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Involvement of Human Micro-RNA in Growth and Response to Chemotherapy in Human Cholangiocarcinoma Cell Lines
Open accessAbstract
Background & aims Micro-RNA (miRNA) are endogenous regulatory RNA molecules that modulate gene expression. Alterations in miRNA expression can contribute to tumor growth by modulating the functional expression of critical genes involved in tumor cell proliferation or survival. Our aims were to identify specific miRNA involved in the regulation of cholangiocarcinoma growth and response to chemotherapy. Methods miRNA expression in malignant and nonmalignant human cholangiocytes was assessed using a microarray. Expression of selected miRNA and their precursors was evaluated by Northern blots and real-time polymerase chain reaction, respectively. The effect of selected miRNA on cell growth and response to chemotherapy was assessed using miRNA-specific antisense oligonucleotides to decrease miRNA expression or with precursor miRNA to increase cellular expression. Results miRNA expression was markedly different in malignant cholangiocytes, with decreased expression of many miRNA compared with nonmalignant cells. A cluster of miRNA, including miR-320, miR-200b, miR-21, miR-23a, miR-141, miR-27a, and miR-34a, were expressed in all cell lines. MiR-21, miR-141, and miR-200b were highly over-expressed in malignant cholangiocytes. Inhibition of miR-21 and miR-200b increased sensitivity to gemcitabine, whereas inhibition of miR-141 decreased cell growth. Treatment of tumor cell xenografts with systemic gemcitabine altered the expression of a significant number of miRNA. miR-21 modulates gemcitabine-induced apoptosis by phosphatase and tensin homolog deleted on chromosome 10 (PTEN)-dependent activation of PI 3-kinase signaling. Potential target genes that were modulated by selected miRNA were identified. Conclusions Alterations in miRNA expression contribute to tumor growth and response to chemotherapy. Aberrantly expressed miRNA or their targets will provide mechanistic insight and therapeutic targets for cholangiocarcinoma.
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“Three miR-21 targets have, thus far, been described: phosphatase and tensin homologue (PTEN), programmed cell death 4 (PDCD4) and Tropomyosin 1 (TPM1; refs.10,[14][15][16].”
From MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells (2008) · cites this paper as [10]
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Cites
MicroRNA expression profiles classify human cancers
Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,637
Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242606799 · Cited by 5,111
TM4: a free, open-source system for microarray data management and analysis
Saeed, A. I., Sharov, V., White, J., Li, J., Liang, W., Bhagabati, N., Braisted, J., Klapa, M., Currier, T., Thiagarajan, M., et al. (2003) · BioTechniques · doi:10.2144/03342mt01 · Cited by 4,837
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
Calin, G. A., Sevignani, C., Dumitru, C. D., Hyslop, T., Noch, E., Yendamuri, S., Shimizu, M., Rattan, S., Bullrich, F., Negrini, M., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307323101 · Cited by 4,096
A microRNA polycistron as a potential human oncogene
He, L., Thomson, J. M., Hemann, M. T., Hernando, E., Mu, D., Goodson, S. G., Powers, S., Cordon‐Cardo, C., Lowe, S. W., Hannon, G. J., et al. (2005) · Nature · doi:10.1038/nature03552 · Cited by 3,642
An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans
Lau, N. C., Lim, L. P., Weinstein, E. G., & Bartel, D. P. (2001) · Science · doi:10.1126/science.1065062 · Cited by 3,345
microRNAs as oncogenes and tumor suppressors
Zhang, B., Pan, X., Cobb, G. P., & Anderson, T. A. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.028 · Cited by 2,782
Modulation of Hepatitis C Virus RNA Abundance by a Liver-Specific MicroRNA
Jopling, C. L., Yi, M., Lancaster, A. M., Lemon, S. M., & Sarnow, P. (2005) · Science · doi:10.1126/science.1113329 · Cited by 2,580
MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells
Chan, J. A., Krichevsky, A. M., & Kosik, K. S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0137 · Cited by 2,557
c-Myc-regulated microRNAs modulate E2F1 expression
O'Donnell, K. A., Wentzel, E. A., Zeller, K. I., Dang, C. V., & Mendell, J. T. (2005) · Nature · doi:10.1038/nature03677 · Cited by 2,347
Self-citation
Flagged first, then by citations
2 of the 44 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
MicroRNA signatures in human cancers
Calin, G. A., & Croce, C. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1997 · Cited by 7,668
MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer
Meng, F., Henson, R., Wehbe–Janek, H., Ghoshal, K., Jacob, S. T., & Patel, T. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.022 · Cited by 2,773
Self-citationA coding-independent function of gene and pseudogene mRNAs regulates tumour biology
Poliseno, L., Salmena, L., Zhang, J., Carver, B. S., Haveman, W. J., & Pandolfi, P. P. (2010) · Nature · doi:10.1038/nature09144 · Cited by 2,364
The functions and regulation of the PTEN tumour suppressor
Song, M. S., Salmena, L., & Pandolfi, P. P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3330 · Cited by 1,926
Asangani, I. A., Rasheed, S. A. K., Nikolova, D. A., Leupold, J. H., Colburn, N. H., Post, S., & Allgayer, H. (2008) · Oncogene · doi:10.1038/sj.onc.1210856 · Cited by 1,882
MicroRNA: Biogenesis, Function and Role in Cancer
MacFarlane, L.-A., & R. Murphy, P. (2010) · Current Genomics · doi:10.2174/138920210793175895 · Cited by 1,584
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review
Iorio, M. V., & Croce, C. M. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201100209 · Cited by 1,778
Schetter, A. J., Leung, S. Y., Sohn, J. J., Zanetti, K. A., Bowman, E. D., Yanaihara, N., Yuen, S. T., Chan, T. L., Kwong, D. L. �., Au, G. K. �., et al. (2008) · JAMA · doi:10.1001/jama.299.4.425 · Cited by 1,591
Lee, Y. S., & Dutta, A. (2008) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092222 · Cited by 1,538
Pathogenesis, Diagnosis, and Management of Cholangiocarcinoma
Ilyas, S. I., & Gores, G. J. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.10.013 · Cited by 1,331
Frankel, L. B., Christoffersen, N. R., Jacobsen, A., Lindow, M., Krogh, A., & Lund, A. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707224200 · Cited by 1,141
MicroRNAs in Development and Disease
Sayed, D. H., & Abdellatif, M. (2011) · Physiological Reviews · doi:10.1152/physrev.00006.2010 · Cited by 1,101
Croce, C. M. (2008) · New England Journal of Medicine · doi:10.1056/nejmra072367 · Cited by 1,055
Tenets of PTEN Tumor Suppression
Salmena, L., Carracedo, A., & Pandolfi, P. P. (2008) · Cell · doi:10.1016/j.cell.2008.04.013 · Cited by 1,050
miR‐21: a small multi‐faceted RNA
Krichevsky, A. M., & Gabriely, G. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00556.x · Cited by 987
MicroRNAs in Cancer: Small Molecules With a Huge Impact
Iorio, M. V., & Croce, C. M. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.24.0317 · Cited by 973
Bloomston, M., Frankel, W. L., Petrocca, F., Volinia, S., Alder, H., Hagan, J. P., Liu, C.-G., Bhatt, D., Taccioli, C., & Croce, C. M. (2007) · JAMA · doi:10.1001/jama.297.17.1901 · Cited by 1,141
MicroRNA-21 targets tumor suppressor genes in invasion and metastasis
Zhu, S., Wu, H., Wu, F., Nie, D., Sheng, S., & Mo, Y.-Y. (2008) · Cell Research · doi:10.1038/cr.2008.24 · Cited by 1,051
Ji, R., Cheng, Y., Yue, J., Yang, J., Liu, X., Chen, H., Dean, D. B., & Zhang, C. (2007) · Circulation Research · doi:10.1161/circresaha.106.141986 · Cited by 918
Thum, T., Galuppo, P., Wolf, C., Fiedler, J., Kneitz, S., Laake, L. W. V., Doevendans, P. A., Mummery, C. L., Borlak, J. T., Haverich, A., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.687947 · Cited by 890
E2F1-Regulated MicroRNAs Impair TGFβ-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer
Petrocca, F., Visone, R., Onelli, M. R., Shah, M. H., Nicoloso, M. S., Martino, I. D., Iliopoulos, D., Pilozzi, E., Liu, C. G., Negrini, M., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.02.013 · Cited by 832
MicroRNAs Play an Essential Role in the Development of Cardiac Hypertrophy
Sayed, D. H., Hong, C., Chen, I.-Y., Lypowy, J., & Abdellatif, M. (2007) · Circulation Research · doi:10.1161/01.res.0000257913.42552.23 · Cited by 777
MicroRNA-221/222 Confers Tamoxifen Resistance in Breast Cancer by Targeting p27Kip1
Miller, T. E., Ghoshal, K., Ramaswamy, B., Roy, S., Datta, J., Shapiro, C. L., Jacob, S. T., & Majumder, S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804612200 · Cited by 759
Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue
Wong, T., Liu, X., Wong, B. Y., Ng, R. W. M., Yuen, A. P. W., & Wei, W. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0666 · Cited by 751
MicroRNA Expression Profiles in Serous Ovarian Carcinoma
Nam, E. J., Yoon, H., Kim, S. W., Kim, H., Kim, Y. T., Kim, J., Kim, J. W., & Kim, S. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1731 · Cited by 740
OncomiRs: the discovery and progress of microRNAs in cancers
Cho, W. C. S. (2007) · Molecular Cancer · doi:10.1186/1476-4598-6-60 · Cited by 717
miR‐15b and miR‐16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells
Xia, L., Zhang, D., Du, R., Pan, Y., Zhao, L., Sun, S., Hong, L., Liu, J., & Fan, D. (2008) · International Journal of Cancer · doi:10.1002/ijc.23501 · Cited by 711
MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene
Lu, Z., Liu, M., Stribinskis, V, Klinge, C. M., Ramos, K. S., Colburn, N. H., & Li, Y. (2008) · Oncogene · doi:10.1038/onc.2008.72 · Cited by 711
MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells
Papagiannakopoulos, T., Shapiro, A., & Kosik, K. S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1305 · Cited by 705
Identification of metastasis-related microRNAs in hepatocellular carcinoma
Budhu, A., Jia, H., Forgues, M., Liu, C., Goldstein, D., Lam, A., Zanetti, K. A., Ye, Q., Qin, L., Croce, C. M., et al. (2008) · Hepatology · doi:10.1002/hep.22160 · Cited by 697
The role of let-7 in cell differentiation and cancer
Boyerinas, B., Park, S.-M., Hau, A., Murmann, A. E., & Peter, M. E. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0184 · Cited by 687
ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development
Choi, Y. H., & Yu, A. (2014) · Current Pharmaceutical Design · doi:10.2174/138161282005140214165212 · Cited by 653
MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia
Garzon, R., Volinia, S., Liu, C., Fernandez-Cymering, C., Palumbo, T., Pichiorri, F., Fabbri, M., Coombes, K. R., Alder, H., Nakamura, T., et al. (2008) · Blood · doi:10.1182/blood-2007-07-098749 · Cited by 643
Real-time PCR quantification of precursor and mature microRNA
Schmittgen, T. D., Lee, E. J., Jiang, J., Sarkar, A., Yang, L., Elton, T. S., & Chen, C. (2008) · Methods · doi:10.1016/j.ymeth.2007.09.006 · Cited by 616
Self-citationMicro-RNA profiling in kidney and bladder cancers
Gottardo, F., Liu, C. G., Ferracin, M., Calin, G. A., Fassan, M., Bassi, P., Sevignani, C., Byrne, D., Negrini, M., Pagano, F. C., et al. (2007) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2007.01.019 · Cited by 601
RETRACTED AND REPLACED: microRNA involvement in human cancer
Iorio, M. V., & Croce, C. M. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs140 · Cited by 577
RetractedZhang, J.-G., Wang, J., Zhao, F., Liu, Q., Jiang, K., & Yang, G. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.02.074 · Cited by 574
Löffler, D., Brocke-Heidrich, K., Pfeifer, G., Stocsits, C., Hackermüller, J., Kretzschmar, A. K., Burger, R., Gramatzki, M., Blumert, C., Bauer, K., et al. (2007) · Blood · doi:10.1182/blood-2007-03-081133 · Cited by 637
Jiang, J., Gusev, Y., Aderca, I., Mettler, T. A., Nagorney, D. M., Brackett, D. J., Roberts, L. R., & Schmittgen, T. D. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0523 · Cited by 518
Self-citationMicroRNAs as regulators of epithelial-mesenchymal transition
Gregory, P. A., Bracken, C. P., Bert, A. G., & Goodall, G. J. (2008) · Cell Cycle · doi:10.4161/cc.7.20.6851 · Cited by 521
Circulating MicroRNAs: a novel class of biomarkers to diagnose and monitor human cancers
Zen, K., & Zhang, C. (2010) · Medicinal Research Reviews · doi:10.1002/med.20215 · Cited by 509
MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression
Liu, L.-Z., Li, C.-Y., Chen, Q., Yi, J., Carpenter, R. L., Jiang, Y., Kung, H., Lai, L., & Jiang, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019139 · Cited by 509
MicroRNAs Are Aberrantly Expressed in Hypertrophic Heart
Cheng, Y., Ji, R., Yue, J., Yang, J., Liu, X., Chen, H., Dean, D. B., & Zhang, C. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061170 · Cited by 492
MicroRNA Biogenesis Is Required for Mouse Primordial Germ Cell Development and Spermatogenesis
Hayashi, K., Lopes, S. M. C. D. S., Kaneda, M., Tang, F., Hájková, P., Lao, K., O’Carroll, D., Das, P. P., Tarakhovsky, A., Miska, E. A., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001738 · Cited by 502
miR-21 plays a pivotal role in gastric cancer pathogenesis and progression
Zhang, Z., Li, Z., Gao, C., Chen, P., Chen, J., Liu, W., Xiao, S., & Lu, H. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.94 · Cited by 477
Giovannetti, E., Funel, N., Peters, G. J., Chiaro, M. D., Erozenci, L. A., Vasile, E., León, L. G., Pollina, L. E., Groen, A., Falcone, A., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4467 · Cited by 460
miR-21 as a key regulator of oncogenic processes
Selçuklu, S. D., Donoghue, M. T. A., & Spillane, C. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370918 · Cited by 460
Hydrodynamic Transfection for Generation of Novel Mouse Models for Liver Cancer Research
Chen, X., & Calvisi, D. F. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.12.002 · Cited by 437
Wong, Q., Lung, R. W. M., Law, P. T. Y., Lai, P. B. S., Chan, K. Y. Y., To, K., & Wong, N. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.003 · Cited by 421
Ali, S. S., Ahmad, A., Banerjee, S., Padhyé, S., Dominiak, K., Schaffert, J. M., Wang, Z., Philip, P. A., & Sarkar, F. H. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4598 · Cited by 424
RetractedVisone, R., Russo, L., Pallante, P., Martino, I. D., Ferraro, A., Leone, V., Borbone, E., Petrocca, F., Alder, H., Croce, C. M., et al. (2007) · Endocrine Related Cancer · doi:10.1677/erc-07-0129 · Cited by 417
The roles of microRNA in cancer and apoptosis
Lynam‐Lennon, N., Maher, S. G., & Reynolds, J. V. (2008) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2008.00061.x · Cited by 412
Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors
Lee, E. J., Baek, M., Gusev, Y., Brackett, D. J., Nuovo, G. J., & Schmittgen, T. D. (2008) · RNA · doi:10.1261/rna.804508 · Cited by 414
Self-citationAnaplastic thyroid cancer: molecular pathogenesis and emerging therapies
Smallridge, R. C., Marlow, L. A., & Copland, J. A. (2008) · Endocrine Related Cancer · doi:10.1677/erc-08-0154 · Cited by 396
Braconi, C., Huang, N., & Patel, T. C. (2009) · Hepatology · doi:10.1002/hep.23381 · Cited by 377
Self-citationmiR-122, a paradigm for the role of microRNAs in the liver
Girard, M., Jacquemin, E., Münnich, A., Lyonnet, S., & Henrion‐Caude, A. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.01.019 · Cited by 383
MicroRNAs modulate the chemosensitivity of tumor cells
Blower, P. E., Chung, J.-H., Verducci, J. S., Lin, S., Park, J. K., Dai, Z., Liu, C., Schmittgen, T. D., Reinhold, W. C., Croce, C. M., et al. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0573 · Cited by 359
Self-citationCirculating microRNA-21 as a novel biomarker for hepatocellular carcinoma
Tomimaru, Y., Eguchi, H., Nagano, H., Wada, H., Kobayashi, S., Marubashi, S., Tanemura, M., Tomokuni, A., Takemasa, I., Umeshita, K., et al. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.04.026 · Cited by 367
Nasser, M. W., Datta, J., Nuovo, G. J., Kutay, H., Motiwala, T., Majumder, S., Wang, B., Suster, S. M., Jacob, S. T., & Ghoshal, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804788200 · Cited by 360
RetractedZhou, X., Ren, Y., Moore, L. M., Mei, M., You, Y., Xu, P., Wang, B., Wang, G., Jia, Z., Pu, P., et al. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2009.126 · Cited by 363
MicroRNAs: New Tools for Diagnosis, Prognosis, and Therapy in Hepatocellular Carcinoma?
Giordano, S., & Columbano, A. (2012) · Hepatology · doi:10.1002/hep.26095 · Cited by 354
Humphries, B. A., & Yang, C. (2015) · Oncotarget · doi:10.18632/oncotarget.3052 · Cited by 343
MicroRNAs: Predictors and modifiers of chemo- and radiotherapy in different tumour types
Hummel, R., Hussey, D. J., & Haier, J. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2009.10.027 · Cited by 350
Shi, L., Chen, J., Yang, J., Pan, T., Zhang, S., & Wang, Z. (2010) · Brain Research · doi:10.1016/j.brainres.2010.07.009 · Cited by 353
The role of microRNAs in cancer: No small matter
Wiemer, E. A. C. (2007) · European Journal of Cancer · doi:10.1016/j.ejca.2007.04.002 · Cited by 348
Lu, T. X., Hartner, J. C., Lim, E. J., Fabry, V., Mingler, M. K., Cole, E. T., Orkin, S. H., Aronow, B. J., & Rothenberg, M. E. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101235 · Cited by 350
Moriyama, T., Ohuchida, K., Mizumoto, K., Yu, J., Sato, N., Nabae, T., Takahata, S., Toma, H., Nagai, E., & Tanaka, M. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0592 · Cited by 341
MiR-200, a new star miRNA in human cancer
Feng, X., Wang, Z., Fillmore, R. A., & Xi, Y. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.11.004 · Cited by 357
Heterogeneity of liver cancer and personalized therapy
Li, L., & Wang, H. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.07.018 · Cited by 344
Cholangiocarcinoma—controversies and challenges
Patel, T. C. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.20 · Cited by 339
Self-citationCauses and Consequences of MicroRNA Dysregulation
Iorio, M. V., & Croce, C. M. (2012) · The Cancer Journal · doi:10.1097/ppo.0b013e318250c001 · Cited by 337
MicroRNAs as Potential Biomarkers in Cancer: Opportunities and Challenges
Lan, H., Lu, H., Wang, X., & Jin, H. (2015) · BioMed Research International · doi:10.1155/2015/125094 · Cited by 333
miR-200 Enhances Mouse Breast Cancer Cell Colonization to Form Distant Metastases
Dykxhoorn, D. M., Wu, Y., Xie, H., Yu, F., Lal, A., Petrocca, F., Martinvalet, D., Song, E., Lim, B., & Lieberman, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007181 · Cited by 329
Chhabra, R., Dubey, R., & Saini, N. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-232 · Cited by 322
Bollati, V., Marinelli, B., Apostoli, P., Bonzini, M., Nordio, F., Hoxha, M., Pegoraro, V., Motta, V., Tarantini, L., Cantone, L., et al. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901300 · Cited by 347
Das, A., Ganesh, K., Khanna, S., Sen, C. K., & Roy, S. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1300613 · Cited by 320
Sayed, D. H., He, M., Hong, C., Gao, S., Rane, S., Yang, Z., & Abdellatif, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.109207 · Cited by 317
Molecular Pathogenesis of Cholangiocarcinoma
Labib, P. L. Z., Goodchild, G., & Pereira, S. P. (2019) · BMC Cancer · doi:10.1186/s12885-019-5391-0 · Cited by 321
Haddadi, N., Lin, Y., Travis, G., Simpson, A. M., Nassif, N. T., & McGowan, E. M. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0803-3 · Cited by 321
Up-regulation of miR-21 Mediates Resistance to Trastuzumab Therapy for Breast Cancer
Gong, C., Yao, Y., Wang, Y., Liu, B., Wu, W. G., Chen, J., Su, F., Yao, H., & Song, E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.216887 · Cited by 313
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Lee, J., Choi, C. H., Choi, J., Park, Y.-A., Kim, S.-J., Hwang, S. Y., Kim, W. Y., Kim, T., Lee, J., Kim, B., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1231 · Cited by 313
Ma, J., Dong, C., & Ji, C. (2010) · Cancer Gene Therapy · doi:10.1038/cgt.2010.18 · Cited by 304
Liu, C., Tsai, M., Hung, P.-S., Kao, S., Liu, T., Wu, K.-J., Chiou, S., Lin, S., & Chang, K. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2291 · Cited by 307
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Gramantieri, L., Fornari, F., Callegari, E., Sabbioni, S., Lanza, G., Croce, C. M., Bolondi, L., & Negrini, M. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00533.x · Cited by 305
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Bach, D., Hong, J., Park, H. J., & Lee, S. K. (2017) · International Journal of Cancer · doi:10.1002/ijc.30669 · Cited by 301
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Tian, Y., Luo, A., Cai, Y., Su, Q., Ding, F., Chen, H., & Liu, Z. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.062877 · Cited by 298
Jung, E., Santarpia, L., Kim, J., Esteva, F. J., Moretti, E., Buzdar, A. U., Leo, A. D., Le, X., Bast, R. C., Park, S., et al. (2011) · Cancer · doi:10.1002/cncr.26565 · Cited by 301
Hwang, J., Voortman, J., Giovannetti, E., Steinberg, S. M., León, L. G., Kim, Y., Funel, N., Park, J. K., Kim, M. A., Kang, G. H., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010630 · Cited by 294
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Zaimy, M. A., Saffarzadeh, N., Mohammadi, A., Pourghadamyari, H., Izadi, P., Sarli, A., Moghaddam, L. K., Paschepari, S. R., Azizi, H., Torkamandi, S., et al. (2017) · Cancer Gene Therapy · doi:10.1038/cgt.2017.16 · Cited by 294
Park, J. K., Lee, E. J., Esau, C., & Schmittgen, T. D. (2009) · Pancreas · doi:10.1097/mpa.0b013e3181ba82e1 · Cited by 293
Self-citationDecreased Expression of MicroRNA-143 and -145 in Human Gastric Cancers
Takagi, T., Iio, A., Nakagawa, Y., Naoe, T., Tanigawa, N., & Akao, Y. (2009) · Oncology · doi:10.1159/000218166 · Cited by 286
Selaru, F. M., Olaru, A., Kan, T., David, S., Cheng, Y., Mori, Y., Yang, J. P., Paun, B. C., Jin, Z., Agarwal, R., et al. (2009) · Hepatology · doi:10.1002/hep.22838 · Cited by 288
Wang, X. W., Heegaard, N. H. H., & Ørum, H. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.04.007 · Cited by 289
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Nelson, K. M., & Weiss, G. J. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0586 · Cited by 282
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Wu, W. K. K., Lee, C., Cho, C. H., Fan, D., Wu, K., Yu, J. Q., & Sung, J. J. �. (2010) · Oncogene · doi:10.1038/onc.2010.352 · Cited by 279
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Kulshreshtha, R., Davuluri, R. V., Calin, G. A., & Ivan, M. (2008) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402310 · Cited by 274
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Marcucci, G., Mrózek, K., Radmacher, M. D., Garzon, R., & Bloomfield, C. D. (2010) · Blood · doi:10.1182/blood-2010-09-191312 · Cited by 274
Kanaan, Z. M., Rai, S. N., Eichenberger, M. R., Roberts, H., Keskey, B., Pan, J., & Galandiuk, S. (2012) · Annals of Surgery · doi:10.1097/sla.0b013e318265bd6f · Cited by 273
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Ferracin, M., Veronese, A., & Negrini, M. (2010) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.10.11 · Cited by 269
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Yang, H., Dinney, C. P., Ye, Y., Zhu, Y., Grossman, H. B., & Wu, X. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5991 · Cited by 265
Metadata
- Authors
- Meng, F., Henson, R., Lang, M., Wehbe, H., Maheshwari, S., Mendell, J. T., Jiang, J., Schmittgen, T. D., & Patel, T.
- Affiliations
- Texas A&M University System (US)
- Johns Hopkins University (US)
- The Ohio State University (US)
- Corresponding author
- Patel, Tushar
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 130
- Issue
- 7
- Pages
- 2113-2129
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1990645475
- Cited by
- 984
- References
- 44
- Citations by year
- 2026: 9 · 2025: 19 · 2024: 13 · 2023: 24 · 2022: 26 · 2021: 27 · 2020: 22 · 2019: 28 · 2018: 27 · 2017: 49 · 2016: 60 · 2015: 64 · 2014: 86 · 2013: 76 · 2012: 65
- FWCI
- 27.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- OakTrust (Texas A&M University Libraries) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-069370, R01DK069370)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Surgery › Cholangiocarcinoma and Gallbladder Cancer Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- microRNA, cholangiocarcinoma, miR-21, miR-200b, miR-141, gemcitabine, chemotherapy response, tumor cell proliferation, PTEN, PI3K signaling, apoptosis, miRNA expression profiling, cholangiocytes, xenografts, therapeutic target
- MeSH terms
- Gemcitabine, Animals, Deoxycytidine, Humans, Male, Mice, Nude, Probability, Sampling Studies, Sensitivity and Specificity, Transfection, Transplantation, Heterologous, Blotting, Northern, Blotting, Western, Gene Expression Regulation, Neoplastic, Apoptosis, Cholangiocarcinoma, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, MicroRNAs, Cell Line, Tumor, Cell Proliferation, Mice
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