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Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration
Open accessAbstract
Background & aims Liver regeneration after loss of hepatic tissue leads to hepatocyte and nonparenchymal cell proliferation and rapid restoration of liver parenchyma. Interleukin (IL)-6 is a key inducer of transcription factors involved in liver regeneration. Whenever IL-6 activates target cells, it binds to a specific IL-6 receptor (IL-6R). The IL-6/IL-6R complex then associates with the signal transducer gp130, leading to activation of intracellular signaling. Methods We have recently constructed the designer cytokine Hyper-IL-6 consisting of soluble IL-6R covalently linked to IL-6, which directly stimulates gp130 even in the absence of membrane-bound IL-6R. We compared the influence of IL-6 and Hyper-IL-6 on liver regeneration after partial hepatectomy in mice. Results The IL-6/soluble IL-6 fusion protein Hyper-IL-6, but not IL-6 alone, led to an earlier onset of hepatocellular proliferation resulting in an acceleration of liver weight restoration. Also, during liver regeneration, soluble IL-6R levels were increased. Conclusions These results emphasize a central role for IL-6 and soluble IL-6R in liver regeneration and indicate a possible therapeutic potential for the designer cytokine Hyper-IL-6 in clinical situations associated with liver regeneration such as acute hepatic failure or resection of chronically damaged liver tissue.
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“Although the classic or cis-signaling of IL-6 is determined to promote the compensatory proliferation of hepatocytes, its trans-signaling in liver regeneration is more important [19, 25–27].”
From The double-edged effects of IL-6 in liver regeneration, aging, inflammation, and diseases (2024) · cites this paper as [25]
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“IL-6 classic and trans-signaling on hepatocytes expressing IL-6R induce STAT3 phosphorylation and accelerate liver regeneration (Peters et al., 2000”
From Targeting Interleukin-6 Signaling in Clinic (2019) · cites this paper as Peters et al., 2000
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Citations
Cites
Experimental pathology of the liver
Higgins, G. (1931) · Medical Entomology and Zoology · Cited by 4,057
Michalopoulos, G. K., & DeFrances, M. C. (1997) · Science · doi:10.1126/science.276.5309.60 · Cited by 2,828
Gratzner, H. G. (1982) · Science · doi:10.1126/science.7123245 · Cited by 2,653
Higgins, G. (1931) · Cited by 2,444
Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice
Cressman, D. E., Greenbaum, L. E., DeAngelis, R. A., Ciliberto, G., Furth, E. E., Poli, V., & Taub, R. (1996) · Science · doi:10.1126/science.274.5291.1379 · Cited by 1,538
gp 130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES
Taga, T., & Kishimoto, T. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.797 · Cited by 1,468
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., & Kishimoto, T. (1989) · Cell · doi:10.1016/0092-8674(89)90438-8 · Cited by 1,396
Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor
Yamasaki, K., Taga, T., Hirata, Y., Yawata, H., Kawanishi, Y., Seed, B., Taniguchi, T., Hirano, T., & Kishimoto, T. (1988) · Science · doi:10.1126/science.3136546 · Cited by 1,059
Molecular cloning and expression of an IL-6 signal transducer, gp130
Hibi, M., Murakami, M., Saito, M., Hirano, T., Taga, T., & Kishimoto, T. (1990) · Cell · doi:10.1016/0092-8674(90)90411-7 · Cited by 1,039
Yamada, Y., Kirillova, I., Peschon, J. J., & Fausto, N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1441 · Cited by 944
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Self-citationLiver regeneration: from myth to mechanism
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Braunersreuther, V. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i8.727 · Cited by 359
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Scheller, J., Garbers, C., & Rose-John, S. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2013.11.002 · Cited by 308
Self-citationInterleukin-6 and its receptor: from bench to bedside
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Self-citationStat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms
Haga, S., Terui, K., Zhang, H. Q., Enosawa, S., Ogawa, W., Inoue, H., Okuyama, T., Takeda, K., Akira, S., Ogino, T., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17970 · Cited by 237
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Kallen, K. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00325-7 · Cited by 205
Hong, F., Radaeva, S., Pan, H., Tian, Z., Veech, R. L., & Gao, B. (2004) · Hepatology · doi:10.1002/hep.20400 · Cited by 202
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Tao, Y.-C., Wang, M.-L., Chen, E., & Tang, H. (2017) · Mediators of Inflammation · doi:10.1155/2017/4256352 · Cited by 191
Paradoxical effects of short- and long-term interleukin-6 exposure on liver injury and repair
Jin, X., Zimmers, T. A., Perez, E. A., Pierce, R. H., Zhang, Z., & Koniaris, L. G. (2006) · Hepatology · doi:10.1002/hep.21087 · Cited by 173
Physiological effects of modulating the interleukin-6 axis
Schett, G. A. (2018) · Rheumatology · doi:10.1093/rheumatology/kex513 · Cited by 148
IL-6 Revisited: From Rheumatoid Arthritis to CAR T Cell Therapy and COVID-19
Kishimoto, T., & Kang, S. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101220-023458 · Cited by 140
Massive Liver Growth in Mice Induced by Systemic Interleukin 6 Administration
Zimmers, T. A., McKillop, I. H., Pierce, R. H., Yoo, J.-Y., & Koniaris, L. G. (2003) · Hepatology · doi:10.1053/jhep.2003.50318 · Cited by 140
Yamaguchi, K., Itoh, Y., Yokomizo, C., Nishimura, T., Niimi, T., Fujii, H., Okanoue, T., & Yoshikawa, T. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.75 · Cited by 127
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Choi, B., Johnson, K. R., Maric, D., & McGavern, D. B. (2023) · Nature Immunology · doi:10.1038/s41590-023-01521-1 · Cited by 123
The role of cytokines in liver failure and regeneration: potential new molecular therapies
Galun, E., & Axelrod, J. H. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00326-9 · Cited by 114
IL‐6 Trans‐signaling Controls Liver Regeneration After Partial Hepatectomy
Fazel Modares, N., Polz, R., Haghighi, F., Lamertz, L., Behnke, K., Zhuang, Y., Kordes, C., Häussinger, D., Sorg, U. R., Pfeffer, K., et al. (2019) · Hepatology · doi:10.1002/hep.30774 · Cited by 113
Unique effects of Stat3 on the early phase of hematopoietic stem cell regeneration
Chung, Y.-J., Park, B.-B., Kang, Y.-J., Kim, T.-M., Eaves, C. J., & Oh, I.-H. (2006) · Blood · doi:10.1182/blood-2006-01-010199 · Cited by 107
The transcription factor NFATc2 controls IL-6–dependent T cell activation in experimental colitis
Weigmann, B., Lehr, H., Yancopouloš, G., Valenzuela, D., Murphy, A., Stevens, S., Schmidt, J., Galle, P., Rose-John, S., & Neurath, M. (2008) · Journal of Experimental Medicine · doi:10.1084/jem.20072484 · Cited by 103
Self-citationADAM17 Activity and IL-6 Trans-Signaling in Inflammation and Cancer
Schumacher, N., & Rose‐John, S. (2019) · Cancers · doi:10.3390/cancers11111736 · Cited by 108
Self-citationInterleukin 6 and hepatocyte regeneration in acetaminophen toxicity in the mouse
James, L. P., Lamps, L. W., McCullough, S. S., & Hinson, J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.08.085 · Cited by 99
Srivatsa, S., Paul, M. C., Cardone, C., Holcmann, M., Amberg, N., Pathria, P., Diamanti, M. A., Linder, M., Timelthaler, G., Dienes, H. P., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.03.053 · Cited by 98
Self-citationAldrighetti, L. A., Pulitanò, C., Arru, M., Finazzi, R., Catena, M., Soldini, L., Comotti, L., & Ferla, G. (2006) · Liver Transplantation · doi:10.1002/lt.20745 · Cited by 93
The double-edged effects of IL-6 in liver regeneration, aging, inflammation, and diseases
Wang, M.-J., Zhang, H.-L., Chen, F., Guo, X.-J., Liu, Q.-G., & Hou, J. (2024) · Experimental Hematology & Oncology · doi:10.1186/s40164-024-00527-1 · Cited by 84
“Although the classic or cis -signaling of IL-6 is determined to promote the compensatory proliferation of hepatocytes, its trans-signaling in liver regeneration is more important [19, 25–27].”
BackgroundInterleukin-6, its role in fibrosing conditions
O’Reilly, S., Ciechomska, M., Cant, R., Hügle, T., & van Laar, J. M. (2012) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2012.04.003 · Cited by 85
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Self-citationLukashevich, I. S., Tikhonov, I., Rodas, J. D., Zapata, J. C., Yang, Y., Djavani, M. M., & Salvato, M. S. (2003) · Journal of Virology · doi:10.1128/jvi.77.3.1727-1737.2003 · Cited by 77
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Sun, R., Jaruga, B., Kulkarni, S., Sun, H., & Gao, B. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.171 · Cited by 73
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Schooltink, H., & Rose‐John, S. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/10799900252981981 · Cited by 67
Self-citationTvedt, T. H. A., Ersvær, E., Tveita, A. A., & Bruserud, Ø. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00667 · Cited by 63
Gerlach, K., Daniel, C., Lehr, H. A., Nikolaev, A., Gerlach, T. H., Atreya, R. N., Rose‐John, S., Neurath, M. F., & Weigmann, B. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-4155 · Cited by 62
Self-citationEffects of cytokines on carbon tetrachloride-induced hepatic fibrogenesis in rats
Zhang, L., Yu, J., Li, D. X., Huang, Y., Chen, Z., & Wang, X. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i1.77 · Cited by 62
Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy
Widjaja, A. A., Chothani, S. P., & Cook, S. A. (2020) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2020.1761203 · Cited by 55
Molecular Engineering of Therapeutic Cytokines
Vazquez-Lombardi, R., Roome, B., & Christ, D. (2013) · Antibodies · doi:10.3390/antib2030426 · Cited by 59
Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis
Li, S., Hsu, D. D., Wang, H., & Feng, G. (2012) · Frontiers of Medicine · doi:10.1007/s11684-012-0216-4 · Cited by 55
Liver Regeneration after Liver Transplantation
Taki‐Eldin, A., Zhou, L., Xie, H., & Zheng, S. (2012) · European Surgical Research · doi:10.1159/000337865 · Cited by 55
Yamaguchi, K., Itoh, Y., Yokomizo, C., Nishimura, T., Niimi, T., Umemura, A., Fujii, H., Okanoue, T., & Yoshikawa, T. (2011) · Laboratory Investigation · doi:10.1038/labinvest.2011.2 · Cited by 55
Remmler, J., Schneider, C., Treuner-Kaueroff, T., Bartels, M., Seehofer, D., Scholz, M., Berg, T., & Kaiser, T. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2017.09.017 · Cited by 56
Therapeutic targeting of IL-6 trans-signaling
Rose‐John, S. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155577 · Cited by 52
Self-citationMatsumoto, T., O’Malley, K. A., Efron, P. A., Burger, C., McAuliffe, P. F., Scumpia, P. O., Uchida, T., Tschoeke, S. K., Fujita, S., Moldawer, L. L., et al. (2006) · Surgery · doi:10.1016/j.surg.2006.04.010 · Cited by 51
Labenz, C., Toenges, G., Huber, Y., Nagel, M., Marquardt, J. U., Schattenberg, J. M., Galle, P. R., Labenz, J., & Wörns, M. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15515 · Cited by 52
Self-citationDai, Z., Wang, X., Peng, R., Zhang, B., Han, Q., Lin, J., Wang, J., Lin, J., Jiang, M., Liu, H., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.10.024 · Cited by 49
Corticosteroids for alcoholic hepatitis—what's next?
Mathurin, P. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.06.003 · Cited by 49
Lukashevich, I. S., Rodas, J. D., Tikhonov, I. I., Zapata, J. C., Yang, Y., Djavani, M. M., & Salvato, M. S. (2004) · Archives of Virology · doi:10.1007/s00705-004-0385-9 · Cited by 47
The soluble interleukin-6 receptor and related proteins
Rose‐John, S. (2015) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2015.07.001 · Cited by 51
Self-citationRole of IL-6 trans-signaling in CCl4 induced liver damage
Gewiese-Rabsch, J., Drucker, C., Malchow, S., Scheller, J., & Rose-John, S. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.07.023 · Cited by 36
Self-citationGP130 stimulation and the maintenance of stem cells
Rose‐John, S. (2002) · Trends in biotechnology · doi:10.1016/s0167-7799(02)02056-5 · Cited by 47
Self-citationIL-6 Promotes compensatory liver regeneration in cirrhotic rat after partial hepatectomy
Tiberio, G. A. M., Tiberio, L., Benetti, A., Cervi, E., Montani, N., Dréano, M., Garotta, G., Cerea, K., Steimberg, N., Pandolfo, G. P., et al. (2008) · Cytokine · doi:10.1016/j.cyto.2008.03.012 · Cited by 45
Signaling pathways of liver regeneration: Biological mechanisms and implications
Zhang, C., Sun, C., Zhao, Y., Ye, B., & Yu, G. (2023) · iScience · doi:10.1016/j.isci.2023.108683 · Cited by 48
Kuroki, H., Hayashi, H., Nakagawa, S., Sakamoto, K., Higashi, T., Nitta, H., Hashimoto, D., Chikamoto, A., Beppu, T., & Baba, H. (2015) · British journal of surgery · doi:10.1002/bjs.9765 · Cited by 44
Blocking only the bad side of IL-6 in inflammation and cancer
Rose‐John, S. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155690 · Cited by 44
Self-citationADAM17 orchestrates Interleukin-6, TNFα and EGF-R signaling in inflammation and cancer
Schumacher, N., & Rose‐John, S. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2021.119141 · Cited by 47
Self-citationNechemia-Arbely, Y., Shriki, A., Denz, U., Drucker, C., Scheller, J., Raub, J., Pappo, O., Rose-John, S., Galun, E., & Axelrod, J. H. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2010.08.017 · Cited by 42
Self-citationGüneş, A., Schmitt, C., Bilodeau, L., Huët, C., Belblidia, A., Baldwin, C., Giard, J., Biertho, L. D., Lafortune, A., Couture, C. Y., et al. (2023) · Diabetes · doi:10.2337/db23-0171 · Cited by 39
Behnke, K., Zhuang, Y., Xu, H. C., Sundaram, B., Reich, M., Shinde, P. V., Huang, J., Modares, N. F., Tumanov, A. V., Polz, R., et al. (2018) · Hepatology · doi:10.1002/hep.30088 · Cited by 34
The Regenerative Activity of Interleukin-6
Galun, E., & Rose-John, S. (2013) · Methods in Molecular Biology · doi:10.1007/978-1-62703-308-4_4 · Cited by 34
Self-citationEndosomes as Signaling Platforms for IL-6 Family Cytokine Receptors
Schmidt‐Arras, D., & Rose‐John, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.688314 · Cited by 33
Self-citationChen, P., Dong, X.-L., Zhu, J., Dong, J.-H., Ding, J.-M., & Zhang, L. (2006) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.12.004 · Cited by 35
Ren, X., Hu, B., & Colletti, L. M. (2008) · Surgery · doi:10.1016/j.surg.2008.03.021 · Cited by 31
Liver regeneration and alcoholic liver disease
Lv, Y., So, K., & Xiao, J. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.02.168 · Cited by 25
Regulation of Fibrotic Processes in the Liver by ADAM Proteases
Schmidt‐Arras, D., & Rose‐John, S. (2019) · Cells · doi:10.3390/cells8101226 · Cited by 28
Self-citationRuscitti, P., Berardicurti, O., Giacomelli, R., & Cipriani, P. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2022.101632 · Cited by 28
Pathophysiological Changes During Ischemia-reperfusion Injury in Rodent Hepatic Steatosis
Neri, A.-A., Dontas, I. A., Iliopoulos, D., & Karatzas, T. (2020) · In Vivo · doi:10.21873/invivo.11863 · Cited by 26
Zhang, F., Yao, S., Zhang, M., Yuan, J., Chen, X., & Zhou, B. (2011) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2010.12.008 · Cited by 24
Uckun, F. M., Özer, Z., & Vassilev, A. O. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06468.x · Cited by 25
Pontisso, P. (2009) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000323 · Cited by 24
Potential effects of L-NAME on alcohol-induced oxidative stress
Uzun, H. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i4.600 · Cited by 22
Zhao, J., Wang, Y., Wu, X., Tong, P., Yue, Y., Gao, S., Huang, D., & Huang, J. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9490 · Cited by 21
Nishio, T., Iimuro, Y., Nitta, T., Harada, N., Yoshida, M., Hirose, T., Yamamoto, N., Morimoto, T., Brenner, D. A., & Yamaoka, Y. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)00013-8 · Cited by 20
Oka, Y., Akagi, Y., Kinugasa, T., Ishibashi, N., Iwakuma, N., Shiratsuchi, I., & Shirouzu, K. (2013) · PubMed · Cited by 17
Clinical translation of liver regeneration therapies: A conceptual road map
Greenbaum, L. E., Ukomadu, C., & Tchorz, J. S. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113847 · Cited by 17
Wang, Y., Wu, J., Yao, J., Chen, J., Cheng, K. K. Y., Ho, M. Y.-M., Lee, C., Lam, K. S. L., Tse, M. A., Panagiotou, G., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.10.013 · Cited by 16
Maeda, N., Watanabe, M., Okamoto, S., Kanai∥, T., Yamada, T., Hata, J., Hozumi, N., Katsume, A., Nuriya, H., Sandhu, J., et al. (2004) · Liver International · doi:10.1111/j.1478-3231.2004.0909.x · Cited by 16
Shimada, M., Harimoto, N., Maehara, S., Tsujita, E., Rikimaru, T., Yamashita, Y., Tanaka, S., & Shirabe, K. (2002) · Surgery · doi:10.1067/msy.2002.120116 · Cited by 16
Hepatocyte Turnover in Chronic HCV-Induced Liver Injury and Cirrhosis
Karidis, N. P., Delladetsima, I. K., & Theocharis, S. E. (2015) · Gastroenterology Research and Practice · doi:10.1155/2015/654105 · Cited by 16
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Schmidt‐Arras, D., Galun, E., & Rose‐John, S. (2021) · Seminars in Immunopathology · doi:10.1007/s00281-021-00861-0 · Cited by 15
Self-citationDrucker, C., Rabe, B., Chalaris, A., Schulz, E., Scheller, J., & Rose‐John, S. (2009) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2008.0095 · Cited by 15
Self-citationDong, J., Viswanathan, S., Adami, E., Schäfer, S., Kuthubudeen, F. F., Widjaja, A. A., & Cook, S. A. (2021) · eLife · doi:10.7554/elife.68843 · Cited by 14
Bakács, T., Mehrishi, J. N., Szabados, T., Varga, L., Szabó, M., & Tusnády, G. (2007) · International Archives of Allergy and Immunology · doi:10.1159/000103282 · Cited by 13
Beaudoin, J. J., Clemens, L., Miedel, M. T., Gough, A., Zaidi, F., Ramamoorthy, P., Wong, K. E., Sarangarajan, R., Battista, C., Shoda, L. K. M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119692 · Cited by 12
Exploring the landscape of synthetic IL ‐6‐type cytokines
Scheller, J., Ettich, J., Wittich, C., Pudewell, S., Floss, D. M., & Rafii, P. (2023) · FEBS Journal · doi:10.1111/febs.16909 · Cited by 13
Fathi, F., Sanei, B., Ganjalıkhani-Hakemi, M., Saidi, R. F., & Rezaei, A. (2021) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2021/5593655 · Cited by 12
DeSantis, D., Ko, C.-W., Wang, L., Lee, P., & Croniger, C. M. (2015) · Mediators of Inflammation · doi:10.1155/2015/909827 · Cited by 12
The role of ADAM17 during liver damage
Al-Salihi, M. A., Bornikoel, A., Zhuang, Y., Stachura, P., Scheller, J., Lang, K. S., & Lang, P. A. (2021) · Biological Chemistry · doi:10.1515/hsz-2021-0149 · Cited by 11
Contribution of organokines in the development of NAFLD/NASH associated hepatocellular carcinoma
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Rafii, P., Seibel, C., Weitz, H. T., Ettich, J., Minafra, A. R., Petzsch, P., Lang, A., Floss, D. M., Behnke, K., Köhrer, K., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-04768-4 · Cited by 10
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Kanaoka, Y., Yagi, T., Sadamori, H., Matsukawa, H., Matsuda, H., Inagaki, M., Ishikawa, T., Saito, S., Iwagaki, H., & Tanaka, N. (2002) · Journal of International Medical Research · doi:10.1177/147323000203000505 · Cited by 10
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Metadata
- Authors
- Peters, M., Blinn, G., Jostock, T., Schirmacher, P., Büschenfelde, K. M. Z., Galle, P. R., & Rose–John, S.
- Affiliations
- University of Cologne (DE)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 119
- Issue
- 6
- Pages
- 1663-1671
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1989052869
- Cited by
- 129
- References
- 36
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 4 · 2023: 8 · 2022: 3 · 2021: 12 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 1 · 2015: 6 · 2014: 2 · 2013: 4 · 2012: 5
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- interleukin-6, soluble IL-6 receptor, liver regeneration, partial hepatectomy, hyper-IL-6, gp130 signaling, hepatocyte proliferation, acute liver failure, cytokine fusion proteins
- MeSH terms
- Animals, Cell Division, DNA-Binding Proteins, Gene Expression Regulation, Hepatectomy, Humans, Liver, Liver Regeneration, Mice, Inbred C57BL, Organ Size, Phosphorylation, Postoperative Period, Solubility, Time Factors, Trans-Activators, Interleukin-6, Receptors, Interleukin-6, STAT3 Transcription Factor, Mice
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