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Advances in RAS Therapeutics for Pancreatic Cancer

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Innate Immunity and Platelets: Unveiling Their Role in Chronic Pancreatitis and Pancreatic Cancer

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CCR-CCL axes as key upstream influencers of pancreatic ductal adenocarcinoma: CCR2–CCL2, CCR5–CCL5, CCR4–CCL17/22, CCR6–CCL20, CCR7–CCL19/21

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Moving Towards Dawn: KRas Signaling and Treatment in Pancreatic Ductal Adenocarcinoma

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Loss of Heterozygosity for KrasG12D Promotes Malignant Phenotype of Pancreatic Ductal Adenocarcinoma by Activating HIF-2α-c-Myc-Regulated Glutamine Metabolism

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Vaccine Therapy for Pancreatic Cancer: A Battle against Deadly Cancer

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Improving the genetic signature of prostate cancer, the somatic mutations

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Genetic Drivers of Pancreatic Cancer Are Identical Between the Primary Tumor and a Secondary Lesion in a Long-Term (>5 Years) Survivor After a Whipple Procedure

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Prolonged MEK inhibition leads to acquired resistance and increased invasiveness in KRAS mutant gastric cancer

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Evaluation of Local Recurrence of Pancreatic Cancer by KRAS Mutation Analysis Using Washes from Endoscopic Ultrasound-Guided Fine-Needle Aspiration

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Pancreatic cystic tumors: an update

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Metabolic Response of Pancreatic Carcinoma Cells under Treatment with Dichloroacetate

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CpG Island Methylator Phenotype Modulates the Immune Response of the Tumor Microenvironment and Influences the Prognosis of Pancreatic Cancer Patients

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The Molecular Pathology of Precursor Lesions of Pancreatic Cancer

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Genomic alterations in pancreatic cystic neoplasms: from molecular characterization to precision clinical management

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Why isn’t an oncogenic mutation in KRAS enough to induce and sustain transformation?

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KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment

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Alteration of chromosome structure impacts gene expressions implicated in pancreatic ductal adenocarcinoma cells

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Inflammation and de-differentiation in pancreatic carcinogenesis

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The stem cell‑specific intermediate filament nestin missense variation p.A1199P is associated with pancreatic cancer

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Clinical Implications of NRAS Overexpression in Resectable Pancreatic Adenocarcinoma Patients

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Could the burden of pancreatic cancer originate in childhood?

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Nuclear GSK-3β and Oncogenic KRas Lead to the Retention of Pancreatic Ductal Progenitor Cells Phenotypically Similar to Those Seen in IPMN

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Oncogenic KRAS, Mucin 4, and Activin A‐Mediated Fibroblast Activation Cooperate for PanIN Initiation

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Bmi1 combines with oncogenic KRAS to induce malignant transformation of human pancreatic duct cells in vitro

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Fhit down-regulation is an early event in pancreatic carcinogenesis

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Clinicopathological and molecular characterization of KRAS wild‐type pancreatic ductal adenocarcinomas reveals precursor lesions with oncogenic mutations and fusions in RAS pathway genes

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Tumor Microenvironment: Recent Advances in Immunotherapies of Pancreatic Cancer

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Induction of Cell Death in Pancreatic Tumors by Zinc and Its Fluorescence Chelator TSQ

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Usefulness of Adding Maspin Staining to p53 Staining for EUS-FNA Specimens of Pancreatic Ductal Adenocarcinoma

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A Probabilistic Approach to Estimate the Temporal Order of Pathway Mutations Accounting for Intra-Tumor Heterogeneity

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Fer governs mTORC1 regulating pathways and sustains viability of pancreatic ductal adenocarcinoma cells

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The RAS Signaling Network and Cancer

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HOXA11-As Promotes Lymph Node Metastasis Through Regulation of IFNL and HMGB Family Genes in Pancreatic Cancer

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Clinical Relevance of High-Grade Pancreatic Intraepithelial Neoplasia at the Pancreatic Transection Margin in Patients with Pancreatic Ductal Adenocarcinoma

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Drivers of Pancreatic Cancer: Beyond the Big 4

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Possible Involvement of Pancreatic Fatty Infiltration in Pancreatic Carcinogenesis

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Circulating Tumour DNA to Guide Treatment of Gastrointestinal Malignancies

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Establishment and Characterization of Immortalized Miniature Pig Pancreatic Cell Lines Expressing Oncogenic K-RasG12D

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Association of Mutant KRAS Alleles With Morphology and Clinical Outcomes in Pancreatic Ductal Adenocarcinoma

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Integration of Surface‐enhanced Raman Spectroscopy with PCR for Monitoring Single Copy of KRAS G12D Mutation

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GNAS is not involved in gastrointestinal tumour formation in Peutz-Jeghers syndrome

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Krüppel-Like Factor 4 Promotes Pancreatic Acinar-to-Ductal Metaplasia and Tumor Initiation

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Enhancing Early Detection of Pancreatic Cancer in Genetically Predisposed Individuals: Integrating Advanced Imaging Modalities with Emerging Biomarkers and Liquid Biopsy

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Multi-Omics Meets Premalignancy: Paving the Way for Early Prevention of Cancer

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Cancer Prevention/Interception Agent Development

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Unlocking the Potentials of Single Extracellular Vesicle Analysis Technologies for Early Detection of Pancreatic Cancer

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A conserved re-epithelialization program underlies malignancy in pancreatic ductal adenocarcinoma

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Asynchronous Evolution of Epithelium and Stroma Differentiates Precursor Lesions from Pancreatic Cancer

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Pancreatic Cancer Screening: What We Do and Do Not Know

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KRAS: Structure, function, and development of anticancer drugs

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Quadruplex nucleic acids in KRAS targeted-cancer therapy

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Long-term survival of a patient with pancreatic cancer and lung metastasis: A case report and review of literature

Yang, W., Yang, L., Lu, H., & Sun, Y. (2021) · World Journal of Clinical Cases · doi:10.12998/wjcc.v9.i30.9134 · Cited by 3

KRAS Mutation Testing on Endoscopic Ultrasound-Guided Fine-Needle Aspiration Samples Improves the Diagnostic Accuracy of Pancreatic Cancer

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Single-cell transcriptome reveals the heterogeneity of malignant ductal cells and the prognostic value of REG4 and SPINK1 in primary pancreatic ductal adenocarcinoma

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Is an atypical flat lesion (AFL) a precursor lesion of the pancreatic ductal adenocarcinoma in human?

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Genetic predisposition for pancreatic cancer

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Epigenetics in precision medicine of pancreatic cancer

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Future Directions in Pancreatic Cancer Therapy

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Usefulness of KL-6 in the subtyping of intraductal papillary mucinous neoplasia of the pancreas, including carcinoma, dysplasia, and hyperplasia

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Carcinoma of the Pancreas

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Metabolism in Pancreatic Cancer

Poursaitidis, I., & Lamb, R. F. (2018) · Springer eBooks · doi:10.1007/978-1-4939-7193-0_68 · Cited by 3

Cancer of Exocrine Pancreas

Fanale, D., Madonia, G., Galvano, A., Peeters, M., ten Tije, A. J., Iovanna, J., & Russo, A. D. (2021) · UNIPA Springer series · doi:10.1007/978-3-030-56051-5_40 · Cited by 3

Aberrant Glycosylation in Pancreatic Ductal Adenocarcinoma 3D Organoids Is Mediated by KRAS Mutations

Nakahashi, H., Oda, T., Shimomura, O., Akashi, Y., Takahashi, K., Miyazaki, Y., Furuta, T., Kuroda, Y., Louphrasitthiphol, P., Mathis, B. J., et al. (2024) · Journal of Oncology · doi:10.1155/2024/1529449 · Cited by 2

Systematic Review on Different Values of Surveillance by Age in Branch Duct Intraductal Papillary Mucinous Neoplasms of the Pancreas

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Clinicopathologic and Genomic Features of Gastric-Type Intraductal Papillary Neoplasm of the Bile Duct

Shimada, Y., Yamamoto, T., Shindo, K., Nakanishi, Y., Matsumoto, T., Noguchi, S., Aishima, S., Nakamura, M., & Oda, Y. (2025) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000002451 · Cited by 2

Pancreatic Cells Are Resistant to KRASQ61L Expression due to Hyperactive ERK/MAPK Signaling and Apoptosis Induction

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Six-Color Multiplex Digital PCR Assays for Comprehensive Screening and Identification of Multiple Driver Mutations Associated with Pancreatic Carcinogenesis

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Immunological and molecular insights into acinar-ductal metaplasia and atypical flat lesions as precursor lesions of pancreatic ductal adenocarcinoma

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Preclinical development of a mutant KRAS targeting therapeutic cancer vaccine

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The Positive Feedback Loop Between Inflammation and Mutant KRAS Genes Promotes Malignant Transformation in Chronic Pancreatitis

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Protein kinase D1 — A targetable mediator of pancreatic cancer development

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Rac1 GTPase Regulates the βTrCP-Mediated Proteolysis of YAP Independently of the LATS1/2 Kinases

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Unraveling (K)RAS in pancreatic ductal adenocarcinoma

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Real-world management and outcome of patients with pancreatic adenocarcinoma. Results of the Spanish RETUD gastrointestinal registry

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Unlocking the Genetic Secrets of Pancreatic Cancer: KRAS Allelic Imbalances in Tumor Evolution

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Liquid biopsy of pancreatic tumors: Challenges for early detection and surveillance based on the molecular landscape during early carcinogenesis

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Bead-Based Isolation of Circulating Tumor DNA from Pancreatic Cancer Patients Enables High Fidelity Next Generation Sequencing

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Epigenetic Alterations in Pancreatic Cancer

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Mutation Profiling of Clinically Advanced Cancers Using Next-Generation Sequencing for Targeted Therapy: A Lifespan Experience.

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Therapeutic vaccines for pancreatic cancer

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Intraductal Papillary Mucinous Neoplasia of the Pancreas - Pathologic Features and Molecular Markers - A Review

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Phytochemical based sestrin2 pharmacological modulators in the treatment of adenocarcinomas

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New Insights into Pathogenesis, Diagnosis, and Treatment of Pancreatic Disorders

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From bench to bedside: Is it time to incorporate molecular testing for diagnostic and management algorithms for pancreatic cystic lesions?

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Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance in a p53-dependent mannerPreprint

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Altered Notch Pathway and Cancer Stem Cells

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Enhancing PDAC therapy: Decitabine-olaparib synergy targets KRAS-dependent tumors

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Genetic Alterations Associated With Progression From Pancreatic Intraepithelial Neoplasia to Invasive Pancreatic Tumor

Murphy, S. J., Hart, S. N., Lima, J. F., Kipp, B. R., Klebig, M. L., Winters, J. L., Szabo, C., Zhang, L., Eckloff, B. W., Petersen, G. M., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.07.049 · Cited by 199

Molecular genetics of pancreatic intraepithelial neoplasia

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Precursor Lesions of Pancreatic Cancer

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KRAS2 Mutations in Human Pancreatic Acinar-Ductal Metaplastic Lesions Are Limited to Those with PanIN: Implications for the Human Pancreatic Cancer Cell of Origin

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Mutational spectrum of intraepithelial neoplasia in pancreatic heterotopia

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