Cited by 233Skin Protection and AgingGenetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

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Fifty Years of Skin Aging

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Yaar, Mina, Eller, Mark S., Gilchrest, Barbara A.·2002·Journal of Investigative Dermatology Symposium Proceedings

DOI 10.1046/j.1523-1747.2002.19636.x

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Abstract

In developed countries, interest in cutaneous aging is in large part the result of a progressive, dramatic rise over the past century in the absolute number and the proportion of the population who are elderly (Smith et al, 2001). The psychosocial as well as physiologic effects of skin aging on older individuals have created a demand for better understanding of the process and particularly for effective interventions. Skin aging is a complex process determined by the genetic endowment of the individual as well as by environmental factors. The appearance of old skin and the clinical consequences of skin aging have been well known for centuries, but only in the past 50 y have mechanisms and mediators been systematically pursued. Still, within this relatively short time there has been tremendous progress, a progress greatly enhanced by basic gerontologic research employing immunologic, biochemical, and particularly molecular biologic approaches (Figs 1, 2).

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Photoaging and the clinical utility of fractional laser
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“As the DNA polymerase cannot transcribe the final sequence of these bases in the DNA strand during replication, the telomeric size is reduced by each mitosis.(46) This reduction of telomere would be then associated with cell aging and with the finite lifetime described by Hayflick.”
Background
Assessing the impact of aging and blood pressure on dermal microvasculature by reactive hyperemia optical coherence tomography angiography
Evers, M., Casper, M. J., Glahn, J. Z., Luo, T., Doyle, A. E., Karasik, D., Kim, A. C., Phothong, W., Nathan, N. R., Heesakker, T., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-92712-z · Cited by 27
Histopathology of Cutaneous Aging
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Synthesis and characterization of new 4H-chromene-3-carboxylates ensuring potent elastase inhibition activity along with their molecular docking and chemoinformatics properties
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Supplementation with a complex of active nutrients improved dermal and epidermal characteristics in skin equivalents generated from fibroblasts from young or aged donors
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Relation of Redox and Structural Alterations of Rat Skin in the Function of Chronological Aging
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AQP5 regulates the proliferation and differentiation of epidermal stem cells in skin aging
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Low molecular polypeptide from oyster hydrolysate recovers photoaging in SKH-1 hairless mice
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“Both intrinsic and extrinsic factors play a major role in this degenerative process resulting in inevitable loss of elasticity, roughness, laxity, sagging, and wrinkle development.(21) Natural biologic aging includes programmed senescence of dermal fibroblasts and epidermal keratinocytes that cause a decreased renewal…”
Background
Dermal Fibroblast SLC3A2 Deficiency Leads to Premature Aging and Loss of Epithelial Homeostasis
Tissot, F. S., Estrach, S., Boulter, E., Cailleteau, L., Tosello, L., Seguin, L., Pisano, S., Audebert, S., Croce, O., & Féral, C. C. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.05.026 · Cited by 26
“INTRODUCTION Intrinsic and extrinsic human skin aging involves a number of changes, such as reduced epidermal proliferation, impaired melanocyte functions, and decreased extracellular matrix (ECM) component biosynthesis, such as collagen types (McCullough and Kelly, 2006; Yaar et al., 2002).”
Background
Effects of oral administration of collagen peptides on skin collagen content and its underlying mechanism using a newly developed low collagen skin mice model
Haratake, A., Watase, D., Fujita, T., Setoguchi, S., Matsunaga, K., & Takata, J. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.04.017 · Cited by 23
Multifunctional biological properties and phytochemical constituents of Mangifera indica L. seed kernel extract for preventing skin aging
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Photodamage to the cutaneous sensory nerves: role in photoaging and carcinogenesis of the skin?
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Potential application of Spirulina in dermatology
Ikeda, I. K., Sydney, E. B., & Sydney, A. C. N. (2022) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.14997 · Cited by 22
Upregulation of Skin-Aging Biomarkers in Aged NHDF Cells by a Sucrose Ester Extract from the Agroindustrial Waste of Physalis peruviana Calyces
Cicchetti, E., Duroure, L., Borgne, E. L., & Laville, R. (2018) · Journal of Natural Products · doi:10.1021/acs.jnatprod.7b01069 · Cited by 22
Burns in the Elderly: Potential Role of Stem Cells
Elloso, M. S., Kambli, A., Aijaz, A., van de Kamp, A., & Jeschke, M. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134604 · Cited by 23
“Moreover, dermal vascularity is diminished, resulting in reduced blood flow, impaired nutrient exchange and impaired thermoregulation [39,40].”
Background
Augmented Therapeutic Efficacy of Naringenin Through Microemulsion-Loaded Sericin Gel Against UVB-Induced Photoaging
Parashar, P., Pal, S., Dwivedi, M., & Saraf, S. A. (2020) · AAPS PharmSciTech · doi:10.1208/s12249-020-01766-1 · Cited by 22
“Loss of the skin tone, dryness, deep furrows, wrinkles, spotted pigmentation (hypo or hyperpigmentation), telangiectasias, rough skin, sallowness leathery appearance, solar elastosis, actinic purpura, precancerous lesions, skin cancer and melanoma are some of the noteworthy consequences of photoaging which need medica…”
Background
In vivo evaluation of novel particle‐free polycaprolactone fillers for safety, degradation, and neocollagenesis in a rat model
Hong, J. Y., Kim, J. H., Kwon, T., Hong, J. K., Li, K., & Kim, B. J. (2021) · Dermatologic Therapy · doi:10.1111/dth.14770 · Cited by 22
Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure
Pambianchi, E., Ferrara, F., Pecorelli, A., Benedusi, M., Choudhary, H., Therrien, J., & Valacchi, G. (2021) · Antioxidants · doi:10.3390/antiox10121928 · Cited by 22
Skin Aging in Long-Lived Naked Mole-Rats Is Accompanied by Increased Expression of Longevity-Associated and Tumor Suppressor Genes
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Similar appearance, different mechanisms: xerosis in HIV , atopic dermatitis and ageing
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Skin Aging: A Brief Summary of Characteristic Changes
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Synthesis and structure-activity relationship of elastase inhibiting novel ethylated thiazole-triazole acetamide hybrids: Mechanistic insights through kinetics and computational contemplations
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A Correlation of the Glogau Scale With VISIA-CR Complexion Analysis Measurements in Assessing Facial Photoaging for Clinical Research
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Protective effects of fermented honeybush (Cyclopia intermedia) extract (HU-018) against skin aging: a randomized, double-blinded, placebo-controlled study
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“PRIMOS lite images of the left crow’s feet of representative subjects in the (A) control, (B) low-dose, and (C) high-dose groups at (1) baseline, (2) 4 weeks, (3) 8 weeks, and (4) 12 weeks.”
Background
Role of Mitochondrial Dynamics in Skin Homeostasis: An Update
Quan, T., Li, R., & Gao, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051803 · Cited by 23
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Total Defense + Repair: A Novel Concept in Solar Protection and Skin Rejuvenation.
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Authors: Yaar, M., Eller, M. S., & Gilchrest, B. A.
Affiliations: Boston University (US)
Corresponding author: Gilchrest, Barbara A.
ORCID: Gilchrest, Barbara A.
Venue: Journal of Investigative Dermatology Symposium Proceedings
Publisher: Elsevier BV
Published: 2002-12
Volume: 7
Issue: 1
Pages: 51-58
ISSN: 1087-0024 (ISSN-L)
DOI: 10.1046/j.1523-1747.2002.19636.x
OpenAlex: W2000936610
Cited by: 233
References: 132
Citations by year: 2026: 5 · 2025: 5 · 2024: 8 · 2023: 14 · 2022: 10 · 2021: 11 · 2020: 15 · 2019: 17 · 2018: 12 · 2017: 14 · 2016: 27 · 2015: 10 · 2014: 11 · 2013: 8 · 2012: 10
FWCI: 21.57
Type: conference paper
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4748 d)
Locations: Journal of Investigative Dermatology Symposium Proceedings (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Keywords: skin aging, aging mechanisms, genetic factors, environmental factors, older adults, aging interventions
MeSH terms: Animals, Dermatology, Humans, Skin Physiological Phenomena, Skin Aging, Gene Expression, Telomere, Oxidative Stress

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Fifty Years of Skin Aging

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