/mg in the first year of life, had increased to 200 ng/mg by the fourth decade and remained stable until 90 years of age. The H-ferritin concentration was also very low (29 ng/mg) during the first year of life but increased rapidly to values of approximately 200 ng/mg at 20 years of age, which then remained constant until the eighth decade of life. L-Ferritin also showed an increasing trend during life although the concentrations were approximately 50% less than that of H-ferritin at each age point. Neuromelanin was not detectable during the first year, increased to approximately 1000 ng/mg in the second decade and then increased continuously to 3500 ng/mg in the 80th year. A Mössbauer study revealed that the high-spin trivalent iron is probably arranged in a ferritin-like iron--oxyhydroxide cluster form in the substantia nigra. Based on this data and on the low H- and L-ferritin content in neurones it is concluded that neuromelanin is the major iron storage in substantia nigra neurones in normal individuals.

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Crossref · 10.1046/j.1471-4159.2001.00186.x

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Research works printed but not linked: 2

  1. Moos T., 2000, Absence of ferritin protein in substantia nigra pars compacta neurons. A reappraisal to the role of iron in Parkinson disease pathogenesis, Mov. Disord., 15, 319A
  2. Zareba M., 1995, The effect of synthetic neuromelanin on yeld of free hydroxyl radicals generated in model system, Biochim. Biophys. Acta, 1138, 6

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Metadata

Authors
Zecca, L., Gallorini, M., Schünemann, V., Trautwein, A. X., Gerlach, M., Riederer, P., Vezzoni, P., & Tampellini, D.
Affiliations
  • Institute of Biomedical Technologies (IT)
  • University of Pavia (IT)
  • University of Lübeck (DE)
  • University of Würzburg (DE)
ORCID
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
2001-03-15
Volume
76
Issue
6
Pages
1766-1773
ISSN
  • 0022-3042 (ISSN-L)
  • 1471-4159
DOI
10.1046/j.1471-4159.2001.00186.x
OpenAlex
W1601438958
Cited by
401
References
61
Citations by year
2026: 7 · 2025: 16 · 2024: 11 · 2023: 13 · 2022: 19 · 2021: 25 · 2020: 13 · 2019: 20 · 2018: 23 · 2017: 18 · 2016: 19 · 2015: 10 · 2014: 14 · 2013: 17 · 2012: 14
FWCI
8.21
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 280 d)
Locations
  • Journal of Neurochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft
  • Fondazione Cariplo
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
brain iron, substantia nigra, neuromelanin, ferritin, iron storage, aging, neurodegeneration, high-spin iron, postmortem brain
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Aging, Child, Child, Preschool, Ferritins, Humans, Infant, Iron, Melanins, Middle Aged, Nerve Degeneration, Reference Values, Substantia Nigra

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