Cited by 233Skin Protection and AgingGenetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

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Fifty Years of Skin Aging

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Yaar, Mina, Eller, Mark S., Gilchrest, Barbara A.·2002·Journal of Investigative Dermatology Symposium Proceedings

DOI 10.1046/j.1523-1747.2002.19636.x

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Abstract

In developed countries, interest in cutaneous aging is in large part the result of a progressive, dramatic rise over the past century in the absolute number and the proportion of the population who are elderly (Smith et al, 2001). The psychosocial as well as physiologic effects of skin aging on older individuals have created a demand for better understanding of the process and particularly for effective interventions. Skin aging is a complex process determined by the genetic endowment of the individual as well as by environmental factors. The appearance of old skin and the clinical consequences of skin aging have been well known for centuries, but only in the past 50 y have mechanisms and mediators been systematically pursued. Still, within this relatively short time there has been tremendous progress, a progress greatly enhanced by basic gerontologic research employing immunologic, biochemical, and particularly molecular biologic approaches (Figs 1, 2).

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Authors: Yaar, M., Eller, M. S., & Gilchrest, B. A.
Affiliations: Boston University (US)
Corresponding author: Gilchrest, Barbara A.
ORCID: Gilchrest, Barbara A.
Venue: Journal of Investigative Dermatology Symposium Proceedings
Publisher: Elsevier BV
Published: 2002-12
Volume: 7
Issue: 1
Pages: 51-58
ISSN: 1087-0024 (ISSN-L)
DOI: 10.1046/j.1523-1747.2002.19636.x
OpenAlex: W2000936610
Cited by: 233
References: 132
Citations by year: 2026: 5 · 2025: 5 · 2024: 8 · 2023: 14 · 2022: 10 · 2021: 11 · 2020: 15 · 2019: 17 · 2018: 12 · 2017: 14 · 2016: 27 · 2015: 10 · 2014: 11 · 2013: 8 · 2012: 10
FWCI: 21.57
Type: conference paper
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4748 d)
Locations: Journal of Investigative Dermatology Symposium Proceedings (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Keywords: skin aging, aging mechanisms, genetic factors, environmental factors, older adults, aging interventions
MeSH terms: Animals, Dermatology, Humans, Skin Physiological Phenomena, Skin Aging, Gene Expression, Telomere, Oxidative Stress

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Fifty Years of Skin Aging

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