The DOI matches its Crossref record; 21 of the 22 references it cites were found in a registry or an index.
Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia
Open accessAbstract
More information is needed about genetic factors that initiate development of pancreatic intraepithelial neoplasms-the most common precursors of pancreatic ductal adenocarcinoma. We show that more than 99% of the earliest-stage, lowest-grade, pancreatic intraepithelial neoplasm-1 lesions contain mutations in KRAS, p16/CDKN2A, GNAS, or BRAF. These findings could improve our understanding of the development and progression of these premalignant lesions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“however, may be acquired as later events during systemic treatment for metastatic disease and have been found as subclonal genetic alterations in a subset of CRC patients ([25-27])”
From Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor (2022) · cites this paper as [26]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“First, KRAS mutations are often a founder genetic event involved in the pathogenesis of PDAC and are consistently found in precancerous pancreatic intraepithelial neoplasms”
From Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor (2022) · cites this paper as [26]
Experimental — accuracy not yet measuredIn the citing paper
“KRAS mutations are observed in most low-grade PanINs and IPMNs, suggesting KRAS is the initiating genetic event driving exocrine neoplasia46,47.”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [46]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Spencer, P. M., Cameron, J. L., & Lin, L. (2000) · Cited by 7,202
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969
Self-citationCirculating mutant DNA to assess tumor dynamics
Diehl, F., Schmidt, K., Choti, M. A., Romans, K. E., Goodman, S. N., Li, M., Thornton, K. A., Agrawal, N., Sokoll, L. J., Szabo, S., et al. (2008) · Nature Medicine · doi:10.1038/nm.1789 · Cited by 2,746
Self-citationVincent, A., Herman, J. M., Schulick, R., Hruban, R. H., & Goggins, M. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62307-0 · Cited by 2,678
Self-citationPreinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471
Self-citationHruban, R. H., Adsay, N. V., Albores–Saavedra, J., Compton, C., Garrett, E. S., Goodman, S. N., Kern, S. E., Klimstra, D. S., Klöppel, G., Longnecker, D. S., et al. (2001) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200105000-00003 · Cited by 1,126
Self-citationSenescence-messaging secretome: SMS-ing cellular stress
Kuilman, T., & Peeper, D. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2560 · Cited by 909
Progression model for pancreatic cancer.
Hruban, R. H., Goggins, M., Parsons, J., & Kern, S. E. (2000) · PubMed · Cited by 872
Self-citationRecurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development
Wu, J., Matthaei, H., Maitra, A., Molin, M. D., Wood, L., Eshleman, J., Goggins, M., Canto, M., Schulick, R., Edil, B., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002543 · Cited by 786
Self-citationWhen cells get stressed: an integrative view of cellular senescence
Ben-Porath, I., & Weinberg, R. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420663 · Cited by 404
Flagged first, then by citations
1 of the 22 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Hruban, 2000, Clin Cancer Res, 6, 2969
- Wu, 2011, Sci Transl Med, 3
- Caldwell, 2011, Oncogene
- Wu, 2011, Sci Transl Med, 3
Cited by
Sorted by citations
Items 601–700 of 743
Yan, B., Fritsche, A., Haußner, E., Inamdar, T. V., Laumen, H., Boettcher, M., Gericke, M. T., Michl, P., & Rosendahl, J. (2025) · Cancers · doi:10.3390/cancers17101676 · Cited by 1
Misfolding CPA1 mutation accelerates precancerous pancreas lesions in KC mice
Demcsák, A., & Sahin-Tóth, M. (2025) · American Journal of Physiology - Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00025.2025 · Cited by 2
Yang, K., He, Z., Jiang, T., Cai, T., Li, X., & Xie, K. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02512-5 · Cited by 1
Girolimetti, G., Bramato, G., Fiore, A., Romanò, R., Guerra, F., Bucci, C., & Basset, A. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105309 · Cited by 1
Molecular Probes for Pancreatic Cancer Diagnosis: Recent Advances and Further Perspectives
Li, J., He, W., Dai, L., Fan, H., & Yu, X. (2026) · Small · doi:10.1002/smll.202513668 · Cited by 1
Progress and challenges in the development of advanced pancreatic cancer organoids
Detert, K., Piotrowsky, A., Marongiu, L., Leischner, C., Lauer, U. M., Venturelli, S., & Burkard, M. (2026) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-026-03717-3 · Cited by 2
Dempke, W. C. M., Sippel, C., Fenchel, K., Heinemann, V., Cutsem, E. V., & Arnold, D. (2026) · Future Oncology · doi:10.1080/14796694.2026.2725499 · Cited by 1
Making Sense of Current and Emerging Therapies in Pancreatic Cancer: Balancing Benefit and Value
Ahn, D. H., Ko, A. H., Meropol, N. J., & Bekaii‐Saab, T. (2015) · American Society of Clinical Oncology Educational Book · doi:10.14694/edbook_am.2015.35.e222 · Cited by 1
Mouse Models of Pancreatic Ductal Adenocarcinoma
Bednar, F., & di Magliano, M. P. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6549-2_7 · Cited by 1
Molecular Pathology of Pancreatic Cancer Precursor Lesions
Brosens, L. A. A., & Offerhaus, G. J. A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6549-2_2 · Cited by 1
Pathology and Molecular Pathology of Pancreatic Cancer
Foo, W. C., & Wang, H. (2016) · Springer eBooks · doi:10.1007/978-3-319-35153-7_26 · Cited by 1
Early detection of pancreatic cancer concomitant with IPMN using pancreatic juice cytology
Ohtsuka, T., Miyasaka, Y., Mori, Y., Nakata, K., Oda, Y., & Nakamura, M. (2017) · Suizo · doi:10.2958/suizo.32.45 · Cited by 1
Endoscopic ultrasound guided fine-needle aspiration and biopsy of pancreatic cysts
Girotra, M., & Park, W. G. (2017) · Techniques in Gastrointestinal Endoscopy · doi:10.1016/j.tgie.2017.10.004 · Cited by 1
Taucher, V., & Haybaeck, J. (2017) · Springer eBooks · doi:10.1007/978-3-319-53661-3_5 · Cited by 1
MicroRNAs and Cancer Signaling Pathways
Manjari, K. S., Srilekha, A., Khan, I. A., & Prasad, D. (2022) · Springer eBooks · doi:10.1007/978-981-16-9186-7_2 · Cited by 1
Sawai, H., Kiriyama, Y., Kuzuya, H., Fujii, Y., Ueno, S., Koide, S., Kurimoto, M., Yamao, K., Matsuo, Y., Morimoto, M., et al. (2023) · Journal of Medical Case Reports · doi:10.1186/s13256-023-03798-0 · Cited by 1
Gopalan, V., & Hannenhalli, S. S. (2023) · Cancers · doi:10.3390/cancers15072159 · Cited by 1
Chopra, A., He, H.-Z., Milošević, J., Tirukkovalur, N. V., Asmar, R. E., Nassour, I., Nunns, G. R., Chen, M., Chen, J., Jiang, S., et al. (2025) · Annals of Surgical Oncology · doi:10.1245/s10434-025-18633-7 · Cited by 1
Pancreatic Cancer and Its Precursor Lesions
Wentz, S. C., & Shi, C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-386456-7.04904-2 · Cited by 1
Corbo, V., Mafficini, A., Amato, E., & Scarpa, A. (2012) · Springer eBooks · doi:10.1007/978-94-007-5842-1_8 · Cited by 1
Solide und zystische nichtendokrine Tumoren des Pankreas
Klöppel, G., Esposito, I., Kasajima, A., Konukiewitz, B., Lüttges, J., & Sipos, B. (2020) · Pathologie · doi:10.1007/978-3-642-04557-8_24 · Cited by 1
Novel Biomarkers of Invasive IPMN
Hasak, S., & Das, K. K. (2020) · Molecular and translational medicine · doi:10.1007/978-3-030-49476-6_3 · Cited by 1
Jesus‐Acosta, A. D., Narang, A. K., Mauro, L. A., Herman, J. M., Jaffee, E. M., & Laheru, D. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-47674-4.00078-5 · Cited by 1
Challenges and Future Developments
Safari, M., Ariff, M., & Mohamad, S. (2014) · Wiley eBooks · doi:10.1002/9781119029236.ch15 · Cited by 1
Noë, M., Brosens, L. A. A., & Offerhaus, G. J. A. (2018) · Wiley eBooks · doi:10.1002/9781119188421.ch93 · Cited by 1
Schäfer, H., Traulsen, A., & Sebens, S. (2019) · HepatoBiliary Surgery and Nutrition · doi:10.21037/hbsn.2019.06.03
Pancreas-specific miR-216a regulates proliferation and endocrine and exocrine cell function in vivoPreprint
Erener, S., Ellis, C. E., Ramzy, A., Glavas, M. M., O’Dwyer, S. M., Pereira, S., Wang, T., Pang, J., Bruin, J. E., Riedel, M. J., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/792655 · Cited by 1
Liu, Y., Deguchi, Y., Wei, D., Moussalli, M. J., Li, D., Wang, H., Valentin, L. A., Colby, J. K., Liu, F., Wang, J., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.04.412320 · Cited by 1
Gong, J., Li, X., Feng, Z., Lou, J., Pu, K., Sun, Y., Hu, S., Wu, J., & Wu, Y. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.20.549805 · Cited by 1
Self-citationPflüger, M. J., Noë, M., & Brosens, L. A. A. (2023) · doi:10.1002/9781119876007.ch126 · Cited by 1
Haçarız, O., Messina‐Pacheco, J., Goodfellow, E., Leibovitch, M., Lowy, A. M., Perrino, S., Jean‐Claude, B. J., Gao, Z., Gregorieff, A., & Brodt, P. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.28.601273 · Cited by 1
Sun, Y., Zhang, A., Li, Y., Hu, T., & Li, M. (2024) · Research Square · doi:10.21203/rs.3.rs-5655084/v1 · Cited by 1
Marco, S., Walsh, P. J., Revenko, A. S., Thomason, P. A., McGarry, L., MacLeod, A. R., Ansel, S., Tataran, D., Bushell, M., Braconi, C., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.05.635637 · Cited by 1
Neuzillet, C. (2018) · theses.fr (ABES) · doi:10.70675/71b3d021zb0eaz45a4z95a5zdb254dc5bde0 · Cited by 1
The Biology of K-Ras Signaling Pathways in Pancreatic Cancer
Court, H., Philips, M. R., & Bar‐Sagi, D. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6549-2_5
Findet die molekulare Diagnostik Einzug in die Pankreaspathologie?
Sipos, B., & Sperveslage, J. (2013) · Der Pathologe · doi:10.1007/s00292-013-1865-z
Neoplasias pancreáticas: avances
Chan, C. H. F., & Santes, Ó. (2012) · Revista de Gastroenterología de México · doi:10.1016/j.rgmx.2012.07.041
The Genetics of Pancreatic Cancer Progression
Iacobuzio–Donahue, C. A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6549-2_8
Genomic Alterations in Sporadic Pancreatic Cancer
Molin, M. D., & Maitra, A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6549-2_1
Self-citationUrata, T., Tonaki, G., Iwasaki, H., Minami, N., Yoshioka, R., Hifumi, M., Minami, N., Naito, Y., Fukuda, S., Izumi, Y., et al. (2012)
Neoplasias pancreáticas: avances Pancreatic tumors: an update
Chan, C., Santes, Ó., & Médicas, C. (2016)
Les auteurs déclarent ne pas avoir de liens d'intérêt en relation avec le contenu de cet article
Buscail, L., Bournet, B., & Cordelier, P. (2012)
Eshleman, J. R., Norris, A. L., Sadakari, Y., Debeljak, M., Borges, M. W., Harrington, C. T., Lin, E. I., Brant, A., Barkley, T., Almario, J. A., et al. (2015)
Self-citationMorales‐Oyarvide, V., & Mino-Kenudson, M. A. (2013) · Pancreatic Disorders and Therapy · doi:10.4172/2165-7092.s4-005
賢一, 佐. (2013) · 日本消化機病學會雜誌. 乙 · doi:10.11405/nisshoshi.110.2042
MEK inhibition in pancreas cancer
Vena, F. (2016) · UCL Discovery (University College London)
Polireddy, K. (2015) · KU ScholarWorks (The University of Kansas)
Deciphering the role of SerpinB2 in cancer invasion and metastasis
Harris, N. L. E. (2017) · Research Online (University of Wollongong)
Metabolism in Pancreatic Cancer
Poursaitidis, I., & Lamb, R. F. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6631-8_68-1
Martinelli, P., & Lonardo, E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804003-4.00007-4
Advances in signaling pathways of pancreatic cancer
Kong, D., & Li, Q. (2015) · Clinical Oncology and Cancer Research · doi:10.3969/j.issn.1000-8179.20150613
Assessment of the presence of pancreatic intraepithelial neoplasia in various diseases of this organ
Zińczuk, J., Zaręba, K. P., Duchnowska, E., Guzińska-Ustymowicz, K., Kędra, B., Kemonä, A., & Pryczynicz, A. (2017) · Progress in Health Sciences · doi:10.5604/01.3001.0010.5718
Screening of Patients with Hereditary Pancreatic Cancer
Goggins, M. (2018) · Wiley eBooks · doi:10.1002/9781119188421.ch98
Self-citationAger, C. R. (2018) · Digital Commons-TMC (Texas Medical Center)
Saha, B. B., Thu, K., & Wijayanta, A. T. (2018) · Evergreen · doi:10.5109/1957499
Chemo-prevention and interception of obesity-promoted pancreatic ductal adenocarcinoma
Chang, H.-H., & Eibl, G. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814704-7.00006-4
Regulation of the kRAS Promoter in Pancreatic Cancer by Proteins and Small Molecules
Batra, H. (2017) · ProQuest Demo Repository
Loss of TIP30 Accelerates Pancreatic Cancer Progression and Metastasis
Williams, I., & Imade, E. (2019)
Role of stromal SPARC in PDAC tumorigenesis and drug delivery
Ramu, I. (2019) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7723
Molecular Biology of Biliopancreatic Lesions
Visani, M., Acquaviva, G., Pession, A., Tallini, G., & de Biase, D. (2020) · Springer eBooks · doi:10.1007/978-3-030-42569-2_51
Li, D., Roeck, K., Zhang, C., Zidek, B., Rodman, E. P. B., Hernandez-Barco, Y. G., Zhang, J., Bamlet, W. R., Oberg, A. L., Zhang, L., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.14.202952
Molecular and morphologic study of pancreatic cancer evolution
Noë, M. (2020) · Utrecht University Repository (Utrecht University) · doi:10.33540/3
Alzhrani, R. M. (2020) · Human Biology
Signaling amplitude molds the Ras mutation tropism of urethanePreprint
Li, S., & Counter, C. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.09.430515
Schäfer, D. (2021) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-8485
Dong, R. (2020) · KU ScholarWorks (University of Kansas)
Ning, G., Li, Y., Chen, W., Tang, W., Shou, D., Luo, Q., Chen, H., & Zhou, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-153446/v1
Willis, J. (2000) · Érudit (Université de Montréal)
Occurrence of Malignant Neoplasms
Shimizu, K. (2014) · Springer eBooks · doi:10.1007/978-3-642-55086-7_26
Pathogenesis, Epidemiology, and Prognosis of Pancreatic Adenocarcinomas
Kim, K. K., Gaddam, S., & Liu, Q. Y. (2021) · Hepato-Pancreato-Biliary Malignancies · doi:10.1007/978-3-030-37482-2_28-1
Offringa, R. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717956882.793461428
Diagnosis and Evaluation of Pancreatic and Periampullary Adenocarcinoma
Lew, D., & Kwok, K. K. (2021) · Springer eBooks · doi:10.1007/978-3-030-37482-2_29-1
Targeting and modulation of the tumor stroma in pancreatic cancer
Schnittert, J. (2018) · doi:10.3990/1.9789036545853
Genomic medicine for the early detection of pancreatic cancer
Sato, H., Takahashi, K., & Mizukami, Y. (2022) · Suizo · doi:10.2958/suizo.37.29
Recent advances in understanding pancreatic cancer
Stott, M. C., Oldfield, L. S., Hale, J. J., Costello, E., & Halloran, C. M. (2022) · Faculty Reviews · doi:10.12703/r/11-10
The Molecular Pathology of Precursor Lesions of Pancreatic Cancer
Singhi, A. D., & Maitra, A. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6631-8_5-2
Self-citationPrecision Medicine in Pancreatic Cancer
Beech, J. (2015) · doi:10.18130/v3hp0v
GSDME with a moonlighting function in pancreatic ductal adenocarcinoma: a narrative review
Huang, B. (2022) · Journal of Pancreatology · doi:10.1097/jp9.0000000000000104
Consortium bibliometric analysis of hotspots and frontiers of immunotherapy in pancreatic cancerPreprint
Xu, Q., Zhou, Y., Zhang, H., Li, H., Qin, H., & Wang, H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.10.515943
Targeted Cancer Therapy: KRAS-Specific Treatments for Pancreatic Cancer
Choudhary, H., & Xodo, L. E. (2022) · Springer eBooks · doi:10.1007/978-981-16-1313-5_69-1
Diagnosis and Evaluation of Pancreatic and Periampullary Adenocarcinoma
Lew, D., & Kwok, K. K. (2022) · Springer eBooks · doi:10.1007/978-3-030-41683-6_29
Pathogenesis, Epidemiology, and Prognosis of Pancreatic Adenocarcinomas
Kim, K. K., Gaddam, S., & Liu, Q. Y. (2022) · Springer eBooks · doi:10.1007/978-3-030-41683-6_28
NAGAI, C., Abue, M., Ota, K., Kusaka, J., Iwai, W., Wakui, Y., Oikawa, T., SUZUKI, S., & Furukawa, T. (2023) · Suizo · doi:10.2958/suizo.38.82
Ductal Adenocarcinoma and Pancreatic Intraepithelial Neoplasia
(2023) · American Registry of PathologyArlington, Virginia eBooks · doi:10.55418/9781933477275-07
Data from CD4+ T Lymphocyte Ablation Prevents Pancreatic Carcinogenesis in Mice
Zhang, Y., Yan, W., Mathew, E., Bednar, F., Wan, S., Collins, M. A., Evans, R. A., Welling, T. H., Vonderheide, R. H., & di Magliano, M. P. (2023) · doi:10.1158/2326-6066.c.6548512.v1
Carpenter, E. S., Elhossiny, A. M., Kadiyala, P., Li, J., McGue, J. J., Griffith, B. D., Zhang, Y., Edwards, J., Nelson, S., Lima, F., et al. (2023) · doi:10.1158/2159-8290.c.6651113.v1
Santos, V. S. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2023.tde-08052023-143100
Carpenter, E. S., Elhossiny, A. M., Kadiyala, P., Li, J., McGue, J. J., Griffith, B. D., Zhang, Y., Edwards, J., Nelson, S., Lima, F., et al. (2023) · doi:10.1158/2159-8290.c.6651113
Targeted Cancer Therapy: KRAS-Specific Treatments for Pancreatic Cancer
Choudhary, H., & Xodo, L. E. (2023) · Springer eBooks · doi:10.1007/978-981-19-9776-1_69
Screening of Hereditary Pancreatic Cancer
Goggins, M. (2023) · Wiley eBooks · doi:10.1002/9781119876007.ch130
Self-citationDynamics of the microbiome in pancreatic cancer from inception to invasion
Pfisterer, N. (2023) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-10152
Inoue, T., Mandai, K., & Uno, K. (2024) · Pancreas · doi:10.1097/mpa.0000000000002332
Pathologic Features of Primary Pancreatic Malignancies
Abi-Saab, T., Cunningham, A. M., Rush, P. S., & Matkowskyj, K. A. (2024) · Cancer treatment and research · doi:10.1007/978-3-031-61238-1_5
Kobayashi-Ooka, Y., Akagi, T., Sukezane, T., Yanagita, E., Itoh, T., & Sasai, K. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155632
Kawabata, H., Yuzawa, S., Takahashi, K., Tanino, M. A., & Mizukami, Y. (2024) · Suizo · doi:10.2958/suizo.39.316
Fatima, A., Weerappuli, P. D., & Basu, A. S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95478-5.00027-3
Marin, A. M., Timoner, B. E., Araújo, D. D., Uno, M., Alves, M. J. F., Chammas, R. J., Namur, G. N., Wosniaki, D. K., Canzian, F., Blanes, L., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-5850874/v1
Elevated KRAS protein level is associated with better survival in pancreatic cancer
Stålberg, S. M., Silwal‐Pandit, L., Hamfjord, J., Nebdal, D. J. H., Lehtiö, J., Lingjærde, O. C., Skålhegg, B. S., & Kure, E. H. (2025) · BMC Cancer · doi:10.1186/s12885-025-14461-w · Cited by 1
Nozawa, Y., Ishida, K., Onozaki, M., Kawabe, A., & Aoki, T. (2025) · Apmis · doi:10.1111/apm.70106
Lin, J., Lin, Y., Cai, M., Chen, Y., Lin, X., Li, L., Lai, J., Huang, H., Li, J., Liu, Q., et al. (2025) · iScience · doi:10.1016/j.isci.2025.114340
Metadata
- Authors
- Kanda, M., Matthaei, H., Wu, J., Hong, S., Yu, J., Borges, M., Hruban, R. H., Maitra, A., Kinzler, K., Vogelstein, B., & Goggins, M.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Goggins, Michael
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 142
- Issue
- 4
- Pages
- 730-733.e9
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC3321090
- OpenAlex
- W2081681778
- Cited by
- 741
- References
- 22
- Citations by year
- 2026: 45 · 2025: 51 · 2024: 47 · 2023: 57 · 2022: 47 · 2021: 76 · 2020: 49 · 2019: 41 · 2018: 61 · 2017: 68 · 2016: 50 · 2015: 44 · 2014: 39 · 2013: 40 · 2012: 25
- FWCI
- 23.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Deutsche Krebshilfe
- Lustgarten Foundation
- National Institutes of Health (CA62924, R01CA120432, P01CA134292, R01CA97075, RC2CA148376)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Keywords
- pancreatic intraepithelial neoplasia, somatic mutations, KRAS, CDKN2A, p16, GNAS, BRAF, pancreatic ductal adenocarcinoma, precancerous lesions, tumor progression, genetic susceptibility
- MeSH terms
- Carcinoma in Situ, Chromogranins, DNA Mutational Analysis, Humans, Mutation, Neoplasm Staging, Pancreatic Neoplasms, Phenotype, Proto-Oncogene Proteins, Baltimore, Proto-Oncogene Proteins p21(ras), ras Proteins, GTP-Binding Protein alpha Subunits, Gs, Cyclin-Dependent Kinase Inhibitor p16, Genetic Predisposition to Disease, Carcinoma, Pancreatic Ductal, Proto-Oncogene Proteins B-raf
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review