The Advanced Glycation End Product Nε-Carboxymethyllysine Is Not a Predictor of Cardiovascular Events and Renal Outcomes in Patients With Type 2 Diabetic Kidney Disease and Hypertension
Open accessAbstract
Background Advanced glycation end products (AGEs) are implicated in the pathogenesis of vascular damage, especially in patients with diabetes and renal insufficiency. The oxidatively formed AGE N(epsilon)-carboxymethyllysine (CML) is thought to be a marker of oxidative stress.Methods Four hundred fifty patients with type 2 diabetes and nephropathy from the Irbesartan in Diabetic Nephropathy Trial cohort (mean age, 58 +/- 8.2 years; 137 women, 313 men) with a mean glomerular filtration rate of 48.2 mL/min (0.80 mL/s; Modification of Diet in Renal Disease formula) were followed up for 2.6 years. Serum CML was measured by using an enzyme-linked immunosorbent assay. Relationships between CML levels, traditional risk factors, and cardiovascular and renal events were tested in Cox proportional hazards models.Results Mean serum CML level was 599.9 +/- 276.0 ng/mL, and mean hemoglobin A1c level was 7.5% +/- 1.6%. One hundred forty-three first cardiovascular events occurred during follow-up; 74 patients died, 44 of cardiovascular causes. Final multivariate analysis showed age (relative risk [RR], 1.87; confidence interval [CI], 1.13 to 3.11; P = 0.016 for the highest compared with lowest quartile), history of prior cardiovascular events (RR, 1.96; CI, 1.35 to 2.85; P < 0.0005), and 24-hour urinary albumin-creatinine ratio (RR, 1.29; CI, 1.11 to 1.50 per doubling; P < 0.0005) to be independent risk factors for a first cardiovascular event, but not CML level. CML level also did not correlate significantly with renal outcome.Conclusion Serum CML level could not be identified as an independent risk factor for cardiovascular or renal outcomes in the examined population. This suggests that traditional risk factors might have a more important role for these end points or that other AGE compounds, as well as tissue AGE levels, might be of greater relevance compared with serum levels, which remains open to further study.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Resveratrol-induced sirtuin activation increased lifespan in model organisms and animal models.
“This led to increased lifespan in model organisms and in animal models (280,281) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [280]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Levey, A. S., Bosch, J. P., Lewis, J. B., Greene, T., Rogers, N., Roth, D., & for the Modification of Diet in Renal Disease Study Group* (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-6-199903160-00002 · Cited by 15,079 · see citing works
Lewis, E. J., Hunsicker, L. G., Clarke, W. R., Berl, T., Pohl, M. A., Lewis, J. B., Ritz, E., Atkins, R. C., Rohde, R., & Raz, I. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011303 · Cited by 5,987 · see citing works
Subcommittee, G. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917020-00001 · Cited by 3,895 · see citing works
Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.
Baynes, J. W., & Thorpe, S. R. (1999) · Diabetes · doi:10.2337/diabetes.48.1.1 · Cited by 2,441 · see citing works
Regression modelling strategies for improved prognostic prediction
Harrell, F. E., Lee, K. L., Califf, R. M., Pryor, D. B., & Rosati, R. A. (1984) · Statistics in Medicine · doi:10.1002/sim.4780030207 · Cited by 1,804 · see citing works
Basta, G. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.05.001 · Cited by 996 · see citing works
Fu, M.-X., Requena, J. R., Jenkins, A. J., Lyons, T. J., Baynes, J. W., & Thorpe, S. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.17.9982 · Cited by 822 · see citing works
Koschinsky, T., He, C.-J., Mitsuhashi, T., Bucala, R., Liu, C., Buenting, C., Heitmann, K., & Vlassara, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6474 · Cited by 792 · see citing works
Simple non-invasive assessment of advanced glycation endproduct accumulation
Meerwaldt, R., Graaff, R., Oomen, P. H. N., Links, T. P., Jager, J. J., Alderson, N. L., Thorpe, S. R., Baynes, J., Gans, R. O. B., & Smit, A. J. (2004) · Diabetologia · doi:10.1007/s00125-004-1451-2 · Cited by 767 · see citing works
Schleicher, E. D., Wagner, E., & Nerlich, A. G. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119180 · Cited by 714 · see citing works
Wendt, T., Tanji, N., Guo, J., Kislinger, T., Qu, W., Lu, Y., Bucciarelli, L. G., Rong, L., Moser, B., Markowitz, G. S., et al. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63909-0 · Cited by 599 · see citing works
Bierhaus, A. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00233-2 · Cited by 555 · see citing works
The Role of Oxidative Stress in Diabetic Complications
Niedowicz, D. M., & Daleke, D. L. (2005) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:43:2:289 · Cited by 528 · see citing works
Miyata, T., de Strihou, C. V. Y., Kurokawa, K., & Baynes, J. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00302.x · Cited by 518 · see citing works
Glycoxidation and lipoxidation in atherogenesis
Baynes, J., & Thorpe, S. R. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00228-8 · Cited by 515 · see citing works
Monnier, V. M., Bautista, O., Kenny, D., Sell, D. R., Fogarty, J., Dahms, W., Cleary, P. A., Lachin, J., & Genuth, S. (1999) · Diabetes · doi:10.2337/diabetes.48.4.870 · Cited by 469 · see citing works
GENUTH, S. M., Sun, W., Cleary, P. A., Sell, D. R., Dahms, W. T., Malone, J. I., Sivitz, W. I., Monnier, V. M., & for the DCCT Skin Collagen Ancillary Study Group (2005) · Diabetes · doi:10.2337/diabetes.54.11.3103 · Cited by 428 · see citing works
Berl, T., Hunsicker, L. G., Lewis, J. B., Pfeffer, M. A., Porush, J. G., Rouleau, J. L., Drury, P., Esmatjes, E., Hricik, D. E., Parikh, C. R., et al. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-138-7-200304010-00010 · Cited by 400 · see citing works
Meerwaldt, R., Hartog, J. W. L., Graaff, R., Huisman, R. J., Links, T. P., den Hollander, N. C., Thorpe, S. R., Baynes, J., Navis, G., Gans, R. O. B., et al. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005020144 · Cited by 395 · see citing works
Progression of nephropathy in type 2 diabetic patients
Rossing, K., Christensen, P. K., Hovind, P. H., Tarnow, L., Rossing, P. R., & Parving, H. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00925.x · Cited by 338 · see citing works
Miyata, T., de Strihou, C. V. Y., Ueda, Y., Ichimori, K., Inagi, R., Onogi, H., Ishikawa, N., Nangaku, M., & Kurokawa, K. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000032418.67267.f2 · Cited by 287 · see citing works
Miyata, T., Ueda, Y., Shinzato, T., Iida, Y., Tanaka, S., Kurokawa, K., de Strihou, C. V. Y., & Maeda, K. (1996) · Journal of the American Society of Nephrology · doi:10.1681/asn.v781198 · Cited by 232 · see citing works
Uribarri, J., Peppa, Μ., Cai, W., Goldberg, T., Lu, M. M., Baliga, S. K., Vassalotti, J. A., & Vlassara, H. (2003) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(03)00779-0 · Cited by 197 · see citing works
Advanced glycation end products and mortality in hemodialysis patients
Schwedler, S. B., Metzger, T., Schinzel, R., & Wanner, C. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00423.x · Cited by 195 · see citing works
Niwa, T., Katsuzaki, T., Miyazaki, S., Miyazaki, T., Ishizaki, Y., Hayase, F., Tatemichi, N., & Takei, Y. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119285 · Cited by 195 · see citing works
New biomarkers of Maillard reaction damage to proteins
Wells‐Knecht, K. J., Brinkmann, E., Wells-Knecht, M. C., Litchfield, J., Ahmed, M., Reddy, S., Zyzak, D. V., Thorpe, S. R., & Baynes, J. (1996) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/11.supp5.41 · Cited by 170 · see citing works
Mechanisms for the formation of glycoxidation products in end-stage renal disease
Weiss, M. F., Erhard, P., Kader-Attia, F. A., Wu, Y. C., DeOreo, P. B., Araki, A., Glomb, M. A., & Monnier, V. M. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00117.x · Cited by 155 · see citing works
Miyata, T., Fu, M.-X., Kurokawa, K., de Strihou, C. V. Y., Thorpe, S. R., & Baynes, J. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00093.x · Cited by 153 · see citing works
Wells-Knecht, M. C., Lyons, T. J., McCance, D. R., Thorpe, S. R., & Baynes, J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119599 · Cited by 138 · see citing works
Guidelines for management of hypertension
Swales, J. D. (1994) · BMJ · doi:10.1136/bmj.308.6932.855a · Cited by 134 · see citing works
The Irbesartan Type II Diabetic Nephropathy Trial: study design and baseline patient characteristics
Rodby, R. A., Rohde, R. D., Clarke, W. R., Hunsicker, L. G., Anzalone, D. A., Atkins, R. C., Ritz, E., & Lewis, E. J. (2000) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/15.4.487 · Cited by 131 · see citing works
Busch, M., Franke, S., Müller, A., Wolf, M., Gerth, J., Ott, U., Niwa, T., & Stein, G. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00736.x · Cited by 121 · see citing works
Boehm, B. O., Schilling, S., Rosinger, S., Lang, G. E., Lang, G. K., Kientsch-Engel, R., & Stahl, P. (2004) · Diabetologia · doi:10.1007/s00125-004-1455-y · Cited by 119 · see citing works
Anavekar, N. S., Gans, D. J., Berl, T., Rohde, R. D., Cooper, W., Bhaumik, A., Hunsicker, L. G., Rouleau, J. L., Lewis, J. B., Rosendorff, C., et al. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.09213.x · Cited by 115 · see citing works
Degenhardt, T. P., Grass, L., Reddy, S., Thorpe, S. R., Diamandis, E. P., & Baynes, J. (1997) · Kidney International · doi:10.1038/ki.1997.429 · Cited by 107 · see citing works
Nϵ-(carboxymethyl)lysine levels in patients with type 2 diabetes: Role of renal function
Wagner, Z., Wittmann, I., Mazák, I., Schinzel, R., Heidland, A., Kientsch-Engel, R., & Nagy, J. (2001) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2001.27695 · Cited by 104 · see citing works
Fan, Q., Liao, J., Kobayashi, M., Yamashita, M., Gu, L., Gohda, T., Suzuki, Y., Wang, L. N., Horikoshi, S., & Tomino, Y. (2004) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh499 · Cited by 93 · see citing works
Serum Carboxymethyllysine Predicts Mortality in Hemodialysis Patients
Wagner, Z., Molnár, M., Molnár, G. A., Tamaskó, M., Laczy, B., Wagner, L. J., Csiky, B. S., Heidland, A., Nagy, J., & Wittmann, I. (2006) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2005.10.010 · Cited by 85 · see citing works
Galler, A., Müller, G., Schinzel, R., Kratzsch, J., Kieß, W., & Münch, G. W. (2003) · Diabetes Care · doi:10.2337/diacare.26.9.2609 · Cited by 80 · see citing works
Hricik, D. E., Wu, Y. C., Schulak, J. A., & Friedlander, M. A. (1996) · Clinical Transplantation · doi:10.1111/j.1399-0012.1996.tb00747.x · Cited by 59 · see citing works
Two immunochemical assays to measure advanced glycation end-products in serum from dialysis patients
Zhang, X., Frischmann, M., Kientsch-Engel, R., Steinmann, K., Stopper, H., Niwa, T., & Pischetsrieder, M. (2005) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2005.089 · Cited by 50 · see citing works
Are advanced glycation end products cardiovascular risk factors in patients with CRF?
Stein, G., Busch, M., Müller, A. M. F., Wendt, T., Franke, C., Niwa, T., & Franke, S. (2003) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2003.50085 · Cited by 27 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus
Nowotny, K., Jung, T., Höhn, A., Weber, D., & Grune, T. (2015) · Biomolecules · doi:10.3390/biom5010194 · Cited by 1,095 · see citing works
Advanced glycation endproducts in food and their effects on health
Poulsen, M. W., Hedegaard, R. V., Andersen, J. M., de Courten, B., Bügel, S., Nielsen, J., Skibsted, L. H., & Dragsted, L. O. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.06.052 · Cited by 751 · see citing works
Baking, Ageing, Diabetes: A Short History of the Maillard Reaction
Hellwig, M., & Henle, T. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201308808 · Cited by 471 · see citing works
Advanced glycation end‐products and the kidney
Busch, M., Franke, S., Rüster, C., & Wolf, G. (2010) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2010.02317.x · Cited by 226 · see citing works
Delgado‐Andrade, C., & Fogliano, V. (2018) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030117-012441 · Cited by 175 · see citing works
Hanssen, N. M. J., Beulens, J. W. J., van Dieren, S., Scheijen, J. L. J. M., van der A, D. L., Spijkerman, A. M. W., van der Schouw, Y. T., Stehouwer, C. D. A., & Schalkwijk, C. G. (2014) · Diabetes · doi:10.2337/db13-1864 · Cited by 156 · see citing works
Semba, R. D., Najjar, S. S., Sun, K., Lakatta, E. G., & Ferrucci, L. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2008.320 · Cited by 144 · see citing works
Prasad, C., Davis, K. E., Imrhan, V., Juma, S., & Vijayagopal, P. (2017) · American Journal of Lifestyle Medicine · doi:10.1177/1559827617708991 · Cited by 134 · see citing works
Hanssen, N. M. J., Engelen, L., Ferreira, I., Scheijen, J. L. J. M., Huijberts, M. S., van Greevenbroek, M. M. J., Kallen, C., Dekker, J. M., Nijpels, G., Stehouwer, C. D. A., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1068 · Cited by 117 · see citing works
Evidence against dietary advanced glycation endproducts being a risk to human health
Ames, J. M. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600304 · Cited by 104 · see citing works
Shi, L., Yu, X., Yang, H., & Wu, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066781 · Cited by 105 · see citing works
Clinical and prognostic value of advanced glycation end-products in chronic heart failure
Hartog, J. W. L., Voors, A. A., Schalkwijk, C., Scheijen, J. L. J. M., Smilde, T. D. J., Damman, K., Bakker, S. J. L., Smit, A. J., & van Veldhuisen, D. J. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm486 · Cited by 100 · see citing works
From Oxidative Stress to Inflammation in the Posterior Ocular Diseases: Diagnosis and Treatment
Dammak, A., Huete‐Toral, F., Carpena‐Torres, C., Martín‐Gil, A., Pastrana, C., & Carracedo, G. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13091376 · Cited by 87 · see citing works
Franke, S., Sommer, M., Rüster, C., Bondeva, T., Marticke, J. K., Hofmann, G. O., Hein, G. E., & Wolf, G. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2807 · Cited by 85 · see citing works
Semba, R. D., Ferrucci, L., Fink, J. C., Sun, K., Beck, J., Dalal, M., Guralnik, J. M., & Fried, L. P. (2008) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2008.06.018 · Cited by 73 · see citing works
Kilhovd, B. K., Juutilainen, A., Lehto, S., Rönnemaa, T., Torjesen, P. A., Hanssen, K. F., & Laakso, M. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.12.041 · Cited by 71 · see citing works
Advanced glycation end-products induce cell cycle arrest and hypertrophy in podocytes
Rüster, C., Bondeva, T., Franke, S., Forster, M., & Wolf, G. (2008) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfn085 · Cited by 66 · see citing works
Baumann, M., Richart, T., Sollinger, D., Pelisek, J., Roos, M., Kuznetsova, T., Eckstein, H., Heemann, U. W., & Staessen, J. A. (2009) · Cardiovascular Diabetology · doi:10.1186/1475-2840-8-45 · Cited by 58 · see citing works
Semba, R. D., Fink, J. C., Sun, K., Windham, B. G., & Ferrucci, L. (2009) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2009.08.001 · Cited by 58 · see citing works
Li, M., Zeng, M., He, Z., Zheng, Z., Qin, F., Tao, G., Zhang, S., & Chen, J. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf505063t · Cited by 57 · see citing works
Guerin-Dubourg, A., Cournot, M., Planesse, C., Debussche, X., Meilhac, O., Rondeau, P., & Bourdon, E. (2017) · BioMed Research International · doi:10.1155/2017/7989180 · Cited by 52 · see citing works
Ahmad, A., Lim, L., Morieri, M. L., Tam, C. H. T., Cheng, F., Chikowore, T., Dudenhöffer‐Pfeifer, M., Fitipaldi, H., Huang, C., Kanbour, S., et al. (2024) · Communications Medicine · doi:10.1038/s43856-023-00429-z · Cited by 60 · see citing works
Stirring the Pot: Can Dietary Modification Alleviate the Burden of CKD?
Snelson, M., Clarke, R., & Coughlan, M. T. (2017) · Nutrients · doi:10.3390/nu9030265 · Cited by 49 · see citing works
Advanced Glycation Endproducts in Chronic Heart Failure
Smit, A. J., Hartog, J. W. L., Voors, A. A., & van Veldhuisen, D. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1433.038 · Cited by 49 · see citing works
Advanced glycation end-products suppress neuropilin-1 expression in podocytes
Bondeva, T., Rüster, C., Franke, S., Hammerschmid, E., Klagsbrun, M., Cohen, C. D., & Wolf, G. (2008) · Kidney International · doi:10.1038/ki.2008.603 · Cited by 48 · see citing works
Angiotensin II Upregulates RAGE Expression on Podocytes: Role of AT2 Receptors
Rüster, C., Bondeva, T., Franke, S., Tanaka, N., Yamamoto, H., & Wolf, G. (2009) · American Journal of Nephrology · doi:10.1159/000191467 · Cited by 47 · see citing works
Role of advanced glycation end products in hypertension and cardiovascular risk: human studies
Baumann, M. (2012) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2012.10.005 · Cited by 47 · see citing works
Gillery, P., & Jaisson, S. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2013.02.015 · Cited by 41 · see citing works
Voziyan, P., Brown, K. L., Chetyrkin, S. V., & Hudson, B. G. (2013) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2012-0818 · Cited by 37 · see citing works
Formation and elimination of pyrraline in the Maillard reaction in a saccharide–lysine model system
Liang, Z., Li, L., Fu, Q., Zhang, X., Xu, Z., & Li, B. (2015) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.7376 · Cited by 31 · see citing works
Kaňková, K. (2008) · Proceedings of The Nutrition Society · doi:10.1017/s0029665108006034 · Cited by 30 · see citing works
Lee, H., Gu, M. J., Lee, J., Lee, S., Kim, Y., & Ha, S. K. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000799 · Cited by 28 · see citing works
Berdowska, I., Matusiewicz, M., & Fecka, I. (2023) · Molecules · doi:10.3390/molecules28237742 · Cited by 26 · see citing works
Liebisch, M., Bondeva, T., Franke, S., Daniel, C., Amann, K., & Wolf, G. (2014) · Kidney International · doi:10.1038/ki.2014.3 · Cited by 26 · see citing works
Fang, M., Wang, J., Li, S., & Guo, Y. (2015) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.12499 · Cited by 26 · see citing works
Skin-Autofluorescence Is an Independent Predictor of Graft Loss in Renal Transplant Recipients
Hartog, J. W. L., Groß, S., Oterdoom, L. H., van Ree, R. M., de Vries, A. P. J., Smit, A. J., Schouten, J. P., Nawroth, P. P., Gans, R. O. B., van Son, W. J., et al. (2009) · Transplantation · doi:10.1097/tp.0b013e31819d3173 · Cited by 26 · see citing works
Bondeva, T., Wojciech, S., & Wolf, G. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00575.2010 · Cited by 25 · see citing works
Maillard Reaction of Proteins and Advanced Glycation End Products (AGEs) in Food
Henle, T. (2008) · Wiley eBooks · doi:10.1002/9780470430101.ch2g · Cited by 24 · see citing works
Semba, R. D., Beck, J., Sun, K., Egan, J. M., Carlson, O. D., Varadhan, R., & Ferrucci, L. (2010) · The journal of nutrition health & aging · doi:10.1007/s12603-010-0105-y · Cited by 22 · see citing works
Podocytes of AT2 Receptor Knockout Mice Are Protected from Angiotensin II-Mediated RAGE Induction
Rüster, C., Franke, S., Wenzel, U. O., Schmidt-Haupt, R., Fraune, C., Krebs, C. F., & Wolf, G. (2011) · American Journal of Nephrology · doi:10.1159/000329321 · Cited by 20 · see citing works
Busch, M., Franke, S., Wolf, G., Rohde, R. D., & Stein, G. (2008) · Nephron Clinical Practice · doi:10.1159/000127838 · Cited by 20 · see citing works
Natale, P., Palmer, S. C., Navaneethan, S. D., Craig, J. C., & Strippoli, G. F. (2024) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006257.pub2 · Cited by 19 · see citing works
Backen, Altern, Diabetes: eine kurze Geschichte der Maillard‐Reaktion
Hellwig, M., & Henle, T. (2014) · Angewandte Chemie · doi:10.1002/ange.201308808 · Cited by 18 · see citing works
Adverse effects of advanced glycation end products on embryonal development.
Lin, H., Noguchi, S., Kamada, Y., Sasaki, A., 松田, 美., Shimizu, K., Hiramatsu, Y., & Nakatsuka, M. (2008) · PubMed · doi:10.18926/amo/30960 · Cited by 15 · see citing works
Takahashi, R., Imamura, A., Yoshikane, M., Suzuki, M., Murakami, R., Cheng, X. W., Numaguchi, Y., Ikeda, N., Murohara, T., & Okumura, K. (2010) · Metabolism · doi:10.1016/j.metabol.2010.06.015 · Cited by 14 · see citing works
Advanced glycation end products as predictors of renal function in youth with type 1 diabetes
Forbes, J. M., Bagge, S. L., Righi, S., Fotheringham, A. K., Gallo, L. A., McCarthy, D. A., Leung, S. S., Baskerville, T., Nisbett, J., Morton, A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-88786-4 · Cited by 13 · see citing works
Erythropoietin Protects Podocytes from Damage by Advanced Glycation End-Products
Rüster, C., Franke, S., Bondeva, T., & Wolf, G. (2010) · Nephron Experimental Nephrology · doi:10.1159/000319653 · Cited by 13 · see citing works
Gawandi, S., Gangawane, S., Chakrabarti, A., Kedare, S., Bantwal, K., Wadhe, V., Kulkarni, A., Kulkarni, S., & Rajan, M. G. R. (2017) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-017-0638-5 · Cited by 12 · see citing works
Chmielewski, M. S., Heimbürger, O., Stenvinkel, P., & Lindholm, B. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-391934-2.00004-7 · Cited by 12 · see citing works
Pinto, R., Machado, U. F., & Passarelli, M. (2020) · Biomarkers in Medicine · doi:10.2217/bmm-2020-0060 · Cited by 11 · see citing works
Aroni, A., Detopoulou, P., Presvelos, D., Kostopoulou, E., Ioannidis, A., Panoutsopoulos, G. I., Zyga, S., Kosmidis, G., Spiliotis, B. E., & Gil, A. P. R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168893 · Cited by 7 · see citing works
The ratio of AGE to sRAGE independently associated with albuminuria in hypertensive patients
Chiang, K., Chen, J., Huang, S., Leu, H., Lin, S., & Huang, P.-H. (2018) · BMC Endocrine Disorders · doi:10.1186/s12902-018-0306-7 · Cited by 7 · see citing works
Advanced glycation endproducts in sepsis and mechanical ventilation: extra or leading man?
Baumann, M. (2009) · Critical Care · doi:10.1186/cc7939 · Cited by 7 · see citing works
Liebisch, M., Bondeva, T., Franke, S., Hause, S., & Wolf, G. (2016) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfw313 · Cited by 5 · see citing works
Ahmad, A., Lim, L., Morieri, M. L., Tam, C., Cheng, F., Chikowore, T., Dudenhöffer‐Pfeifer, M., Fitipaldi, H., Huang, C., Kanbour, S., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2929263/v1 · Cited by 5 · see citing works
ADMA: a Specific Biomarker for Pathologic Progress in Diabetic Microvascular Complications?
Jing, Z., Kuang, L., Wang, Y., He, J., Sun, Z., Liu, N., & Yang, J. (2016) · Biomarkers in Medicine · doi:10.2217/bmm-2015-0007 · Cited by 4 · see citing works
Ahmad, A., Lim, L., Morieri, M. L., Tam, C. H. T., Cheng, F., Chikowore, T., Dudenhöffer‐Pfeifer, M., Fitipaldi, H., Huang, C., Kanbour, S., et al. (2023) · medRxiv · doi:10.1101/2023.04.26.23289177 · Cited by 4 · see citing works
Serum advanced glycation end products as a putative biomarker in Type2 DKD patients’ prognosis
Wang, Z., Zhang, Z., Wang, Y.-F., Xie, J., Li, Y., Shen, C., Meng, Y., Zhao, W., Sun, L., & Liu, W. J. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1541198 · Cited by 3 · see citing works
Natural Bioactives in the Management of Glaucoma: A Recent Update
Divya, Mazumder, R., Rani, A., & Mishra, R. (2025) · Journal of Natural Remedies · doi:10.18311/jnr/2025/49241 · Cited by 1 · see citing works
The analysis of advanced glycation endproducts
Scheijen (2017) · doi:10.26481/dis.20170621js · Cited by 1 · see citing works
Diabetic Nephropathy: A Cardiovascular Risk Factor
Magri, C. J., & Fav, S. (2012) · InTech eBooks · doi:10.5772/25431
- Authors
- Busch, M., Franke, S., Wolf, G., Brandstädt, A., Ott, U., Gerth, J., Hunsicker, L. G., & Stein, G.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Busch, Martin
- ORCID
- Busch, Martin
- Venue
- American Journal of Kidney Diseases
- Publisher
- Elsevier BV
- Published
- 2006-10
- Volume
- 48
- Issue
- 4
- Pages
- 571-579
- ISSN
- 0272-6386 (ISSN-L)
- OpenAlex
- W2036685670
- Cited by
- 63
- References
- 42
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2021: 3 · 2020: 1 · 2018: 2 · 2017: 5 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 3
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Kidney Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Keywords
- advanced glycation end products, type 2 diabetes, diabetic nephropathy, hypertension, cardiovascular events, renal outcomes, oxidative stress, cardiovascular risk factors, albuminuria, serum biomarkers, HbA1c, age as risk factor, cardiovascular mortality
- MeSH terms
- Aged, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Diabetic Nephropathies, Female, Humans, Hypertension, Lysine, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Risk Factors, Multivariate Analysis, Proportional Hazards Models, Glycation End Products, Advanced, Oxidative Stress, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
