The DOI matches its Crossref record; 21 of the 22 references it cites were found in a registry or an index.
Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia
Open accessAbstract
More information is needed about genetic factors that initiate development of pancreatic intraepithelial neoplasms-the most common precursors of pancreatic ductal adenocarcinoma. We show that more than 99% of the earliest-stage, lowest-grade, pancreatic intraepithelial neoplasm-1 lesions contain mutations in KRAS, p16/CDKN2A, GNAS, or BRAF. These findings could improve our understanding of the development and progression of these premalignant lesions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“however, may be acquired as later events during systemic treatment for metastatic disease and have been found as subclonal genetic alterations in a subset of CRC patients ([25-27])”
From Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor (2022) · cites this paper as [26]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“First, KRAS mutations are often a founder genetic event involved in the pathogenesis of PDAC and are consistently found in precancerous pancreatic intraepithelial neoplasms”
From Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor (2022) · cites this paper as [26]
Experimental — accuracy not yet measuredIn the citing paper
“KRAS mutations are observed in most low-grade PanINs and IPMNs, suggesting KRAS is the initiating genetic event driving exocrine neoplasia46,47.”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [46]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Spencer, P. M., Cameron, J. L., & Lin, L. (2000) · Cited by 7,202
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969
Self-citationCirculating mutant DNA to assess tumor dynamics
Diehl, F., Schmidt, K., Choti, M. A., Romans, K. E., Goodman, S. N., Li, M., Thornton, K. A., Agrawal, N., Sokoll, L. J., Szabo, S., et al. (2008) · Nature Medicine · doi:10.1038/nm.1789 · Cited by 2,746
Self-citationVincent, A., Herman, J. M., Schulick, R., Hruban, R. H., & Goggins, M. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62307-0 · Cited by 2,678
Self-citationPreinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471
Self-citationHruban, R. H., Adsay, N. V., Albores–Saavedra, J., Compton, C., Garrett, E. S., Goodman, S. N., Kern, S. E., Klimstra, D. S., Klöppel, G., Longnecker, D. S., et al. (2001) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200105000-00003 · Cited by 1,126
Self-citationSenescence-messaging secretome: SMS-ing cellular stress
Kuilman, T., & Peeper, D. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2560 · Cited by 909
Progression model for pancreatic cancer.
Hruban, R. H., Goggins, M., Parsons, J., & Kern, S. E. (2000) · PubMed · Cited by 872
Self-citationRecurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development
Wu, J., Matthaei, H., Maitra, A., Molin, M. D., Wood, L., Eshleman, J., Goggins, M., Canto, M., Schulick, R., Edil, B., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002543 · Cited by 786
Self-citationWhen cells get stressed: an integrative view of cellular senescence
Ben-Porath, I., & Weinberg, R. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420663 · Cited by 404
Flagged first, then by citations
1 of the 22 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Hruban, 2000, Clin Cancer Res, 6, 2969
- Wu, 2011, Sci Transl Med, 3
- Caldwell, 2011, Oncogene
- Wu, 2011, Sci Transl Med, 3
Cited by
Sorted by citations
Items 401–500 of 743
Team work and cytopathology molecular diagnosis of solid pancreatic lesions
Fabbri, C., Gibiino, G., Fornelli, A., Cennamo, V., Grifoni, D., Visani, M., Acquaviva, G., Fassan, M., Fiorino, S., Giovanelli, S., et al. (2017) · Digestive Endoscopy · doi:10.1111/den.12845 · Cited by 14
Role of genetic testing in hepatic, pancreatic, and biliary cancers
Hewitt, D. B., Aziz, H., Brown, Z. J., & Pawlik, T. M. (2022) · Surgical Oncology · doi:10.1016/j.suronc.2022.101844 · Cited by 14
Allan, Z., Liu, D. S., Lee, M., Tie, J., & Clemons, N. J. (2024) · Clinical Chemistry · doi:10.1093/clinchem/hvad188 · Cited by 14
Neue Einblicke in die Entstehung des Pankreaskarzinoms
Esposito, I., Konukiewitz, B., Schlitter, A. M., & Klöppel, G. (2012) · Der Pathologe · doi:10.1007/s00292-012-1673-x · Cited by 14
Das, K. K., Brown, J. W., del-Castillo, C. F., Huynh, T. G., Mills, J. C., Matsuda, Y., Das, K. M., & Mino-Kenudson, M. A. (2021) · Human Pathology · doi:10.1016/j.humpath.2021.01.003 · Cited by 12
Zhang, J., Li, X., Lu, Y., Wang, G., & Ma, Y. (2023) · Cancers · doi:10.3390/cancers15123146 · Cited by 14
Grizzi, F., Fiorino, S., Qehajaj, D., Fornelli, A., Russo, C., de Biase, D., Masetti, M., Mastrangelo, L., Zanello, M., Lombardi, R., et al. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1817-3 · Cited by 14
Epigenetic Landscape of DNA Methylation in Pancreatic Ductal Adenocarcinoma
Liu, P., Jacques, J., & Hwang, C. (2024) · Epigenomes · doi:10.3390/epigenomes8040041 · Cited by 13
Roth, S., Apte, M. V., Balachandran, V. P., Biffi, G., Conroy, T., Cukierman, E., Dotan, E., Esposito, I., Grünwald, B. T., Klauß, M., et al. (2026) · Nature Reviews Disease Primers · doi:10.1038/s41572-026-00699-6 · Cited by 19
Stem/progenitor cells in normal physiology and disease of the pancreas
Fallas, M. E. A., Pedraza‐Arévalo, S., Cujba, A.-M., Manea, T., Lambert, C., Morrugares, R., & Sancho, R. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111459 · Cited by 16
Novel strategy for oncogenic alteration-induced lipid metabolism reprogramming in pancreatic cancer
Guo, D., Ye, L., Wu, W., Yu, X., & Jin, K. (2023) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2023045 · Cited by 13
Personalized treatment in localized pancreatic cancer
Neoptolemos, J. P., Hu, K., Bailey, P. J., Springfeld, C., Cai, B., Miao, Y., Michalski, C. W., Carvalho, C. T., Hackert, T., & Büchler, M. W. (2023) · European surgery. Supplement/European surgery · doi:10.1007/s10353-023-00814-x · Cited by 13
Genetic Signature of Human Pancreatic Cancer and Personalized Targeting
Reshkin, S. J., Cardone, R. A., & Koltai, T. (2024) · Cells · doi:10.3390/cells13070602 · Cited by 14
Kim, M., Kim, M., Kim, S. J., An, S., Park, H., Park, H., Lee, J. H., Song, K.-B., Hwang, D. W., Chang, S., et al. (2017) · Cancer Cell International · doi:10.1186/s12935-017-0416-8 · Cited by 14
Self-citationPharmacotherapeutic Management of Pancreatic Ductal Adenocarcinoma: Current and Emerging Concepts
Ruess, D. A., Görgülü, K., Wörmann, S. M., & Algül, H. (2017) · Drugs & Aging · doi:10.1007/s40266-017-0453-y · Cited by 15
Signaling levels mold the RAS mutation tropism of urethane
Li, S., & Counter, C. M. (2021) · eLife · doi:10.7554/elife.67172 · Cited by 13
GLP-1 Receptor Agonist Effects on Normal and Neoplastic Pancreata
Goggins, M. (2012) · Diabetes · doi:10.2337/db12-0233 · Cited by 13
Self-citationHyun, S., & Park, D. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.08.064 · Cited by 11
Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression
Chowdhury, N. N., Yang, Y., Dutta, A., Luo, M., Wei, Z., Abrahams, S. R., Revenko, A. S., Shah, F., Miles, L. A., Parmer, R. J., et al. (2023) · Molecular Oncology · doi:10.1002/1878-0261.13552 · Cited by 12
Mottini, C., Auciello, F. R., Manni, I., Pilarsky, C. P., Caputo, D. D., Caracciolo, G., Rossetta, A., Gennaro, E. D., Budillon, A., Blandino, G., et al. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03117-5 · Cited by 12
Identification and analysis of pancreatic intraepithelial neoplasia: opportunities and challenges
Pian, L.-L., Song, M.-H., Wang, T., Qi, L., Peng, T.-L., & Xie, K.-P. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1401829 · Cited by 15
Genetics of pancreatic cancer and implications for therapy
Bhosale, P., Cox, V. L., Faria, S. C., Javadi, S., Viswanathan, C., Koay, E. J., & Tamm, E. P. (2017) · Abdominal Radiology · doi:10.1007/s00261-017-1394-y · Cited by 12
Transportome Malfunctions and the Hallmarks of Pancreatic Cancer
Ling, Q., & Kalthoff, H. (2020) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2020_20 · Cited by 12
Asano, G., Miyabe, K., Kato, H., Yoshida, M., Sawada, T., Okamoto, Y., Sahashi, H., Atsuta, N., Kachi, K., Kato, A., et al. (2022) · Scientific Reports · doi:10.1038/s41598-021-04335-z · Cited by 13
Palanivel, C., Chaudhary, N., Seshacharyulu, P., Cox, J. L., Yan, Y., Batra, S. K., & Ouellette, M. M. (2022) · Neoplasia · doi:10.1016/j.neo.2022.01.002 · Cited by 12
Itonaga, M., Ashida, R., Murata, S., Yamashita, Y., Hatamaru, K., Tamura, T., Kawaji, Y., Kayama, Y., Emori, T., Kawai, M., et al. (2022) · Cancers · doi:10.3390/cancers14030551 · Cited by 12
Maeda, C., Ono, Y., Hayashi, A., Takahashi, K., Taniue, K., Kakisaka, R., Mori, M., Ishii, T. M., Sato, H., Okada, T., et al. (2023) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2023.02.007 · Cited by 12
Ma, X., Liu, X., Ou, K., Zhang, M., Gao, L., & Yang, L. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1151178 · Cited by 12
High-Content, Full Genome siRNA Screen for Regulators of Oncogenic HRAS -Driven Macropinocytosis
Fennell, M., Commisso, C., Ramírez, C., Garippa, R. J., & Bar‐Sagi, D. (2015) · Assay and Drug Development Technologies · doi:10.1089/adt.2015.660 · Cited by 12
Zhu, Z., Liu, T., Han, F., Zhan, S., & Wang, C. (2015) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(15)60331-9 · Cited by 12
Fendrich, V., Jendryschek, F. S., Beeck, S., Albers, M. B., Lauth, M., Esni, F., Heeger, K., Dengler, J., Slater, E. P., Holler, J. P. N., et al. (2018) · Oncogene · doi:10.1038/s41388-017-0100-4 · Cited by 12
Molecular Approaches Using Body Fluid for the Early Detection of Pancreatic Cancer
Satoh, K. (2021) · Diagnostics · doi:10.3390/diagnostics11020375 · Cited by 12
Reyes, J., Priore, I. S. D., Chaikovsky, A. C., Pasnuri, N., Elhossiny, A. M., Park, J., Weiler, P., Krause, T., Moorman, A. R., Snopkowski, C., et al. (2026) · Cell · doi:10.1016/j.cell.2026.03.032 · Cited by 12
Emerging applications of cancer bacteriotherapy towards treatment of pancreatic cancer
Henderson, E. A., Łukomski, S., & Boone, B. A. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1217095 · Cited by 11
Gong, J., Li, X., Feng, Z., Lou, J., Pu, K., Sun, Y., Hu, S., Zhou, Y., Song, T., Shangguan, M., et al. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01346-4 · Cited by 11
Self-citationPersonalized Management of Pancreatic Ductal Adenocarcinoma Patients through Computational Modeling
Yamamoto, K. N., Yachida, S., Nakamura, A., Niida, A., Oshima, M., De, S., Rosati, L. M., Herman, J. M., Iacobuzio–Donahue, C. A., & Haeno, H. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-1208 · Cited by 11
Velasco, R. M., Sánchez, P. J., García, A. G., Martínez-Illescas, R. B., Senovilla, Á. P., Yagüe, M. L., Trento, A., García-Martín, R., Navarro, D., Sáinz, B., et al. (2022) · Cancers · doi:10.3390/cancers14061518 · Cited by 11
Jin, H., Koh, M., Lim, H., Yong, H., Kim, E., Kim, S. Y., Kim, K., Jung, J., Ryu, W., Choi, K., et al. (2023) · International Journal of Cancer · doi:10.1002/ijc.34443 · Cited by 12
An, S., Kim, M., Kim, S. J., Sung, Y.-N., Kim, Y. W., Song, K. B., Hwang, D. W., Kim, S. C., Hruban, R. H., & Hong, S. (2019) · Histopathology · doi:10.1111/his.13897 · Cited by 11
Self-citationHareendran, S., Yang, X.-Y., Lou, H., Xiao, L., & Loh, Y. P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225725 · Cited by 11
Li, C., Peng, Z., Wang, Y., Lam, G., Nissen, N. N., Tang, J., Yuan, X., Lewis, M. S., Greene, M. I., Pandol, S. J., et al. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00185.2020 · Cited by 11
Nissinen, S. I., VENÄLÄINEN, M. K., Kumpulainen, P. S., Roine, A., Häkkinen, M. R., Vepsäläinen, J., Oksala, N., & Rantanen, T. K. (2021) · Cancer Control · doi:10.1177/10732748211039762 · Cited by 11
Kopp, J. L., & Sander, M. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.11.023 · Cited by 11
Kim, J., Ekstrom, T. J., Yang, W., Donahue, G., Grygoryev, D., Ngo, T. T. M., Muschler, J. L., Morgan, T. K., & Zaret, K. S. (2021) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-21-0483 · Cited by 10
Zhao, H., Collet, C., Peng, D., Sinha, U. K., & Lin, D. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.09.026 · Cited by 9
Kumar, S., Singh, S. K., Srivastava, P., Suresh, S., Rana, B., & Rana, A. (2023) · Advances in cancer research · doi:10.1016/bs.acr.2023.02.003 · Cited by 10
Bastea, L. I., Liu, X., Martinez, A. K. F., Pandey, V., Döppler, H. R., Edenfield, B. H., Krishna, M., Zhang, L., Thompson, E. A., Grandgenett, P. M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-55043-x · Cited by 13
Hashimoto, A., & Hashimoto, S. (2024) · Cancers · doi:10.3390/cancers16234094 · Cited by 11
Leiting, J. L., Alva‐Ruiz, R., Yonkus, J. A., Abdelrahman, A. M., Lynch, I. T., Carlson, D. M., Carr, R. M., Salomão, D. R., McWilliams, R. R., Starlinger, P. P., et al. (2025) · Annals of Surgical Oncology · doi:10.1245/s10434-025-17036-y · Cited by 10
Zhao, Y., Wen, C., Wang, Q., Yue, Q., Tondi, S., Reina, C., Šabanović, B., Chang, C. Y., Lai, C., Wang, H., et al. (2025) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70067 · Cited by 10
PHF13 epigenetically activates TGFβ driven epithelial to mesenchymal transition
Sun, Y., Li, D., Liu, H., Huang, Y., Meng, F., Tang, J., Li, Z., & Xie, W. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04940-4 · Cited by 10
Molecular analysis of mucinous nonneoplastic cyst of the pancreas
Zhu, B. Y., Finkelstein, S. D., Feng, G., Keswani, R. N., & Lin, X. (2016) · Human Pathology · doi:10.1016/j.humpath.2016.05.009 · Cited by 10
Shibayama, Y., Takahashi, K., Yamaguchi, H., Yasuda, J., Yamazaki, D., Rahman, A., Fujimori, T., Fujisawa, Y., Takai, S., Furukawa, T., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-01434-x · Cited by 10
He, Y., Huang, W. J., Tang, Y., Li, Y., Peng, X., Li, J., Wu, J. Y., You, N., Li, L., Liu, C., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1167144 · Cited by 10
Self-citationPancreatic Cancer Genomes: Toward Molecular Subtyping and Novel Approaches to Diagnosis and Therapy
Wood, L. D. (2013) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-013-0043-6 · Cited by 10
Recent Anti-KRASG12D Therapies: A “Possible Impossibility” for Pancreatic Ductal Adenocarcinoma
Sobhani, N., Pittacolo, M., D’Angelo, A., & Marchegiani, G. (2025) · Cancers · doi:10.3390/cancers17040704 · Cited by 12
Fibroblast STAT3 Activation Drives Organ-Specific Premetastatic Niche Formation
Opsahl, E. L. L., Espinoza, C. E., Olivei, A. C., Okoye, J. O., Watkoske, H. R., Hoffman, M. T., Avritt, F. R., Elhossiny, A. M., Bischoff, A. C., Donahue, K. L., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-25-3472 · Cited by 9
Aberrant transcription factors in the cancers of the pancreas
Uddin, M. H., Al-Hallak, M. N., Philip, P. A., Chen, H., El‐Rayes, B. F., & Azmi, A. S. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.08.011 · Cited by 9
Circulating Cell-Free Nucleic Acids as Biomarkers for Diagnosis and Prognosis of Pancreatic Cancer
Marin, A. M., Sanchuki, H. B. S., Namur, G. N., Uno, M., Zanette, D. L., & Aoki, M. N. (2023) · Biomedicines · doi:10.3390/biomedicines11041069 · Cited by 9
Kuvendjiska, J., Müller, F., Bronsert, P., Timme‐Bronsert, S., Fichtner‐Feigl, S., & Kulemann, B. (2023) · Life · doi:10.3390/life13071570 · Cited by 10
Tang, S., Duan, Y., Yuan, T., Hu, Y., Yuan, L., Shen, N., Fu, Y., Pu, C., Wang, X., Xu, J. Q., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106955 · Cited by 9
Scianò, F., Terrana, F., Pecoraro, C., Parrino, B., Cascioferro, S., Diana, P., Giovannetti, E., & Carbone, D. (2024) · Future Medicinal Chemistry · doi:10.4155/fmc-2023-0234 · Cited by 9
Tan, Y. Q., Sun, B., Zhang, X., Zhang, S., Guo, H., Basappa, B., Zhu, T., Sethi, G., Lobie, P. E., & Pandey, V. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06551-7 · Cited by 10
Nagawkar, S. S., Abu-Funni, S., Simon, E., Bick, T., Prinz, E., Sabo, E., Ben‐Izhak, O., & Hershkovitz, D. (2015) · Pancreas · doi:10.1097/mpa.0000000000000562 · Cited by 9
Korhan, P., Verkerk, R. M., & Critchley, W. R. (2017) · Integrative Molecular Medicine · doi:10.15761/imm.1000310 · Cited by 8
Fujiwara, S., Saiki, Y., Ishizawa, K., Fukushige, S., Yamanaka, M., Sato, M., Ishida, M., Motoi, F., Unno, M., & Horii, A. (2019) · Cancer Medicine · doi:10.1002/cam4.2016 · Cited by 9
Deletion of NEMO Inhibits EMT and Reduces Metastasis in KPC Mice
Tsesmelis, M., Tiwary, K., Steiger, K., Sperb, N., Gerstenlauer, M., Manfras, U., Maier, H. J., Hermann, P. C., Chan, L. K., & Wirth, T. (2021) · Cancers · doi:10.3390/cancers13184541 · Cited by 9
The Functional Role of LncRNA UCA1 in Pancreatic Cancer: a mini-review
Sun, C.-C., Li, L., Jiang, Z., Liu, Z., Wang, L., & Wang, H. (2023) · Journal of Cancer · doi:10.7150/jca.79171 · Cited by 9
Durante, S., Vecchiarelli, S., Astolfi, A., Grassi, E., Casadei, R., Santini, D., Panzacchi, R., Ricci, C., Serravalle, S., Tarantino, G., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11501 · Cited by 9
Treatment of Pancreatic Cancer by Aptamer Conjugated C/EBPα-saRNA
Yoon, S., & Rossi, J. J. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-4310-9_12 · Cited by 9
Roscigno, G., Jacobs, S., Toledo, B., Borea, R., Russo, G., Pepe, F., Serrano, M. J., Calabrò, V., Troncone, G., Giovannoni, R., et al. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.05.003 · Cited by 9
Pinho, D. F., & Subramaniam, R. M. (2017) · PET Clinics · doi:10.1016/j.cpet.2017.05.003 · Cited by 8
Kiemen, A. L., Wu, P.-H., Braxton, A. M., Cornish, T. C., Hruban, R. H., Wood, L. D., Wirtz, D., & Zwicker, D. (2024) · Science Advances · doi:10.1126/sciadv.ado5103 · Cited by 8
Self-citationYang, J., Guo, F., Yuan, L., Lv, G., Gong, J., & Chen, J. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28448 · Cited by 8
Herman, J. M., Crane, C. H., Iacobuzio–Donahue, C. A., & Abrams, R. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-24098-7.00048-4 · Cited by 8
Intraduktale Pankreasneoplasien
Esposito, I., Häberle, L., Yavas, A., Kraft, A., & Gaida, M. M. (2021) · Der Pathologe · doi:10.1007/s00292-021-00966-1 · Cited by 9
The genetic classification of pancreatic neoplasia
Matthaei, H., Semaan, A., & Hruban, R. H. (2015) · Journal of Gastroenterology · doi:10.1007/s00535-015-1037-4 · Cited by 10
Self-citationBaiting for Cancer: Using the Zebrafish as a Model in Liver and Pancreatic Cancer
Hwang, K. L., & Goessling, W. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-30654-4_17 · Cited by 8
Proteasome activity is required for the initiation of precancerous pancreatic lesions
Furuyama, T., Tanaka, S., Shimada, S., Akiyama, Y., Matsumura, S., Mitsunori, Y., Aihara, A., Ban, D., Ochiai, T., Kudo, A., et al. (2016) · Scientific Reports · doi:10.1038/srep27044 · Cited by 8
Veite-Schmahl, M. J., Rivers, A. C., Regan, D. P., & Kennedy, M. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187552 · Cited by 8
Saeki, K., Miyasaka, Y., Ohishi, Y., Yamamoto, T., Matsuda, R., Mochidome, N., Mori, Y., Nakata, K., Ohtsuka, T., Ishigami, K., et al. (2018) · Surgical Case Reports · doi:10.1186/s40792-018-0497-1 · Cited by 8
Kawalerski, R. R., Leach, S. D., & Escobar‐Hoyos, L. F. (2021) · Oncotarget · doi:10.18632/oncotarget.27901 · Cited by 8
Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice
Ikuta, K., Fukuda, A., Ogawa, S., Masuo, K., Goto, N., Hiramatsu, Y., Tsuda, M., Kimura, Y., Matsumoto, Y., Kimura, Y., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315425 · Cited by 7
Braxton, A. M., Kiemen, A. L., Grahn, M. P., Forjaz, A., Babu, J. M., Zheng, L., Jiang, L., Cheng, H., Song, Q., Reichel, R., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.27.525553 · Cited by 8
Self-citationZhang, D., Luo, Y., Lin, Y., Fang, Z., Zheng, H., An, M., Xie, Q., Wu, Z. K., Yu, C., Yang, J., et al. (2024) · Advanced Science · doi:10.1002/advs.202405092 · Cited by 9
Erreni, M., Fumagalli, M. R., D’Anna, R., Sollai, M., Bozzarelli, S., Nappo, G., Zanini, D., Parente, R., Garlanda, C., Rimassa, L., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1472433 · Cited by 7
The supporting role of Schwann cells in perineural invasion of pancreatic ductal adenocarcinoma
He, Y., Chen, Z., Yang, L., Qiao, S., Su, Z., Ding, F., Ding, F., Xin, F., Xiang, S., Lü, A., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1540027 · Cited by 9
SP1‐Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer
Hang, H., Yu, M., Zhu, L., Tang, N., Fu, X., Cai, Z., Yan, M., Chen, Y., Yang, L., Wu, J., et al. (2025) · Advanced Science · doi:10.1002/advs.202510071 · Cited by 7
Self-citationSrinivasan, D., Gout, J., Kleger, A., & Roger, É. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115697 · Cited by 7
Cancer interception with KRAS inhibitors in preclinical models of pancreatic ductal adenocarcinoma
Than, M. T., Dequiedt, L., Sor, R., Nair, S., Markosyan, N., Furth, E. E., Yang, C., Ray-Fofana, C., Menard, M. J., Quintana, E., et al. (2026) · Science · doi:10.1126/science.aec7929 · Cited by 9
Chronic jetlag accelerates pancreatic neoplasia in conditional Kras -mutant mice
Schwartz, P. B., Walcheck, M. T., Nukaya, M., Pavelec, D. M., Matkowskyj, K. A., & Ronnekleiv‐Kelly, S. M. (2023) · Chronobiology International · doi:10.1080/07420528.2023.2186122 · Cited by 7
Matsuda, Y., Tanaka, M., Sawabe, M., Mori, S., Muramatsu, M., Mieno, M., Furukawa, T., & Arai, T. (2017) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22479 · Cited by 7
Endoscopic Ultrasonography with Fine-needle Aspiration
Haghighi, M., Packey, C. D., & Gonda, T. A. (2017) · Gastrointestinal Endoscopy Clinics of North America · doi:10.1016/j.giec.2017.06.003 · Cited by 8
Nabeta, R., Katselis, G. S., Chumala, P., Dickinson, R., Fernandez, N. J., & Meachem, M. D. (2022) · Veterinary and Comparative Oncology · doi:10.1111/vco.12826 · Cited by 7
Chen, H., Yu, Y., Zhou, L., Chen, J., Li, Z., & Tan, X. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1049454 · Cited by 7
Huo, Q., Li, K., Sun, X., Zhuang, A., Minami, K., Tamari, K., Ogawa, K., Fishel, M. L., Li, B., & Yokota, H. (2023) · Scientific Reports · doi:10.1038/s41598-023-41835-6 · Cited by 7
Ingle, K., LaComb, J. F., Graves, L. M., Baines, A. T., & Bialkowska, A. B. (2023) · PLoS ONE · doi:10.1371/journal.pone.0294065 · Cited by 7
Utomo, W. K., Braat, H., Bruno, M. J., van Eijck, C. H. J., Koerkamp, B. G., Krak, N. C., van de Vreede, A., Fuhler, G. M., Peppelenbosch, M. P., & Biermann, K. (2015) · Medicine · doi:10.1097/md.0000000000000988 · Cited by 7
Xia, L., Dai, L., & Yang, Q. (2018) · Veterinary Research · doi:10.1186/s13567-018-0591-1 · Cited by 7
Biology, pathophysiology, and epidemiology of pancreatic cancer
Dariya, B., Alam, A., & Nagaraju, G. P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-819457-7.00001-3 · Cited by 7
Metadata
- Authors
- Kanda, M., Matthaei, H., Wu, J., Hong, S., Yu, J., Borges, M., Hruban, R. H., Maitra, A., Kinzler, K., Vogelstein, B., & Goggins, M.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Goggins, Michael
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 142
- Issue
- 4
- Pages
- 730-733.e9
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC3321090
- OpenAlex
- W2081681778
- Cited by
- 741
- References
- 22
- Citations by year
- 2026: 45 · 2025: 51 · 2024: 47 · 2023: 57 · 2022: 47 · 2021: 76 · 2020: 49 · 2019: 41 · 2018: 61 · 2017: 68 · 2016: 50 · 2015: 44 · 2014: 39 · 2013: 40 · 2012: 25
- FWCI
- 23.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Deutsche Krebshilfe
- Lustgarten Foundation
- National Institutes of Health (CA62924, R01CA120432, P01CA134292, R01CA97075, RC2CA148376)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Keywords
- pancreatic intraepithelial neoplasia, somatic mutations, KRAS, CDKN2A, p16, GNAS, BRAF, pancreatic ductal adenocarcinoma, precancerous lesions, tumor progression, genetic susceptibility
- MeSH terms
- Carcinoma in Situ, Chromogranins, DNA Mutational Analysis, Humans, Mutation, Neoplasm Staging, Pancreatic Neoplasms, Phenotype, Proto-Oncogene Proteins, Baltimore, Proto-Oncogene Proteins p21(ras), ras Proteins, GTP-Binding Protein alpha Subunits, Gs, Cyclin-Dependent Kinase Inhibitor p16, Genetic Predisposition to Disease, Carcinoma, Pancreatic Ductal, Proto-Oncogene Proteins B-raf
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review