Cited by 455Inflammatory Bowel DiseaseGut microbiota and healthGastrointestinal motility and disorders

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Targeted Epithelial Tight Junction Dysfunction Causes Immune Activation and Contributes to Development of Experimental Colitis

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Su, Liping, Shen, Le, Clayburgh, Daniel R., Nalle, Sam C., Sullivan, Erika A., Meddings, Jon B., Abraham, Clara, Turner, Jerrold R.·2009·Gastroenterology

DOI 10.1053/j.gastro.2008.10.081PMC PMC2712351

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Abstract

Background & aims Inflammatory bowel disease (IBD) is a multifactorial disease thought to be caused by alterations in epithelial function, innate and adaptive immunity, and luminal microbiota. The specific role of epithelial barrier function remains undefined, although increased activity of intestinal epithelial myosin light chain kinase (MLCK), which is the primary mechanism of tumor necrosis factor-induced barrier dysfunction, occurs in human IBD. Our aim was to determine whether, in an intact epithelium, primary dysregulation of the intestinal epithelial barrier by pathophysiologically relevant mechanisms can contribute to development of colitis.Methods We developed transgenic (Tg) mice that express constitutively active MLCK (CA-MLCK) specifically within intestinal epithelia. Their physiology, immune status, and susceptibility to disease were assessed and compared with non-Tg littermate controls.Results CA-MLCK Tg mice demonstrated significant barrier loss but grew and gained weight normally and did not develop spontaneous disease. CA-MLCK Tg mice did, however, develop mucosal immune activation demonstrated by increased numbers of lamina propria CD4(+)lymphocytes, redistribution of CD11c+cells, increased production of interferon-gamma and tumor necrosis factor, as well as increased expression of epithelial major histocompatibility complex class I. When challenged with CD4+CD45+Rb(hi) lymphocytes, Tg mice developed an accelerated and more severe form of colitis and had shorter survival times than non-Tg littermates.Conclusions Primary pathophysiologically relevant intestinal epithelial barrier dysfunction is insufficient to cause experimental intestinal disease but can broadly activate mucosal immune responses and accelerate the onset and severity of immune-mediated colitis.

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Clinicopathologic study of dextran sulfate sodium experimental acute colitis
Shichijo, K., Matuu, M., Ikeda, Y., Naito, S., Ito, M., & Sekine, I. (1998) · The Japanese Journal of Pharmacology · doi:10.1016/s0021-5198(19)41298-5 · Cited by 1,945
Microbial Influences in Inflammatory Bowel Diseases
Sartor, R. B. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.059 · Cited by 1,927
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease
Zeißig, S., Bürgel, N., Günzel, D., Richter, J. F., Mankertz, J., Wahnschaffe, U., Kroesen, A. J., Zeitz, M., Fromm, M., & Schulzke, J. (2006) · Gut · doi:10.1136/gut.2006.094375 · Cited by 1,218
Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
Powrie, F., Leach, M. W., Mauze, S., Menon, S., Barcomb Caddle, L., & Coffman, R. L. (1994) · Immunity · doi:10.1016/1074-7613(94)90045-0 · Cited by 1,146
Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells
Mottet, C., Uhlig, H. H., & Powrie, F. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.8.3939 · Cited by 928
Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives
Hollander, D., Vadheim, C. M., Brettholz, E., Petersen, G. M., Delahunty, T., & Rotter, J. I. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-6-883 · Cited by 762
Inflammatory Bowel Disease and Adenomas in Mice Expressing a Dominant Negative N-Cadherin
Hermiston, M. L., & Gordon, J. I. (1995) · Science · doi:10.1126/science.270.5239.1203 · Cited by 669
Intestinal permeability and the prediction of relapse in Crohn's disease
Wyatt, J., Vogelsang, H., Hübl, W., Waldhoer, T., & Lochs, H. (1993) · The Lancet · doi:10.1016/0140-6736(93)90882-h · Cited by 626
Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation
Turner, J. R., Rill, B. K., Carlson, S. L., Carnes, D., Kerner, R., Mrsny, R. J., & Madara, J. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.4.c1378 · Cited by 553
A porous defense: the leaky epithelial barrier in intestinal disease
Clayburgh, D. R., Shen, L., & Turner, J. R. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700050 · Cited by 496

Show all 41 references

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Role of NADH: quinone oxidoreductase-1 in the tight junctions of colonic epithelial cells
Nam, S. T., Hwang, J. H., Kim, D. H., Park, M. J., Lee, I. H., Nam, H. J., Kang, J. K., Kim, S. K., Hwang, J. S., Chung, H. K., et al. (2014) · BMB Reports · doi:10.5483/bmbrep.2014.47.9.196 · Cited by 20
Protective function of interleukin 27 in colitis-associated cancer via suppression of inflammatory cytokines in intestinal epithelial cells
Cui, B., Shen, L., Lai, L., Xie, Y., He, J., Xue, Y., Xiao, P., Pan, T. S., Chen, L., Liu, Y., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2016.1268309 · Cited by 21
Epithelial Cells
Edelblum, K. L., & Turner, J. R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-415847-4.00012-4 · Cited by 20
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Qian, W., Li, W., Chen, X., Cui, L., Liu, X., Yao, J., Wang, X., Liu, Y., Li, C., Wang, Y., et al. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154653 · Cited by 19
Nintedanib Alleviates Experimental Colitis by Inhibiting CEBPB/PCK1 and CEBPB/EFNA1 Pathways
Li, H., Li, J., Xiao, T., Hu, Y., Yang, Y., Gu, X., Jin, G., Cao, H., Zhou, H., & Yang, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.904420 · Cited by 19
Consumption of honey ameliorates lipopolysaccharide-induced intestinal barrier dysfunction via upregulation of tight junction proteins
Nathani, S., Das, N., Katiyar, P., Waghmode, B., Sircar, D., & Roy, P. (2023) · European Journal of Nutrition · doi:10.1007/s00394-023-03203-y · Cited by 19
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Kook, S., Choi, K. C., Cho, S., Cho, H.-K., Lee, K. D., & Lee, J. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.10.003 · Cited by 18
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Singh, A. P., Mia, M. B., & Saxena, R. K. (2020) · Journal of Biosciences · doi:10.1007/s12038-020-9989-9 · Cited by 15
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Authors: Su, L., Shen, L., Clayburgh, D. R., Nalle, S. C., Sullivan, E. A., Meddings, J. B., Abraham, C., & Turner, J. R.
Affiliations: University of Chicago (US)
University of Alberta (CA)
Yale University (US)
Corresponding author: Abraham, Clara
Turner, Jerrold R.
ORCID: Su, Liping
Shen, Le
Clayburgh, Daniel R.
Nalle, Sam C.
Meddings, Jon B.
Abraham, Clara
Turner, Jerrold R.
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2009-02
Volume: 136
Issue: 2
Pages: 551-563
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2008.10.081
PMC: PMC2712351
OpenAlex: W2131810438
Cited by: 455
References: 41
Citations by year: 2026: 17 · 2025: 17 · 2024: 21 · 2023: 20 · 2022: 29 · 2021: 32 · 2020: 30 · 2019: 19 · 2018: 18 · 2017: 34 · 2016: 29 · 2015: 35 · 2014: 23 · 2013: 23 · 2012: 38
FWCI: 12.94
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (T32HL007237)
National Cancer Institute (P30CA014599)
National Institute of General Medical Sciences (T32GM007281)
National Institute of Diabetes and Digestive and Kidney Diseases (P01DK067887, R56DK094954, R01DK077905, R01DK058964, R01DK068271, R01DK061931)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: intestinal epithelial barrier dysfunction, tight junctions, myosin light chain kinase, transgenic mice, experimental colitis, inflammatory bowel disease, mucosal immune activation, interferon-gamma, TNF-α, MHC class I expression, disease susceptibility
MeSH terms: Animals, Cell Membrane Permeability, Colitis, Disease Models, Animal, Epithelial Cells, Immunity, Innate, Interferon-gamma, Major Histocompatibility Complex, Mice, Transgenic, Mucous Membrane, Myosin-Light-Chain Kinase, Severity of Illness Index, Tumor Necrosis Factor-alpha, CD4-Positive T-Lymphocytes, Tight Junctions, Mice

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Targeted Epithelial Tight Junction Dysfunction Causes Immune Activation and Contributes to Development of Experimental Colitis

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