Cited by 974Gut microbiota and healthLiver Disease Diagnosis and TreatmentAlcohol Consumption and Health Effects

The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.

Interactions Between the Intestinal Microbiome and Liver Diseases

Open access

Schnabl, Bernd, Brenner, David A.·2014·Gastroenterology

DOI 10.1053/j.gastro.2014.01.020PMC PMC3996054

Open this paper in CoChat — free account Open PDF

Abstract

The human intestine harbors a diverse community of microbes that promote metabolism and digestion in their symbiotic relationship with the host. Disturbance of its homeostasis can result in disease. We review factors that disrupt intestinal homeostasis and contribute to nonalcoholic fatty liver disease, steatohepatitis, alcoholic liver disease, and cirrhosis. Liver disease has long been associated with qualitative and quantitative (overgrowth) dysbiotic changes in the intestinal microbiota. Extrinsic factors, such as the Western diet and alcohol, contribute to these changes. Dysbiosis results in intestinal inflammation, a breakdown of the intestinal barrier, and translocation of microbial products in animal models. However, the contribution of the intestinal microbiome to liver disease goes beyond simple translocation of bacterial products that promote hepatic injury and inflammation. Microbial metabolites produced in a dysbiotic intestinal environment and host factors are equally important in the pathogenesis of liver disease. We review how the combination of liver insult and disruptions in intestinal homeostasis contribute to liver disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1053/j.gastro.2014.01.020

Cites

86 of 86 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952
Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity
Browning, J. D., Szczepaniak, L. S., Dobbins, R., Nuremberg, P., Horton, J. D., Cohen, J. C., Grundy, S. M., & Hobbs, H. H. (2004) · Hepatology · doi:10.1002/hep.20466 · Cited by 3,664
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,400
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
Bäckhed, F., Manchester, J. K., Semenkovich, C. F., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605374104 · Cited by 2,615

Flagged first, then by citations

Show all 86 references

Sorted by citations

Items 501–600 of 974

Enhancing flora balance in the gastrointestinal tract of mice by lactic acid bacteria from Chinese sourdough and enzyme activities indicative of metabolism of protein, fat, and carbohydrate by the flora
Yang, D. L., Yu, X., Wu, Y., Chen, X., Wei, H., Shah, N. P., & Xu, F. (2016) · Journal of Dairy Science · doi:10.3168/jds.2016-11467 · Cited by 22
Porphyromonas gingivalis as a Possible Risk Factor in the Development/Severity of Acute Alcoholic Hepatitis
Zhou, Y., Vatsalya, V., Gobejishvili, L., Lamont, R. J., McClain, C. J., & Feng, W. (2018) · Hepatology Communications · doi:10.1002/hep4.1296 · Cited by 23
Double Trouble: How Microbiome Dysbiosis and Mitochondrial Dysfunction Drive Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis
Bahitham, W., Alghamdi, S., Omer, I., Alsudais, A. S., Hakeem, I., Alghamdi, A., Abualnaja, R., Sanai, F. M., Rosado, A. S., & Sergi, C. M. (2024) · Biomedicines · doi:10.3390/biomedicines12030550 · Cited by 22
Sepsis and high-density lipoproteins: Pathophysiology and potential new therapeutic targets
Parolini, C. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167761 · Cited by 24
RSPO4-CRISPR alleviates liver injury and restores gut microbiota in a rat model of liver fibrosis
Yu, L., Wang, L., Wu, X., & Yi, H. (2021) · Communications Biology · doi:10.1038/s42003-021-01747-5 · Cited by 21
Emerging Pharmacotherapies in Alcohol-Associated Hepatitis
Wakil, A., Niazi, M. A., Meybodi, M. A., & Pyrsopoulos, N. (2022) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2022.06.012 · Cited by 21
The toxic mechanism of 6:2 Cl-PFESA in adolescent male rats: Endocrine disorders and liver inflammation regulated by the gut microbiota-gut-testis/liver axis
Zhao, N., Kong, Y., Yuan, Q., Wei, Z., Gu, J., Ji, C., Jin, H., & Zhao, M. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.132155 · Cited by 22
Gut microbial signatures of patients with primary hepatocellular carcinoma and their healthy first-degree relatives
Feng, J., Wu, Y., Dai, P., Wang, D., Liu, L., & Chai, B. (2023) · Journal of Applied Microbiology · doi:10.1093/jambio/lxad221 · Cited by 22
The Pan-liver Network Theory
Zhang, Y., & Fang, X.-M. (2023) · The Chinese Journal of Physiology · doi:10.4103/cjop.cjop-d-22-00131 · Cited by 22
Blackcurrants shape gut microbiota profile and reduce risk of postmenopausal osteoporosis via the gut-bone axis: Evidence from a pilot randomized controlled trial
Nosal, B. M., Thornton, S., Mofrad, M. D., Sakaki, J. R., Mahoney, K. J., Macdonald, Z., Daddi, L., Tran, T. D. B., Weinstock, G. M., Zhou, Y., et al. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109701 · Cited by 24
Bioactive Moringa oleifera and Nigella sativa oils microcapsules alleviate high-fat-diet induced hepatic oxidative damage and inflammation in rats
Mohammed, D. M., Yang, X., El-Messery, T. M., Jiang, X., Zahran, H. A., Gebremeskal, Y. H., & Farouk, A. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.105873 · Cited by 22
Future therapy of portal hypertension in liver cirrhosis – a guess
Sauerbruch, T., & Trebicka, J. (2014) · F1000Prime Reports · doi:10.12703/p6-95 · Cited by 21
Immunodysfunction in Acute-on-Chronic Liver Failure
Lange, C. M., & Moreau, R. (2018) · Visceral Medicine · doi:10.1159/000488690 · Cited by 21
Probiotic Yogurt Fortified with Vitamin D Can Improve Glycemic Status in Non-Alcoholic Fatty Liver Disease Patients: a Randomized Clinical Trial
Morvaridzadeh, M., Nachvak, S. M., Mohammadi, R., Moradi, S., Mostafai, R., Pizarro, A. B., & Abdollahzad, H. (2021) · Clinical Nutrition Research · doi:10.7762/cnr.2021.10.1.36 · Cited by 21
Nonalcoholic fatty liver disease, diet and gut microbiota
Finelli, C., & Tarantino, G. (2014) · Europe PMC (PubMed Central) · doi:10.17877/de290r-15828 · Cited by 20
Retracted
Fenofibrate improves hepatic steatosis, insulin resistance, and shapes the gut microbiome via TFEB-autophagy in NAFLD mice
Zhang, D., Ma, Y., Liu, J., Wang, D., Geng, Z., Wen, D.-Y., Chen, H., Wang, H., Li, L., Zhu, X., et al. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176159 · Cited by 20
Alterations in fecal virome and bacteriome virome interplay in children with autism spectrum disorder
Wan, Y., Zhang, L., Xu, Z., Su, Q., Leung, T.-F., Chan, D., Wong, O. W. H., Chan, S. S. M., Chan, F. K. L., Tun, H. M., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101409 · Cited by 23
Aromatic Amino Acids Promote Lipid Metabolism Disorders by Increasing Hepatic Bile Acid Synthesis
Chen, J., Qin, Y., Li, Z., Shan, A., & Ma, Q. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.12.047 · Cited by 21
Ursolic acid improves the bacterial community mapping of the intestinal tract in liver fibrosis mice
Wan, S., Huang, C., Wang, A., & Zhu, X. (2020) · PeerJ · doi:10.7717/peerj.9050 · Cited by 18
Serum zonulin levels in patients with liver cirrhosis: Prognostic implications
Voulgaris, T. A., Karagiannakis, D. S., Hadziyannis, E. S., Manolakopoulos, S., Karamanolis, G. P., Papatheodoridis, G., & Vlachogiannakos, J. (2021) · World Journal of Hepatology · doi:10.4254/wjh.v13.i10.1394 · Cited by 19
Regulation of Progression and Resolution of Liver Fibrosis by Immune Cells
Koda, Y., Nakamoto, N., & Kanai∥, T. (2022) · Seminars in Liver Disease · doi:10.1055/a-1957-6384 · Cited by 19
Gut Lactobacillus and Probiotics Lactobacillus lactis/rhamnosis Ameliorate Liver Fibrosis in Prevention and Treatment
Won, S. M., Lee, N. Y., Oh, K., Gupta, H., Sharma, S. P., Kim, K. H., Kim, B. K., Joung, H., Jeong, J., Ganesan, R., et al. (2023) · The Journal of Microbiology · doi:10.1007/s12275-023-00014-y · Cited by 19
Integrated Analysis of Gut Microbiome and Liver Metabolome to Evaluate the Effects of Fecal Microbiota Transplantation on Lipopolysaccharide/D-galactosamine-Induced Acute Liver Injury in Mice
Yuan, C., Fan, J., Jiang, L., Ye, W., Chen, Z., Wu, W., Huang, Q., & Qian, L. (2023) · Nutrients · doi:10.3390/nu15051149 · Cited by 19
Antibiotic-Induced Dysbiosis of the Gut Microbiota Impairs Gene Expression in Gut-Liver Axis of Mice
Liu, P., Zhang, Y., Zhang, Z., Huang, X., Su, X., Yang, S., & Xie, Y. (2023) · Genes · doi:10.3390/genes14071423 · Cited by 19
Insights into the molecular mechanisms of malnutrition‐associated steatohepatitis: A review
Sharma, V., & Patial, V. (2024) · Liver International · doi:10.1111/liv.15932 · Cited by 21
The Role of Intestinal Fungi and Its Metabolites in Chronic Liver Diseases
You, N., Zhuo, L., Zhou, J., Song, Y., & Shi, J. (2019) · Gut and Liver · doi:10.5009/gnl18579 · Cited by 19
The Integrated “Multiomics” Landscape at Peak Injury and Resolution From Alcohol‐Associated Liver Disease
Das, S., Ge, X., Han, H., Désert, R., Song, Z., Athavale, D., Chen, W., Gaskell, H., Lantvit, D. D., Guzman, G., et al. (2021) · Hepatology Communications · doi:10.1002/hep4.1793 · Cited by 18
Gut microbiota mediates the alleviative effect of polar lipids-enriched milk fat globule membrane on obesity-induced glucose metabolism disorders in peripheral tissues in rat dams
Li, T., Yuan, Q., Gong, H., Du, ‬., & Mao, X. (2022) · International Journal of Obesity · doi:10.1038/s41366-021-01029-4 · Cited by 19
Saccharomyces Boulardii Ameliorates Non-alcoholic Steatohepatitis in Mice Induced by a Methionine-Choline-Deficient Diet Through Gut-Liver Axis
Yang, A., Lin, C., Liu, S.-H., Syu, G., Sun, H.-J., Lee, K., Lin, H.-C., & Hou, M. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.887728 · Cited by 18
An Energy-Restricted Diet Including Yogurt, Fruit, and Vegetables Alleviates High-Fat Diet–Induced Metabolic Syndrome in Mice by Modulating the Gut Microbiota
Kong, C., Li, Z., Chen, H., Mao, Y., Han, B., Guo, J.-J., & Wang, L. (2022) · Journal of Nutrition · doi:10.1093/jn/nxac181 · Cited by 18
Citrus Honey Ameliorates Liver Disease and Restores Gut Microbiota in Alcohol–Feeding Mice
Yi, S., Zhang, G., Liu, M., Yu, W., Cheng, G., Luo, L., & Ning, F. (2023) · Nutrients · doi:10.3390/nu15051078 · Cited by 20
Zexie-Baizhu Decoction ameliorates non-alcoholic fatty liver disease through gut-adipose tissue crosstalk
Shi, J., Liu, Y., Zhang, Z., Zhong, X., Cao, Y., Ni, H., He, Q., Wang, Z., Liu, Y., Chen, Q., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118700 · Cited by 18
Lupus and inflammatory bowel disease share a common set of microbiome features distinct from other autoimmune disorders
Zhou, H., Balint, D., Shi, Q., Vartanian, T., Kriegel, M. A., & Brito, I. (2024) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2024-225829 · Cited by 20
Systemic levels of human β-defensin 1 are elevated in patients with cirrhosis.
Kaltsa, G., Bamias, G., Siakavellas, S. I., Goukos, D., Karagiannakis, D., Zampeli, E., Vlachogiannakos, J., Michopoulos, S., Vafiadi, I., Daikos, G. L., et al. (2016) · Europe PMC (PubMed Central) · Cited by 18
Attenuated fibrosis in specific pathogen‐free microbiota in experimental cholestasis‐ and toxin‐induced liver injury
Moghadamrad, S., Hassan, M., McCoy, K. D., Kirundi, J., Kellmann, P., & Gottardi, A. D. (2019) · The FASEB Journal · doi:10.1096/fj.201901113r · Cited by 18
Bugs, drugs, and cancer: can the microbiome be a potential therapeutic target for cancer management?
Chen, B., Du, G., Guo, J., & Zhang, Y. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.02.009 · Cited by 18
Structural characterisation of Cistanche tubulosa polysaccharides and their effects against non-alcoholic steatohepatitis via gut microbiota regulation
Wang, Y., Zheng, D., Ji, S., Tan, J. J., Tian, Z., Aihaiti, X., Bai, Y., Yao, J. H., Chang, J., & Shen, J. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.124495 · Cited by 17
Helminth infection and helminth-derived products: A novel therapeutic option for non-alcoholic fatty liver disease
Liu, X., Jiang, Y., Ye, J., & Wang, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.999412 · Cited by 18
Fungal translocation measured by serum 1,3‐ß‐D‐glucan correlates with severity and outcome of liver cirrhosis—A pilot study
Egger, M., Horvath, A., Prüller, F., Fickert, P., Finkelman, M., Kriegl, L., Grønbæk, H., Møller, H. J., Prattes, J., Krause, R., et al. (2023) · Liver International · doi:10.1111/liv.15648 · Cited by 17
Use of cannabis and risk of advanced liver fibrosis in patients with chronic hepatitis C virus infection: A systematic review and meta‐analysis
Wijarnpreecha, K., Panjawatanan, P., & Ungprasert, P. (2018) · Journal of Evidence-Based Medicine · doi:10.1111/jebm.12317 · Cited by 17
The role of gut microbiota in hepatitis B disease progression and treatment
Chen, B., Huang, H. J., & Pan, C. Q. (2021) · Journal of Viral Hepatitis · doi:10.1111/jvh.13595 · Cited by 17
Hepatoprotective effects of gamma-aminobutyric acid-enriched fermented Hovenia dulcis extract on ethanol-induced liver injury in mice
Park, N.-H., Lee, S.-J., Mechesso, A. F., Boby, N., Yixian, Q., Yoon, W.-K., Lee, S.-P., Lee, J.-S., & Park, S.-C. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-2866-0 · Cited by 16
New insights into the combined effects of aflatoxin B1 and Eimeria ovinoidalis on uterine function by disrupting the gut–blood–reproductive axis in sheep
Huang, S.-C., Liu, K., Chen, P., Xu, B., Ding, W., Yue, T.-J., Lu, Y., Li, S., Li, J., & Jian, F. (2024) · Microbiome · doi:10.1186/s40168-024-01966-y · Cited by 16
Diet-Induced Non-alcoholic Fatty Liver Disease and Associated Gut Dysbiosis Are Exacerbated by Oral Infection
Simas, A. M., Kramer, C. D., & Genco, C. A. (2022) · Frontiers in Oral Health · doi:10.3389/froh.2021.784448 · Cited by 17
Nutritional and Lifestyle Therapy for NAFLD in People with HIV
Cinque, F., Cespiati, A., Lombardi, R., Guaraldi, G., & Sebastiani, G. (2023) · Nutrients · doi:10.3390/nu15081990 · Cited by 19
Effect of probiotics on nutritional status, biochemical parameters, and disease severity in cirrhotic patients referred for liver transplantation–A randomised double blind, placebo-controlled trial
Ramachandran, G., Pottakkat, B., Basu, S., & Mohan, P. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.08.021 · Cited by 16
Research reviews and prospects of gut microbiota in liver cirrhosis: a bibliometric analysis (2001–2023)
Zhu, X., Zhou, Z., & Pan, X. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1342356 · Cited by 17
Indole alleviates nonalcoholic fatty liver disease in an ACE2 ‐dependent manner
Gao, Y., Chen, Q., Yang, S., Cao, J., Li, F., Li, R., Wu, Z., Wang, Y., & Li, Y. (2024) · The FASEB Journal · doi:10.1096/fj.202401172rr · Cited by 16
Circulating levels of 3‐hydroxymyristate, a direct quantification of endotoxaemia in noninfected cirrhotic patients
Weil, D., de Barros, J.-P. P., Mourey, G., Laheurte, C., Cypriani, B., Badet, N., Delabrousse, É., Grandclément, É., Martino, V. D., Saas, P., et al. (2018) · Liver International · doi:10.1111/liv.13916 · Cited by 18
Liver DCs in health and disease
Wirtz, T. H., Brandt, E. F., & Berres, M. (2019) · International review of cytology · doi:10.1016/bs.ircmb.2019.08.001 · Cited by 16
Clinicopathological and immunological characteristics and outcome of concomitant coeliac disease and non-alcoholic fatty liver disease in adults: a large prospective longitudinal study
Kamal, S. M., Aldossari, K. K., Ghoraba, D., Abdelhakam, S. M., Kamal, A. H., Bedewi, M. A., Nabegh, L., Bahnasy, K., & Hafez, T. A. (2018) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2017-000150 · Cited by 16
The interplay between dietary factors, gut microbiome and colorectal cancer: a new era of colorectal cancer prevention
Seesaha, P. K., Chen, X., Wu, X., Xu, H., Li, C., Jheengut, Y., Zhao, F., Liu, L., & Zhang, D. (2020) · Future Oncology · doi:10.2217/fon-2019-0552 · Cited by 20
Beneficial effects of Chinese herbs in the treatment of fatty liver diseases
Panyod, S., & Sheen, L. (2020) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2020.02.008 · Cited by 16
Parkinson’s disease and the gut-brain connection: unveiling pathways, mechanisms and promising therapies
Hajare, S., & Kulkarni, Y. A. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149975 · Cited by 18
International Normalized Ratio to Albumin Ratio (PTAR): An Objective Risk Stratification Tool in Patients with Sepsis
Wang, S., Ding, S., Luo, H., & Chai, X. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s305085 · Cited by 15
Amelioration of alcohol-induced acute liver injury in C57BL/6 mice by a mixture of TCM phytochemicals and probiotics with antioxidative and anti-inflammatory effects
Li, Z., Fang, X., Hu, X., Li, C., Wan, Y., & Yu, D. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1144589 · Cited by 16
Intestinal Escherichia coli and related dysfunction as potential targets of Traditional Chinese Medicine for respiratory infectious diseases
Wei, L., Zhang, L., Zhang, Y., Yan, L., Liu, B., Cao, Z., Zhao, N., He, X., Li, L., & Lu, C. C. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116381 · Cited by 14
Recent advances of hepatoprotective peptides: Production, structure, mechanisms, and interactions with intestinal microbiota
Zhong, H., Jin, Y., Abdullah, Hussain, M., Liu, X., Feng, F., & Guan, R. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.103744 · Cited by 15
Mitochondrial Aldehyde Dehydrogenase 2 (ALDH2) Protects against Binge Alcohol-Mediated Gut and Brain Injury
Ray, B., Rungratanawanich, W., LeFort, K. R., Chidambaram, S. B., & Song, B. (2024) · Cells · doi:10.3390/cells13110927 · Cited by 16
Chemoprevention of obesity-related liver carcinogenesis by using pharmaceutical and nutraceutical agents
Sakai, H. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i1.394 · Cited by 15
Gut Microbiota and Liver Injury (I)—Acute Liver Injury
Wu, G., Win, S., Than, T. A., Chen, P., & Kaplowitz, N. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-2385-4_3 · Cited by 15
Is it time for microbiome-based therapies in viral infections?
Sadiq, F. A. (2020) · Virus Research · doi:10.1016/j.virusres.2020.198203 · Cited by 15
Gastrointestinal disorders and intestinal bacteria: Advances in research and applications in therapy
Ohkusa, T., Nishikawa, Y., & Sato, N. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2022.935676 · Cited by 16
Microbial Therapy in Liver Disease: Probiotics Probe the Microbiome–Gut–Liver–Brain Axis
Victor, D. W., & Quigley, E. M. M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.10.023 · Cited by 15
Unmet needs in pediatric NAFLD research: what do we need to prioritize for the future?
Hatton, G. B., Alterio, T., Nobili, V., & Mann, J. P. (2018) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2018.1512853 · Cited by 15
The concomitant use of cannabis and cocaine coexists with increased LPS levels and systemic inflammation in male drug users
Ribeiro, C. B., de Castro, F. D. O. F., Dorneles, G. P., Barros, J. B. D. S., Silva, J. M., Tavares, C., Carvalho, H. R., da Cunha, L. C., Nagib, P. R. A., Hoffmann, C., et al. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155472 · Cited by 15
Schisandra chinensis lignans ameliorate hepatic inflammation and steatosis in methionine choline-deficient diet-fed mice by modulating the gut-liver axis
Yan, L.-S., Kang, J.-Y., Gu, C.-Y., Qiu, X., Li, J., Cheng, B. C., Wang, Y., Luo, G., & Zhang, Y. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119801 · Cited by 14
Microbiota reprogramming for treatment of alcohol-related liver disease
Siddiqui, M. T., & Cresci, G. (2020) · Translational research · doi:10.1016/j.trsl.2020.07.004 · Cited by 14
The relationship between oral‐origin bacteria in the fecal microbiome and albumin–bilirubin grade in patients with hepatitis C
Yamamoto, K., Honda, T., Ito, T., Ishizu, Y., Kuzuya, T., Nakamura, M., Miyahara, R., Kawashima, H., Ishigami, M., & Fujishiro, M. (2020) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15206 · Cited by 14
MicroRNA‐29a Compromises Hepatic Adiposis and Gut Dysbiosis in High Fat Diet‐Fed Mice via Downregulating Inflammation
Yang, Y., Huang, Y., Wang, F., Tsai, M., Chen, C., & Lian, W. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200348 · Cited by 14
Chronic binge drinking-induced susceptibility to colonic inflammation is microbiome-dependent
Fonseca‐Pereira, D., Bae, S., Michaud, M., Glickman, J. N., & Garrett, W. S. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2392874 · Cited by 14
Effects of dachaihu decoction and its “prescription elements” on intestinal flora of nonalcoholic fatty liver disease model rats
Li, Y., Sun, Y., Wang, M., Zhang, S., Gao, Y.-S., Chen, L., Wu, M., Zhang, X., Zhou, L., Yuan, H.-M., et al. (2020) · World Journal of Traditional Chinese Medicine · doi:10.4103/wjtcm.wjtcm_38_19 · Cited by 14
Association of small intestinal bacterial overgrowth with nonalcoholic fatty liver disease in children: A meta-analysis
Kuang, L., Zhou, W. L., & Jiang, Y. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260479 · Cited by 14
Hepatocellular carcinoma and microbiota: Implications for clinical management and treatment
Spanu, D., Pretta, A., Lai, E., Persano, M., Donisi, C., Mariani, S., Dubois, M., Migliari, M., Saba, G., Ziranu, P., et al. (2022) · World Journal of Hepatology · doi:10.4254/wjh.v14.i7.1319 · Cited by 16
Biological modeling of mucus to modulate mucus barriers
Desseyn, J., Gouyer, V., & Gottrand, F. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00274.2015 · Cited by 14
Current Management and Future Treatment of Alcoholic Hepatitis.
Mitchell, M. C., Kerr, T. A., & Herlong, H. F. (2020) · PubMed Central · Cited by 14
Gut Microbiota as an Emerging Therapeutic Avenue for the Treatment of Nonalcoholic Fatty Liver Disease
Ralli, T., Neupane, Y. R., Saifi, Z., & Kohli, K. (2021) · Current Pharmaceutical Design · doi:10.2174/1389201022666210625141526 · Cited by 14
GUT MICROBIOTA, PREBIOTICS, PROBIOTICS, AND SYNBIOTICS IN GASTROINTESTINAL AND LIVER DISEASES: PROCEEDINGS OF A JOINT MEETING OF THE BRAZILIAN SOCIETY OF HEPATOLOGY (SBH), BRAZILIAN NUCLEUS FOR THE STUDY OF HELICOBACTER PYLORI AND MICROBIOTA (NBEHPM), AND BRAZILIAN FEDERATION OF GASTROENTEROLOGY (FBG)
Barbuti, R. C., Schiavon, L. D. L., de Oliveira, C. P. M. S., Álvares‐da‐Silva, M. R., Sassaki, L. Y., Passos, M. D. C. F., Farias, A. Q., Barros, L. L., Barreto, B. A. P., de Albuquerque, G. B. D. M. L., et al. (2020) · Arquivos de Gastroenterologia · doi:10.1590/s0004-2803.202000000-72 · Cited by 16
Gut dysbiosis and systemic inflammation promote cardiomyocyte abnormalities in an experimental model of steatohepatitis
Longo, L., Rampelotto, P. H., Filippi‐Chiela, E. C., de Souza, V. E. G., Salvati, F., Cerski, C. T. S., da Silveira, T. R., de Oliveira, C. P. M. S., Cruz, C. U., & Álvares‐da‐Silva, M. R. (2021) · World Journal of Hepatology · doi:10.4254/wjh.v13.i12.2052 · Cited by 13
The Origins of NAFLD: The Potential Implication of Intrauterine Life and Early Postnatal Period
Valentini, F., Rocchi, G., Gentilucci, U. V., Guarino, M. P. L., Altomare, A., & Carotti, S. (2022) · Cells · doi:10.3390/cells11030562 · Cited by 13
Sustained oral intake of nano-iron oxide perturbs the gut-liver axis
Li, J., Wang, L., Li, S., Liang, X., Zhang, Y., Wang, Y., & Liu, Y. (2023) · NanoImpact · doi:10.1016/j.impact.2023.100464 · Cited by 15
Omics in acute‐on‐chronic liver failure
Li, P., Liang, X., Luo, J., & Li, J. (2023) · Liver International · doi:10.1111/liv.15634 · Cited by 15
Fecal microbiota transplantation regulates TFH/TFR cell imbalance via TLR/MyD88 pathway in experimental autoimmune hepatitis
Ma, L., Song, J., Chen, X., Dai, D., Chen, J., & Zhang, L. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e20591 · Cited by 13
Nanoparticles alleviate non-alcoholic steatohepatitis via ER stress sensor-mediated intestinal barrier damage and gut dysbiosis
Zhu, M., Cheng, Y., Tang, Y., Li, S., Rao, P., Zhang, G., Xiao, L., & Liu, J. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1271835 · Cited by 13
The Intestinal Thread of Fate: How the Microbiota Shapes the Story of Liver Disease
Acierno, C., Nevola, R., Rinaldi, L., Sasso, F. C., Adinolfi, L. E., & Caturano, A. (2025) · Livers · doi:10.3390/livers5020017 · Cited by 14
Gut-Liver Axis reveals the protective effect of exopolysaccharides isolated from Sporidiobolus pararoseus on alcohol-induced liver injury
Hu, B., Jiang, W., Yang, Y. K., Xu, W., Liu, C., Zhang, S., Qian, H., & Zhang, W. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104737 · Cited by 13
Moxifloxacin Induced Liver Injury by Causing Lachnospiraceae Deficiency and Interfering with Butyric Acid Production through Gut–Liver Axis
Sun, Y., Cong, L., Yang, S., Zhao, R., An, Z., & Liu, L. (2022) · Disease Markers · doi:10.1155/2022/9302733 · Cited by 13
Narrative Review: Glucocorticoids in Alcoholic Hepatitis—Benefits, Side Effects, and Mechanisms
Lü, H. (2022) · Journal of Xenobiotics · doi:10.3390/jox12040019 · Cited by 13
Management and diagnosis of fatty liver disease
Schneier, A., Citti, C., & Dieterich, D. T. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2015.1003209 · Cited by 13
Dietary infection of Enterobacter ludwigii causes fat accumulation and resulted in the diabetes-like condition in Drosophila melanogaster
Priyadarsini, S., Mukherjee, S., Samikshya, S., Bhanja, A., Paikra, S. K., Nayak, N., & Mishra, M. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104276 · Cited by 13
Maintaining intestinal structural integrity is a potential protective mechanism against inflammation in goose fatty liver
Gu, W., Wen, K., Yan, C., Li, S., Liu, T., Cheng, X., Liu, L., Zhao, M., Zhang, J., Geng, T., et al. (2020) · Poultry Science · doi:10.1016/j.psj.2020.08.052 · Cited by 13
IGF-1 alleviates CCL4-induced hepatic cirrhosis and dysfunction of intestinal barrier through inhibition TLR4/NF-κB signaling mediated by down-regulation HMGB1
Zhao, T., Zhu, Y., Yao, L., Liu, L., & Li, N. (2021) · Annals of Hepatology · doi:10.1016/j.aohep.2021.100560 · Cited by 13
Targeting Gut–Liver Axis for Treatment of Liver Fibrosis and Portal Hypertension
Kalo, E., Read, S. A., & Ahlenstiel, G. (2021) · Livers · doi:10.3390/livers1030014 · Cited by 12
35kDa hyaluronan ameliorates ethanol driven loss of anti-microbial defense and intestinal barrier integrity in a TLR4-dependent manner
Ray, S., Huang, E., West, G. A., Mrdjen, M., McMullen, M. R., de la Motte, C., & Nagy, L. E. (2022) · Matrix Biology · doi:10.1016/j.matbio.2022.11.008 · Cited by 12
Alleviation of cholestatic liver injury and intestinal permeability by lubiprostone treatment in bile duct ligated rats: role of intestinal FXR and tight junction proteins claudin-1, claudin-2, and occludin
Safari, F., Sharifi, M., Talebi, A., Mehranfard, N., & Ghasemi, M. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02455-z · Cited by 12
Ellagic Acid Protects against Alcohol-Related Liver Disease by Modulating the Hepatic Circadian Rhythm Signaling through the Gut Microbiota–NPAS2 Axis
Zhang, H., Zhou, W., Gao, P., Li, Z., Li, C., Li, J., Bian, J., Gong, L., He, C., Han, L., et al. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c06992 · Cited by 13
Dysregulation in the microbiota by HBV and HCV infection induces an altered cytokine profile in the pathobiome of infection
Padilha, M. D. M., Melo, F. T. D. V., Laurentino, R. V., da Silva, A. N. M. R., & Feitosa, R. N. M. (2024) · The Brazilian Journal of Infectious Diseases · doi:10.1016/j.bjid.2024.104468 · Cited by 13
Gut Microbiota in Alcoholic Hepatitis is Disparate from Those in Acute Alcoholic Pancreatitis and Biliary Disease
Philips, C. A., Phadke, N. D., Ganesan, K., Rajesh, S., Padsalgi, G., Ahamed, R., John, S. K., Valiathan, G. C., & Augustine, P. (2019) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2019.04.001 · Cited by 12
LPS stimulation during HCV infection induces MMP/TIMP1 imbalance in macrophages
Fan, C., Zhang, X., Zhang, P., Zhao, J., Shen, H., Zhang, Y., Wu, X., Zhansheng, J., & Wang, Y. (2020) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001185 · Cited by 12
Prevention of non‐alcoholic steatohepatitis by long‐term exercise via the induction of phenotypic changes in Kupffer cells of hyperphagic obese mice
Miura, I., Komine, S., Okada, K., Wada, S., Warabi, E., Uchida, F., Oh, S., Suzuki, H., Mizokami, Y., & Shoda, J. (2021) · Physiological Reports · doi:10.14814/phy2.14859 · Cited by 13

Authors: Schnabl, B., & Brenner, D. A.
Affiliations: University of California San Diego (US)
Corresponding author: Schnabl, Bernd
ORCID: Schnabl, Bernd
Brenner, David A.
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2014-05
Volume: 146
Issue: 6
Pages: 1513-1524
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2014.01.020
PMC: PMC3996054
OpenAlex: W1975691929
Cited by: 971
References: 86
Citations by year: 2026: 37 · 2025: 56 · 2024: 88 · 2023: 101 · 2022: 88 · 2021: 92 · 2020: 102 · 2019: 88 · 2018: 89 · 2017: 58 · 2016: 64 · 2015: 77 · 2014: 31
FWCI: 7.23
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health (U01 AA021856, R01 AA020703, 2 P42 ES010337, K08 DK081830)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords: gut microbiota, gut-liver axis, non-alcoholic fatty liver disease, steatohepatitis, alcoholic liver disease, liver cirrhosis, dysbiosis, intestinal homeostasis, intestinal barrier dysfunction, intestinal inflammation, microbial translocation, microbial metabolites, Western diet, alcohol
MeSH terms: Animals, Bacteria, Bile Acids and Salts, Fatty Liver, Humans, Intestines, Liver Cirrhosis, Liver Diseases, Liver Diseases, Alcoholic, Risk Factors, Host-Pathogen Interactions, Microbiota, Dysbiosis, Non-alcoholic Fatty Liver Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Interactions Between the Intestinal Microbiome and Liver Diseases

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks