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Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C
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Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Melmed, G., Thomas, L. S., Lee, N., Tesfay, S. Y., Lukasek, K., Michelsen, K. S., Zhou, Y., Hu, B., Arditi, M., & Abreu, M. T. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1406 · Cited by 431
Species-specific Regulation of Toll-like Receptor 3 Genes in Men and Mice
Heinz, S., Haehnel, V., Karaghiosoff, M., Schwarzfischer, L., Müller, M., Krause, S. W., & Rehli, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301476200 · Cited by 202
Research works printed but not linked: 68
- Mitic, 2000, Molecular physiology and pathophysiology of tight junctions I. Tight junction structure and function: lessons from mutant animals and proteins, Am J Physiol, 279, G250
- Stuart, 1995, Regulated assembly of tight junctions by protein kinase C, Proc Natl Acad Sci U S A, 92, 6072, 10.1073/pnas.92.13.6072 · DOI · Paper page
- Berkes, 2003, Intestinal epithelial responses to enteric pathogens, Gut, 52, 439, 10.1136/gut.52.3.439 · DOI · Paper page
- Kindon, 1995, Trefoil peptide protection of intestinal epithelial barrier function, Gastroenterology, 109, 516, 10.1016/0016-5085(95)90340-2 · DOI · Paper page
- Czerucka, 2000, Saccharomyces boulardii preserves the barrier function and modulates the signal transduction pathway induced in enteropathogenic Escherichia coli-infected T84 cells, Infect Immun, 68, 5998, 10.1128/IAI.68.10.5998-6004.2000 · DOI
- Madsen, 2001, Probiotic bacteria enhance murine and human intestinal epithelial barrier function, Gastroenterology, 121, 580, 10.1053/gast.2001.27224 · DOI · Paper page
- Cario, 2000, Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors, J Immunol, 164, 966, 10.4049/jimmunol.164.2.966 · DOI · Paper page
- Cario, 2000, Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease, Infect Immun, 68, 7010, 10.1128/IAI.68.12.7010-7017.2000 · DOI · Paper page
- Gewirtz, 2001, Cutting edge, J Immunol, 167, 1882, 10.4049/jimmunol.167.4.1882 · DOI · Paper page
- Abreu, 2001, Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide, J Immunol, 167, 1609, 10.4049/jimmunol.167.3.1609 · DOI · Paper page
- Fusunyan, 2001, Evidence for an innate immune response in the immature human intestine, Pediatr Res, 49, 589, 10.1203/00006450-200104000-00023 · DOI
- Haller, 2002, IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell lines, J Biol Chem, 277, 38168, 10.1074/jbc.M205737200 · DOI
- Cario, 2002, Commensal-associated molecular patterns induce selective toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epithelium, Am J Pathol, 160, 165, 10.1016/S0002-9440(10)64360-X · DOI · Paper page
- Cario, 2002, Toll-like receptors and gastrointestinal disease, Curr Opin Gastroenterol, 18, 696, 10.1097/00001574-200211000-00011 · DOI
- Otte, 2004, Mechanisms of cross-hyporesponsiveness to Toll-like receptor ligands in intestinal epithelial cells, Gastroenterology, 126, 1054, 10.1053/j.gastro.2004.01.007 · DOI · Paper page
- Suzuki, 2003, Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated up-regulation of LPS uptake and expression of the intracellular Toll-like receptor 4-MD-2 complex, Infect Immun, 71, 3503, 10.1128/IAI.71.6.3503-3511.2003 · DOI
- Abreu, 2002, TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells, J Biol Chem, 277, 20431, 10.1074/jbc.M110333200 · DOI · Paper page
- Newton, 1995, Protein kinase C, J Biol Chem, 270, 28495, 10.1074/jbc.270.48.28495 · DOI · Paper page
- Dekker, 1994, Protein kinase C—a question of specificity, Trends Biochem Sci, 19, 73, 10.1016/0968-0004(94)90038-8 · DOI · Paper page
- Avila, 2002, The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathway, Mol Cell Biol, 22, 8787, 10.1128/MCB.22.24.8787-8795.2002 · DOI
- Aksoy, 2002, Critical role of protein kinase C epsilon for lipopolysaccharide-induced IL-12 synthesis in monocyte-derived dendritic cells, Eur J Immunol, 32, 3040, 10.1002/1521-4141(200211)32:11<3040::AID-IMMU3040>3.0.CO;2-M · DOI
- Rhee, 2003, Toll-like receptors 2 and 4 activate STAT1 serine phosphorylation by distinct mechanisms in macrophages, J Biol Chem, 278, 22506, 10.1074/jbc.M208633200 · DOI
- Castrillo, 2001, Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection, J Exp Med, 194, 1231, 10.1084/jem.194.9.1231 · DOI
- Franchi-Gazzola, 1996, Involvement of protein kinase Cepsilon in the stimulation of anionic amino acid transport in cultured human fibroblasts, J Biol Chem, 271, 26124, 10.1074/jbc.271.42.26124 · DOI
- Deszo, 2001, CD45 negatively regulates monocytic cell differentiation by inhibiting phorbol 12-myristate 13-acetate-dependent activation and tyrosine phosphorylation of protein kinase Cdelta, J Biol Chem, 276, 10212, 10.1074/jbc.M010589200 · DOI
- Fantini, 1989, In vitro differentiated HT 29-D4 clonal cell line generates leakproof and electrically active monolayers when cultured in porous-bottom culture dishes, Biol Cell, 65, 163, 10.1016/0248-4900(89)90024-5 · DOI
- Peterson, 1993, An in vitro model for the analysis of intestinal brush border assembly. I. Ultrastructural analysis of cell contact-induced brush border assembly in Caco-2BBe cells, J Cell Sci, 105, 445, 10.1242/jcs.105.2.445 · DOI
- Peterson, 1993, An in vitro model for the analysis of intestinal brush border assembly. II. Changes in expression and localization of brush border proteins during cell contact-induced brush border assembly in Caco-2BBe cells, J Cell Sci, 105, 461, 10.1242/jcs.105.2.461 · DOI
- Xu, 2000, Structural basis for signal transduction by the Toll/interleukin-1 receptor domains, Nature, 408, 111, 10.1038/35047056 · DOI · Paper page
- Smith, 2003, Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells, J Biol Chem, 278, 32552, 10.1074/jbc.M305536200 · DOI · Paper page
- Faure, 2000, Bacterial lipopolysaccharide activates NF-kappaB through toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells. Differential expression of TLR-4 and TLR-2 in endothelial cells, J Biol Chem, 275, 11058, 10.1074/jbc.275.15.11058 · DOI · Paper page
- Bulut, 2002, Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway, J Immunol, 168, 1435, 10.4049/jimmunol.168.3.1435 · DOI · Paper page
- Ahn, 2002, Inhibitory effects of novel AP-1 decoy oligodeoxynucleotides on vascular smooth muscle cell proliferation in vitro and neointimal formation in vivo, Circ Res, 90, 1325, 10.1161/01.RES.0000023200.19316.D5 · DOI
- Knight, 1999, Non-viral neuronal gene delivery mediated by the HC fragment of tetanus toxin, Eur J Biochem, 259, 762, 10.1046/j.1432-1327.1999.00108.x · DOI
- Sabroe, 2003, Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span, J Immunol, 170, 5268, 10.4049/jimmunol.170.10.5268 · DOI · Paper page
- Hirschfeld, 2000, Cutting edge, J Immunol, 165, 618, 10.4049/jimmunol.165.2.618 · DOI · Paper page
- Iwaki, 2002, The extracellular toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus, J Biol Chem, 277, 24315, 10.1074/jbc.M107057200 · DOI
- Inohara, 2003, Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn’s disease, J Biol Chem, 278, 5509, 10.1074/jbc.C200673200 · DOI · Paper page
- Girardin, 2003, Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection, J Biol Chem, 278, 8869, 10.1074/jbc.C200651200 · DOI · Paper page
- Hisamatsu, 2003, CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells, Gastroenterology, 124, 993, 10.1053/gast.2003.50153 · DOI · Paper page
- Morr, 2002, Differential recognition of structural details of bacterial lipopeptides by toll-like receptors, Eur J Immunol, 32, 3337, 10.1002/1521-4141(2002012)32:12<3337::AID-IMMU3337>3.0.CO;2-I · DOI
- Shirai, 2002, Activation mechanisms of protein kinase C, J Biochem (Tokyo), 132, 663, 10.1093/oxfordjournals.jbchem.a003271 · DOI
- Li, 2002, Expression of toll-like receptors 2 and 4 and CD14 during differentiation of HL-60 cells induced by phorbol 12-myristate 13-acetate and 1 alpha, 25-dihydroxy-vitamin D(3), Cell Growth Differ, 13, 27
- Ways, 1994, Effects of chronic phorbol ester treatment on protein kinase C activity, content, and gene expression in the human monoblastoid U937 cell, Cell Growth Differ, 5, 161
- Song, 2002, Opposing effects of PKCalpha and PKCepsilon on basolateral membrane dynamics in intestinal epithelia, Am J Physiol, 283, C1548, 10.1152/ajpcell.00105.2002 · DOI
- Yoo, 2003, Bryostatin-1 attenuates TNF-induced epithelial barrier dysfunction, Am J Physiol, 284, G703
- Ahmed, 1991, The cysteine-rich domain of human proteins, neuronal chimaerin, protein kinase C and diacylglycerol kinase binds zinc. Evidence for the involvement of a zinc-dependent structure in phorbol ester binding, Biochem J, 280, 233, 10.1042/bj2800233 · DOI
- Balda, 1993, Assembly of the tight junction, J Cell Biol, 123, 293, 10.1083/jcb.123.2.293 · DOI · Paper page
- Turner, 1999, PKC-dependent regulation of transepithelial resistance, Am J Physiol, 277, C554, 10.1152/ajpcell.1999.277.3.C554 · DOI
- Hsu, 2001, Ceramide inhibits lipopolysaccharide-mediated nitric oxide synthase and cyclooxygenase-2 induction in macrophages, J Immunol, 166, 5388, 10.4049/jimmunol.166.9.5388 · DOI
- Kontny, 2000, Rottlerin, a PKC isozyme-selective inhibitor, affects signaling events and cytokine production in human monocytes, J Leukoc Biol, 67, 249, 10.1002/jlb.67.2.249 · DOI
- Hecht, 1994, Reversible disassembly of an intestinal epithelial monolayer by prolonged exposure to phorbol ester, Am J Physiol, 266, G214
- Mullin, 2000, Increased tight junction permeability can result from protein kinase C activation/translocation and act as a tumor promotional event in epithelial cancers, Ann N Y Acad Sci, 915, 231, 10.1111/j.1749-6632.2000.tb05246.x · DOI
- Song, 2001, Regulation of epithelial transport and barrier function by distinct protein kinase C isoforms, Am J Physiol, 281, C649, 10.1152/ajpcell.2001.281.2.C649 · DOI
- Gschwendt, 1994, Rottlerin, a novel protein kinase inhibitor, Biochem Biophys Res Commun, 199, 93, 10.1006/bbrc.1994.1199 · DOI · Paper page
- Mukherjee, 1996, Protein kinase Calpha is a major mediator of the stimulatory effect of phorbol ester on phospholipase D-mediated hydrolysis of phosphatidylethanolamine, J Biol Chem, 271, 28912, 10.1074/jbc.271.46.28912 · DOI
- Tai, 1996, Regulation of tight junction resistance in T84 monolayers by elevation in intracellular Ca2+, J Membr Biol, 149, 71, 10.1007/s002329900008 · DOI
- Balda, 1991, Assembly and sealing of tight junctions, J Membr Biol, 122, 193, 10.1007/BF01871420 · DOI · Paper page
- Kinugasa, 2000, Claudins regulate the intestinal barrier in response to immune mediators, Gastroenterology, 118, 1001, 10.1016/S0016-5085(00)70351-9 · DOI · Paper page
- Hartwig, 1992, MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin, Nature, 356, 618, 10.1038/356618a0 · DOI · Paper page
- Fanning, 1998, The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton, J Biol Chem, 273, 29745, 10.1074/jbc.273.45.29745 · DOI · Paper page
- Brose, 2002, Move over protein kinase C, you’ve got company, J Cell Sci, 115, 4399, 10.1242/jcs.00122 · DOI · Paper page
- Nakashima, 2002, Protein kinase C alpha (PKC alpha), J Biochem (Tokyo), 132, 669, 10.1093/oxfordjournals.jbchem.a003272 · DOI · Paper page
- Kazanietz, 2002, Novel “nonkinase” phorbol ester receptors, Mol Pharmacol, 61, 759, 10.1124/mol.61.4.759 · DOI
- Fitzgerald, 2001, Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction, Nature, 413, 78, 10.1038/35092578 · DOI · Paper page
- Horng, 2001, TIRAP, Nat Immunol, 2, 835, 10.1038/ni0901-835 · DOI · Paper page
- Chen, 2002, Protein kinase C signaling regulates ZO-1 translocation and increased paracellular flux of T84 colonocytes exposed to Clostridium difficile toxin A, J Biol Chem, 277, 4247, 10.1074/jbc.M109254200 · DOI
- Podolsky, 2002, Inflammatory bowel disease, N Engl J Med, 347, 417, 10.1056/NEJMra020831 · DOI · Paper page
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Baumgart, D. C., & Carding, S. R. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60750-8 · Cited by 2,147
Abreu, M. T. (2010) · Nature Reviews Immunology · doi:10.1038/nri2707 · Cited by 1,288
Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components1,2
Ulluwishewa, D., Anderson, R. C., McNabb, W. C., Moughan, P. J., Wells, J. M., & Roy, N. C. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.135657 · Cited by 1,177
Kelly, J. R., Kennedy, P. J., Cryan, J. F., Dinan, T. G., Clarke, G., & Hyland, N. P. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00392 · Cited by 1,110
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Metadata
- Authors
- Cario, E., Gerken, G., & Podolsky, D. K.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2004-07
- Volume
- 127
- Issue
- 1
- Pages
- 224-238
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2158516918
- Cited by
- 475
- References
- 3
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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