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La fonction sécrétrice du tissu adipeux : implication dans les complications métaboliques et cardiovasculaires de l'obésité
Open accessAbstract
The adipose tissue exerts a double function that is crucial for energy homeostasis. On the one hand, it is the only organ suited to stock triglycerides in highly specialized cells, the adipocytes. On the other hand, the adipose tissue produces biologically active molecules, collectively named "adipokines", which have been implicated in energy balance and glucose and lipid metabolism. Both adipocytes and cells of the stromal fraction participate in this function of secretion. The adipokines acts locally, in an autocrine or paracrine manner, and distantly (endocrine), on various targets, including muscles, the liver and the hypothalamus. Some adipokines, as TNFalpha and IL6, promote insulin resistance and inflammation, whereas others, as leptin and adiponectin, are required for energy and glucose homeostasis. In obesity, adipose cell hypertrophy and the recruitment of macrophages alter the secretory function and induce an inflammatory profile in the adipose tissue. Analyses of gene expression suggest that hypoxia is one of the factors favoring the attraction of the macrophages. The local and systemic consequences of interactions between macrophages and adipocytes are currently actively studied, to understand their potential implication in the metabolic and cardiovascular complications associated with obesity.
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Measures of endothelial activation improve after weight reduction.
“Measures of endothelial activation also improve after weight reduction (108 -110) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [108]
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Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Metadata
- Authors
- Guerre-Millo, M.
- Affiliations
- Inserm (FR)
- Corresponding author
- Guerre-Millo, Michèle
- Venue
- Journal de la Société de Biologie
- Publisher
- EDP Sciences
- Published
- 2006
- Volume
- 200
- Issue
- 1
- Pages
- 37-43
- ISSN
- 1295-0661 (ISSN-L)
- OpenAlex
- W2024249911
- Cited by
- 16
- References
- 50
- Citations by year
- 2025: 1 · 2022: 1 · 2017: 1 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 0.49
- Type
- journal article
- Language
- fr
- Open access
- bronze
- doi.org
- Locations
- Journal de la Société de Biologie (publishedVersion)
- PubMed (publishedVersion)
- Springer Link (Chiba Institute of Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipokines, obesity, insulin resistance, inflammation, leptin, adiponectin, TNF-α, interleukin-6, adipocyte hypertrophy, macrophage recruitment, hypoxia, energy homeostasis, glucose metabolism, lipid metabolism, cardiovascular complications, metabolic complications
- MeSH terms
- Adipose Tissue, Cardiovascular Diseases, Humans, Macrophages, Models, Biological, Obesity, Leptin
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