Cited by 123Liver physiology and pathologyImmune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative Mechanisms

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Innate Immune Cell Trafficking and Function During Sterile Inflammation of the Liver

McDonald, Braedon, Kubes, Paul·2016·Gastroenterology

DOI 10.1053/j.gastro.2016.09.048

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Abstract

The sterile inflammatory response (inflammation in the absence of infection) to tissue injury and cell death is required for normal wound healing. However, dysregulated sterile inflammation leads to various acute and chronic inflammatory diseases, including those of the liver and gastrointestinal tract. It is therefore important to increase our understanding of the mechanisms that control physiological versus pathological sterile inflammation. We have begun to clarify the cellular and molecular mechanisms that coordinate the innate immune response to tissue damage and cell death in the liver. In this review, we summarize the mechanisms that alert the immune system to the presence of tissue damage and highlight recent advances in our understanding of innate immune cell trafficking to sites of hepatic sterile inflammation. We explore the functions of various innate immune cells in the coordination of tissue repair, including previously underappreciated roles of peritoneal macrophages and platelets. We propose that dysregulation of immune cell trafficking or function at sites of tissue injury contributes to the misdirection of sterile inflammation to promote chronic inflammatory disease.

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Authors: McDonald, B., & Kubes, P.
Affiliations: University of Calgary (CA)
Corresponding author: Kubes, Paul
ORCID: McDonald, Braedon
Kubes, Paul
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2016-12
Volume: 151
Issue: 6
Pages: 1087-1095
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2016.09.048
OpenAlex: W2531302392
Cited by: 123
References: 63
Citations by year: 2026: 3 · 2025: 9 · 2024: 11 · 2023: 10 · 2022: 20 · 2021: 19 · 2020: 13 · 2019: 16 · 2018: 16 · 2017: 6
FWCI: 1.59
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: sterile inflammation, innate immunity, immune cell trafficking, liver, tissue damage, cell death, peritoneal macrophages, platelets, tissue repair, wound healing, chronic inflammatory diseases
MeSH terms: Animals, Blood Platelets, Chemotaxis, Hepatitis, Humans, Immunity, Innate, Macrophages, Monocytes, Neutrophils, Cell Death

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Innate Immune Cell Trafficking and Function During Sterile Inflammation of the Liver

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