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Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
Open accessAbstract
Background & aims The mechanisms underlying abdominal pain perception in irritable bowel syndrome (IBS) are poorly understood. Intestinal mast cell infiltration may perturb nerve function leading to symptom perception. We assessed colonic mast cell infiltration, mediator release, and spatial interactions with mucosal innervation and their correlation with abdominal pain in IBS patients.Methods IBS patients were diagnosed according to Rome II criteria and abdominal pain quantified according to a validated questionnaire. Colonic mucosal mast cells were identified immunohistochemically and quantified with a computer-assisted counting method. Mast cell tryptase and histamine release were analyzed immunoenzymatically. Intestinal nerve to mast cell distance was assessed with electron microscopy.Results Thirty-four out of 44 IBS patients (77%) showed an increased area of mucosa occupied by mast cells as compared with controls (9.2% +/- 2.5% vs. 3.3 +/- 0.8%, respectively; P < 0.001). There was a 150% increase in the number of degranulating mast cells (4.76 +/- 3.18/field vs. 2.42 +/- 2.26/field, respectively; P = 0.026). Mucosal content of tryptase was increased in IBS and mast cells spontaneously released more tryptase (3.22 +/- 3.48 pmol/min/mg vs. 0.87 +/- 0.65 pmol/min/mg, respectively; P = 0.015) and histamine (339.7 +/- 59.0 ng/g vs. 169.3 +/- 130.6 ng/g, respectively; P = 0.015). Mast cells located within 5 microm of nerve fibers were 7.14 +/- 3.87/field vs. 2.27 +/- 1.63/field in IBS vs. controls (P < 0.001). Only mast cells in close proximity to nerves were significantly correlated with severity and frequency of abdominal pain/discomfort (P < 0.001 and P = 0.003, respectively).Conclusions Colonic mast cell infiltration and mediator release in proximity to mucosal innervation may contribute to abdominal pain perception in IBS patients.
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“Notably, approximately 70%–84% of patients with IBS exhibit local mast cell infiltration of mast cells in their intestinal tissues.”
From Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization (2026) · cites this paper as [72]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Moreover, the phenomenon of mast cell infiltration surrounding intestinal nerves occurs approximately three times more frequently in IBS patients than in controls, and the number of degranulated mast cells is increased by approximately 1.5-fold (72).”
From Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization (2026) · cites this paper as [72]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Mucosal mast cell degranulation within the gut can affect host intestinal integrity (Santos et al., 2001) and has been related to visceral pain (Barbara et al., 2004).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Barbara et al., 2004
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In the citing paper
“The severity and frequency of abdominal pain correlates with the presence of activated mast cells in close proximity to nerve endings in the gut mucosa in some studies, 56 but in others mast cell proliferation associates with a reduction, 57 or no change, 58 in visceral sensitivity.”
From British Society of Gastroenterology guidelines on the management of irritable bowel syndrome (2021) · cites this paper as [56]
In the citing paper
“An increase in mucosal immune cells including mast cells, macrophages or monocytes, T-cells, and eosinophils has been reported in both pediatric and adult FGID populations79, 113, 114.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [113]
In the citing paper
“Mast cells were located in closer vicinity to mucosal innervation and correlated with the severity and frequency of abdominal pain in patients with IBS.152”
From Intestinal microbiota in functional bowel disorders: a Rome foundation report (2013) · cites this paper as [152]
In the citing paper
“Studies on mast cells and cytokines point out that inflammation is present in IBS. 2, 13-20”
From Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota (2008) · cites this paper as [13]
In the citing paper
“Evidence supporting this hypothesis includes increased concentrations of inflammatory/immune cells in intestinal tissue from IBS patients, altered levels of pro- and anti-inflammatory cytokines in the GI tract and peripheral blood of patients with IBS (Table 1) (11, 13, 24, 36, 46, 50, 51, 62, 73, 75, 89, 90, 94, 98, 102, 118, 121–124, 168, 174, 185, 187), and IBS-associated polymorphisms in genes”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
In the citing paper
“Other studies have reported elevated levels of histamine and tryptase release in patients with IBS compared with controls (11, 13, 35, 73).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
In the citing paper
“Evidence supporting this hypothesis includes increased concentrations of inflammatory/immune cells in intestinal tissue from IBS patients, altered levels of pro- and anti-inflammatory cytokines in the GI tract and peripheral blood of patients with IBS (Table 1) (11, 13, 24, 36, 46, 50, 51, 62, 73, 75, 89, 90, 94, 98, 102, 118, 121–124, 168, 174, 185, 187), and IBS-associated polymorphisms in genes”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
In the citing paper
“Notably, some studies demonstrated an increase in activated mast cells in biopsies from specific regions of the GI tract (i.e., cecum and terminal ileum) but not from other regions (e.g., ascending colon, descending colon, rectum) (89, 121, 187), whereas other studies have found activated mast cells in the descending colon (11, 13).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
In the citing paper
“Several studies have demonstrated increased concentrations of activated mast cells in patients with IBS compared with controls (11, 13, 24, 46, 89, 94, 121, 187).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
In the citing paper
“Interestingly, the activated mast cells were found to be in close proximity to enteric nerves and correlated with abdominal pain/discomfort (11).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
In the citing paper
“At the peripheral level, the close interaction between the immune system and the ENS in IBS is demonstrated by the increased infiltration of mast cells in the colonic mucosa in close proximity to enteric nerve fibers and by the increased number of sensory nerve fibers surrounding the mast cells (2, 11, 13).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
In the citing paper
“One study that supports this association demonstrated a strong correlation between number of infiltrated colonic mast cells around nerves and the severity and frequency of abdominal pain in patients with IBS (11).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
In the citing paper
“In addition, human and animal studies have shown anatomical changes in the enteric nervous system (ENS) around inflammatory infiltrates in the gut wall (2, 11, 13).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
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Cites
Measurement of protein using bicinchoninic acid
Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., & Klenk, D. C. (1985) · Analytical Biochemistry · doi:10.1016/0003-2697(85)90442-7 · Cited by 18,482
Functional bowel disorders and functional abdominal pain
Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Müller-Lissner, S. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii43 · Cited by 2,440
Metcalfe, D. D., Baram, D., & Mekori, Y. A. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.4.1033 · Cited by 1,723
Proteinase-activated Receptors
Macfarlane, S. R., Seatter, M. J., Kanke, T., Hunter, G. D., & Plevin, R. J. (2006) · Springer eBooks · doi:10.1007/3-540-29832-0_1335 · Cited by 1,137
Postinfectious Irritable Bowel Syndrome
Spiller, R., & Garsed, K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.074 · Cited by 1,024
Activation of the mucosal immune system in irritable bowel syndrome
Chadwick, V. S., Chen, W., Shu, D., Paulus, B., Bethwaite, P., Tie, A., & Wilson, I. (2002) · Gastroenterology · doi:10.1053/gast.2002.33579 · Cited by 833
The role of psychological and biological factors in postinfective gut dysfunction
Gwee, K.-A., Leong, Y.-L., Graham, C., McKendrick, M. W., Collins, S. M., Walters, S. J., Underwood, J. E., & Read, N. W. (1999) · Gut · doi:10.1136/gut.44.3.400 · Cited by 764
Self-citationInteractions of Mast Cell Tryptase with Thrombin Receptors and PAR-2
Molino, M., Barnathan, E. S., Numerof, R. P., Clark, J., Dreyer, M. L., Cumashi, A., Hoxie, J. A., Schechter, N. M., Woolkalís, M. J., & Brass, L. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4043 · Cited by 592
Effects of gender and sex steroids on the immune response
Schuurs, A. H. W. M., & Verheul, H. A. M. (1990) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(90)90270-3 · Cited by 587
Neal, K. R., Hebden, J., & Spiller, R. (1997) · BMJ · doi:10.1136/bmj.314.7083.779 · Cited by 586
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2 of the 60 references couldn’t be matched to a known paper.
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Items 401–500 of 1,001
Mast cell ontogeny: From fetal development to life‐long health and disease
Chia, S. L., Kapoor, S. S., Carvalho, C., Bajénoff, M., & Gentek, R. (2023) · Immunological Reviews · doi:10.1111/imr.13191 · Cited by 60
Bongaers, E., Alenus, J., Horemans, F., Weustenraed, A., Lutsen, L., Vanderzande, D. J. M., Cleij, T. J., Troost, F. J., Brummer, R. J., & Wagner, P. (2010) · physica status solidi (a) · doi:10.1002/pssa.200983307 · Cited by 59
Postinfectious Functional Gastrointestinal Disorders in Children: A Multicenter Prospective Study
Pensabene, L., Talarico, V., Concolino, D., Ciliberto, D., Campanozzi, A., Gentile, T., Rutigliano, V., Salvatore, S., Staiano, A., Lorenzo, C. D., et al. (2015) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.12.050 · Cited by 60
Diagnosis and treatment of diarrhea-predominant irritable bowel syndrome
Lacy, B. E. (2016) · International Journal of General Medicine · doi:10.2147/ijgm.s93698 · Cited by 59
Patient-reported outcomes and gut dysmotility in functional gastrointestinal disorders
Cogliandro, R. F., Antonucci, A., GIORGIO, R. D., Barbara, G., Cremon, C., Cogliandro, L., Frisoni, C., Pezzilli, R., Morselli‐Labate, A. M., Corinaldesi, R., et al. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01783.x · Cited by 57
Self-citationGastrointestinal Parasites and the Neural Control of Gut Functions
Halliez, M. C. M., & Buret, A. G. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00452 · Cited by 58
Use of rifaximin in gastrointestinal and liver diseases
Shayto, R. H., Mrad, R. A., & Sharara, A. I. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i29.6638 · Cited by 57
Martin‐Viñas, J. J., & Quigley, E. M. M. (2016) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12379 · Cited by 57
Weinstock, L. B., Fern, S. E., & Duntley, S. P. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-0021-0 · Cited by 56
Willot, S., Gauthier, C., Patey, N., & Faure, C. C. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01933.x · Cited by 57
Chey, W. D., Shah, E. D., & DuPont, H. L. (2020) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284819897531 · Cited by 57
Sex-Bias in Irritable Bowel Syndrome: Linking Steroids to the Gut-Brain Axis
So, S. Y., & Savidge, T. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.684096 · Cited by 62
Intestinal Barrier Function and the Brain-Gut Axis
Alonso, C., Vicario, M., Pigrau, M., Lobo, B., & Santos, J. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0897-4_4 · Cited by 58
Bengtsson, M., Hammar, O., Mandl, T., & Ohlsson, B. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-122 · Cited by 57
Irritable bowel syndrome and endometriosis: New insights for old diseases
Viganò, D., Zara, F., & Usai, P. (2017) · Digestive and Liver Disease · doi:10.1016/j.dld.2017.12.017 · Cited by 57
Cottrell, G. S., Amadesi, S., Pikios, S., Camerer, E., Willardsen, J. A., Murphy, B. R., Caughey, G. H., Wolters, P. J., Coughlin, S. R., Peterson, A., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.101 · Cited by 56
Self-citationEnhanced Nerve–Mast Cell Interaction by a Neuronal Short Isoform of Cell Adhesion Molecule-1
Hagiyama, M., Furuno, T., Hosokawa, Y., Iino, T., Ito, T., Inoué, T., Nakanishi, M., Murakami, Y., & Ito, A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002244 · Cited by 56
Ouyang, A., & Wrzos, H. F. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00975.x · Cited by 57
Histopathological alterations in irritable bowel syndrome
Kirsch, R., & Riddell, R. H. (2006) · Modern Pathology · doi:10.1038/modpathol.3800704 · Cited by 57
Pierce, A. N., Ryals, J. M., Wang, R., & Christianson, J. A. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.022 · Cited by 55
Duodenal inflammation: an emerging target for functional dyspepsia?
Wauters, L. I., Burns, G. L., Ceulemans, M., Walker, M. M., Vanuytsel, T., Keely, S., & Talley, N. J. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1752181 · Cited by 56
New Targets in Pain, Non-Neuronal Cells, and the Role of Palmitoylethanolamide
Hesselink, J. M. K. (2012) · The Open Pain Journal · doi:10.2174/1876386301205010012 · Cited by 55
Review article: new receptor targets for medical therapy in irritable bowel syndrome
Camilleri, M. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04153.x · Cited by 57
Mearin, F., Juan, A. P., Balboa, A., Perona, M. C., Sans, M., Salas, A., Angulo, S., Lloreta, J., Benasayag, R., García-González, M. A., et al. (2009) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520903171276 · Cited by 55
5-HT system in the gut: roles in the regulation of visceral sensitivity and motor functions.
Grundy, D. (2008) · PubMed · Cited by 55
Roka, R., Demaude, J., Cénac, N., Ferrier, L., Salvador‐Cartier, C., Garcia-Villar, R., Fioramonti, J., & Bueno, L. (2007) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2006.00851.x · Cited by 62
Kraneveld, A. D., Rijnierse, A., Nijkamp, F. P., & Garssen, J. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.095 · Cited by 57
Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome.
Buckley, M. M., O’Mahony, S. M., & O’Malley, D. (2014) · PubMed Central · doi:10.3748/wjg.v20.i27.8846 · Cited by 55
Mahurkar‐Joshi, S., Rankin, C. R., Videlock, E. J., Soroosh, A., Verma, A., Khandadash, A., Iliopoulos, D., Pothoulakis, C., Mayer, E. A., & Chang, L. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.02.040 · Cited by 55
Friesen, C. A., Lin, Z., Singh, M., Singh, V., Schurman, J. V., Burchell, N. A., Cocjin, J. T., & McCallum, R. W. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0207-0 · Cited by 54
Mechanisms in IBS: something old, something new, something borrowed…
Camilleri, M. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00632.x · Cited by 54
Arebi, N., Gurmany, S., Bullas, D. C., Hobson, A. R., Stagg, A. J., & Kamm, M. A. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03801.x · Cited by 53
Using human intestinal biopsies to study the pathogenesis of irritable bowel syndrome
Nasser, Y., Boeckxstaens, G. E., Wouters, M. M., Schemann, M., & Vanner, S. J. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12316 · Cited by 53
Allergy and intestinal dysmotility – evidence of genuine causal linkage?
MURCH, S. H. (2006) · Current Opinion in Gastroenterology · doi:10.1097/01.mog.0000245546.18279.7e · Cited by 53
The two faces of mast cells in food allergy and allergic asthma: The possible concept of Yin Yang
Kraneveld, A. D., Sagar, S., Garssen, J., & Folkerts, G. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.06.013 · Cited by 55
Wang, G., Wang, X.-Y., Liu, S., Qu, M., Xia, Y. L., NEEDLEMAN, B. J., Mikami, D. J., & Wood, J. D. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00125.2014 · Cited by 52
Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal
Fabisiak, A., Włodarczyk, J., Fabisiak, N., Storr, M., & Fichna, J. (2017) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16203 · Cited by 54
Is gastroparesis a gastric disease?
Cogliandro, R. F., Rizzoli, G., Bellacosa, L., GIORGIO, R. D., Cremon, C., Barbara, G., & Stanghellini, V. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13562 · Cited by 55
Self-citationKamphuis, J. B. J., Guiard, B. P., Leveque, M., Olier, M., Jouanin, I., Yvon, S., Tondereau, V., Rivière, P., Guéraud, F., Chevolleau, S., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.10.037 · Cited by 53
Uranga, J. A., Martı́nez, V., & Abalo, R. (2020) · Molecules · doi:10.3390/molecules25184314 · Cited by 54
Sethi, A., Jain, D., Roland, B. C., Kinzel, J., Gibson, J. A., Schrader, R., & Hanson, J. A. (2015) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2013-0594-oa · Cited by 52
Hussain, Z., & Park, H. (2022) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm22100 · Cited by 57
Irritable pouch syndrome is characterized by visceral hypersensitivity
Shen, B., Sanmiguel, C. P., Bennett, A. E., Lian, L., Larive, B., Remzi, F. H., Fazio, V. W., & Soffer, E. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21412 · Cited by 52
Ishihara, S., Tada, Y., Fukuba, N., Oka, A., Kusunoki, R., Mishima, Y., Oshima, N., Moriyama, I., Yuki, T., Kawashima, K., et al. (2013) · Digestion · doi:10.1159/000350054 · Cited by 51
Immune responses in the irritable bowel syndromes: time to consider the small intestine
Burns, G. L., Talley, N. J., & Keely, S. (2022) · BMC Medicine · doi:10.1186/s12916-022-02301-8 · Cited by 54
Quigley, E. M. M. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2005.02.010 · Cited by 52
Interplay between mast cells, enterochromaffin cells, and sensory signaling in the aging human bowel
Yu, Y., Daly, D., Adam, I. J., Kitsanta, P., Hill, C. J., Wild, J. R. L., Shorthouse, A. J., Grundy, D., & Jiang, W. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12842 · Cited by 51
Ex vivo study of human visceral nociceptors
McGuire, C., Boundouki, G., Hockley, J. R. F., Reed, D. E., Cibert‐Goton, V., Peiris, M., Kung, V., Broad, J., Aziz, Q., Chan, C. T., et al. (2016) · Gut · doi:10.1136/gutjnl-2016-311629 · Cited by 51
Bühner, S., Li, Q., Berger, T., Vignali, S., Barbara, G., GIORGIO, R. D., Stanghellini, V., & Schemann, M. (2012) · Neurogastroenterology & Motility · doi:10.1111/nmo.12011 · Cited by 50
Self-citationSurawicz, C. M. (2010) · Current Gastroenterology Reports · doi:10.1007/s11894-010-0113-4 · Cited by 52
Crowell, M. D., Harris, L. A., Jones, M. P., & Chang, L. (2005) · Current Gastroenterology Reports · doi:10.1007/s11894-005-0019-8 · Cited by 50
Barbaro, M. R., Sabatino, A. D., Cremon, C., Giuffrida, P., Fiorentino, M., Altimari, A., Bellacosa, L., Stanghellini, V., & Barbara, G. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00368.2015 · Cited by 50
Self-citationChatoo, M., Li, Y., Ma, Z., Coote, J. H., Du, J.-Z., & Chen, X. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00021 · Cited by 50
Innate Lymphoid Cells: Regulators of Gut Barrier Function and Immune Homeostasis
Fan, H. J., Wang, A., Wang, Y., Sun, Y., Han, J., Chen, W., Wang, S., Wu, Y., & Lu, Y. (2019) · Journal of Immunology Research · doi:10.1155/2019/2525984 · Cited by 50
Singh, M., Singh, V., Schurman, J. V., Colombo, J. M., & Friesen, C. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-68961-9 · Cited by 50
Söderholm, J. D. (2009) · Digestive Diseases · doi:10.1159/000268133 · Cited by 52
Ceuleers, H., Hanning, N., Heirbaut, J., Van Remoortel, S., Joossens, J., Van Der Veken, P., Francque, S. M., De bruyn, M., Lambeir, A., De Man, J. G., et al. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14396 · Cited by 49
Kanazawa, M., Watanabe, S., Tana, C., Komuro, H., Aoki, M., & Fukudo, S. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01732.x · Cited by 48
Larauche, M. H. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01867.x · Cited by 49
Pharmacologic attenuation of pelvic pain in a murine model of interstitial cystitis
Rudick, C. N., Schaeffer, A. J., & Klumpp, D. J. (2009) · BMC Urology · doi:10.1186/1471-2490-9-16 · Cited by 49
Hayashi, R., Xiao, W., Kawamoto, M., Yuge, O., & Bennett, G. J. (2008) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fp0072181 · Cited by 49
Tryptase and Protease-Activated Receptor 2 Expression Levels in Irritable Bowel Syndrome
Liang, W.-J., Zhang, G., Luo, H.-S., Liang, L., Huang, D., & Zhang, F.-C. (2015) · Gut and Liver · doi:10.5009/gnl14319 · Cited by 49
Fetal-Derived Immune Cells at the Roots of Lifelong Pathophysiology
Mass, E., & Gentek, R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.648313 · Cited by 47
Protease-activated receptors: protease signaling in the gastrointestinal tract
Amadesi, S., & Bunnett, N. W. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.08.004 · Cited by 49
Self-citationIrritable bowel syndrome and chronic gastritis, hemorrhoid, urolithiasis.
Helvacı, M. R., Algın, M. C., & Kaya, H. (2009) · PubMed Central · Cited by 48
Endometriosis and irritable bowel syndrome: A systematic review and meta-analyses
Nabi, M., Nauhria, S., Reel, M., Londono, S., Vasireddi, A., ELMIRY, M., & Ramdass, P. V. A. K. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.914356 · Cited by 49
Nerve-mast cell and smooth muscle-mast cell interaction mediated by cell adhesion molecule-1, CADM1
Ito, A., Hagiyama, M., & Oonuma, J. (2008) · Journal of Smooth Muscle Research · doi:10.1540/jsmr.44.83 · Cited by 48
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Winston, J. H., & Sarna, S. K. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.11.001 · Cited by 48
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Current and novel therapeutic options for irritable bowel syndrome management
Camilleri, M., & Andresen, V. (2009) · Digestive and Liver Disease · doi:10.1016/j.dld.2009.07.009 · Cited by 48
Rodríguez-Fandíño, O., Hernández-Ruíz, J., & Schmulson, M. (2010) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2010.16.4.363 · Cited by 54
Oliveira, S. M., Silva, C. R., & Ferreira, J. (2012) · Anesthesiology · doi:10.1097/aln.0b013e31827d415f · Cited by 48
Camilleri, M., Carlson, P., McKinzie, S., Zucchelli, M., D’Amato, M., Busciglio, I., Burton, D., & Zinsmeister, A. R. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01749.x · Cited by 47
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Brun, P., Scarpa, M., Marchiori, C., Sarasin, G., Caputi, V., Porzionato, A., Giron, M. C., Palù, G., & Castagliuolo, I. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181863 · Cited by 48
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Pontarollo, G., Mann, A., Brandão, I., Malinarich, F., Schöpf, M., & Reinhardt, C. (2019) · The FEBS Journal · doi:10.1111/febs.15055 · Cited by 39
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Scott, L. V., Clarke, G. A., & Dinan, T. G. (2013) · Modern trends in psychiatry · doi:10.1159/000343971 · Cited by 46
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Abdollahi, M. R., Esmaily, H., Baeeri, M., Asadi-Shahmirzadi, A., Mozaffari, S., Rahimi, R., Sanei, Y., & Salehi-Surmaghi, M.-H. (2011) · Pharmacognosy Magazine · doi:10.4103/0973-1296.84235 · Cited by 47
Drossman, D. A. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000156107.13247.69 · Cited by 46
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Wood, J. D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809954-4.00015-3 · Cited by 45
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Thijssen, A. Y., Clemens, C. H. M., Vankerckhoven, V., Goossens, H., Jonkers, D. M. A. E., & Masclee, A. (2015) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000484 · Cited by 46
Beckers, A. B., Weerts, Z. Z. R. M., Helyes, Z., Masclee, A., & Keszthelyi, D. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14294 · Cited by 45
Lucarini, E., Parisio, C., Branca, J. J. V., Segnani, C., Ippolito, C., Pellegrini, C., Antonioli, L., Fornai, M., Micheli, L., Pacini, A., et al. (2020) · Cells · doi:10.3390/cells9081772 · Cited by 45
Bertrand, J., Ghouzali, I., Guérin, C., Bôle‐Feysot, C., Gouteux, M., Déchelotte, P., Ducrotte, P. R., & Coëffier, M. (2015) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607115587330 · Cited by 45
Elevated pro-inflammatory and lipotoxic mucosal lipidscharacterise irritable bowel syndrome
Kajander, K., Myllyluoma, E., Kyrönpalo, S., Rasmussen, M., Sipponen, P., Mattila, I. M., Seppänen‐Laakso, T., Vapaatalo, H., Orešič, M., & Korpela, R. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.6068 · Cited by 45
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Spiller, R. E. (2007) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31812e66da · Cited by 44
Nakov, R., Dimitrova‐Yurukova, D., Snegarova, V., Nakov, V., Fox, M. R., & Heinrich, H. S. (2021) · Neurogastroenterology & Motility · doi:10.1111/nmo.14197 · Cited by 47
Dothel, G., Barbaro, M. R., Vito, A. D., Ravegnini, G., Gorini, F., Monesmith, S., Coschina, E., Benuzzi, E., Fuschi, D., Palombo, M., et al. (2023) · Journal of Gastroenterology · doi:10.1007/s00535-023-01997-6 · Cited by 49
Self-citationMullin, G. E., Shepherd, S. J., Roland, B. C., Ireton-Jones, C. S., & Matarese, L. E. (2014) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607114545329 · Cited by 47
Duncker, S., Wang, L., Pascal Hols, A., & Bienenstock, J. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01085.x · Cited by 44
Metadata
- Authors
- Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., Collins, S. M., & Corinaldesi, R.
- Affiliations
- University of Bologna (IT)
- University of California, San Francisco (US)
- McMaster University (CA)
- Corresponding author
- Barbara, Giovanni
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 126
- Issue
- 3
- Pages
- 693-702
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1976068711
- Cited by
- 1,475
- References
- 60
- Citations by year
- 2026: 49 · 2025: 39 · 2024: 49 · 2023: 70 · 2022: 64 · 2021: 74 · 2020: 55 · 2019: 44 · 2018: 74 · 2017: 73 · 2016: 77 · 2015: 71 · 2014: 79 · 2013: 66 · 2012: 84
- FWCI
- 56.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 57840, DK 43207, R01DK057840)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
- Keywords
- irritable bowel syndrome, mast cells, abdominal pain, colonic mucosa, enteric nerves, mast cell degranulation, tryptase, histamine release, visceral pain perception, mast cell infiltration
- MeSH terms
- Adult, Aged, Cell Count, Colon, Female, Histamine Release, Humans, Immunohistochemistry, Intestinal Mucosa, Male, Mast Cells, Microscopy, Electron, Middle Aged, Nervous System, Serine Endopeptidases, Blotting, Western, Cell Degranulation, Abdominal Pain, Irritable Bowel Syndrome, Tryptases
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