Cited by 176Gastrointestinal motility and disordersPain Mechanisms and TreatmentsUrinary Bladder and Prostate Research

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Rectal Instillation of Butyrate Provides a Novel Clinically Relevant Model of Noninflammatory Colonic Hypersensitivity in Rats

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Bourdu, Sophie, Dapoigny, Michel, Chapuy, Eric, Artigue, Fabrice, Vasson, Marie-Paule, Dechelotte, Pierre, Bommelaer, Gilles, Eschalier, Alain, Ardid, Denis·2005·Gastroenterology

DOI 10.1053/j.gastro.2005.03.082

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Abstract

Background & aims The treatment of irritable bowel syndrome (IBS), characterized by abdominal pain and bloating, is empirical and often poorly efficient. Research lacks suitable models for studying the pathophysiologic mechanisms of the colonic hypersensitivity and new pharmacologic targets. The present study aimed to develop a novel model of colonic hypersensitivity possessing several of the characteristics encountered in patients with IBS.Methods Rats received enemas of a butyrate solution (8-1000 mmol/L) twice daily for 3 days. A time course was determined for colonic hypersensitivity (colorectal distention test) and referred cutaneous lumbar hyperalgesia (von Frey hairs). Macroscopic and histologic analyses were performed on colonic mucosa. The efficacy of morphine, U50488H (a kappa opioid agonist), and trimebutine on the 2 pain parameters was determined. Finally, the involvement of peptidergic C-fibers was evaluated using capsaicin-pretreated animals and treatments with calcitonin gene-related peptide (CGRP) and neurokinin 1 receptor antagonists.Results Butyrate enemas induced a sustained, concentration-dependent colonic hypersensitivity and, to a lesser extent, a referred cutaneous mechanical hyperalgesia, particularly in female rats, but no macroscopic and histologic modifications of the colonic mucosa, as observed in patients with IBS. Both pain parameters were sensitive to morphine, U50488H, trimebutine, neonatal capsaicin treatment, and the CGRP receptor antagonist but not to the neurokinin 1 receptor antagonist.Conclusions These results present our noninflammatory model of chronic colonic hypersensitivity as a useful novel tool for studying IBS. The CGRP receptor antagonist-induced reduction of colonic hypersensitivity suggests that CGRP receptors may provide a promising target for treatment of IBS.

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Authors: Bourdu, S., Dapoigny, M., Chapuy, E., Artigue, F., Vasson, M.-P., Dechelotte, P., Bommelaer, G., Eschalier, A., & Ardid, D.
Affiliations: Université Clermont Auvergne (FR)
Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
Corresponding author: Ardid, Denis
ORCID: Vasson, Marie-Paule
Bommelaer, Gilles
Eschalier, Alain
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2005-06
Volume: 128
Issue: 7
Pages: 1996-2008
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2005.03.082
OpenAlex: W1963485882
Cited by: 176
References: 78
Citations by year: 2026: 2 · 2025: 2 · 2024: 8 · 2023: 5 · 2022: 9 · 2021: 8 · 2020: 10 · 2019: 7 · 2018: 11 · 2017: 11 · 2016: 12 · 2015: 9 · 2014: 15 · 2013: 9 · 2012: 9
FWCI: 4.59
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
Keywords: irritable bowel syndrome, colonic hypersensitivity, animal models, kappa opioid receptor, morphine, trimebutine, calcitonin gene-related peptide, CGRP receptor antagonists, neurokinin-1 receptor, sex differences, chronic pain
MeSH terms: Animals, Butyrates, Colonic Diseases, Disease Models, Animal, Dose-Response Relationship, Drug, Enema, Female, Humans, Hyperalgesia, Hypersensitivity, Male, Pain, Rectum, Rats, Sprague-Dawley, Receptors, Calcitonin Gene-Related Peptide, Irritable Bowel Syndrome, Rats

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Rectal Instillation of Butyrate Provides a Novel Clinically Relevant Model of Noninflammatory Colonic Hypersensitivity in Rats

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