Dynamics of fat absorption and effect of sham feeding on postprandial lipema
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Background & aims Given the importance of postprandial hyperlipidemia to increase risk for atherosclerosis, in the present study, stable isotope-labeled meals were fed to healthy subjects (7 males and 3 females) to investigate the kinetics chylomicron synthesis and the effect of sensory exposure to lipid on metabolism.Methods Subjects performed two, 24-hour inpatient studies that entailed consumption of a liquid formula evening meal containing 30 g of oil (+ (13)C(2) triolein) on day 1. Breakfast (day 2) consisted of triacylglycerols (TAGs) fed as capsules (30 g oil + (13)C(7) triolein) to avoid activation of mouth taste receptors. Next, modified sham feeding of cream cheese occurred over 2 hours. In the 2 trials, the stimulus was either higher fat (HF) or lower fat (LF) cream cheese. A liquid meal was consumed at lunch. Blood sampling occurred intermittently, and chylomicron particles S(f) >400 TAGs were analyzed by gas chromatography-mass spectrometry.Results (13)C(2)-Label was found in fasting-state lipoproteins, and persons with higher body fat percentages showed greater dilution of meal TAGs from endogenous sources. For both trials, 13% ± 4% of lipoprotein TAGs oleic acid was derived from the previous evening meal. Incremental area under the curve for TAGs during HF was ∼2.5 times higher than after LF exposure (46 ± 15 vs 17 ± 5 μmol/L/h; P = .04). The greater HF morning lipemia occurred with elevated glucose, insulin, and nonesterified fatty acids peak after lunch.Conclusions These data support a connection between enteral lipid metabolism and oral fat exposure, resulting in elevated postprandial lipemia. The results suggest that the intestine may participate in a mechanism coordinating oral fat signaling with control of subsequent macronutrient disposal in the body.
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Tracer studies showed that dietary lipids remain in the circulation for up to 18 h after a high-fat meal but not after a low-fat meal.
“Tracer studies showed that dietary lipids remain in the circulation for up to 18 h after a high-fat meal but not after a low-fat meal,50”
From Lipid metabolism in MASLD and MASH: From mechanism to the clinic (2024) · cites this paper as [50]
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- Authors
- Chavez–Jauregui, R. N., Mattes, R. D., & Parks, E. J.
- Affiliations
- Purdue University West Lafayette (US)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Parks, Elizabeth J.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 139
- Issue
- 5
- Pages
- 1538-1548
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC2948783
- OpenAlex
- W2051747725
- Cited by
- 109
- References
- 59
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 12 · 2021: 8 · 2020: 7 · 2019: 9 · 2018: 9 · 2017: 3 · 2016: 13 · 2015: 5 · 2014: 9 · 2013: 3 · 2012: 8
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Diabetes Association
- National Institute of Diabetes and Digestive and Kidney Diseases (PL1DK081183, R01DK079913, R01DK063185, 5R01 DK04520414)
- National Institute of Dental and Craniofacial Research (UL1DE019584)
- National Center for Research Resources (M01RR000633, UL1RR024982, M01 RR00633)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- postprandial lipemia, fat absorption, sham feeding, triolein, stable isotope tracers, body fat percentage, free fatty acids
- MeSH terms
- Adipose Tissue, Adult, Dietary Fats, Female, Follow-Up Studies, Humans, Hyperlipidemias, Intestinal Absorption, Lipids, Male, Gas Chromatography-Mass Spectrometry, Prognosis, Risk Factors, Postprandial Period, Enterocytes, Atherosclerosis
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