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Cited by 156Cancer survivorship and careSleep and related disordersSleep and Work-Related Fatigue

Sleep Disturbances in Women With Metastatic Breast Cancer

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Koopman, Cheryl, Nouriani, Bita, Erickson, Vanessa, Anupindi, Renu, Butler, Lisa D., Bachmann, Michael H., Sephton, Sandra E., Spiegel, David·2002·The Breast Journal
DOI 10.1046/j.1524-4741.2002.08606.x
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Abstract

We examined sleeping problems in women with metastatic breast cancer in relation to depression, social support, and salivary cortisol. Ninety-seven women with metastatic breast cancer were drawn from a larger study on the effects of group therapy on quality of life and survival. This study is based on the baseline assessments conducted prior to randomization into treatment conditions. Sleep, depression symptoms, and social support were assessed by self-reporting. Cortisol was assessed from saliva samples taken over a 3-day period. Medical status and demographic characteristics were also examined in relation to each sleep variable in multiple regression analysis. Most women (63%) reported one or more types of sleep disturbance and 37% reported using sleeping pills in the previous 30 days. Problems with falling to sleep were significantly related to greater pain and depressive symptoms. Problems of waking during the night were significantly associated with greater depression and less education. Problems in waking/getting up were significantly associated with greater depressive symptoms and less social support. Sleepiness during the day was not significantly related to the variables in the regression model. Fewer hours of sleep were significantly associated with metastases to the bone, higher depressive symptoms, and more social support. Women who reported sleeping 9 or more hours per night, compared to those who reported a moderate amount of sleep (6.5-8.5 hours), had significantly lower 9 p.m. cortisol levels. Use of sleeping pills was more frequent among women reporting greater pain and depressive symptoms. These results suggest that women with metastatic breast cancer who are at higher risk for having sleeping problems are those who are less educated, in pain, depressed, have bony metastases, or lack social support.

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  • The most prevalent, persistent, and disabling symptoms in MBC patients include pain, fatigue, sleep disturbance, depression, and anxiety.

    “The most prevalent, persistent, and disabling symptoms in MBC patients include pain, fatigue, sleep disturbance, depression, and anxiety [2,9–12].”

    From Acceptance and commitment therapy for symptom interference in metastatic breast cancer patients: a pilot randomized trial (2018) · cites this paper as [11]

    The Discussion reports sleep disturbance in 63% of the women with metastatic breast cancer and clinically significant depressive symptoms in 30%; it also discusses pain. Fatigue is mentioned but was not assessed, and the paper does not establish anxiety—or the five symptoms collectively—as the most prevalent, persistent, and disabling symptoms in this population. Page numbers are unavailable in our copy. (LLM, conf=0.86)

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  • Common symptoms in metastatic breast cancer patients include depression, anxiety, sleep disturbance, pain, and fatigue.

    “Common symptoms in this population include depression, anxiety, sleep disturbance, pain, and fatigue [6–10].”

    From Symptom experiences in metastatic breast cancer patients: relationships to activity engagement, value-based living, and psychological inflexibility (2017) · cites this paper as [9]

    The Discussion reports sleep disturbance in 63% of the women studied, depressive symptoms in 30%, and pain among factors affecting them. The paper discusses fatigue in relation to cancer and sleep but says it was not assessed in this study; it does not establish anxiety as a common symptom in this population. Page numbers are unavailable in our copy. (LLM, conf=0.88)

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Research works printed but not linked: 1

  1. [16]16. Portenoy RK, Miransky J, Thaler HT, et al. Pain in ambulatory patients with lung or colon cancer. Cancer 1992;70:1616±24.

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Authors
Koopman, C., Nouriani, B., Erickson, V., Anupindi, R., Butler, L. D., Bachmann, M. H., Sephton, S. E., & Spiegel, D.
Affiliations
  • Stanford Medicine (US)
  • University of Michigan (US)
  • University of Louisville (US)
Corresponding author
Koopman, Cheryl
ORCID
Venue
The Breast Journal
Publisher
Hindawi Limited
Published
2002-11
Volume
8
Issue
6
Pages
362-370
ISSN
  • 1075-122X (ISSN-L)
  • 1524-4741
DOI
10.1046/j.1524-4741.2002.08606.x
OpenAlex
W1975805640
Cited by
156
References
32
Citations by year
2026: 1 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 2 · 2021: 3 · 2020: 11 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 10 · 2015: 4 · 2014: 5 · 2013: 14 · 2012: 16
FWCI
1.92
Type
journal article
Language
en
Open access
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 4687 d)
Locations
  • The Breast Journal (publishedVersion)
  • PubMed (publishedVersion)
  • Deep Blue (University of Michigan) (submittedVersion)
Funders
  • John D. and Catherine T. MacArthur Foundation
  • Fetzer Institute
  • National Institute of Mental Health (MH47226, R01MH047226)
  • National Cancer Institute
Topics
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
sleep disorders, metastatic breast cancer, depression, social support, salivary cortisol, pain, hypnotics, bone metastasis, sleep duration, educational attainment, women
MeSH terms
Adult, Aged, Aged, 80 and over, Analysis of Variance, Bone Neoplasms, Breast Neoplasms, Depression, Educational Status, Female, Health Status, Humans, Hydrocortisone, Sleep Initiation and Maintenance Disorders, Middle Aged, Pain, Quality of Life, Surveys and Questionnaires, Risk Factors, Saliva, Sleep Wake Disorders, Social Support, Stress, Psychological, Randomized Controlled Trials as Topic

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