La fonction sécrétrice du tissu adipeux : implication dans les complications métaboliques et cardiovasculaires de l'obésité
Open accessAbstract
The adipose tissue exerts a double function that is crucial for energy homeostasis. On the one hand, it is the only organ suited to stock triglycerides in highly specialized cells, the adipocytes. On the other hand, the adipose tissue produces biologically active molecules, collectively named "adipokines", which have been implicated in energy balance and glucose and lipid metabolism. Both adipocytes and cells of the stromal fraction participate in this function of secretion. The adipokines acts locally, in an autocrine or paracrine manner, and distantly (endocrine), on various targets, including muscles, the liver and the hypothalamus. Some adipokines, as TNFalpha and IL6, promote insulin resistance and inflammation, whereas others, as leptin and adiponectin, are required for energy and glucose homeostasis. In obesity, adipose cell hypertrophy and the recruitment of macrophages alter the secretory function and induce an inflammatory profile in the adipose tissue. Analyses of gene expression suggest that hypoxia is one of the factors favoring the attraction of the macrophages. The local and systemic consequences of interactions between macrophages and adipocytes are currently actively studied, to understand their potential implication in the metabolic and cardiovascular complications associated with obesity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Measures of endothelial activation improve after weight reduction.
“Measures of endothelial activation also improve after weight reduction (108 -110) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [108]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755 · see citing works
Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529 · see citing works
Novel Modulator for Endothelial Adhesion Molecules
Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., Hotta, K., Nishida, M., Takahashi, M., Nakamura, T., et al. (1999) · Circulation · doi:10.1161/01.cir.100.25.2473 · Cited by 2,139 · see citing works
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
Minokoshi, Y., Kim, Y.-B., Peroni, O. D., Fryer, L. G. D., Müller, C., Carling, D., & Kahn, B. B. (2002) · Nature · doi:10.1038/415339a · Cited by 2,053 · see citing works
Maeda, N., Takahashi, M., Funahashi, T., Kihara, S., Nishizawa, H., Kishida, K., Nagaretani, H., Matsuda, M., Komuro, R., Ouchi, N., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.9.2094 · Cited by 1,659 · see citing works
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
Weisberg, S. P., Hunter, D., Huber, R., Lemieux, J., Slaymaker, S., Vaddi, K., Charo, I., Leibel, R. L., & Jr., A. W. F. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24335 · Cited by 1,497 · see citing works
Khovidhunkit, W., Kim, M.-S., Memon, R. A., Shigenaga, J. K., Moser, A. H., Feingold, K. R., & Grunfeld, C. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r300019-jlr200 · Cited by 1,481 · see citing works
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
Weisberg, S. P. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24335c1 · Cited by 1,424 · see citing works
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism
Berg, A. H., Combs, T. P., & Scherer, P. E. (2002) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00524-0 · Cited by 1,211 · see citing works
Tumor necrosis factor alpha inhibits signaling from the insulin receptor.
Hotamışlıgil, G. S., Murray, D. L., Choy, L., & Spiegelman, B. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4854 · Cited by 1,206 · see citing works
Cancello, R., Henegar, C., Viguerie, N., Taleb, S., Poitou, C., Rouault, C., Coupaye, M., Pelloux, V., Hugol, D., Bouillot, J.-L., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2277 · Cited by 1,164 · see citing works
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1995) · Nature · doi:10.1038/374479a0 · Cited by 1,125 · see citing works
Bastard, J., Jardel, C., Bruckert, É., Blondy, P., Capeau, J., Laville, M., Vidal, H., & Hainque, B. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6839 · Cited by 1,102 · see citing works
Suganami, T., Nishida, J., & Ogawa, Y. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000183883.72263.13 · Cited by 1,056 · see citing works
Adiponectin acts in the brain to decrease body weight
Qi, Y., Takahashi, N., Hileman, S. M., Patel, H. R., Berg, A. H., Pajvani, U. B., Scherer, P. E., & Ahima, R. S. (2004) · Nature Medicine · doi:10.1038/nm1029 · Cited by 809 · see citing works
Bruun, J. M., Lihn, A. S., Verdich, C., Pedersen, S. B., Toubro, S., Astrup, A. V., & Richelsen, B. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00110.2003 · Cited by 779 · see citing works
Obesity, adiponectin and vascular inflammatory disease
Ouchi, N., Kihara, S., Funahashi, T., Matsuzawa, Y., & Walsh, K. (2003) · Current Opinion in Lipidology · doi:10.1097/00041433-200312000-00003 · Cited by 740 · see citing works
Regulation of Fasted Blood Glucose by Resistin
Banerjee, R. R., Rangwala, S. M., Shapiro, J. S., Rich, A. S., Rhoades, B., Qi, Y., Wang, J., Rajala, M. W., Pocai, A., Scherer, P. E., et al. (2004) · Science · doi:10.1126/science.1092341 · Cited by 727 · see citing works
Yu, J. G., Javorschi, S., Hevener, A. L., Kruszynska, Y. T., Norman, R. A., Sinha, M. K., & Olefsky, J. M. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2968 · Cited by 724 · see citing works
Resistin Promotes Endothelial Cell Activation
Verma, S., Li, S., Wang, C., Fedak, P. W. M., Li, R., Weisel, R. D., & Mickle, D. A. G. (2003) · Circulation · doi:10.1161/01.cir.0000084503.91330.49 · Cited by 670 · see citing works
Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes
Fasshauer, M., Klein, J., Neumann, S., Eszlinger, M., & Paschke, R. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6307 · Cited by 655 · see citing works
Weight loss regulates inflammation‐related genes in white adipose tissue of obese subjects
ClÉment, K., Viguerie, N., Poitou, C., Carette, C., Pelloux, V., Curat, C. A., Sicard, A., Rome, S., Benis, A., Zucker, J., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-2204com · Cited by 640 · see citing works
Bastard, J., Maachi, M., Nhieu, J. T. V., Jardel, C., Bruckert, É., Grimaldi, A., Robert, J., Capeau, J., & Hainque, B. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8450 · Cited by 625 · see citing works
From Blood Monocytes to Adipose Tissue-Resident Macrophages
Curat, C. A., Miranville, A., Sengenès, C., Diehl, M., Tonus, C., Busse, R., & Bouloumié, A. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1285 · Cited by 600 · see citing works
Combs, T. P., Wagner, J. A., Berger, J. P., Doebber, T. W., Wang, W., Zhang, B. B., Tanen, M. R. L., Berg, A. H., O’Rahilly, S., Savage, D. B., et al. (2002) · Endocrinology · doi:10.1210/endo.143.3.8662 · Cited by 565 · see citing works
Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes
Faßhauer, M., Kralisch, S., Klier, M., Lössner, U., Blüher, M., Klein, J. C., & Paschke, R. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00090-1 · Cited by 534 · see citing works
Differential Effects of Interleukin-6 and -10 on Skeletal Muscle and Liver Insulin Action In Vivo
Kim, H.-J., Higashimori, T., Park, S.-Y., Choi, H., Dong, J., Kim, Y.-J., Noh, H.-L., Cho, Y.-R., Cline, G., Kim, Y.-B., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.4.1060 · Cited by 534 · see citing works
Preadipocyte Conversion to Macrophage
Charrière, G. M., Cousin, B., Arnaud, E., André, M., Bacou, F., Pénicaud, L., & Casteilla, L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210811200 · Cited by 528 · see citing works
Rajala, M. W., Obici, S., Scherer, P. E., & Rossetti, L. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16521 · Cited by 525 · see citing works
An Inflammatory Cascade Leading to Hyperresistinemia in Humans
Lehrke, M., Reilly, M. P., Millington, S. C., Iqbal, N., Rader, D. J., & Lazar, M. A. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010045 · Cited by 523 · see citing works
Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation
Massiéra, F., Bloch-Faure, M., Ceiler, D. L., Murakami, K., Fukamizu, A., Gasc, J., Quignard‐Boulangé, A., Négrel, R., Ailhaud, G. P., Seydoux, J., et al. (2001) · The FASEB Journal · doi:10.1096/fj.01-0457fje · Cited by 505 · see citing works
Kawanami, D., Maemura, K., Takeda, N., Harada, T., Nojiri, T., Imai, Y., Manabe, I., Utsunomiya, K., & Nagai, R. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.12.104 · Cited by 470 · see citing works
Association between adiponectin and mediators of inflammation in obese women
Engeli, S., Feldpausch, M., Gorzelniak, K., Hartwig, F., Heintze, U., Janke, J., Möhlig, M., Pfeiffer, A. F. H., Luft, F. C., & Sharma, A. M. (2003) · Diabetes · doi:10.2337/diabetes.52.4.942 · Cited by 422 · see citing works
Lagathu, C., Bastard, J.-P., Auclair, M., Maachi, M., Capeau, J., & Caron, M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.10.013 · Cited by 385 · see citing works
Imai, T., Takakuwa, R., Marchand, S., Dentz, E., Bornert, J., Messaddeq, N., Wendling, O., Mark, M. P., Desvergne, B., Wahli, W., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400356101 · Cited by 383 · see citing works
Activation of SOCS-3 by Resistin
Steppan, C. M., Wang, J., Whiteman, E. L., Birnbaum, M. J., & Lazar, M. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.4.1569-1575.2005 · Cited by 280 · see citing works
ACRP30, a new hormone controlling fat and glucose metabolism
Tsao, T., Lodish, H. F., & Fruebis, J. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01430-9 · Cited by 278 · see citing works
Hypoxia-inducible Factor 1 Transactivates the Human Leptin Gene Promoter
Grosfeld, A., André, J., Mouzon, S. H., Berra, E., Pouysségur, J., & Guerre-Millo, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206775200 · Cited by 263 · see citing works
Self-citationRole of macrophage tissue infiltration in metabolic diseases
Bouloumié, A., Curat, C. A., Sengenès, C., Lolmède, K., Miranville, A., & Busse, R. (2005) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000172571.41149.52 · Cited by 262 · see citing works
Diet Induction of Monocyte Chemoattractant Protein‐1 and its Impact on Obesity
Chen, A., Mumick, S., Zhang, C., Lamb, J., Dai, H., Weingarth, D., Mudgett, J., Chen, H., MacNeil, D. J., Reitman, M. L., et al. (2005) · Obesity Research · doi:10.1038/oby.2005.159 · Cited by 231 · see citing works
Novel modulator for endothelial adhesion molecules : Adipocyte-derived plasma protein adiponectin
大内, 乗. (2001) · Medical Entomology and Zoology · doi:10.11501/3184399 · Cited by 172 · see citing works
Hypoxia increases leptin expression in human PAZ6 adipose cells
Grosfeld, A., Zilberfarb, V., Turban, S., André, J., Guerre-Millo, M., & Issad, T. (2002) · Diabetologia · doi:10.1007/s00125-002-0804-y · Cited by 112 · see citing works
Self-citationHainault, I., Nebout, G., Turban, S., Ardouin, B., Ferré, P., & Quignard‐Boulangé, A. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2002.282.1.e59 · Cited by 99 · see citing works
Villena, J. A., Cousin, B., Pénicaud, L., & Casteilla, L. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801680 · Cited by 61 · see citing works
Preadipocyte conversion to macrophage. Evidence of plasticity
Charrière, G. M., Cousin, B., Arnaud, E., André, M., Bacou, F., Pénicaud, L., & Casteilla, L. (2003) · HAL · Cited by 45 · see citing works
Insulin depletion leads to adipose-specific cell death in obese but not lean mice
Loftus, T. M., Kuhajda, F. P., & Lane, M. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14168 · Cited by 35 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Ahima R. S. & Flier J. S., Leptin. Annu. Rev. Physiol., 2000, 62, 413-437.
- Grosfeld A., Zilberfarb V., Turban S., Andre J., Guerre-Millo M. & Issad T., Effects of hypoxia on human PAZ6 adipocytes. Diabetologia, 2002b, 45, 527-530.
- Khovidhunkit W., Kim M. S., Memon R. A., Shigenaga J. K., Moser A. H., Feingold K. R. & Grunfeld C., Effects of infection and inflammation on lipid and lipoprotein meta- bolism: mechanisms and consequences to the host. J. Lipid Res., 2004, 45, 1169-1196.
Cited by
Sorted by citations
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
- Authors
- Guerre-Millo, M.
- Affiliations
- Inserm (FR)
- Corresponding author
- Guerre-Millo, Michèle
- Venue
- Journal de la Société de Biologie
- Publisher
- EDP Sciences
- Published
- 2006
- Volume
- 200
- Issue
- 1
- Pages
- 37-43
- ISSN
- 1295-0661 (ISSN-L)
- OpenAlex
- W2024249911
- Cited by
- 16
- References
- 50
- Citations by year
- 2025: 1 · 2022: 1 · 2017: 1 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 0.49
- Type
- journal article
- Language
- fr
- Open access
- bronze
- doi.org
- Locations
- Journal de la Société de Biologie (publishedVersion)
- PubMed (publishedVersion)
- Springer Link (Chiba Institute of Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipokines, obesity, insulin resistance, inflammation, leptin, adiponectin, TNF-α, interleukin-6, adipocyte hypertrophy, macrophage recruitment, hypoxia, energy homeostasis, glucose metabolism, lipid metabolism, cardiovascular complications, metabolic complications
- MeSH terms
- Adipose Tissue, Cardiovascular Diseases, Humans, Macrophages, Models, Biological, Obesity, Leptin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
