The DOI matches its Crossref record; 58 of the 60 references it cites were found in a registry or an index.
Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
Open accessAbstract
Background & aims The mechanisms underlying abdominal pain perception in irritable bowel syndrome (IBS) are poorly understood. Intestinal mast cell infiltration may perturb nerve function leading to symptom perception. We assessed colonic mast cell infiltration, mediator release, and spatial interactions with mucosal innervation and their correlation with abdominal pain in IBS patients.Methods IBS patients were diagnosed according to Rome II criteria and abdominal pain quantified according to a validated questionnaire. Colonic mucosal mast cells were identified immunohistochemically and quantified with a computer-assisted counting method. Mast cell tryptase and histamine release were analyzed immunoenzymatically. Intestinal nerve to mast cell distance was assessed with electron microscopy.Results Thirty-four out of 44 IBS patients (77%) showed an increased area of mucosa occupied by mast cells as compared with controls (9.2% +/- 2.5% vs. 3.3 +/- 0.8%, respectively; P < 0.001). There was a 150% increase in the number of degranulating mast cells (4.76 +/- 3.18/field vs. 2.42 +/- 2.26/field, respectively; P = 0.026). Mucosal content of tryptase was increased in IBS and mast cells spontaneously released more tryptase (3.22 +/- 3.48 pmol/min/mg vs. 0.87 +/- 0.65 pmol/min/mg, respectively; P = 0.015) and histamine (339.7 +/- 59.0 ng/g vs. 169.3 +/- 130.6 ng/g, respectively; P = 0.015). Mast cells located within 5 microm of nerve fibers were 7.14 +/- 3.87/field vs. 2.27 +/- 1.63/field in IBS vs. controls (P < 0.001). Only mast cells in close proximity to nerves were significantly correlated with severity and frequency of abdominal pain/discomfort (P < 0.001 and P = 0.003, respectively).Conclusions Colonic mast cell infiltration and mediator release in proximity to mucosal innervation may contribute to abdominal pain perception in IBS patients.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Notably, approximately 70%–84% of patients with IBS exhibit local mast cell infiltration of mast cells in their intestinal tissues.”
From Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization (2026) · cites this paper as [72]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Moreover, the phenomenon of mast cell infiltration surrounding intestinal nerves occurs approximately three times more frequently in IBS patients than in controls, and the number of degranulated mast cells is increased by approximately 1.5-fold (72).”
From Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization (2026) · cites this paper as [72]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Studies on mast cells and cytokines point out that inflammation is present in IBS. 2, 13-20”
From Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota (2008) · cites this paper as [13]
The cited source says what the claim attributes to it.
In the citing paper
“Mucosal mast cell degranulation within the gut can affect host intestinal integrity (Santos et al., 2001) and has been related to visceral pain (Barbara et al., 2004).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Barbara et al., 2004
The cited source says what the claim attributes to it.
In the citing paper
“The severity and frequency of abdominal pain correlates with the presence of activated mast cells in close proximity to nerve endings in the gut mucosa in some studies, 56 but in others mast cell proliferation associates with a reduction, 57 or no change, 58 in visceral sensitivity.”
From British Society of Gastroenterology guidelines on the management of irritable bowel syndrome (2021) · cites this paper as [56]
In the citing paper
“An increase in mucosal immune cells including mast cells, macrophages or monocytes, T-cells, and eosinophils has been reported in both pediatric and adult FGID populations79, 113, 114.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [113]
In the citing paper
“Mast cells were located in closer vicinity to mucosal innervation and correlated with the severity and frequency of abdominal pain in patients with IBS.152”
From Intestinal microbiota in functional bowel disorders: a Rome foundation report (2013) · cites this paper as [152]
In the citing paper
“Evidence supporting this hypothesis includes increased concentrations of inflammatory/immune cells in intestinal tissue from IBS patients, altered levels of pro- and anti-inflammatory cytokines in the GI tract and peripheral blood of patients with IBS (Table 1) (11, 13, 24, 36, 46, 50, 51, 62, 73, 75, 89, 90, 94, 98, 102, 118, 121–124, 168, 174, 185, 187), and IBS-associated polymorphisms in genes”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
In the citing paper
“Other studies have reported elevated levels of histamine and tryptase release in patients with IBS compared with controls (11, 13, 35, 73).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
In the citing paper
“Evidence supporting this hypothesis includes increased concentrations of inflammatory/immune cells in intestinal tissue from IBS patients, altered levels of pro- and anti-inflammatory cytokines in the GI tract and peripheral blood of patients with IBS (Table 1) (11, 13, 24, 36, 46, 50, 51, 62, 73, 75, 89, 90, 94, 98, 102, 118, 121–124, 168, 174, 185, 187), and IBS-associated polymorphisms in genes”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
In the citing paper
“Notably, some studies demonstrated an increase in activated mast cells in biopsies from specific regions of the GI tract (i.e., cecum and terminal ileum) but not from other regions (e.g., ascending colon, descending colon, rectum) (89, 121, 187), whereas other studies have found activated mast cells in the descending colon (11, 13).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
In the citing paper
“Several studies have demonstrated increased concentrations of activated mast cells in patients with IBS compared with controls (11, 13, 24, 46, 89, 94, 121, 187).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
In the citing paper
“Interestingly, the activated mast cells were found to be in close proximity to enteric nerves and correlated with abdominal pain/discomfort (11).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
In the citing paper
“At the peripheral level, the close interaction between the immune system and the ENS in IBS is demonstrated by the increased infiltration of mast cells in the colonic mucosa in close proximity to enteric nerve fibers and by the increased number of sensory nerve fibers surrounding the mast cells (2, 11, 13).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
In the citing paper
“One study that supports this association demonstrated a strong correlation between number of infiltrated colonic mast cells around nerves and the severity and frequency of abdominal pain in patients with IBS (11).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
In the citing paper
“In addition, human and animal studies have shown anatomical changes in the enteric nervous system (ENS) around inflammatory infiltrates in the gut wall (2, 11, 13).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Measurement of protein using bicinchoninic acid
Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., & Klenk, D. C. (1985) · Analytical Biochemistry · doi:10.1016/0003-2697(85)90442-7 · Cited by 18,482
Functional bowel disorders and functional abdominal pain
Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Müller-Lissner, S. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii43 · Cited by 2,440
Metcalfe, D. D., Baram, D., & Mekori, Y. A. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.4.1033 · Cited by 1,723
Proteinase-activated Receptors
Macfarlane, S. R., Seatter, M. J., Kanke, T., Hunter, G. D., & Plevin, R. J. (2006) · Springer eBooks · doi:10.1007/3-540-29832-0_1335 · Cited by 1,137
Postinfectious Irritable Bowel Syndrome
Spiller, R., & Garsed, K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.074 · Cited by 1,024
Activation of the mucosal immune system in irritable bowel syndrome
Chadwick, V. S., Chen, W., Shu, D., Paulus, B., Bethwaite, P., Tie, A., & Wilson, I. (2002) · Gastroenterology · doi:10.1053/gast.2002.33579 · Cited by 833
The role of psychological and biological factors in postinfective gut dysfunction
Gwee, K.-A., Leong, Y.-L., Graham, C., McKendrick, M. W., Collins, S. M., Walters, S. J., Underwood, J. E., & Read, N. W. (1999) · Gut · doi:10.1136/gut.44.3.400 · Cited by 764
Self-citationInteractions of Mast Cell Tryptase with Thrombin Receptors and PAR-2
Molino, M., Barnathan, E. S., Numerof, R. P., Clark, J., Dreyer, M. L., Cumashi, A., Hoxie, J. A., Schechter, N. M., Woolkalís, M. J., & Brass, L. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4043 · Cited by 592
Effects of gender and sex steroids on the immune response
Schuurs, A. H. W. M., & Verheul, H. A. M. (1990) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(90)90270-3 · Cited by 587
Neal, K. R., Hebden, J., & Spiller, R. (1997) · BMJ · doi:10.1136/bmj.314.7083.779 · Cited by 586
Cited by
Sorted by citations
Items 701–800 of 1,001
The role of intestinal mast cell infiltration in irritable bowel syndrome
Cheng, L., Luo, Q., & Chen, S. (2021) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12971 · Cited by 25
Zhang, H., Zhang, Y., Zhang, Y., Jiang, Z., Cui, Y., & Wang, Q. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.03.118 · Cited by 25
Systematic Review and Meta-analysis: Efficacy of Mesalamine in Irritable Bowel Syndrome
Goodoory, V. C., Tuteja, A. K., Black, C. J., & Ford, A. C. (2023) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2023.02.014 · Cited by 30
Carroccio, A., Mansueto, P., Morfino, G., D’Alcamo, A., Paola, V. D., Iacono, G., Soresi, M., Scerrino, G., Maresi, E., Gulotta, G., et al. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.58 · Cited by 25
Recent advances in pharmacological treatment of irritable bowel syndrome.
Geórgia, Lazaraki, Grigoris, Chatzimavroudis, Panagiotis, & Katsinelos (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i27.8867 · Cited by 30
Lieu, T., Savage, E. E., Zhao, P., Edgington‐Mitchell, L. E., Barlow, Ν., Bron, R., Poole, D. P., McLean, P. G., Lohman, R., Fairlie, D. P., et al. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13554 · Cited by 25
Self-citationTsai, J., Wang, I. J., Shen, T., Lin, C., & Wei, C. (2018) · Journal of Investigative Medicine · doi:10.1136/jim-2017-000631 · Cited by 25
Yang, X., Sheng, L., Guan, Y., Qian, W., & Hou, X. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0444-2 · Cited by 25
Choi, K., Chen, J., MITRA, S. P., & Sarna, S. K. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.074 · Cited by 25
Ahmed, S., Ansari, A., Li, Z., Mazumdar, H., Siddiqui, M. A., Khan, A., Ranjan, P., Kaushik, A. K., Vinu, A., & Kumar, P. (2024) · Advanced Sensor Research · doi:10.1002/adsr.202400132 · Cited by 26
Ostertag, D., Bühner, S., Michel, K., Pehl, C., Kurjak, M., Götzberger, M., Schulte‐Frohlinde, E., Frieling, T., Enck, P., Phillip, J., et al. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00465 · Cited by 24
Inflammation and Chronic Pelvic Pain: A Biological Trigger for Depression in Women?
Graziottin, A. (2014) · Journal of Depression & Anxiety · doi:10.4172/2167-1044.1000142 · Cited by 23
Fuentes, I. M., Walker, N. K., Pierce, A. N., Holt, B., Silvestro, E. R. D., & Christianson, J. A. (2016) · IBRO Reports · doi:10.1016/j.ibror.2016.07.001 · Cited by 24
Berg, L. K., Goll, R., Fagerli, E., Ludviksen, J. K., Fure, H., Moen, O. S., Sørbye, S. W., Mollnes, T. E., & Florholmen, J. (2020) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2020.1754455 · Cited by 24
Sarnelli, G., Pesce, M., Seguella, L., Lu, J., Efficie, E., Tack, J. F., Palma, F. D. E. D., D’Alessandro, A., & Esposito, G. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.10.001 · Cited by 24
Clinical relevance of intestinal barrier dysfunction in common gastrointestinal diseases
Muehler, A. R., Slizgi, J. R., Kohlhof, H., Groeppel, M., Peelen, E., & Vitt, D. (2020) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v11.i6.114 · Cited by 25
Probiotics and Irritable Bowel Syndrome
Barbara, G., Stanghellini, V., Cremon, C., GIORGIO, R. D., Gargano, L., Cogliandro, R. F., Pallotti, F., & Corinaldesi, R. (2008) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31817da129 · Cited by 24
Self-citationCutaneous immunopathology of long‐standing complex regional pain syndrome
Osborne, S., Farrell, J., Dearman, R. J., MacIver, K., Naisbitt, D. J., Moots, R. J., Edwards, S. W., & Göebel, A. (2015) · European Journal of Pain · doi:10.1002/ejp.685 · Cited by 24
Irritable bowel syndrome: A comparison of subtypes
de Castro, N. R., Miller, V., Carruthers, H. R., & Whorwell, P. J. (2014) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12704 · Cited by 24
Activity of Protease-Activated Receptors in Primary Cultured Human Myenteric Neurons
Kugler, E. M., Mazzuoli‐Weber, G., Demir, İ. E., Ceyhan, G. O., Zeller, F., & Schemann, M. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00133 · Cited by 24
Kovacic, K. K., & Lorenzo, C. D. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001076 · Cited by 24
Gong, L., Li, J., Tang, Y., Han, T., Wei, C., Yu, X., Li, J., Wang, R., Ma, X., Liu, K., et al. (2016) · Scientific Reports · doi:10.1038/srep31452 · Cited by 24
Lashermes, A., Boudieu, L., Barbier, J., Sion, B., Gelot, A., Barnich, N., Ardid, D., & Carvalho, F. (2018) · Gut microbes · doi:10.1080/19490976.2017.1361091 · Cited by 22
Nybacka, S., Öhman, L., Störsrud, S., Mybeck, M., Böhn, L., Wilpart, K., Winkvist, A., Bengtsson, U. J., Törnblom, H., & Simrén, M. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13379 · Cited by 25
Zhang, L., Song, J., Bai, T., Wang, R., & Hou, X. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13430 · Cited by 24
Bennet, S., Sundin, J., Magnusson, M. K., Strid, H., Tap, J., Derrien, M., Nevé, B. L., Dore, J. M., Törnblom, H., Simrén, M., et al. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13468 · Cited by 24
Nerve fiber overgrowth in patients with symptomatic diverticular disease
Barbaro, M. R., Cremon, C., Fuschi, D., Scaioli, E., Veneziano, A., Marasco, G., Festi, D., Stanghellini, V., & Barbara, G. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13575 · Cited by 24
Self-citationClinical Management of the Microbiome in Irritable Bowel Syndrome
Andrews, C. N., Sidani, S., & Marshall, J. K. (2019) · Journal of the Canadian Association of Gastroenterology · doi:10.1093/jcag/gwz037 · Cited by 25
Application of metabolomics to the study of irritable bowel syndrome
Bennet, S., Keshteli, A. H., Berčík, P., Madsen, K. L., Reed, D. E., & Vanner, S. J. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13884 · Cited by 26
Microflora imbalance and gastrointestinal diseases
Ojetti, V., Gigante, G. E., Ainora, M. E., Fiore, F., Barbaro, F., & Gasbarrini, A. (2009) · Digestive and Liver Disease Supplements · doi:10.1016/s1594-5804(09)60017-6 · Cited by 24
East meets West: infection, nerves, and mast cells in the irritable bowel syndrome
Collins, S. M. (2004) · Gut · doi:10.1136/gut.2004.038893 · Cited by 24
Self-citation"Choice" in health care: what do people really want?
Lambrew, J. M. (2005) · PubMed · Cited by 24
Mucosal neuroimmune mechanisms in gastro-oesophageal reflux disease (GORD) pathogenesis
Leech, T., & Peiris, M. (2024) · Journal of Gastroenterology · doi:10.1007/s00535-023-02065-9 · Cited by 24
Characterisation of MRGPRX2 + mast cells in irritable bowel syndrome
Decraecker, L., Estévez, M. C., Remoortel, S. V., Quan, R., Stakenborg, N., Wang, Z., Marco, E. D., Denadai‐Souza, A., Viola, M. F., Garcia‐Caraballo, S., et al. (2025) · Gut · doi:10.1136/gutjnl-2024-334037 · Cited by 28
Review: Do probiotics improve symptoms in patients with irritable bowel syndrome?
Whorwell, P. J. (2009) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x09335637 · Cited by 23
Zhao, J., Li, L., Chen, L., Shi, Y., Li, Y., Shang, H.-X., Wu, L., Weng, Z., Bao, C., & Wu, H. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i16.2928 · Cited by 23
Physiological mechanisms of unexplained (functional) gastrointestinal disorders
Burns, G. L., Hoedt, E. C., Walker, M. M., Talley, N. J., & Keely, S. (2021) · The Journal of Physiology · doi:10.1113/jp281620 · Cited by 23
Biological Relevance of Goat Milk Oligosaccharides to Infant Health
van der Toorn, M. V., Chatziioannou, A. C., Pellis, L., Haandrikman, A. J., van der Zee, L., & Dijkhuizen, L. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c02194 · Cited by 23
Treatment of irritable bowel syndrome: sex and gender specific aspects.
Voss, U., Lewerenz, A., & Nieber, K. (2012) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-30726-3_21 · Cited by 23
Ludidi, S., Jonkers, D., Elamin, E., Pieters, H.-J. H. M., Schaepkens, E., Bours, P., Kruimel, J., Conchillo, J., & Masclee, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123498 · Cited by 25
Katiraei, P., & Bultron, G. (2011) · PubMed Central · doi:10.3748/wjg.v17.i23.2791 · Cited by 27
Persistent epithelial barrier alterations in a rat model of postinfectious gut dysfunction
Fernández-Blanco, J. A., Barbosa, S., de Medina, F. S., Martı́nez, V., & Vergara, P. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01777.x · Cited by 23
Early Life Events and the Development of Visceral Hyperalgesia
Miranda, A. (2008) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000338958.94313.99 · Cited by 23
Lessons Learnt from Post-Infectious IBS
Sarna, S. K. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00049 · Cited by 24
The role of colonic mast cells and myenteric plexitis in patients with diverticular disease
Bassotti, G., Villanacci, V., Nascimbeni, R., Antonelli, E., Cadei, M., Manenti, S., Lorenzi, L., Titi, A., & Salerni, B. (2012) · International Journal of Colorectal Disease · doi:10.1007/s00384-012-1554-z · Cited by 23
Ma, X., Wang, X., Kang, N., Chen, T., Ji, H., Lv, L. L., Yin, X., Tian, Y., Zheng, R., Duan, Y., et al. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/9086034 · Cited by 24
Kodani, M., Fukui, H., Tomita, T., Oshima, T., Watari, J., & Miwa, H. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8926 · Cited by 23
Aguilera‐Lizarraga, J., Florens, M. V., Brussel, T. V., Clevers, E., Oudenhove, L. V., Lambrechts, D., Wouters, M. M., & Boeckxstaens, G. E. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13579 · Cited by 23
Botschuijver, S., van Diest, S. A., van Thiel, I. A. M., Saia, R. S., Strik, A. S., Yu, Z., Ferreira, D. M., Welting, O., Keszthelyi, D., Jennings, G. S., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-49096-y · Cited by 23
Cytokine responses of intraepithelial lymphocytes are regulated by histamine H2 receptor
Takagaki, K., Osawa, S., Horio, Y., Yamada, T., Hamaya, Y., Takayanagi, Y., Furuta, T., Hishida, A., & Ikuma, M. (2009) · Journal of Gastroenterology · doi:10.1007/s00535-009-0019-9 · Cited by 23
Neuroimmunomodulation in the Gut: Focus on Inflammatory Bowel Disease
Bernardazzi, C., Pêgo, B., & de Souza, H. S. P. (2016) · Mediators of Inflammation · doi:10.1155/2016/1363818 · Cited by 23
Malone, M. (2011) · Primary Care · doi:10.1016/j.pop.2011.05.003 · Cited by 7
Belmer, S. V., Васильевна, В. Г., Gorelov, A. V., Гурова, М. М., Zvyagin, A. A., Корниенко, Е. А., Novikova, V. P., Печкуров, Д. В., Privorotskiy, V. F., Александровна, Т. А., et al. (2020) · Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) · doi:10.21508/1027-4065-2020-65-4-150-161 · Cited by 25
Aberrant Gut-To-Brain Signaling in Irritable Bowel Syndrome - The Role of Bile Acids
Dhonnabháín, R. N., Xiao, Q., & O’Malley, D. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.745190 · Cited by 25
Zhu, X. H., Hong, G., Li, Y., Yang, P., Cheng, M., Zhang, L., Li, Y., Ji, L., Li, G., Chen, C., et al. (2021) · Microbiology Spectrum · doi:10.1128/spectrum.01255-21 · Cited by 22
Probióticos y aparato digestivo. Evidencias actuales
Mearin, F., Guarner, F., & Verdu, E. F. (2009) · Gastroenterología y Hepatología · doi:10.1016/s0210-5705(09)71003-9 · Cited by 22
Irritable bowel syndrome; update on pathophysiology and management
Quigley, E. M. M., & Craig, O. F. (2012) · The Turkish Journal of Gastroenterology · doi:10.4318/tjg.2012.0551 · Cited by 22
Histopathological changes in the gastroduodenal mucosa of children with functional dyspepsia
Singh, V., Singh, M., Schurman, J. V., & Friesen, C. A. (2018) · Pathology - Research and Practice · doi:10.1016/j.prp.2018.06.014 · Cited by 23
New insights and directions in travelers' diarrhea.
DuPont, H. (2006) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2006.03.008 · Cited by 24
Kim, D. H., Cho, Y. J., Kim, J., Kim, Y. B., & Lee, K.-J. (2010) · Journal of Korean medical science · doi:10.3346/jkms.2010.25.9.1330 · Cited by 22
Neuroendocrine and Neuroimmune Markers in IBS: Pathophysiological Role or Epiphenomenon?
Chang, L. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.12.047 · Cited by 22
Recent developments in the therapy of irritable bowel syndrome
Saad, R. J., & Chey, W. D. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.2.117 · Cited by 21
Belmer, S. V., Васильевна, В. Г., Gorelov, A. V., Гурова, М. М., Zvyagin, A. A., Корниенко, Е. А., Novikova, V. P., Печкуров, Д. В., Privorotskiy, V. F., Александровна, Т. А., et al. (2020) · Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) · doi:10.21508/1027-4065-2020-65-5-100-111 · Cited by 22
Role of inflammation in pediatric irritable bowel syndrome
Nardo, G. D., Cremon, C., Staiano, A., Stanghellini, V., Borrelli, O., Strisciuglio, C., Romano, C., Mallardo, S., Scarpato, E., Marasco, G., et al. (2022) · Neurogastroenterology & Motility · doi:10.1111/nmo.14365 · Cited by 21
Self-citationvon Rahden, B. H. A., Jurowich, C. F., Kircher, S., Lazariotou, M., Jung, M., Germer, C., & Grimm, M. R. (2011) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-011-1702-8 · Cited by 21
Bafutto, M., de Almeida, J. R., Leite, N. V., Costa, M. B., de Oliveira, Ê. C., & RESENDE-FILHO, J. (2013) · Arquivos de Gastroenterologia · doi:10.1590/s0004-28032013000400012 · Cited by 22
Fernández, L. M. B., Lasa, J. S., & Man, F. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000153 · Cited by 21
Glioplasticity in irritable bowel syndrome
Lilli, N. L., Quénéhervé, L., Haddara, S., Brochard, C., Aubert, P., Rolli‐Derkinderen, M., Durand, T., Naveilhan, P., Hardouin, J.-B., GIORGIO, R. D., et al. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13232 · Cited by 21
Self-citationA Practical Guide for Treatment of Pain in Patients with Systemic Mast Cell Activation Disease
Molderings, G. J. (2017) · Pain Physician · doi:10.36076/ppj.20.5.e849 · Cited by 19
Wei, W., Wang, H., Zhang, Y., Zhang, Y., Niu, B.-Y., Chen, S., Zhang, W., & Yao, S. (2021) · Digestive and Liver Disease · doi:10.1016/j.dld.2021.04.022 · Cited by 23
Corticotropin releasing factor—Distribution in rat intestine and role in neuroprotection
Sand, E., Themner-Persson, A., & Ekblad, E. (2010) · Regulatory Peptides · doi:10.1016/j.regpep.2010.08.011 · Cited by 22
Chang, H.-C., Yen, A. M.-F., Fann, J. C. ‐., Chiu, S. Y., Liao, C., Chen, H.-H., Yang, K.-C., Chen, L. S., & Lin, Y.-M. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.575 · Cited by 21
Koido, S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i39.14420 · Cited by 21
Innervation of the Gastrointestinal Tract by Spinal and Vagal Afferent Nerves
Brierley, S. M., Hughes, P. A., Harrington, A. M., & Blackshaw, L. A. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00024-5 · Cited by 21
The Use of Probiotics in Functional Bowel Disease
Quigley, E. M. M. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2005.05.008 · Cited by 20
Toll-like receptor 4 plays a vital role in irritable bowel syndrome: a scoping review
Wan, X., Wang, L., Wang, Z., & Wan, C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1490653 · Cited by 22
Kumari, M. V., Devanarayana, N. M., Amarasiri, L., & Rajindrajith, S. (2018) · World Journal of Clinical Cases · doi:10.12998/wjcc.v6.i15.944 · Cited by 20
Yadav, Y., Eslick, G. D., & Talley, N. J. (2021) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16624 · Cited by 23
Metabolomics: The Key to Unraveling the Role of the Microbiome in Visceral Pain Neurotransmission
Shute, A., Bihan, D. G., Lewis, I. A., & Nasser, Y. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.917197 · Cited by 21
Torres-Maravilla, E., Holowacz, S., Delannoy, J., Lenoir, L., Jacouton, E., Gervason, S., Meynier, M., Boucard, A.-S., Carvalho, F. A., Barbut, F., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-21746-8 · Cited by 20
Salari, P. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i38.4251 · Cited by 20
Ferjan, I., & Lipnik‐Štangelj, M. (2013) · Mediators of Inflammation · doi:10.1155/2013/340473 · Cited by 21
An observational study of headaches in children and adolescents with functional abdominal pain
Friesen, C. A., Singh, M., Singh, V., & Schurman, J. V. (2018) · Medicine · doi:10.1097/md.0000000000011395 · Cited by 20
Peripheral neurons: Master regulators of skin and mucosal immune response
Basso, L., Serhan, N., Tauber, M., & Gaudenzio, N. (2019) · European Journal of Immunology · doi:10.1002/eji.201848027 · Cited by 25
Food allergy and irritable bowel syndrome
ki, M. K. (2005) · Current Opinion in Gastroenterology · doi:10.1097/01.mog.0000181712.81657.0a · Cited by 20
Chronic pain syndromes, mechanisms, and current treatments.
Sirianni, J., Ibrahim, M. M., & Patwardhan, A. M. (2015) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2015.01.004 · Cited by 19
Functional Gastrointestinal Disorders and the Potential Role of Eosinophils
Walker, M. M., & Talley, N. J. (2008) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2008.02.007 · Cited by 20
Xu, X., Li, Z., Zou, D., Yang, M., Liu, Z., & Wang, X. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2308-z · Cited by 20
Rijnierse, A., Kroese, A. B. A., Redegeld, F. A., Blokhuis, B. R. J., van der Heijden, M. W., Koster, A. S., Timmermans, J., Nijkamp, F. P., & Kraneveld, A. D. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.01.008 · Cited by 20
Rat tracheal epithelial responses to water avoidance stress
Akiyama, H., Amano, H., & Bienenstock, J. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.03.040 · Cited by 20
Almost All Irritable Bowel Syndromes Are Post-Infectious and Respond to Probiotics: Consensus Issues
Cuomo, R., Savarese, M. F., & Gargano, R. (2007) · Digestive Diseases · doi:10.1159/000103893 · Cited by 20
Probiotics in irritable bowel syndrome: an immunomodulatory strategy?
Quigley, E. M. M. (2007) · Journal of the American College of Nutrition · doi:10.1080/07315724.2007.10719648 · Cited by 19
Ostertag, D., Annaházi, A., Krueger, D., Michel, K., Demir, İ. E., Ceyhan, G. O., Zeller, F., & Schemann, M. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13070 · Cited by 19
Zhang, M., Dang, M., Wu, X., Li, O., Li, M., Zhao, C., Wei, P.-F., Dong, T., Li, Y., & Wu, C. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118275 · Cited by 22
Song, J., Zhang, L., Bai, T., Qian, W., Li, R., & Hou, X. (2015) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14095 · Cited by 19
Immune Activation and Gut Microbes in Irritable Bowel Syndrome
Al-Khatib, K., & Lin, H. C. (2009) · Gut and Liver · doi:10.5009/gnl.2009.3.1.14 · Cited by 19
Hagel, A., deRossi, T., Zopf, Y., Konturek, P. C., Dauth, W., Kressel, J., Hahn, E. G., & Raithel, M. (2012) · International Archives of Allergy and Immunology · doi:10.1159/000341634 · Cited by 19
Síndrome del intestino irritable y enfermedad inflamatoria intestinal: ¿alguna conexión?
Mearin, F., Juan, A. P., & Balboa, A. (2009) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2008.12.007 · Cited by 19
Current and emerging drug options in the treatment of diarrhea predominant irritable bowel syndrome
Nee, J. W., Zakari, M., & Lembo, A. J. (2015) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2015.1101449 · Cited by 19
Mondelaers, S., Theofanous, S., Florens, M. V., Perna, E., Aguilera‐Lizarraga, J., Boeckxstaens, G. E., & Wouters, M. M. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12759 · Cited by 23
Metadata
- Authors
- Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., Collins, S. M., & Corinaldesi, R.
- Affiliations
- University of Bologna (IT)
- University of California, San Francisco (US)
- McMaster University (CA)
- Corresponding author
- Barbara, Giovanni
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 126
- Issue
- 3
- Pages
- 693-702
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1976068711
- Cited by
- 1,475
- References
- 60
- Citations by year
- 2026: 49 · 2025: 39 · 2024: 49 · 2023: 70 · 2022: 64 · 2021: 74 · 2020: 55 · 2019: 44 · 2018: 74 · 2017: 73 · 2016: 77 · 2015: 71 · 2014: 79 · 2013: 66 · 2012: 84
- FWCI
- 56.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 57840, DK 43207, R01DK057840)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
- Keywords
- irritable bowel syndrome, mast cells, abdominal pain, colonic mucosa, enteric nerves, mast cell degranulation, tryptase, histamine release, visceral pain perception, mast cell infiltration
- MeSH terms
- Adult, Aged, Cell Count, Colon, Female, Histamine Release, Humans, Immunohistochemistry, Intestinal Mucosa, Male, Mast Cells, Microscopy, Electron, Middle Aged, Nervous System, Serine Endopeptidases, Blotting, Western, Cell Degranulation, Abdominal Pain, Irritable Bowel Syndrome, Tryptases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
