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The Commensal Microbiota and Enteropathogens in the Pathogenesis of Inflammatory Bowel Diseases
Open accessAbstract
Intestinal inflammation arises from abnormal host-microbe interactions. The perturbations of homeostatic coexistence involve host genetic factors, barrier function, innate and adaptive immunity, as well as qualitative and quantitative changes in the composition of the microbiota. Dysbiosis toward selected micro-organisms and decreased complexity of commensal bacteria have been observed in patients with Crohn's disease and ulcerative colitis, but it is not clear whether the dysbiosis contributes to development of inflammatory bowel disease or is instead a consequence of the disease. Pathogens with virulence factors that allow them to breach the intestinal barrier and induce chronic inflammation might mediate the pathogenesis of these diseases. To identify new therapeutic approaches for inflammatory bowel disease, it is important to identify host susceptibility factors involved in the control of microbial infection, characterize potential pathogens, and eliminate them or block the expression of their virulence factors.
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“There is a decreased complexity in composition, with a loss of normal anaerobic bacteria [33] , a temporary composition instability during clinical remission [34] , and a dysbiosis towards selected microorganisms, with over-and under-representation of certain species [35] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [35]
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Self-citationSYSTEMS BIOLOGY OF MICROBIOTA METABOLITES AND ADIPOCYTE TRANSCRIPTION FACTOR NETWORK
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Metadata
- Authors
- Chassaing, B., & Darfeuille–Michaud, A.
- Affiliations
- Université Clermont Auvergne (FR)
- Corresponding author
- Darfeuille–Michaud, Arlette
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 140
- Issue
- 6
- Pages
- 1720-1728.e3
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2061275484
- Cited by
- 443
- References
- 129
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 18 · 2023: 22 · 2022: 24 · 2021: 24 · 2020: 30 · 2019: 22 · 2018: 41 · 2017: 27 · 2016: 45 · 2015: 35 · 2014: 50 · 2013: 42 · 2012: 32
- FWCI
- 17.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- European Commission
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
- Keywords
- inflammatory bowel disease, Crohn's disease, ulcerative colitis, commensal microbiota, dysbiosis, enteric pathogens, host-microbe interactions, intestinal barrier function, virulence factors, host susceptibility, gut microbiota
- MeSH terms
- Animals, Bacterial Infections, Colitis, Ulcerative, Crohn Disease, Humans, Intestines, Paratuberculosis, Mycobacterium avium subsp. paratuberculosis, Genetic Predisposition to Disease
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