Altered Mycobiota Signatures and Enriched Pathogenic Aspergillus rambellii Are Associated With Colorectal Cancer Based on Multicohort Fecal Metagenomic Analyses

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21660 · Cited by 108,699 · see citing works

Human gut microbiome viewed across age and geography

Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works

Receiver Operating Characteristic Curve in Diagnostic Test Assessment

Mandrekar, J. N. (2010) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3181ec173d · Cited by 4,506 · see citing works

Environment dominates over host genetics in shaping human gut microbiota

Rothschild, D., Weissbrod, O., Barkan, E., Kurilshikov, A., Korem, T., Zeevi, D., Costea, P. I., Godneva, A., Kalka, I. N., Bar, N., et al. (2018) · Nature · doi:10.1038/nature25973 · Cited by 2,859 · see citing works

Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy

Yu, T., Guo, F., Yu, Y., Sun, T., Ma, D., Han, J., Qian, Y., Kryczek, I., Sun, D., Nagarsheth, N., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.008 · Cited by 2,198 · see citing works

Gut microbiome development along the colorectal adenoma-carcinoma sequence

Feng, Q., Liang, S., Jia, H., Stadlmayr, A., Tang, L., Lan, Z., Zhang, D., Xia, H., Xu, X., Jie, Z., et al. (2015) · Nature Communications · doi:10.1038/ncomms7528 · Cited by 1,506 · see citing works

Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer

Yachida, S., Mizutani, S., Shiroma, H., Shiba, S., Nakajima, T., Sakamoto, T., Watanabe, H., Masuda, K., Nishimoto, Y., Kubo, M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0458-7 · Cited by 1,429 · see citing works

Potential of fecal microbiota for early-stage detection of colorectal cancer

Zeller, G., Tap, J., Voigt, A. Y., Sunagawa, S., Kultima, J. R., Costea, P. I., Amiot, A., Böhm, J., Brunetti, F., Habermann, N., et al. (2014) · Molecular Systems Biology · doi:10.15252/msb.20145645 · Cited by 1,375 · see citing works

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer

Wirbel, J., Pyl, P. T., Kartal, E., Zych, K., Kashani, A., Milanese, A., Fleck, J. S., Voigt, A. Y., Palleja, A., Ponnudurai, R., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0406-6 · Cited by 1,373 · see citing works

Gut microbiota in colorectal cancer: mechanisms of action and clinical applications

Wong, S. H., & Yu, J. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0209-8 · Cited by 1,355 · see citing works

Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer

Yu, J. Q., Feng, Q., Wong, S. H., Zhang, D., Liang, Q. Y., Qin, Y., Tang, L., Zhao, H., Stenvang, J., Li, Y., et al. (2015) · Gut · doi:10.1136/gutjnl-2015-309800 · Cited by 1,247 · see citing works

Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation

Thomas, A. M., Manghi, P., Asnicar, F., Pasolli, E., Armanini, F., Zolfo, M., Beghini, F., Manara, S., Karcher, N., Pozzi, C., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0405-7 · Cited by 1,030 · see citing works

Characterizing and measuring bias in sequence data

Ross, M. G., Russ, C., Costello, M., Hollinger, A., Lennon, N. J., Hegarty, R., Nusbaum, C., & Jaffe, D. B. (2013) · Genome Biology · doi:10.1186/gb-2013-14-5-r51 · Cited by 909 · see citing works

The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL

Aykut, B., Pushalkar, S., Chen, R., Li, Q., Abengozar, R., Kim, J. I., Shadaloey, S. A., Wu, D., Preiss, P., Verma, N., et al. (2019) · Nature · doi:10.1038/s41586-019-1608-2 · Cited by 883 · see citing works

Gut mucosal microbiome across stages of colorectal carcinogenesis

Nakatsu, G., Li, X., Zhou, H., Sheng, J., Wong, S. H., Wu, W. K. K., Ng, S. C., Tsoi, H., Dong, Y., Zhang, N., et al. (2015) · Nature Communications · doi:10.1038/ncomms9727 · Cited by 701 · see citing works

The mycobiota: interactions between commensal fungi and the host immune system

Underhill, D. M., & Iliev, I. D. (2014) · Nature reviews. Immunology · doi:10.1038/nri3684 · Cited by 692 · see citing works

Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers

Dai, Z., Coker, O. O., Nakatsu, G., Wu, W. K. K., Zhao, L., Chen, Z., Chan, F. K. L., Kristiansen, K., Sung, J. J. Y., Wong, S. H., et al. (2018) · Microbiome · doi:10.1186/s40168-018-0451-2 · Cited by 545 · see citing works

Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer

Coker, O. O., Nakatsu, G., Dai, R. Z., Wu, W. K. K., Wong, S. H., Ng, S. C., Chan, F. K. L., Sung, J. J. Y., & Yu, J. (2019) · Gut · doi:10.1136/gutjnl-2018-317178 · Cited by 511 · see citing works

Alterations in Enteric Virome Are Associated With Colorectal Cancer and Survival Outcomes

Nakatsu, G., Zhou, H., Wu, W. K. K., Wong, S. H., Coker, O. O., Dai, Z., Li, X., Szeto, C.-H., Sugimura, N., Lam, T. Y.-T., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.04.018 · Cited by 386 · see citing works

Colorectal Cancer and the Human Gut Microbiome: Reproducibility with Whole-Genome Shotgun Sequencing

Vogtmann, E., Hua, X., Zeller, G., Sunagawa, S., Voigt, A. Y., Hercog, R., Goedert, J. J., Shi, J., Bork, P., & Sinha, R. (2016) · PLOS ONE · doi:10.1371/journal.pone.0155362 · Cited by 366 · see citing works

Diagnostic potential and interactive dynamics of the colorectal cancer virome

Hannigan, G. D., Duhaime, M. B., Ruffin, M. T., Koumpouras, C. C., & Schloss, P. D. (2018) · mBio · doi:10.1128/mbio.02248-18 · Cited by 298 · see citing works

DGCA: A comprehensive R package for Differential Gene Correlation Analysis

McKenzie, A. T., Katsyv, I., Song, W.-M., Wang, M., & Zhang, B. (2016) · BMC Systems Biology · doi:10.1186/s12918-016-0349-1 · Cited by 249 · see citing works

Aspergillus derived mycotoxins in food and the environment: Prevalence, detection, and toxicity

Navale, V. D., Vamkudoth, K. R., Ajmera, S., & Dhuri, V. C. (2021) · Toxicology Reports · doi:10.1016/j.toxrep.2021.04.013 · Cited by 235 · see citing works

Exosomes derived from Fusobacterium nucleatum -infected colorectal cancer cells facilitate tumour metastasis by selectively carrying miR-1246/92b-3p/27a-3p and CXCL16

Guo, S., Chen, J., Chen, F., Zeng, Q., Liu, W., & Zhang, G. (2020) · Gut · doi:10.1136/gutjnl-2020-321187 · Cited by 227 · see citing works

Taxonomic comparison of three different groups of aflatoxin producers and a new efficient producer of aflatoxin B1, sterigmatocystin and 3-O-methylsterigmatocystin, Aspergillus rambellii sp. nov.

Frisvad, J. C., Skouboe, P., & Samson, R. A. (2005) · Systematic and Applied Microbiology · doi:10.1016/j.syapm.2005.02.012 · Cited by 223 · see citing works

Library preparation methodology can influence genomic and functional predictions in human microbiome research

Jones, M. B., Highlander, S. K., Anderson, E. L., Li, W., Dayrit, M., Klitgord, N., Fabani, M. M., Seguritan, V., Green, J., Pride, D. T., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1519288112 · Cited by 204 · see citing works

Comparison of normalization methods for the analysis of metagenomic gene abundance data

Pereira, M. B., Wallroth, M., Jönsson, V., & Kristiansson, E. (2018) · BMC Genomics · doi:10.1186/s12864-018-4637-6 · Cited by 197 · see citing works

Mycobiome in the Gut: A Multiperspective Review

Chin, V. K., Yong, P. V. C., Chong, P. P., Nordin, S. A., Basir, R., & Abdullah, M. (2020) · Mediators of Inflammation · doi:10.1155/2020/9560684 · Cited by 156 · see citing works

Clustering by soft-constraint affinity propagation: applications to gene-expression data

Leone, M., Sumedha, M. L., & Weigt, M. (2007) · Bioinformatics · doi:10.1093/bioinformatics/btm414 · Cited by 128 · see citing works

Aspergillus Species and Their Associated Mycotoxins

Perrone, G., & Gallo, A. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6707-0_3 · Cited by 120 · see citing works

Mechanisms underlying aflatoxin-associated mutagenesis – Implications in carcinogenesis

McCullough, A. K., & Lloyd, R. S. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.03.004 · Cited by 110 · see citing works

Modulation of macrophage activity by aflatoxins B1 and B2 and their metabolites aflatoxins M1 and M2

Bianco, G., Russo, R., Marzocco, S., Velotto, S., Autore, G., & Severino, L. (2012) · Toxicon · doi:10.1016/j.toxicon.2012.02.010 · Cited by 87 · see citing works

Mycotoxigenic Fungi

Scala, V., VISENTIN, I., & CARDINALE, F. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6707-0 · Cited by 78 · see citing works

Characterization of theAspergillus ochraceoroseusaflatoxin/sterigmatocystin biosynthetic gene cluster

Cary, J. W., Ehrlich, K., Beltz, S. B., Harris-Coward, P. Y., & Klich, M. A. (2009) · Mycologia · doi:10.3852/08-173 · Cited by 61 · see citing works

Chemical repertoire and biosynthetic machinery of the Aspergillus flavus secondary metabolome: A review

Uka, V., Cary, J. W., Lebar, M. D., Puel, O., Saeger, S. D., & Mavungu, J. D. D. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12638 · Cited by 51 · see citing works

Environmentally Relevant Level of Aflatoxin B 1 Dysregulates Human Dendritic Cells Through Signaling on Key Toll-Like Receptors

Mohammadi, A., Mehrzad, J., Mahmoudi, M., & Schneider, M. (2014) · International Journal of Toxicology · doi:10.1177/1091581814526890 · Cited by 50 · see citing works

Regulatory Circuits That Enable Proliferation of the Fungus Candida albicans in a Mammalian Host

Pérez, J. C., & Johnson, A. D. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003780 · Cited by 38 · see citing works

Fungal dysbiosis of the gut microbiota is associated with colorectal cancer in Chinese patients.

Wang, Y. H. D., Ren, Y., Huang, Y., Yu, X., Yang, Y., Wang, D., Shi, L., Tao, K.-X., Wang, G., & Wu, K. (2021) · PubMed Central · Cited by 27 · see citing works

Artificial intelligence and metagenomics in intestinal diseases

Lin, Y., Wang, G., Yu, J. Q., & Sung, J. J. �. (2021) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15501 · Cited by 23 · see citing works

Gut microbiota in colorectal cancer development and therapy

Wong, C. C., & Yu, J. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00766-x · Cited by 751 · see citing works

Gut Microbiota in Colorectal Cancer: Biological Role and Therapeutic Opportunities

Pandey, H., Tang, D. W. T., Wong, S. H., & Lal, D. (2023) · Cancers · doi:10.3390/cancers15030866 · Cited by 165 · see citing works

Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy

Thomas, A. M., Fidelle, M., Routy, B., Kroemer, G., Wargo, J. A., Segata, N., & Zitvogel, L. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00785-8 · Cited by 141 · see citing works

Colorectal cancer and gut microbiota studies in China

Wang, Z., Dan, W., Zhang, N., Fang, J., & Yang, Y. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2236364 · Cited by 145 · see citing works

Intestinal bacteria and colorectal cancer: etiology and treatment

Dougherty, M. W., & Jobin, C. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2185028 · Cited by 138 · see citing works

The role of gut microbiota and metabolites in cancer chemotherapy

Li, S., Zhu, S., & Yu, J. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.11.027 · Cited by 106 · see citing works

A Fecal MicroRNA Signature by Small RNA Sequencing Accurately Distinguishes Colorectal Cancers: Results From a Multicenter Study

Pardini, B., Ferrero, G., Tarallo, S., Gallo, G., Francavilla, A., Licheri, N., Trompetto, M., Clerico, G. F., Senore, C., Peyre, S., et al. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.05.037 · Cited by 78 · see citing works

Unraveling the Role of the Human Gut Microbiome in Health and Diseases

Khalil, M., Ciaula, A. D., Mahdi, L., Jaber, N., Palo, D. M. D., Graziani, A., Baffy, G., & Portincasa, P. (2024) · Microorganisms · doi:10.3390/microorganisms12112333 · Cited by 98 · see citing works

Statistical normalization methods in microbiome data with application to microbiome cancer research

Xia, Y. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2244139 · Cited by 71 · see citing works

Fungi and cancer

Saftien, A., Puschhof, J., & Elinav, E. (2023) · Gut · doi:10.1136/gutjnl-2022-327952 · Cited by 67 · see citing works

Implications of gut microbiota-mediated epigenetic modifications in intestinal diseases

Zhang, Q., Liu, Y., Li, Y., Bai, G., Pang, J., Wu, M., Li, J., Zhao, X., & Xia, Y. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2508426 · Cited by 68 · see citing works

Effects of gut microbiota on immune checkpoint inhibitors in multi-cancer and as microbial biomarkers for predicting therapeutic response

Lin, Y., Xie, M., Lau, H. C.-H., Zeng, R., Zhang, R., Wang, L., Li, Q., Wang, Y., Chen, D., Jiang, L., et al. (2024) · Med · doi:10.1016/j.medj.2024.10.007 · Cited by 64 · see citing works

Commensal fungi in intestinal health and disease

Ost, K. S., & Round, J. L. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00816-w · Cited by 65 · see citing works

The mycobiome as integral part of the gut microbiome: crucial role of symbiotic fungi in health and disease

Huang, H., Wang, Q., Yang, Y., Zhong, W., He, F., & Li­, ­. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2440111 · Cited by 71 · see citing works

Male‐Biased Gut Microbiome and Metabolites Aggravate Colorectal Cancer Development

Wang, L., Tu, Y., Chen, L., Zhang, Y., Pan, X., Yang, S., Zhang, S., Li, S., Yu, K., Song, S., et al. (2023) · Advanced Science · doi:10.1002/advs.202206238 · Cited by 57 · see citing works

Emerging clinical relevance of microbiome in cancer: promising biomarkers and therapeutic targets

Dai, J.-H., Tan, X.-R., Qiao, H., & Liu, N. (2023) · Protein & Cell · doi:10.1093/procel/pwad052 · Cited by 56 · see citing works

The gut microbiome in human health and disease—Where are we and where are we going? A bibliometric analysis

Huang, Z., Liu, K., Ma, W., Li, D., Mo, T., & Liu, Q. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1018594 · Cited by 59 · see citing works

Multi-cohort analysis reveals colorectal cancer tumor location-associated fecal microbiota and their clinical impact

Lin, Y., Lau, H. C.-H., Liu, C., Ding, X., Sun, Y., Rong, J., Zhang, X., Wang, L., Yuan, K., Miao, Y., et al. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.03.012 · Cited by 42 · see citing works

Multi-Cohort Analysis Reveals Altered Archaea in Colorectal Cancer Fecal Samples Across Populations

Li, T., Coker, O. O., Sun, Y., Li, S., Liu, C., Lin, Y., Wong, S. H., Miao, Y., Sung, J. J. �., & Yu, J. Q. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.10.023 · Cited by 40 · see citing works

The mycobiome in human cancer: analytical challenges, molecular mechanisms, and therapeutic implications

Ding, T., Liu, C., & Li, Z. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02227-8 · Cited by 44 · see citing works

Harnessing gut microbiota for colorectal cancer therapy: from clinical insights to therapeutic innovations

Chen, C., Su, Q., Zi, M., Hua, X., & Zhang, Z. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00818-3 · Cited by 41 · see citing works

The microbiome and rise of early-onset cancers: knowledge gaps and research opportunities

Mima, K., Hamada, T., Inamura, K., Baba, H., Ugai, T., & Ogino, S. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2269623 · Cited by 38 · see citing works

Microbial genes outperform species and SNVs as diagnostic markers for Crohn’s disease on multicohort fecal metagenomes empowered by artificial intelligence

Gao, S., Gao, X., Zhu, R., Wu, D., Feng, Z., Jiao, N., Sun, R., Gao, W., He, Q., Liu, Z., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2221428 · Cited by 36 · see citing works

Candida spp. in Human Intestinal Health and Disease: More than a Gut Feeling

Kreulen, I. A. M., de Jonge, W. J., van den Wijngaard, R. M., & van Thiel, I. A. M. (2023) · Mycopathologia · doi:10.1007/s11046-023-00743-z · Cited by 35 · see citing works

Gut fungal mycobiome: A significant factor of tumor occurrence and development

Li, F., Gao, Y., Cheng, W., Su, L., & Yang, R. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216302 · Cited by 36 · see citing works

Multimodal metagenomic analysis reveals microbial single nucleotide variants as superior biomarkers for early detection of colorectal cancer

Gao, W., Gao, X., Zhu, L., Gao, S., Sun, R., Feng, Z., Wu, D., Liu, Z., Zhu, R., & Jiao, N. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2245562 · Cited by 34 · see citing works

The Gut Microbiome and Its Implication in the Mucosal Digestive Disorders

Bozomitu, L. I., Miron, I. C., Răileanu, A. A., Lupu, A., Păduraru, G., Marcu, F. M., Buga, A. M. L., Rusu, D. C., Dragan, F., & Lupu, V. V. (2022) · Biomedicines · doi:10.3390/biomedicines10123117 · Cited by 33 · see citing works

Antibiotics and Probiotics for Irritable Bowel Syndrome

Goodoory, V. C., & Ford, A. C. (2023) · Drugs · doi:10.1007/s40265-023-01871-y · Cited by 32 · see citing works

Intestinal dysbiosis and colorectal cancer

Kang, Z., Jiang, S., Fang, J., & Chen, H. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003617 · Cited by 34 · see citing works

Exploring the gut microbiome’s role in colorectal cancer: diagnostic and prognostic implications

Chen, G., Ren, Q., Zhong, Z., Li, Q., Huang, Z., Zhang, C., Yuan, H., Feng, Z., Chen, B., Wang, N., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1431747 · Cited by 30 · see citing works

Comprehensive Analysis of Early-onset Colorectal Cancer: A Review

Takada, K., Hotta, K., Kishida, Y., Ito, S., Imai, K., & Ono, H. (2023) · Journal of the Anus Rectum and Colon · doi:10.23922/jarc.2023-032 · Cited by 26 · see citing works

IL-1β mediates Candida tropicalis-induced immunosuppressive function of MDSCs to foster colorectal cancer

Zhang, Z., Chen, Y., Pan, X., Li, P., Ren, Z., Wang, X., Chen, Y., Shen, S., Wang, T., & Lin, A. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01771-y · Cited by 26 · see citing works

Fungi and tumors: The role of fungi in tumorigenesis (Review)

Cheng, W., Li, F., Gao, Y., & Yang, R. (2024) · International Journal of Oncology · doi:10.3892/ijo.2024.5640 · Cited by 24 · see citing works

Oral Bacteria, Virus and Fungi in Saliva and Tissue Samples from Adult Subjects with Oral Squamous Cell Carcinoma: An Umbrella Review

Spirito, F. D., Palo, M. P. D., Folliero, V., Cannatà, D., Franci, G., Martina, S., & Amato, M. (2023) · Cancers · doi:10.3390/cancers15235540 · Cited by 23 · see citing works

Multi-kingdom microbial signatures in excess body weight colorectal cancer based on global metagenomic analysis

Zhu, X., Xu, P., Zhu, R., Gao, W., Yin, W., Lan, P., Zhu, L., & Jiao, N. (2024) · Communications Biology · doi:10.1038/s42003-023-05714-0 · Cited by 25 · see citing works

Fungal gut microbiota dysbiosis in systemic lupus erythematosus

Yang, P., Xu, R. C., Chen, F., Chen, S., Khan, A., Li, L., Zhang, X., Wang, Y., Xu, Z., & Shen, H. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1149311 · Cited by 20 · see citing works

Gut mycobiome as a potential non-invasive tool in early detection of lung adenocarcinoma: a cross-sectional study

Liu, Q., Zhang, W., Pei, Y., Tao, H., Ma, J., Li, R., Zhang, F., Wang, L., Shen, L., Liu, Y., et al. (2023) · BMC Medicine · doi:10.1186/s12916-023-03095-z · Cited by 20 · see citing works

Unveiling the hidden players: exploring the role of gut mycobiome in cancer development and treatment dynamics

Li, L., Huang, X., & Chen, H. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2328868 · Cited by 20 · see citing works

The gut mycobiome signatures in long-lived populations

Pu, L., Pang, S., Mu, W., Chen, X., Zou, Y., Wang, Y., Ding, Y., Yan, Q., Huang, Y., Chen, X., et al. (2024) · iScience · doi:10.1016/j.isci.2024.110412 · Cited by 22 · see citing works

Optimizing anti-PD-1/PD-L1 therapy efficacy and fecal microbiota transplantation donor selection through gut mycobiome-based enterotype

Hu, M., Zhu, X., Huang, X., Li, H., Lin, X., Zhang, H., Hu, Y., Tong, T., Li, L., Xuan, B., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115589 · Cited by 18 · see citing works

Oral mycobiota and pancreatic ductal adenocarcinoma

Wei, A., Zhao, H., Cong, X., Wang, L., Chen, Y., Gou, J., Hu, Z., Hu, X., Tian, Y., Li, K., et al. (2022) · BMC Cancer · doi:10.1186/s12885-022-10329-5 · Cited by 18 · see citing works

The mycobiome: interactions with host and implications in diseases

Fan, Y., Wu, L., & Zhai, B. (2023) · Current Opinion in Microbiology · doi:10.1016/j.mib.2023.102361 · Cited by 17 · see citing works

Identification of microbial markers associated with lung cancer based on multi‐cohort 16 s rRNA analyses: A systematic review and meta‐analysis

Han, W., Wang, N., Han, M., Liu, X., Sun, T., & Xu, J. (2023) · Cancer Medicine · doi:10.1002/cam4.6503 · Cited by 18 · see citing works

Fungi, immunosenescence and cancer

Xu, B., Luo, Z., Niu, X., Li, Z., Lu, Y., & Li, J. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.01.002 · Cited by 17 · see citing works

The interplay between tissue‐resident microbiome and host proteins by integrated multi‐omics during progression of colorectal adenoma to carcinoma

Wu, D., Wang, A., Bu, D., Sun, Y., Li, C., Hong, Y.-M., Zhang, S., Chen, S., Zhou, J., Zhang, T., et al. (2025) · iMeta · doi:10.1002/imt2.70090 · Cited by 16 · see citing works

Beneficial microbiome and diet interplay in early-onset colorectal cancer

Zhou, Z., Kleis, L., Depetris-Chauvin, A., Jaskulski, S., Damerell, V., Michels, K. B., Gigic, B., Nöthlings, U., & Panagiotou, G. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00177-0 · Cited by 19 · see citing works

Oral fungal profiling and risk of nasopharyngeal carcinoma: a population-based case-control study

Chen, Y., Li, W., Chang, E. T., Debelius, J. W., Manoharan, L., Zheng, Y., Li, Y., Huang, G., Adami, H., Knight, R. D., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104813 · Cited by 15 · see citing works

Mechanism-guided fine-tuned microbiome potentiates anti-tumor immunity in HCC

Liu, T., Guo, Y., Liao, Y., & Liu, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1333864 · Cited by 15 · see citing works

Gut microbiome in colorectal cancer: metagenomics from bench to bedside

Esfahani, A. T., Zafarjafarzadeh, N., Vakili, F., Bizhanpour, A., Mashaollahi, A., Kordestani, B. K., Baratinamin, M., & Mohammadpour, S. (2025) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkaf026 · Cited by 15 · see citing works

The gastrointestinal mycobiome in inflammation and cancer: unraveling fungal dysbiosis, pathogenesis, and therapeutic potential

Kiran, N. S., Chatterjee, A., Yashaswini, C., Deshmukh, R., Alsaidan, O. A., Bhattacharya, S., & Prajapati, B. G. (2025) · Medical Oncology · doi:10.1007/s12032-025-02761-x · Cited by 15 · see citing works

Host-microbiota interactions contributing to the heterogeneous tumor microenvironment in colorectal cancer

Li, X., Wu, D., Li, Q., Gu, J., Gao, W., Zhu, X., Yin, W., Zhu, R., Zhu, L., & Jiao, N. (2023) · Physiological Genomics · doi:10.1152/physiolgenomics.00103.2023 · Cited by 15 · see citing works

The oncomicrobiome: New insights into microorganisms in cancer

Ma, Y., Chen, T., Sun, T., Dilinuer, D., & Xiao, Y. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.107091 · Cited by 14 · see citing works

Short-Chain Fatty Acids and Colorectal Cancer: A Systematic Review and Integrative Bayesian Meta-Analysis of Microbiome–Metabolome Interactions and Intervention Efficacy

He, Y., Peng, K., Tan, J., Hao, Y., Zhang, S., Gao, C., & Li, L. (2025) · Nutrients · doi:10.3390/nu17223552 · Cited by 15 · see citing works

Oral Fungal Alterations in Patients with COVID‐19 and Recovered Patients

Hu, X., Wang, H., Yu, B., Yu, J. Y., Lu, H., Sun, J., Sun, Y., Zou, Y., Luo, H., Zeng, Z., et al. (2023) · Advanced Science · doi:10.1002/advs.202205058 · Cited by 13 · see citing works

Influence of tumor mycobiome on cancer pathogenesis (Review)

Liu, W., Li, Z., Li, X., Cao, H., Jiang, H., Niu, Q., & Hu, B. (2023) · Oncology Letters · doi:10.3892/ol.2023.14128 · Cited by 13 · see citing works

“Nutrient–fungi–host” tripartite interaction in cancer progression

Wu, D., Guan, Y., Li, C., Zheng, Q., Yin, Z., Wang, H., & Liu, N. (2024) · iMeta · doi:10.1002/imt2.170 · Cited by 13 · see citing works

Potential and application of Fusobacterium nucleatum in the diagnosis and treatment of colorectal cancer

He, X., Zhao, Q., Zhang, J., Shi, J., Wan, N., Tang, B., Tian, B., & Li, P. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1652702 · Cited by 12 · see citing works

Microbiome Differences in Colorectal Cancer Patients and Healthy Individuals: Implications for Vaccine Antigen Discovery

Ibeanu, G. C., Rowaiye, A. B., Okoli, J., & Eze, D. (2024) · ImmunoTargets and Therapy · doi:10.2147/itt.s486731 · Cited by 12 · see citing works

The Gut Mycobiome for Precision Medicine

Jaddaoui, I. E., Sehli, S., Idrissi, N. A., Bakri, Y., Belyamani, L., & Ghazal, H. (2025) · Journal of Fungi · doi:10.3390/jof11040279 · Cited by 13 · see citing works

Fungi and cancer: unveiling the complex role of fungal infections in tumor biology and therapeutic resistance

Zhang, W., Zhang, H., Gao, Y., Lei, J., & Suo, C. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1596688 · Cited by 12 · see citing works

Emerging trends in the global burden of colorectal cancer

Lee, D., Parikh, A., Sirohi, B., Cao, Y., & Chan, A. T. (2026) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-026-01149-8 · Cited by 11 · see citing works

Innovative approaches in colorectal cancer screening: advances in detection methods and the role of artificial intelligence

Duan, C., Sheng, J.-Q., & Ma, X. (2025) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848251314829 · Cited by 12 · see citing works

Diet, Gastric Microbiota, and Metabolites in Gastric Tumorigenesis

Jiang, L., Lau, H. C.-H., Zeng, R., & Yu, J. Q. (2025) · Research · doi:10.34133/research.0693 · Cited by 11 · see citing works

Progress of gut microbiome and its metabolomics in early screening of colorectal cancer

Zhou, L., Jiang, Z., Zhang, Z., Xing, J., Wang, D., & Tang, D. (2023) · Clinical & Translational Oncology · doi:10.1007/s12094-023-03097-6 · Cited by 11 · see citing works

Gut mycobiome: A “black box” of gut microbiome–host interactions

Zhao, X., Hu, X., Han, J., Yin, R., Zhang, S., & Liu, H. (2023) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1611 · Cited by 10 · see citing works

Multi-omics insights into the interplay between gut microbiota and colorectal cancer in the “microworld” age

Wang, A.-J., Song, D., Hong, Y.-M., & Liu, N. (2023) · Molecular Omics · doi:10.1039/d2mo00288d · Cited by 9 · see citing works

The role of gut mycobiome in responses to cancer immunotherapy

Szóstak, N., Kozłowski, P., Zuo, T., & Philips, A. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2571433 · Cited by 9 · see citing works

Insights into gut fungi in pigs: A comprehensive review

Wei, G. (2024) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.14036 · Cited by 8 · see citing works

Fungal influence on immune cells and inflammatory responses in the tumor microenvironment (Review)

Zhang, J., Feng, Y., Li, D., & Shi, D. (2024) · Oncology Letters · doi:10.3892/ol.2024.14796 · Cited by 8 · see citing works

Fungal Influences on Cancer Initiation, Progression, and Response to Treatment

Bilal, H., Khan, M. N., Khan, S., Shafiq, M., Fang, W., Zeng, Y., Guo, Y., Li, X., Zhao, B., Lv, Q., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-1609 · Cited by 8 · see citing works

Brain Tumors and Beyond: Multi-Compartment Microbiome and Mycobiome Analysis

Sípos, L., Banczerowski, P., Juhász, J., Fedorcsák, I., Berényi, G., Makra, N., Dunai, Z. A., Szabó, D., & Erőss, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26030991 · Cited by 9 · see citing works

Gut Microbial Signatures Associated With Clinical Remission in Inflammatory Bowel Disease Treated With Biologics: A Comprehensive Multi‐Cohort Analysis

Zheng, Q., Zhong, Y., Lian, H., Zhuang, J., Wang, L., Chen, J., Wang, H., Wang, H., Ye, X., Huang, Z., et al. (2025) · United European Gastroenterology Journal · doi:10.1002/ueg2.70064 · Cited by 8 · see citing works

Research progress on the correlation between intestinal flora and colorectal cancer

Wang, X., Zhang, Q., Xu, R., Li, X., & Hong, Z. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1416806 · Cited by 7 · see citing works

The bidirectional effects and mechanisms of the oral and gut microbiomes: a narrative review

Huo, T., Huang, X., Liao, J., Zhang, H., Hu, L., & Xie, M. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1697413 · Cited by 7 · see citing works

The power of microbes: the key role of gut microbiota in the initiation and progression of colorectal cancer

Han, B. R., Zhang, Y., Feng, X., Yang, J. J. J., Wang, B., Fang, J., Wang, Z., Zhu, J., Niu, G., & Guo, Y. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1563886 · Cited by 7 · see citing works

Mineral crude drug mirabilite (Mangxiao) inhibits the occurrence of colorectal cancer by regulating the Lactobacillus–bile acid–intestinal farnesoid X receptor axis based on multiomics integration analysis

Zhou, X., Sun, H. J., Ren, J., Yan, G., Yang, L., Zhang, H., Lu, H., Li, X., Makino, T., Yin, F., et al. (2024) · MedComm · doi:10.1002/mco2.556 · Cited by 6 · see citing works

Changes of gut mycobiota in the third trimester of pregnant women with preeclampsia

Zou, H., Zou, W., Li, Q., Chen, Z., Shi, Y., & Li, C. (2023) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2023.2228964 · Cited by 6 · see citing works

Measuring gut microbiome as a colorectal cancer screening tool: potential and challenges

Severino, A., Marchitto, S. A., Bisegna, P., Porcari, S., Rondinella, D., Schepis, T., Barbaro, F., Pecere, S., Maida, M. F., Spada, C., et al. (2025) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2025.2592078 · Cited by 5 · see citing works

Update on the role of mycobiome in Gastrointestinal cancers: mechanisms and therapeutic implications

Zhang, X., Li, Y., & Cao, D. (2025) · Medical Oncology · doi:10.1007/s12032-025-03207-0 · Cited by 5 · see citing works

Role of Gut Microbiota in Predisposition to Colon Cancer: A Narrative Review

Kamath, H. S., Shukla, R. K., Shah, U., Patel, S. D., Das, S., Chordia, A., Poorvikha, S., & Ghosh, D. (2024) · Indian Journal of Microbiology · doi:10.1007/s12088-024-01242-5 · Cited by 6 · see citing works

The disparate effects of omega-3 PUFAs on intestinal microbial homeostasis in experimental rodents under physiological condition

Chai, Z., Zhang, H., Ji, X., Hu, X., He, Y., Zhao, F., Song, C., Zhou, Y., Li, T., He, C., et al. (2024) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2024.102643 · Cited by 5 · see citing works

Profile of intestinal fungal microbiota in acute pancreatitis patients and healthy individuals

Zhao, M.-Q., Fan, M.-Y., Cui, M.-Y., Chen, S., Wang, J.-J., Lü, Y., & Jiang, Q. (2025) · Gut Pathogens · doi:10.1186/s13099-024-00675-z · Cited by 5 · see citing works

Intestinal fungal signatures and their impact on immune checkpoint inhibitor efficacy: a multi-cohort meta-analysis

Zhang, L., Zhou, D., Feng, J., Liao, Z.-J., Shu, X.-L., Yang, R., Gao, Y., Zhou, H., Zhang, W., Zou, Y. F., et al. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00827-2 · Cited by 4 · see citing works

Bronchoalveolar lavage fluid (BALF): Clinical applications for present and future

Mei, J., Chen, Y.-S., Tian, H., Wang, L., Zeng, J., Wang, L., Rong, D., Wong, R. C. B., Gao, Y., Guo, C., et al. (2025) · The Innovation Medicine · doi:10.59717/j.xinn-med.2025.100115 · Cited by 4 · see citing works

The role of fungi in the diagnosis of colorectal cancer

Li, X.-H., Luo, M., Wang, Z.-X., Wang, Q., & Xu, B. (2023) · Mycology&#58 An International Journal on Fungal Biology · doi:10.1080/21501203.2023.2249492 · Cited by 4 · see citing works

Visual analysis of colorectal cancer and gut microbiota: A bibliometric analysis from 2002 to 2022

Long, D., Mao, C., Zhang, Z., Zou, J., & Zhu, Y. (2023) · Medicine · doi:10.1097/md.0000000000035727 · Cited by 4 · see citing works

Mycobiome: an underexplored kingdom in cancer

Sun, Y.-Y., & Liu, N. (2025) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00261-24 · Cited by 5 · see citing works

Biodiversity responses of gut mycobiota and bacteriophages induced by probiotic consumption

Li, J., Ma, C., Liu, X., Jiang, S., Huo, D., Cai, K., & Zhang, J. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105615 · Cited by 4 · see citing works

B-GUT reference genome database improves biomarker discovery and fungal identification in gut metagenomesPreprint

Khannous‐Lleiffe, O., & Gabaldón, T. (2025) · Research Square · doi:10.21203/rs.3.rs-6766778/v1 · Cited by 4 · see citing works

Mechanisms of intestinal flora in colorectal cancer

Li, J., Liu, L., Zhong, X. Y., & Yang, R. (2025) · Postgraduate Medical Journal · doi:10.1093/postmj/qgaf026 · Cited by 3 · see citing works

Pseudomonas aeruginosa enhances anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8+ T cells

Chen, L., Ruan, G., Zhao, X., Yi, A., Xiao, Z., Tian, Y., Cheng, Y., Chen, D., & Wei, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1553757 · Cited by 3 · see citing works

Identification of microbial species and proteins associated with colorectal cancer by reanalyzing CPTAC proteomic datasets

Canderan, J., & Ye, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-97984-3 · Cited by 3 · see citing works

The hidden players: The mycobiome of pancreatic ductal adenocarcinoma tumors

Estrin, C., Bertout, S., & Bellet, V. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128392 · Cited by 3 · see citing works

Development and treatment of colorectal cancer: Insights from multi‐kingdom microbiota

Hong, Y.-M., Song, D., Liu, N., & Wang, H. (2023) · Aging and Cancer · doi:10.1002/aac2.12063 · Cited by 3 · see citing works

Differential analysis of serum immunology and gut microbiota in patients with gastrointestinal diseases

Chen, H., Zeng, Y., Cai, G. X., Gu, W., & Yang, Y. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1323842 · Cited by 3 · see citing works

Alterations in the intestinal fungal microbiome of patients with severe fever with thrombocytopenia syndrome

Liu, M., He, S.-Y., Li, Y., Shen, J., Li, J., Li, J., Liu, Y., Wu, T., Li, J., & Hu, L. Q. (2025) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2025.102837 · Cited by 3 · see citing works

The Human Mycobiome

Zhang, H., & Zhai, B. (2025) · Current topics in microbiology and immunology · doi:10.1007/82_2025_315 · Cited by 2 · see citing works

Characteristics of cancer mycobiome in patients with acral melanoma

Huang, R., Su, X., Wang, J., Sun, Q., Kang, D., Li, L., Wu, Y., Zhao, L., Xie, Z., & Zou, Z. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-011097 · Cited by 2 · see citing works

Mycobiota dynamics in inflammatory bowel disease: Fungal biomarkers and Clostridioides difficile co-infection

Chu, X., Wang, Z., Cheng, S., Khan, A., Dong, N., Xie, S., Zheng, Q., Yang, P., & Shen, H. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.108000 · Cited by 2 · see citing works

Effect of immune-related intratumoral microbiota and host gene expression on cancer prognosis

Fu, Q., Zhao, N., Li, X., Li, Y., Tian, T., Gao, L., Cao, Y., Wang, L., Liu, J., Wang, F., et al. (2025) · mSystems · doi:10.1128/msystems.01146-25 · Cited by 2 · see citing works

Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer

Coker, O. O., Nakatsu, G., Dai, R. Z., Wu, W. K. K., Wong, S. H., Ng, S. C., Chan, F. K. L., Sung, J. J. Y., & Yu, J. (2019) · Gut · doi:10.1136/gutjnl-2018-317178 · Cited by 511 · see citing works

Gut fungal signatures in colorectal cancer and their potential for supporting diagnosis: a multi-cohort metagenomic analysis

Zhang, Z. D., Lu, T., Dong, B., Liu, J. Q., Zhang, Y., Li, S., Liu, H., Xin, L., Guan, T., Guo, H., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08403-8 · Cited by 2 · see citing works

Alterations of Gut Mycobiota Profiles in Adenoma and Colorectal Cancer

Gao, R., Xia, K., Wu, M., Zhong, H., Sun, J., Zhu, Y., Huang, L., Wu, X., Yin, L., Yang, R., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.839435 · Cited by 32 · see citing works

Features of combined gut bacteria and fungi from a Chinese cohort of colorectal cancer, colorectal adenoma, and post-operative patients

Li, X., Feng, J., Wang, Z., Liu, G., & Wang, F. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1236583 · Cited by 12 · see citing works

Dysbiosis signature of mycobiota in colon polyp and colorectal cancer

Gao, R., Kong, C., Li, H., Huang, L., Qu, X., Qin, N., & Qin, H. (2017) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-017-3085-6 · Cited by 144 · see citing works