Diagnostic potential and interactive dynamics of the colorectal cancer virome
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Abstract
Colorectal cancer is a leading cause of cancer-related death in the United States and worldwide. Its risk and severity have been linked to colonic bacterial community composition. Although human-specific viruses have been linked to other cancers and diseases, little is known about colorectal cancer virus communities. We addressed this knowledge gap by identifying differences in colonic virus communities in the stool of colorectal cancer patients and how they compared to bacterial community differences. The results suggested an indirect role for the virome in impacting colorectal cancer by modulating the associated bacterial community. These findings both support the idea of a biological role for viruses in colorectal cancer and provide a new understanding of basic colorectal cancer etiology.
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The enteric virome and mycobiome have been linked with colorectal cancer.
“The enteric virome and mycobiome (fungal microbiome) have also been linked with CRC.72–74”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [74]
These findings indicate an interaction between the virome and bacteriome in colorectal cancer risk.
“These findings indicate an interaction between the virome and bacteriome in risk of CRC.72, 74”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [74]
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- Authors
- Hannigan, G. D., Duhaime, M. B., Ruffin, M. T., Koumpouras, C. C., & Schloss, P. D.
- Affiliations
- University of Michigan (US)
- Pennsylvania State University (US)
- Corresponding author
- Schloss, Patrick D.
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2018-12-21
- Volume
- 9
- Issue
- 6
- ISSN
- 2150-7511 (ISSN-L)
- 2161-2129
- PMC
- PMC6247079
- OpenAlex
- W2950868848
- Cited by
- 298
- References
- 53
- Citations by year
- 2026: 32 · 2025: 40 · 2024: 34 · 2023: 45 · 2022: 48 · 2021: 52 · 2020: 18 · 2019: 25 · 2018: 1 · 2017: 2 · 2016: 1
- FWCI
- 18.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mBio (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- HHS | National Institutes of Health (P30DK034933, T32AI007528, 5U01CA86400)
- Topics
- Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- colorectal cancer, virome, human viruses, colonic microbiota, gut bacterial community, cancer etiology, viral-bacterial interactions, cancer diagnosis
- MeSH terms
- Bacteria, Bacteriophages, Feces, Humans, RNA, Ribosomal, 16S, Viruses, Colorectal Neoplasms, Cohort Studies, Metagenomics, Microbiota
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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