Pathways of Colorectal Carcinogenesis

A genetic model for colorectal tumorigenesis

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Mutations of the BRAF gene in human cancer

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PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

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Comprehensive molecular characterization of human colon and rectal cancer

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Cancer Genome Landscapes

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Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

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The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population‐based to a more “personalized” approach to cancer staging

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The consensus molecular subtypes of colorectal cancer

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Lessons from hereditary colorectal cancer

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Identification of c- <i>MYC</i> as a Target of the APC Pathway

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A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.

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CpG-rich islands and the function of DNA methylation

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High Frequency of Mutations of the PIK3CA Gene in Human Cancers

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MYC on the Path to Cancer

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Microsatellite Instability in Cancer of the Proximal Colon

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The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis

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Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

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CpG island methylator phenotype in colorectal cancer

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Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

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Stromal fibroblasts in cancer initiation and progression

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<i>KRAS</i> Mutation Status Is Predictive of Response to Cetuximab Therapy in Colorectal Cancer

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Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer

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Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

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Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

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CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

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APC mutations occur early during colorectal tumorigenesis

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Multitarget Stool DNA Testing for Colorectal-Cancer Screening

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Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

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Systematic Review of Microsatellite Instability and Colorectal Cancer Prognosis

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Vemurafenib in Multiple Nonmelanoma Cancers with <i>BRAF</i> V600 Mutations

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Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis

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The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

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Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value

Marisa, L., de Reyniès, A., Duval, A., Selves, J., Gaub, M. P., Vescovo, L., Etienne-Grimaldi, M.-C., Schiappa, R., Guenot, D., Ayadi, M., et al. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001453 · Cited by 1,507 · see citing works

Long-term colorectal-cancer incidence and mortality after lower endoscopy

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KRAS Mutations As an Independent Prognostic Factor in Patients With Advanced Colorectal Cancer Treated With Cetuximab

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Tumor Microsatellite Instability and Clinical Outcome in Young Patients with Colorectal Cancer

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Capecitabine as Adjuvant Treatment for Stage III Colon Cancer

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Colorectal Cancer Incidence Patterns in the United States, 1974–2013

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RAF/RAS oncogenes and mismatch-repair status

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The COX-2/PGE2 pathway, key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

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Increasing Disparities in the Age-Related Incidences of Colon and Rectal Cancers in the United States, 1975-2010

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Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

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p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.

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Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

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Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

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A colorectal cancer classification system that associates cellular phenotype and responses to therapy

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Genomic and Epigenetic Instability in Colorectal Cancer Pathogenesis

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Increasing incidence of colorectal cancer in young adults in Europe over the last 25 years

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Multiple Colorectal Adenomas, Classic Adenomatous Polyposis, and Germ-Line Mutations inMYH

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Aspirin Use for the Primary Prevention of Cardiovascular Disease and Colorectal Cancer: U.S. Preventive Services Task Force Recommendation Statement

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Target genes of β-catenin–T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas

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Prospective evaluation of methylated SEPT9 in plasma for detection of asymptomatic colorectal cancer

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Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

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The colorectal adenoma–carcinoma sequence

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Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression.

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Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.

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Sulindac causes regression of rectal polyps in familial adenomatous polyposis

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BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum

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Phase II Pilot Study of Vemurafenib in Patients With Metastatic <i>BRAF</i> -Mutated Colorectal Cancer

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Allelic Loss of Chromosome 18q and Prognosis in Colorectal Cancer

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Colon Cancer

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Analysis of <i>PTEN</i> , <i>BRAF</i> , and <i>EGFR</i> Status in Determining Benefit From Cetuximab Therapy in Wild-Type <i>KRAS</i> Metastatic Colon Cancer

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Host cyclooxygenase-2 modulates carcinoma growth

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Update on the serrated pathway to colorectal carcinoma

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Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer

Latham, A. J., Srinivasan, P., Kemel, Y. M., Shia, J., Bandlamudi, C., Mandelker, D. L., Middha, S., Hechtman, J. F., Zehir, A., Dubard-Gault, M. E., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.18.00283 · Cited by 618 · see citing works

Genome-scale analysis of aberrant DNA methylation in colorectal cancerPreprint

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Evaluation of a Large, Population-Based Sample Supports a CpG Island Methylator Phenotype in Colon Cancer

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High Prevalence of Sessile Serrated Adenomas With BRAF Mutations: A Prospective Study of Patients Undergoing Colonoscopy

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Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas

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Comparison of Microsatellite Instability, CpG Island Methylation Phenotype, BRAF and KRAS Status in Serrated Polyps and Traditional Adenomas Indicates Separate Pathways to Distinct Colorectal Carcinoma End Points

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DNA Methylation Biomarkers for Blood-Based Colorectal Cancer Screening

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Aspirin for the Chemoprevention of Colorectal Adenomas: Meta-analysis of the Randomized Trials

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Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer

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RNF43 is frequently mutated in colorectal and endometrial cancers

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The Increasing Incidence of Young-Onset Colorectal Cancer: A Call to Action

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Prevalence and Heterogeneity of <i>KRAS, BRAF</i>, and <i>PIK3CA</i> Mutations in Primary Colorectal Adenocarcinomas and Their Corresponding Metastases

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