Cited by 233Skin Protection and AgingGenetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

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Fifty Years of Skin Aging

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Yaar, Mina, Eller, Mark S., Gilchrest, Barbara A.·2002·Journal of Investigative Dermatology Symposium Proceedings

DOI 10.1046/j.1523-1747.2002.19636.x

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Abstract

In developed countries, interest in cutaneous aging is in large part the result of a progressive, dramatic rise over the past century in the absolute number and the proportion of the population who are elderly (Smith et al, 2001). The psychosocial as well as physiologic effects of skin aging on older individuals have created a demand for better understanding of the process and particularly for effective interventions. Skin aging is a complex process determined by the genetic endowment of the individual as well as by environmental factors. The appearance of old skin and the clinical consequences of skin aging have been well known for centuries, but only in the past 50 y have mechanisms and mediators been systematically pursued. Still, within this relatively short time there has been tremendous progress, a progress greatly enhanced by basic gerontologic research employing immunologic, biochemical, and particularly molecular biologic approaches (Figs 1, 2).

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Background
Clinical and histologic findings after use of a novel combined retinol, tripeptide, and glaucine containing cream in the treatment of photo‐aged skin
Rao, S., & Goldberg, D. J. (2023) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.15945 · Cited by 4
Aging skin and non-surgical procedures: a basic science overview
Vandiver, A. R., & Hogan, S. R. (2020) · Plastic and Aesthetic Research · doi:10.20517/2347-9264.2020.159 · Cited by 9
“Skin aging is associated with extensive changes in the structure and function of all aspects of the skin and serves as a major risk factor for multiple pathologies including atopy, impaired wound healing, infection and malignancy([1-5]).”
Background
The Use of Reconstructed Skin to Create New In Vitro Models of Skin Aging with Special Emphasis on the Flexibility of Reconstructed Skin
Asselineau, D., Ricois, S., Pageon, H., Zucchi, H., Mine, S., Girardeau‐Hubert, S., Nallet, F., Teluob, S., & Claviez-Homberg, G. (2009) · Springer eBooks · doi:10.1007/978-3-540-89656-2_48 · Cited by 4
Skin Aging: An Immunohistochemical Evaluation
El-Domyati, M. M., & Medhat, W. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_121-1 · Cited by 3
Open-Label Study to Evaluate the Efficacy of a Topical Anhydrous Formulation with 15% Pure Ascorbic Acid and Ginger as a Potent Antioxidant
Martínez-Valverde, T., Crespo, N., & Suñer, E. (2022) · Cosmetics · doi:10.3390/cosmetics9040074 · Cited by 3
“Clinical signs of photoaging include wrinkles, mottled pigmentation (hypo- or hyperpigmentation), rough skin, loss of skin tone, dryness, sallowness, deep furrows, severe atrophy, telangiectasias, laxity, leathery appearance, solar elastosis, actinic purpura, precancerous lesions, skin cancer, and melanoma [14,15].”
Background
Effectiveness of acupuncture therapy on improvement of nasolabial folds and marionette lines: A retrospective study
Cheng, H., Xie, L., Wang, T., & Shi, B. (2024) · Health Science Reports · doi:10.1002/hsr2.70014 · Cited by 3
A variety of processes that affect the perception of skin aging
Kasprzak, D., & Wnorowski, A. (2019) · Current Issues in Pharmacy and Medical Sciences · doi:10.2478/cipms-2019-0027 · Cited by 3
Skin Aging: A Brief Summary of Characteristic Changes
Wiegand, C., Raschke, C., & Elsner, P. U. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_5-2 · Cited by 3
The molecular basis of cutaneous aging
Reddy, K. K., & Gilchrest, B. A. (2011) · Expert Review of Dermatology · doi:10.1586/edm.11.48 · Cited by 3
Clarifying the Vitamin D Controversy: The Health Benefits of Supplementation by Diet Versus Sunshine
Wolpowitz, D., & Gilchrest, B. A. (2006) · Springer eBooks · doi:10.1007/3-540-32953-6_8 · Cited by 3
Transcriptomic and epigenetic assessment of ageing female skin and fibroblasts identifies age related reduced oxidative phosphorylation is exacerbated by smokingPreprint
Pease, L. I., Wordsworth, J., & Shanley, D. P. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.16.504111 · Cited by 3
Biophysical and biological effects from infrared Low-Level-Laser-Therapy
Joensen, J. (2013) · NORA - Norwegian Open Research Archives · Cited by 3
Photoaging in skin of color
Bennett, M. F., & Cooper, K. D. (2009) · Light-Based Therapies for Skin of Color · doi:10.1007/978-1-84882-328-0_2 · Cited by 2
Design and evaluation of complex plant extract-loaded dissolving microneedle for improving periocular wrinkles
Xu, B., Chen, J., Gao, Y., Fan, N., & Zhang, S. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107355 · Cited by 2
Seed Oils in Treatment of Skin Aging and Photoaging
Kothapalli, L., Raut, V., & Thomas, A. B. (2023) · Current Cosmetic Science · doi:10.2174/2666779702666230125142357 · Cited by 2
SPRY1 regulates macrophage M1 polarization in skin aging and melanoma prognosis
Zhao, R., Zhang, X., Geng, Y., Lu, D., Wang, Y., Xie, H., Zhang, X., Xu, S., & Cao, Y. (2025) · Translational Oncology · doi:10.1016/j.tranon.2025.102331 · Cited by 2
“In summary, skin aging is a complex biological process involving cellular damage accumulation, environmental influences, cell cycle arrest, chronic inflammation, and down-regulation of growth-controlling transcription factors [45,46].”
Avoiding the Hazards of Ultraviolet Light in the Adolescent Population
Auchus, A. P., Brodell, R. T., Nahar, V. K., & Ward, K. H. M. (2020) · SKIN The Journal of Cutaneous Medicine · doi:10.25251/skin.4.3.1 · Cited by 2
Protective Effects of Forsythiaside A, Forsythiaside B, and Phillyrin against UVA-Induced Cell Damage
Jin, F., Zhao, H., Yuan, X. L., Wu, Z.-Y., Wang, Q.-L., Ma, C., Ren, Z., & Wang, Y. (2014) · Journal of Food and Nutrition Research · doi:10.12691/jfnr-2-9-10 · Cited by 2
“Skin aging is characterized as either intrinsic or extrinsic aging senescence, with the latter mainly due to environmental factors like UV radiation, smoking, wind, sun, harmful chemicals [2,3].”
Background
Skin Aging: An Immunohistochemical Evaluation
El-Domyati, M. M., & Medhat, W. (2016) · Springer eBooks · doi:10.1007/978-3-662-47398-6_121 · Cited by 2
Air Pollution and the Skin Health
Neto, A. H. P., Leite, L. L., de Rossi, S. D., & Bonamigo, R. R. (2023) · Springer eBooks · doi:10.1007/978-3-031-13505-7_37 · Cited by 1
Skin photoprotection and nutraceuticals: an overview
Morganti, P. (2012) · Human health handbooks · doi:10.3920/978-90-8686-729-5_13 · Cited by 1
“, 2002; Urbach, 2001) Aging is associated, in fact, with progressive skin changes that are strongly influenced by environmental factors, as life-time UV exposure, smoking, life-style, and genetic factors (Kaminer, 1995; Kennedy et al., 2003; Makratonaki, 2010: Reylye et al., 2006; Yaar et al., 2002; Yaar and Gilchrest…”
Background
Immunohistochemical and light and electron microscopic study of the basement membrane in photoaged skin
Deif, E. A., EL‐SHIEMY, S., Lotfi, R. A., & Mohammed, G. F. (2014) · The Egyptian Journal of Histology · doi:10.1097/01.ehx.0000452034.51095.b1 · Cited by 1
Opinions regarding skin ageing in the elderly inhabitants of Bialystok, Poland
Cybulski, M., & Krajewska-Kułak, E. (2016) · PeerJ · doi:10.7717/peerj.2028 · Cited by 1
Aging Challenges. Perceived Age – a New Predictor of Longevity?
Shalnova, S. A., Imaeva, N. A., Имаева, А. Э., & Владимировна, К. А. (2022) · Rational Pharmacotherapy in Cardiology · doi:10.20996/1819-6446-2022-02-06 · Cited by 2
Cutaneous Aging
Scharffetter‐Kochanek, K., & Wlaschek, M. (2009) · Springer eBooks · doi:10.1007/978-3-540-29316-3_78 · Cited by 1
Photoaging
Mokashi, A. A., & Scheinfeld, N. S. (2008) · Springer eBooks · doi:10.1007/978-1-84628-678-0_3 · Cited by 1
Skin microvasculature determined using OCT angiography: first evidence of its relation with aging
Patiño, C. P. B., de Oliveira, L. O., Mattos, V. S., Stringasci, M. D., Requena, M. B., & Bagnato, V. S. (2023) · Laser Physics Letters · doi:10.1088/1612-202x/acb1ac · Cited by 1
“Men take less care of their skin than women, and this can result in greater risks [33–37].”
Aging of Scalp and Age-Related Disorders of Scalp
Gan, D., & Sinclair, R. D. (2010) · Springer eBooks · doi:10.1007/978-3-642-02636-2_16 · Cited by 1
フルボ酸とアンチエイジング ― 線維芽細胞，MMP へのフルボ酸の効果 ―
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Novel anti-aging composition for topical skin care
Wawrzyniak, D., Celewicz, L., & Barciszewski, J. (2016) · Biotechnologia · doi:10.5114/bta.2016.57720 · Cited by 1
“Chronologic skin aging, in contrast, is characterized by laxity and fine wrinkling, as well as development of benign growth such as seborrheic keratoses and angiomas, but it is not associated with increased pigmentation or deep wrinkles that characterize photoaging (Yaar et al. 2002).”
Background
EVALUATION OF BIOLOGICAL ACTIVITIES AND STABILITY OF THAI ORGANIC RICEBERRY BROKEN RICE EXTRACTS FOR THE ANTI-AGING COSMETOLOGY
Poomanee, W., Doungsaard, P., NANTHARAT, N., & Leelapornpisid, P. (2021) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2021.v13s1.y0027 · Cited by 1
“By virtue of ROS, oxidative stress, lipid peroxidation, inflammation, and DNAbase alteration are potentiated, which eventually generates several skin aging signs [16].”
Background
Rhitidoplasty with Fat Grafting and Platelet-Rich Plasma on Every Face
Leão, C. F., Leão, C. C. N., Filho, G. A. G., Felipe, J., & Rocha, R. (2021) · Springer eBooks · doi:10.1007/978-3-030-57973-9_41 · Cited by 1
Non-ablative Lasers for Photorejuvenation
Angelo-Khattar, M. (2017) · Clinical approaches and procedures in cosmetic dermatology · doi:10.1007/978-3-319-20251-8_5-2 · Cited by 1
Nutri Complex 150+: a new and effective approach to facial rejuvenationPreprint
Privitera, A., Ferruggia, G., Contino, M., Maugeri, S., Zimbone, M., Cardile, V., Caruso, G., & Brundo, M. V. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.05.616805 · Cited by 1
“…protein molecules that significantly support the repair of damaged skin, as a result of aging, and several studies, over the past 15 years, have highlighted the potential benefits of growth factors, showing improvements in the appearance of wrinkles, texture, fine lines and discoloration [25-29].”
Background

Authors: Yaar, M., Eller, M. S., & Gilchrest, B. A.
Affiliations: Boston University (US)
Corresponding author: Gilchrest, Barbara A.
ORCID: Gilchrest, Barbara A.
Venue: Journal of Investigative Dermatology Symposium Proceedings
Publisher: Elsevier BV
Published: 2002-12
Volume: 7
Issue: 1
Pages: 51-58
ISSN: 1087-0024 (ISSN-L)
DOI: 10.1046/j.1523-1747.2002.19636.x
OpenAlex: W2000936610
Cited by: 233
References: 132
Citations by year: 2026: 5 · 2025: 5 · 2024: 8 · 2023: 14 · 2022: 10 · 2021: 11 · 2020: 15 · 2019: 17 · 2018: 12 · 2017: 14 · 2016: 27 · 2015: 10 · 2014: 11 · 2013: 8 · 2012: 10
FWCI: 21.57
Type: conference paper
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4748 d)
Locations: Journal of Investigative Dermatology Symposium Proceedings (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Keywords: skin aging, aging mechanisms, genetic factors, environmental factors, older adults, aging interventions
MeSH terms: Animals, Dermatology, Humans, Skin Physiological Phenomena, Skin Aging, Gene Expression, Telomere, Oxidative Stress

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Fifty Years of Skin Aging

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