Comparative efficacy on dogs of a single topical treatment with the pioneer fipronil/(S)-methoprene and an oral treatment with spinosad against Ctenocephalides felis
Open accessAbstract
In the study reported here, the pioneer fipronil/(S)-methoprene topical product (Frontline® Plus, Merial Limited, Duluth, GA) was compared to the oral spinosad product (Comfortis® Elanco, Greenfield, IN) for efficacy against adult fleas and preventing egg production. The product presentations, doses and labelling were the one applicable in the USA. Using a standard protocol, 200 cat fleas of mixed sex were applied to dogs on Days 1, 7, 14, 21, 28, 35, and 42. Dogs were combed to remove fleas 24 hours post-infestation, the fleas were counted, collected, and then reapplied to each dog following completion of their respective count. At 48 hours post-infestation, comb counts were performed and fleas were removed. No fleas were collected from any dog in the fipronil/(S)-methoprene group at any 24 or 48 hours post-infestation assessment throughout the six weeks study, yielding a preventive efficacy of 100%. For the spinosad treatment, efficacy was 100% at 24 hours and 48 hours through Day 16, and thereafter declined. The results observed in the spinosad-treated dogs were highly variable between animals. At the 24 and 48 hours counts following the Day 21 infestation, only five of eight spinosad-treated dogs (62.5%) were flea-free. Following the Day 28 infestation, spinosad efficacy fell to 85% and 89%, for the 24 hours and 48 hours counts, and only two dogs (25%) were flea free, compared to 100% flea-free dogs in the fipronil/(S)-methoprene group. No fleas were collected from the fipronil/(S)-methoprene treated dogs throughout the entire study, therefore, no eggs were collected at any time from any dog in the group. However, in the spinosad group adult fleas were found on dogs starting on Day 21 and by Day 30, 42 eggs were collected from one dog that had 107 adult fleas counted at 48 hours. At Day 37 and Day 49, more than 100 eggs were collected from each dog in the spinosad-treated and control groups.
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Most insecticides may suffer from decreasing levels of killing speed throughout the month following administration.
“Given that most insecticides may suffer from decreasing levels of killing speed throughout the month following administration [105,106,123,124], environmental control is mandatory.”
From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [124]
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- Authors
- Beugnet, F., Doyle, V., Murray, M., & Chalvet-Monfray, K.
- Corresponding author
- Beugnet, F.
- ORCID
- Beugnet, F.
- Venue
- Parasite
- Publisher
- EDP Sciences
- Published
- 2011-11
- Volume
- 18
- Issue
- 4
- Pages
- 325-331
- ISSN
- 1252-607X (ISSN-L)
- 1776-1042
- PMC
- PMC3677592
- OpenAlex
- W2106921990
- Cited by
- 18
- References
- 22
- Citations by year
- 2021: 1 · 2017: 5 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 4
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Parasite (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Dermatological diseases and infestations
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
- Keywords
- Ctenocephalides felis, flea control, spinosad, dogs, drug efficacy comparison, flea infestation
- MeSH terms
- Administration, Oral, Administration, Topical, Animals, Dog Diseases, Dogs, Drug Combinations, Female, Insecticides, Juvenile Hormones, Male, Methoprene, Parasite Egg Count, Pyrazoles, Macrolides, Ctenocephalides, Flea Infestations
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