Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia

Pancreatic Cancer

Spencer, P. M., Cameron, J. L., & Lin, L. (2000) · Cited by 7,202

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969

Circulating mutant DNA to assess tumor dynamics

Diehl, F., Schmidt, K., Choti, M. A., Romans, K. E., Goodman, S. N., Li, M., Thornton, K. A., Agrawal, N., Sokoll, L. J., Szabo, S., et al. (2008) · Nature Medicine · doi:10.1038/nm.1789 · Cited by 2,746

Pancreatic cancer

Vincent, A., Herman, J. M., Schulick, R., Hruban, R. H., & Goggins, M. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62307-0 · Cited by 2,678

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471

Pancreatic Intraepithelial Neoplasia: A New Nomenclature and Classification System for Pancreatic Duct Lesions

Hruban, R. H., Adsay, N. V., Albores–Saavedra, J., Compton, C., Garrett, E. S., Goodman, S. N., Kern, S. E., Klimstra, D. S., Klöppel, G., Longnecker, D. S., et al. (2001) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200105000-00003 · Cited by 1,126

Senescence-messaging secretome: SMS-ing cellular stress

Kuilman, T., & Peeper, D. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2560 · Cited by 909

Progression model for pancreatic cancer.

Hruban, R. H., Goggins, M., Parsons, J., & Kern, S. E. (2000) · PubMed · Cited by 872

Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development

Wu, J., Matthaei, H., Maitra, A., Molin, M. D., Wood, L., Eshleman, J., Goggins, M., Canto, M., Schulick, R., Edil, B., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002543 · Cited by 786

When cells get stressed: an integrative view of cellular senescence

Ben-Porath, I., & Weinberg, R. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420663 · Cited by 404

RNAi-Based Approaches for Pancreatic Cancer Therapy

Kim, M. J., Chang, H., Nam, G., Ko, Y., Kim, S. H., Roberts, T. M., & Ryu, J. H. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101638 · Cited by 25

BRAF-Driven Pancreatic Cancer: Prevalence, Molecular Features, and Therapeutic Opportunities

Ciner, A., Jiang, Y., & Hausner, P. F. (2022) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-22-0626 · Cited by 25

KRASG12D- and BRAFV600E-Induced Transformation of Murine Pancreatic Epithelial Cells Requires MEK/ERK-Stimulated IGF1R Signaling

Appleman, V. A., Ahronian, L. G., Cai, J., Klimstra, D. S., & Lewis, B. C. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0340-t · Cited by 28

Loss of p27Kip1 promotes metaplasia in the pancreasviathe regulation of Sox9 expression

Jeannot, P., Callot, C., Baer, R., Duquesnes, N., Guerra, C. E., Guillermet‐Guibert, J., Bachs, O., & Besson, A. (2015) · Oncotarget · doi:10.18632/oncotarget.5770 · Cited by 25

Epithelial to Stromal Re-Distribution of Primary Cilia during Pancreatic Carcinogenesis

Schimmack, S. J., Kneller, S., Dadabaeva, N., Bergmann, F., Taylor, A., Hackert, T., Werner, J., & Strobel, O. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164231 · Cited by 26

Verteporfin- and sodium porfimer-mediated photodynamic therapy enhances pancreatic cancer cell death without activating stromal cells in the microenvironment

Lu, J., Roy, B., Anderson, M. A., Leggett, C. L., Levy, M. J., Pogue, B. W., Hasan, T. G., & Wang, K. K. (2019) · Journal of Biomedical Optics · doi:10.1117/1.jbo.24.11.118001 · Cited by 25

Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance

Stigliani, A., Ialchina, R., Yao, J., Czaplińska, D., Dai, Y., Andersen, H. B., Rennie, S., Andersson, R., Pedersen, S. F., & Sandelin, A. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114409 · Cited by 27

Circulating antibodies to p16 protein-derived peptides in breast cancer

Chen, C., Huang, Y., Zhang, C., Liu, T., ZHENG, H., Shuli, W., Sun, S., Meng, Q., Chen, Y., & Wei, J. (2015) · Molecular and Clinical Oncology · doi:10.3892/mco.2015.485 · Cited by 24

Pancreatic cancer in young adults: changes, challenges, and solutions

Primavesi, F., Stättner, S., Schlick, K., Kiesslich, T., Mayr, C., Klieser, E., Urbas, R., & Neureiter, D. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s176700 · Cited by 24

A Circulating Exosome RNA Signature Is a Potential Diagnostic Marker for Pancreatic Cancer, a Systematic Study

Wu, Y., Zeng, H., Yu, Q., Huang, H., Fervers, B., Chen, Z., & Lu, L. (2021) · Cancers · doi:10.3390/cancers13112565 · Cited by 24

KRAS as a Key Oncogene in the Clinical Precision Diagnosis and Treatment of Pancreatic Cancer

Dai, M., Chen, S., Teng, X., Chen, K., & Cheng, W. (2022) · Journal of Cancer · doi:10.7150/jca.76695 · Cited by 28

Overcoming therapeutic resistance in pancreatic cancer: Emerging opportunities by targeting BRCAs and p53

Calheiros, J., Corbo, V., & Saraiva, L. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188914 · Cited by 26

Bioengineering Approaches for the Pancreatic Tumor Organoids Research and Application

Song, T., Kong, B., Liu, R., Luo, Y., Wang, Y., & Zhao, Y. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300984 · Cited by 24

Autoantibodies against p16 protein-derived peptides may be a potential biomarker for non-small cell lung cancer

Zhang, C., Ye, L., Guan, S., Jin, S., Wang, W., Sun, S., Lee, K.-H., Wei, J., & Liu, B. (2013) · Tumor Biology · doi:10.1007/s13277-013-1271-4 · Cited by 24

Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations

Sawai, Y., Kodama, Y., Shimizu, T., Ota, Y., Maruno, T., Eso, Y., Kurita, A., Shiokawa, M., Tsuji, Y., Uza, N., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3028 · Cited by 24

Pancreatic Cancer, A Mis-interpreter of the Epigenetic Language.

Iguchi, E., Safgren, S. L., Marks, D. L., Olson, R., & Fernández-Zapico, M. E. (2016) · Europe PMC (PubMed Central) · Cited by 24

Mutant KRAS vaccine with dual checkpoint blockade in resected pancreatic cancer: a phase I trial

Huff, A. L., Haldar, S. D., Girgis, A. A., Wang, H. H., Danilova, L., Heumann, T. R., Berg, M., Wang, Y., Andaloori, L., Hernandez, A., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-68324-4 · Cited by 26

Detection of Circulating Tumor DNA in Patients with Pancreatic Cancer Using Digital Next-Generation Sequencing

Macgregor-Das, A. M., Yu, J., Tamura, K., Abe, T., Suenaga, M., Shindo, K., Borges, M. W., Koi, C., Kohi, S., Sadakari, Y., et al. (2020) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2020.02.010 · Cited by 25

Peritoneal Lavage Tumor DNA as a Novel Biomarker for Predicting Peritoneal Recurrence in Pancreatic Ductal Adenocarcinoma

Suenaga, M., Fujii, T., Yamada, S., Hayashi, M., Shinjo, K., Takami, H., Niwa, Y., Sonohara, F., Shimizu, D., Kanda, M., et al. (2020) · Annals of Surgical Oncology · doi:10.1245/s10434-020-08990-w · Cited by 23

4-Hydroxyphenylpyruvate Dioxygenase-Like Protein Promotes Pancreatic Cancer Cell Progression and Is Associated With Glutamine-Mediated Redox Balance

Ye, X., Wei, X., Liao, J., Chen, P., Li, X., Chen, Y., Yang, Y., Zhao, Q., Sun, H., Pan, L., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.617190 · Cited by 24

Efficient and accurate KRAS genotyping using digital PCR combined with melting curve analysis for ctDNA from pancreatic cancer patients

Tanaka, J., Nakagawa, T., Harada, K., Morizane, C., Tanaka, H., Shiba, S., Ohba, A., Hijioka, S., Takai, E., Yachida, S., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-30131-y · Cited by 23

The Gut Microbiome and Pancreatic Cancer Development and Treatment

Attebury, H., & Daley, D. (2023) · The Cancer Journal · doi:10.1097/ppo.0000000000000647 · Cited by 24

Simple Detection of Telomere Fusions in Pancreatic Cancer, Intraductal Papillary Mucinous Neoplasm, and Pancreatic Cyst Fluid

Hata, T., Molin, M. D., McGregor-Das, A., Song, T. J., Wolfgang, C. L., Eshleman, J. R., Hruban, R. H., & Goggins, M. (2017) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2017.09.006 · Cited by 23

Therapeutic Potential of Targeting Stromal Crosstalk-Mediated Immune Suppression in Pancreatic Cancer

Du, W., di Magliano, M. P., & Zhang, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.682217 · Cited by 22

Single Amino Acid Variant Discovery in Small Numbers of Cells

Tan, Z., Yi, X., Carruthers, N. J., Stemmer, P. M., & Lubman, D. M. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00694 · Cited by 21

Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS–Dependent Pancreatic Ductal Adenocarcinoma

Mottini, C., Tomihara, H., Carrella, D., Lamolinara, A., Iezzi, M., Huang, J. K.-L., Amoreo, C. A., Buglioni, S., Manni, I., Robinson, F. S., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-0187 · Cited by 22

Biological Significance of YAP/TAZ in Pancreatic Ductal Adenocarcinoma

Hayashi, H., Uemura, N., Liu, Z., Matsumura, K., Sato, H., Shiraishi, Y., & Baba, H. A. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.700315 · Cited by 25

SYT8 promotes pancreatic cancer progression via the TNNI2/ERRα/SIRT1 signaling pathway

Fu, Z., Liang, X., Shi, L., Tang, L., Chen, D., Liu, A., & Shao, C. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00779-4 · Cited by 22

Intraductal Papillary Mucinous Neoplasms in Hereditary Cancer Syndromes

Ardeshna, D. R., Rangwani, S. M., Cao, T., Pawlik, T. M., Stanich, P. P., & Krishna, S. G. (2022) · Biomedicines · doi:10.3390/biomedicines10071475 · Cited by 24

Emerging Potential Mechanism and Therapeutic Target of Ferroptosis in PDAC: A Promising Future

Li, C., Yin, X., Liu, Z., & Wang, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315031 · Cited by 24

Earlier Diagnosis of Pancreatic Cancer: Is It Possible?

Koltai, T. (2023) · Cancers · doi:10.3390/cancers15184430 · Cited by 22

Cancer Immunoprevention—The Next Frontier

Smit, M.-A. D., Jaffee, E. M., & Lutz, E. R. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0178 · Cited by 22

Multiple KRAS Mutations in Pancreatic Adenocarcinoma

Visani, M., de Biase, D., Baccarini, P., Fabbri, C., Polifemo, A. M., Zanini, N., Pession, A., & Tallini, G. (2013) · International Journal of Surgical Pathology · doi:10.1177/1066896912475073 · Cited by 22

Genomic Landscapes of Pancreatic Neoplasia

Wood, L. D., & Hruban, R. H. (2015) · Journal of Pathology and Translational Medicine · doi:10.4132/jptm.2014.12.26 · Cited by 22

Pancreatic Cancer Chemoprevention Translational Workshop

Miller, M. S., Allen, P., Brentnall, T. A., Goggins, M., Hruban, R. H., Petersen, G. M., Rao, C. V., Whitcomb, D. C., Brand, R. E., Chari, S. T., et al. (2016) · Pancreas · doi:10.1097/mpa.0000000000000705 · Cited by 23

Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development

Rozengurt, E., & Eibl, G. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i15.1797 · Cited by 22

Human pancreatic cancer progression: an anarchy among CCN-siblings

Banerjee, S. K., Maity, G., Haque, I., Ghosh, A., Sarkar, S., Gupta, V. G., Campbell, D. R., Hoff, D. D. V., & Banerjee, S. (2016) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-016-0343-9 · Cited by 21

Protein kinase C isoforms in the normal pancreas and in pancreatic disease

Martinez, A. K. F., & Störz, P. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.08.005 · Cited by 20

Animal models for modeling pancreatic cancer and novel drug discovery

Bisht, S., & Feldmann, G. (2019) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2019.1566319 · Cited by 21

MSP-RON Signaling Is Activated in the Transition From Pancreatic Intraepithelial Neoplasia (PanIN) to Pancreatic Ductal Adenocarcinoma (PDAC)

Li, C., Morvaridi, S., Lam, G., Chheda, C., Kamata, Y., Katsumata, M., Edderkaoui, M., Yuan, X., Nissen, N. N., Pandol, S. J., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00147 · Cited by 21

Pancreatic Macrophages: Critical Players in Obesity-Promoted Pancreatic Cancer

Teper, Y., & Eibl, G. (2020) · Cancers · doi:10.3390/cancers12071946 · Cited by 21

In vivo serial selection of human pancreatic cancer cells in orthotopic mouse models produces high metastatic variants irrespective of Kras status

Metildi, C. A., Kaushal, S., Hoffman, R. M., & Bouvet, M. (2013) · Journal of Surgical Research · doi:10.1016/j.jss.2013.03.049 · Cited by 20

The curious case of Gαs gain-of-function in neoplasia

Innamorati, G., Wilkie, T. M., Kantheti, H. S., Valenti, M. T., Carbonare, L. D., Giacomello, L., Parenti, M. D., Melisi, D., & Bassi, C. (2018) · BMC Cancer · doi:10.1186/s12885-018-4133-z · Cited by 21

An exosome-mimicking membrane hybrid nanoplatform for targeted treatment toward Kras-mutant pancreatic carcinoma

Deng, L., Zhang, H., Zhang, Y., Luo, S., Du, Z., Lin, Q., Zhang, Z., & Zhang, L. (2021) · Biomaterials Science · doi:10.1039/d1bm00446h · Cited by 20

Investigating underlying molecular mechanisms, signaling pathways, emerging therapeutic approaches in pancreatic cancer

Mustafa, M., Abbas, K., Alam, M., Habib, S., Zulfareen, Hasan, G. M., Islam, S., Shamsi, A., & Hassan, M. I. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1427802 · Cited by 25

The anti-oxidative transcription factor Nuclear factor E2 related factor-2 (Nrf2) counteracts TGF-β1 mediated growth inhibition of pancreatic ductal epithelial cells -Nrf2 as determinant of pro-tumorigenic functions of TGF-β1

Genrich, G., Kruppa, M., Lenk, L., Helm, O., Broich, A., Freitag‐Wolf, S., Röcken, C., Sipos, B., Schäfer, H., & Sebens, S. (2016) · BMC Cancer · doi:10.1186/s12885-016-2191-7 · Cited by 20

Intraductal papillary mucinous neoplasms of the pancreas: Clinical association with KRAS

Chang, X., Wu, Y., Li, Y., Wang, J., & Chen, J. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8875 · Cited by 20

Inhibition of miR-21 Regulates Mutant KRAS Effector Pathways and Intercepts Pancreatic Ductal Adenocarcinoma Development

Chu, N. J., Anders, R. A., Fertig, E. J., Cao, M., Hopkins, A. C., Keenan, B. P., Popović, A., Armstrong, T. D., Jaffee, E. M., & Zimmerman, J. W. (2020) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-20-0053 · Cited by 20

KRAS-Driven Tumorigenesis and KRAS-Driven Therapy in Pancreatic Adenocarcinoma

Than, M. T., O’Hara, M. H., Stanger, B. Z., & Reiss, K. A. (2024) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-23-0519 · Cited by 22

Somatic molecular analysis augments cytologic evaluation of pancreatic cyst fluids as a diagnostic tool

Sakhdari, A., Moghaddam, P. A., Ok, C. Y., Walter, O., Tomaszewicz, K., Caporelli, M., Meng, X., LaFemina, J., Whalen, G. F., Belkin, E., et al. (2019) · Oncotarget · doi:10.18632/oncotarget.26999 · Cited by 19

Design, synthesis and biological evaluation of 2-((4-sulfamoylphenyl)amino)-pyrrolo[2,3-d]pyrimidine derivatives as CDK inhibitors

Yang, B., Quan, Y., Zhao, W., Ji, Y., Yang, X., Li, J., Li, Y., Liu, X., Wang, Y., & Li, Y. (2023) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2023.2169282 · Cited by 20

Bibliometric Analysis of Hotspots and Frontiers of Immunotherapy in Pancreatic Cancer

Xu, Q., Zhou, Y., Zhang, H., Li, H., Qin, H., & Wang, H. (2023) · Healthcare · doi:10.3390/healthcare11030304 · Cited by 21

Co-occurring IPMN and pancreatic cancer: the same or different? An overview from histology to molecular pathology

Omori, Y., Furukawa, T., Scarpa, A., & Luchini, C. (2023) · Journal of Clinical Pathology · doi:10.1136/jcp-2023-209012 · Cited by 19

Genetic Testing by Cancer Site

Axilbund, J. E., & Wiley, E. (2012) · The Cancer Journal · doi:10.1097/ppo.0b013e3182624694 · Cited by 20

Overexpression of ankyrin1 promotes pancreatic cancer cell growth

Omura, N., Mizuma, M., Macgregor, A. M., Hong, S., Ayars, M., Almario, J. A., Borges, M. W., Kanda, M., Li, A., Vincent, A., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9009 · Cited by 19

Simple mucinous cysts of the pancreas have heterogeneous somatic mutations

Attiyeh, M. A., Zhang, L., Iacobuzio–Donahue, C. A., Allen, P. J., Imam, R., Baştürk, O., Klimstra, D. S., & Sigel, C. (2020) · Human Pathology · doi:10.1016/j.humpath.2020.04.006 · Cited by 19

Mutational spectrum of intraepithelial neoplasia in pancreatic heterotopia

Ma, C., Gocke, C. D., Hruban, R. H., & Belchis, D. (2015) · Human Pathology · doi:10.1016/j.humpath.2015.09.023 · Cited by 19

The Effect of Pancreatic Juice Collection Time on the Detection of KRAS Mutations

Suenaga, M., Dudley, B., Karloski, E., Borges, M. W., Canto, M. I., Brand, R. E., & Goggins, M. (2017) · Pancreas · doi:10.1097/mpa.0000000000000956 · Cited by 18

Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice

Erener, S., Ellis, C. E., Ramzy, A., Glavas, M. M., O’Dwyer, S. M., Pereira, S., Wang, T., Pang, J., Bruin, J. E., Riedel, M. J., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100434 · Cited by 16

Targeting the ERK mitogen-activated protein kinase cascade for the treatment of KRAS-mutant pancreatic cancer

Diehl, J. N., Hibshman, P. S., Ozkan‐Dagliyan, I., Goodwin, C. M., Howard, S. V., Cox, A. D., & Der, C. J. (2022) · Advances in cancer research · doi:10.1016/bs.acr.2021.07.008 · Cited by 18

Recent advances in understanding pancreatic cancer

Stott, M. C., Oldfield, L. S., Hale, J. J., Costello, E., & Halloran, C. M. (2022) · Faculty Reviews · doi:10.12703/r/11-9 · Cited by 19

The molecular landscape of pancreatic ductal adenocarcinoma

Sivapalan, L., Kocher, H. M., Ross‐Adams, H., & Chelala, C. (2022) · Pancreatology · doi:10.1016/j.pan.2022.07.010 · Cited by 21

Exploring the Biology of Cancer-Associated Fibroblasts in Pancreatic Cancer

Bryce, A. S., Dreyer, S. B., Froeling, F. E. M., & Chang, D. K.-F. (2022) · Cancers · doi:10.3390/cancers14215302 · Cited by 19

Single-cell omics: a new perspective for early detection of pancreatic cancer?

Wang, Q., Šabanović, B., Awada, A., Reina, C., Aicher, A., Tang, J., & Heeschen, C. (2023) · European Journal of Cancer · doi:10.1016/j.ejca.2023.112940 · Cited by 19

KDM5B promotes SMAD4 loss-driven drug resistance through activating DLG1/YAP to induce lipid accumulation in pancreatic ductal adenocarcinoma

Wang, Y., Liu, S., Wang, Y., Li, B., Liang, J., Chen, Y., Tang, B., Yu, S., & Wang, H. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02020-4 · Cited by 18

Anti-p16 autoantibodies may be a useful biomarker for early diagnosis of esophageal cancer

Jin, Y., Guan, S., Liu, L., Sun, S., Lee, K.-H., & Wei, J. (2014) · Asia-Pacific Journal of Clinical Oncology · doi:10.1111/ajco.12198 · Cited by 18

Immune checkpoint and inflammation as therapeutic targets in pancreatic carcinoma

Kimbara, S., & Kondo, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i33.7440 · Cited by 18

Novel Biomarkers for Pancreatic Cysts

Singh, H., McGrath, K., & Singhi, A. D. (2017) · Digestive Diseases and Sciences · doi:10.1007/s10620-017-4491-4 · Cited by 18

Utility of “liquid biopsy” using pancreatic juice for early detection of pancreatic cancer

Okada, T., Iwano, H., Ono, Y., Karasaki, H., Sato, T., Yamada, M., Omori, Y., Sato, H., Hayashi, A., Kawabata, H., et al. (2018) · Endoscopy International Open · doi:10.1055/a-0721-1747 · Cited by 18

Worth a Pound of Cure? Emerging Strategies and Challenges in Cancer Immunoprevention

Haldar, S. D., Vilar, E., Maitra, A., & Zaidi, N. (2023) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-22-0478 · Cited by 19

Molecular Genetics of Pancreatic Neoplasms

Hosoda, W., & Wood, L. D. (2016) · Surgical pathology clinics · doi:10.1016/j.path.2016.05.011 · Cited by 20

The antioxidant transcription factor Nrf2 modulates the stress response and phenotype of malignant as well as premalignant pancreatic ductal epithelial cells by inducing expression of the ATF3 splicing variant ΔZip2

Pianka, M.-L., Hesse, L., Deisinger, F., Sipos, B., Röcken, C., Arlt, A., Sebens, S., Helm, O., & Schäfer, H. (2018) · Oncogene · doi:10.1038/s41388-018-0518-3 · Cited by 17

PYK2 Is Involved in Premalignant Acinar Cell Reprogramming and Pancreatic Ductal Adenocarcinoma Maintenance by Phosphorylating β-CateninY654

Gao, C., Chen, G., Zhang, D. H., Zhang, J., Kuan, S., Hu, W., Esni, F., Gao, X., Guan, J., Chu, E., et al. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.07.004 · Cited by 17

MicroRNA-Regulated Signaling Pathways: Potential Biomarkers for Pancreatic Ductal Adenocarcinoma

Mortoglou, M., Wallace, D., Djordjević, A. B., Djordjevic, V. R., Arısan, E. D., & Onganer, P. U. (2021) · Stresses · doi:10.3390/stresses1010004 · Cited by 17

Intraductal tubulopapillary neoplasm of the pancreas with somatic BRAF mutation

Urata, T., Naito, Y., Nagamine, M., Izumi, Y., Tonaki, G., Iwasaki, H., Sasaki, A., Yamasaki, A., Minami, N., Yoshioka, R., et al. (2012) · Clinical Journal of Gastroenterology · doi:10.1007/s12328-012-0342-1 · Cited by 17

Viro-immune therapy: A new strategy for treatment of pancreatic cancer

Ibrahim, A. M. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i2.748 · Cited by 17

Prkci Regulates Autophagy and Pancreatic Tumorigenesis in Mice

Inman, K. S., Liu, Y., Scotti, M. L., Leitges, M., Krishna, M., Crawford, H. C., Fields, A. P., & Murray, N. R. (2022) · Cancers · doi:10.3390/cancers14030796 · Cited by 17

Current Pathology Model of Pancreatic Cancer

Szymoński, K., Milian-Ciesielska, K., Lipiec, E. W., & Adamek, D. (2022) · Cancers · doi:10.3390/cancers14092321 · Cited by 15

Heterogeneous tumor microenvironment in pancreatic ductal adenocarcinoma: An emerging role of single‐cell analysis

Byeon, S., du Toit‐Thompson, T., Gillson, J., Gill, A. J., Samra, J. S., Mittal, A., & Sahni, S. (2023) · Cancer Medicine · doi:10.1002/cam4.6407 · Cited by 15

Clinicopathological Implications of Wingless/int1 (WNT) Signaling Pathway in Pancreatic Ductal Adenocarcinoma

Nakamoto, M., & Hisaoka, M. (2016) · Journal of UOEH · doi:10.7888/juoeh.38.1 · Cited by 16

Expression of neuropeptide Y and its receptors Y1 and Y2 in pancreatic intraepithelial neoplasia and invasive pancreatic cancer in a transgenic mouse model and human samples of pancreatic cancer

Waldmann, J., Fendrich, V., Reichert, M., Hecker, A., Bartsch, D. K., Padberg, W. M., & Holler, J. P. N. (2017) · Journal of Surgical Research · doi:10.1016/j.jss.2017.11.010 · Cited by 16

Advances in Translational Research and Clinical Care in Pancreatic Cancer: Where Are We Headed?

Satyananda, V., Gupta, R., Hari, D. M., Yeh, J. J.-C., & Chen, K. T. (2019) · Gastroenterology Research and Practice · doi:10.1155/2019/7690528 · Cited by 16

Deletion of Histone Methyltransferase G9a Suppresses Mutant Kras-driven Pancreatic Carcinogenesis

Kato, H., Tateishi, K., Fujiwara, H., Ijichi, H., Yamamoto, K., Nakatsuka, T., Kakiuchi, M., Sano, M., Kudo, Y., Hayakawa, Y., et al. (2020) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20224 · Cited by 16

KRAS, A Prime Mediator in Pancreatic Lipid Synthesis through Extra Mitochondrial Glutamine and Citrate Metabolism

Muyinda, I. J., Park, J. G., Jang, E., & Yoo, B. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105070 · Cited by 16

Large-duct pattern invasive adenocarcinoma of the pancreas–a variant mimicking pancreatic cystic neoplasms: A minireview

Sato, H., Liss, A. S., & Mizukami, Y. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i23.3262 · Cited by 16

Using an endoscopic distal cap to collect pancreatic fluid from the ampulla (with video)

Suenaga, M., Sadakari, Y., Almario, J. A., Borges, M. W., Lennon, A. M., Shin, E.-J., Canto, M. I., & Goggins, M. (2017) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2017.02.026 · Cited by 16

Radiation-induced alterations in immunogenicity of a murine pancreatic ductal adenocarcinoma cell line

Schröter, P., Hartmann, L., Osen, W., Baumann, D., Offringa, R., Eisel, D., Debus, J., Eichmüller, S. B., & Rieken, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-57456-2 · Cited by 16

Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice

Salaymeh, Y., Farago, M., Sebban, S., Shalom, B., Pikarsky, E., & Katzav, S. (2020) · Life Science Alliance · doi:10.26508/lsa.202000661 · Cited by 18

Mutational Analysis of Bile Cell‐Free DNA in Primary Sclerosing Cholangitis: A Pilot Study

Arechederra, M., Bik, E., Rojo, C., Elurbide, J., Elizalde, M., Kruk, B., Krasnodębski, M., Pertkiewicz, J., Kozieł, S., Grąt, M., et al. (2025) · Liver International · doi:10.1111/liv.70049 · Cited by 15

Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with pancreatic cancer

Tai, D. W.-M., Conroy, T., Lee, J. J. X., Chee, C. E., Hao, C., Wijaya, I., Aggarwal, S., Ueno, M., Jeung, H., Hashim, N. M., et al. (2025) · ESMO Open · doi:10.1016/j.esmoop.2025.105826 · Cited by 19

Circulating tumor DNA for diagnosis, prognosis and treatment of gastrointestinal malignancies

Kirchweger, P., Wundsam, H., & Rumpold, H. (2022) · World Journal of Clinical Oncology · doi:10.5306/wjco.v13.i6.473 · Cited by 15

NMR-based metabolic profiling of urine, serum, fecal, and pancreatic tissue samples from the Ptf1a-Cre; LSL-KrasG12D transgenic mouse model of pancreatic cancer

Veite-Schmahl, M. J., Regan, D. P., Rivers, A. C., Joesten, W. C., & Kennedy, M. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200658 · Cited by 15

A Network-Based Approach for Identification of Subtype-Specific Master Regulators in Pancreatic Ductal Adenocarcinoma

Zhang, Y., Zhu, L., & Wang, X. (2020) · Genes · doi:10.3390/genes11020155 · Cited by 15

Molecular Alterations in Pancreatic Cancer: Transfer to the Clinic

Gil, Y. R., Sánchez, P. J., Velasco, R. M., García, A. G., & Lobo, V. J. S.-A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042077 · Cited by 18

Overcoming the Tumor Microenvironmental Barriers of Pancreatic Ductal Adenocarcinomas for Achieving Better Treatment Outcomes

Alzhrani, R. M., Alsaab, H. O., Vanamala, K., Bhise, K., Tatiparti, K., Barari, A., Sau, S., & Iyer, A. K. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202000262 · Cited by 16

Models of pancreatic ductal adenocarcinoma

Dennaoui, R., Shrestha, H., & Wagner, K. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-09989-9 · Cited by 19

Cell Dissemination in Pancreatic Cancer

Kim, J. (2022) · Cells · doi:10.3390/cells11223683 · Cited by 17

Genetic assessment of recurrent pancreatic high-risk lesions in the remnant pancreas: Metachronous multifocal lesion or local recurrence?

Gotoh, Y., Ohtsuka, T., Nakamura, S., Shindo, K., Ohuchida, K., Miyasaka, Y., Mori, Y., Mochidome, N., Oda, Y., & Nakamura, M. (2018) · Surgery · doi:10.1016/j.surg.2018.10.025 · Cited by 15

From precursor to cancer: decoding the intrinsic and extrinsic pathways of pancreatic intraepithelial neoplasia progression

Graham, S., Dmitrieva, M., Costa, D. B. V., Francescone, R., Trujillo, M. A. M., Cukierman, E., & Wood, L. D. (2024) · Carcinogenesis · doi:10.1093/carcin/bgae064 · Cited by 15

Reprogramming of glucose metabolism in pancreatic cancer: mechanisms, implications, and therapeutic perspectives

Zhang, Y., Li, W., Niu, J., Fan, Z., Li, X., & Zhang, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1586959 · Cited by 15

Genetic Alterations Associated With Progression From Pancreatic Intraepithelial Neoplasia to Invasive Pancreatic Tumor

Murphy, S. J., Hart, S. N., Lima, J. F., Kipp, B. R., Klebig, M. L., Winters, J. L., Szabo, C., Zhang, L., Eckloff, B. W., Petersen, G. M., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.07.049 · Cited by 199

Molecular genetics of pancreatic intraepithelial neoplasia

Feldmann, G., Beaty, R., Hruban, R. H., & Maitra, A. (2007) · Journal of Hepato-Biliary-Pancreatic Surgery · doi:10.1007/s00534-006-1166-5 · Cited by 269

Precursor Lesions of Pancreatic Cancer

Yonezawa, S., Higashi, M., Yamada, N., & Goto, M. (2008) · Gut and Liver · doi:10.5009/gnl.2008.2.3.137 · Cited by 91

KRAS2 Mutations in Human Pancreatic Acinar-Ductal Metaplastic Lesions Are Limited to Those with PanIN: Implications for the Human Pancreatic Cancer Cell of Origin

Shi, C., Hong, S., Lim, P., Kamiyama, H., Khan, M. A., Anders, R. A., Goggins, M., Hruban, R. H., & Eshleman, J. R. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0206 · Cited by 109

Mutational spectrum of intraepithelial neoplasia in pancreatic heterotopia

Ma, C., Gocke, C. D., Hruban, R. H., & Belchis, D. (2015) · Human Pathology · doi:10.1016/j.humpath.2015.09.023 · Cited by 19