Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers
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BACKGROUND: Alterations of gut microbiota are associated with colorectal cancer (CRC) in different populations and several bacterial species were found to contribute to the tumorigenesis. The potential use of gut microbes as markers for early diagnosis has also been reported. However, cohort specific noises may distort the structure of microbial dysbiosis in CRC and lead to inconsistent results among studies. In this regard, our study targeted at exploring changes in gut microbiota that are universal across populations at species level. RESULTS: Based on the combined analysis of 526 metagenomic samples from Chinese, Austrian, American, and German and French cohorts, seven CRC-enriched bacteria (Bacteroides fragilis, Fusobacterium nucleatum, Porphyromonas asaccharolytica, Parvimonas micra, Prevotella intermedia, Alistipes finegoldii, and Thermanaerovibrio acidaminovorans) have been identified across populations. The seven enriched bacterial markers classified cases from controls with an area under the receiver-operating characteristics curve (AUC) of 0.80 across the different populations. Abundance correlation analysis demonstrated that CRC-enriched and CRC-depleted bacteria respectively formed their own mutualistic networks, in which the latter was disjointed in CRC. The CRC-enriched bacteria have been found to be correlated with lipopolysaccharide and energy biosynthetic pathways. CONCLUSIONS: Our study identified potential diagnostic bacterial markers that are robust across populations, indicating their potential universal use for non-invasive CRC diagnosis. We also elucidated the ecological networks and functional capacities of CRC-associated microbiota.
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A meta-analysis of four case-control metagenome studies found Bacteroides fragilis was the only species consistently enriched in intestinal microbiomes of colorectal cancer patients worldwide.
“A meta-analysis of 4 case–control studies of metagenomes of patients with CRC found that Bacteroides fragilis was the only species that was consistently enriched in intestinal microbiomes of patients with CRC worldwide.46”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [46]
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Cites
Cortes, C., & Vapnik, V. (1995) · Machine Learning · doi:10.1007/bf00994018 · Cited by 59,421 · see citing works
Cortes, C., & Vapnik, V. N. (1995) · Machine Learning · doi:10.1023/a:1022627411411 · Cited by 34,565 · see citing works
Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D., & Bray, F. (2015) · International Journal of Cancer · doi:10.1002/ijc.29210 · Cited by 28,766 · see citing works
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
Langille, M. G. I., Zaneveld, J., Caporaso, J. G., McDonald, D., Knights, D., Reyes, J. A., Clemente, J. C., Burkepile, D. E., Vega Thurber, R. L., Knight, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2676 · Cited by 9,116 · see citing works
AFRC, R. F. (1989) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1989.tb05105.x · Cited by 4,831 · see citing works
Kraken: ultrafast metagenomic sequence classification using exact alignments
Wood, D. E., & Salzberg, S. L. (2014) · Genome Biology · doi:10.1186/gb-2014-15-3-r46 · Cited by 4,521 · see citing works
Fixed-and random-effects models in meta-analysis.
Hedges, L. V., & Vevea, J. L. (1998) · Psychological Methods · doi:10.1037/1082-989x.3.4.486 · Cited by 2,977 · see citing works
Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718 · see citing works
Inferring Correlation Networks from Genomic Survey Data
Friedman, J., & Alm, E. J. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002687 · Cited by 2,688 · see citing works
Neutrophils in cancer: Neutral no more
Coffelt, S. B., Wellenstein, M. D., & de Visser, K. E. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.52 · Cited by 1,830 · see citing works
Metagenomic microbial community profiling using unique clade-specific marker genes
Segata, N., Waldron, L., Ballarini, A., Narasimhan, V., Jousson, O., & Huttenhower, C. (2012) · Nature Methods · doi:10.1038/nmeth.2066 · Cited by 1,776 · see citing works
Gut microbiome development along the colorectal adenoma-carcinoma sequence
Feng, Q., Liang, S., Jia, H., Stadlmayr, A., Tang, L., Lan, Z., Zhang, D., Xia, H., Xu, X., Jie, Z., et al. (2015) · Nature Communications · doi:10.1038/ncomms7528 · Cited by 1,506 · see citing works
Self-citationGur, C., Ibrahim, Y., Isaacson, B., Yamin, R., Abed, J., Gamliel, M., Enk, J., Bar-On, Y., Stanietsky-Kaynan, N., Coppenhagen-Glazer, S., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.01.010 · Cited by 1,490 · see citing works
Rainer Breitling, A., Armengaud, P., Anna Amtmann, A., & Herzyk, P. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.055 · Cited by 1,478 · see citing works
Potential of fecal microbiota for early-stage detection of colorectal cancer
Zeller, G., Tap, J., Voigt, A. Y., Sunagawa, S., Kultima, J. R., Costea, P. I., Amiot, A., Böhm, J., Brunetti, F., Habermann, N., et al. (2014) · Molecular Systems Biology · doi:10.15252/msb.20145645 · Cited by 1,375 · see citing works
Probiotics in man and animals.
Fuller, R. (1989) · PubMed · Cited by 1,292 · see citing works
Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers
Wang, T., Cai, G., Qiu, Y., Fei, N., Zhang, M., Pang, X., Jia, W., Cai, S., & Zhao, L. (2012) · The ISME Journal · doi:10.1038/ismej.2011.109 · Cited by 1,287 · see citing works
Self-citationYu, J. Q., Feng, Q., Wong, S. H., Zhang, D., Liang, Q. Y., Qin, Y., Tang, L., Zhao, H., Stenvang, J., Li, Y., et al. (2015) · Gut · doi:10.1136/gutjnl-2015-309800 · Cited by 1,247 · see citing works
Metabolic Reconstruction for Metagenomic Data and Its Application to the Human Microbiome
Abubucker, S., Segata, N., Goll, J. B., Schubert, A. M., Izard, J., Cantarel, B. L., Rodriguez-Mueller, B., Zucker, J., Thiagarajan, M., Henrissat, B., et al. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002358 · Cited by 1,050 · see citing works
The UCSC Genome Browser database: 2015 update
Rosenbloom, K., Armstrong, J., Barber, G. P., Casper, J., Clawson, H., Diekhans, M., Dreszer, T. R., Fujita, P. A., Guruvadoo, L., Haeussler, M., et al. (2014) · Nucleic Acids Res. · doi:10.1093/nar/gku1177 · Cited by 1,011 · see citing works
Rhodes, D. R., Yu, J., Sundaram, S. K., Deshpande, N., Varambally, R., Ghosh, D., Barrette, T. R., Pandey, A., & Chinnaiyan, A. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401994101 · Cited by 1,010 · see citing works
Human Gut Microbiome and Risk for Colorectal Cancer
Ahn, J., Sinha, R., Pei, Z., Dominianni, C., Wu, J., Shi, J., Goedert, J. J., Hayes, R. B., & Yang, L. (2013) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djt300 · Cited by 947 · see citing works
Characterizing and measuring bias in sequence data
Ross, M. G., Russ, C., Costello, M., Hollinger, A., Lennon, N. J., Hegarty, R., Nusbaum, C., & Jaffe, D. B. (2013) · Genome Biology · doi:10.1186/gb-2013-14-5-r51 · Cited by 909 · see citing works
Microbial Dysbiosis in Colorectal Cancer (CRC) Patients
Sobhani, I., Tap, J., Roudot‐Thoraval, F., Roperch, J. P., Letulle, S., Langella, P., Corthier, G., Nhieu, J. T. V., & Furet, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016393 · Cited by 832 · see citing works
RankProd: a bioconductor package for detecting differentially expressed genes in meta-analysis
Hong, F., Breitling, R., McEntee, C., Wittner, B. S., Nemhauser, J. L., & Chory, J. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl476 · Cited by 741 · see citing works
Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults
Weir, T. L., Manter, D. K., Sheflin, A. M., Barnett, B. A., Heuberger, A. L., & Ryan, E. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070803 · Cited by 642 · see citing works
Goodwin, A. C., Shields, C. E. D., Wu, S., Huso, D. L., Wu, X., Murray-Stewart, T. R., Hacker-Prietz, A., Rabizadeh, S., Woster, P. M., Sears, C. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010203108 · Cited by 612 · see citing works
Microbiota disbiosis is associated with colorectal cancer
Gao, Z., Guo, B., Gao, R., Zhu, Q., & Qin, H. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00020 · Cited by 537 · see citing works
How meta-analysis increases statistical power.
Cohn, L. D., & Becker, B. J. (2003) · Psychological Methods · doi:10.1037/1082-989x.8.3.243 · Cited by 500 · see citing works
Dichotomization of continuous variables: The implications for meta-analysis.
Hunter, J. E., & Schmidt, F. L. (1990) · Journal of Applied Psychology · doi:10.1037/0021-9010.75.3.334 · Cited by 376 · see citing works
Innate immune responses in rainbow trout (Oncorhynchus mykiss, Walbaum) induced by probiotics
Kim, D., & Austin, B. P. (2006) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2006.02.007 · Cited by 369 · see citing works
Colorectal Cancer and the Human Gut Microbiome: Reproducibility with Whole-Genome Shotgun Sequencing
Vogtmann, E., Hua, X., Zeller, G., Sunagawa, S., Voigt, A. Y., Hercog, R., Goedert, J. J., Shi, J., Bork, P., & Sinha, R. (2016) · PLOS ONE · doi:10.1371/journal.pone.0155362 · Cited by 366 · see citing works
Fecal bacteria act as novel biomarkers for noninvasive diagnosis of colorectal cancer
Liang, Q., Chiu, J., Chen, Y., Huang, Y., Higashimori, A., Fang, J., Brim, H., Ashktorab, H., Ng, S. C., Ng, S. S. M., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-1599 · Cited by 332 · see citing works
Whitmore, S. E., & Lamont, R. J. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003933 · Cited by 319 · see citing works
Wong, S. H., Kwong, T. N. Y., Chow, T.-C., Luk, A. K. C., Dai, R. Z. W., Nakatsu, G., Lam, T. Y. T., Zhang, L., Wu, J. C. Y., Chan, F. K. L., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-312766 · Cited by 310 · see citing works
Self-citationHsu, R. Y., Chan, C., Spicer, J., Rousseau, M., Giannias, B., Rousseau, S., & Ferri, L. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2833 · Cited by 270 · see citing works
Prevention of antibiotic‐associated diarrhea in children by <i>Clostridium butyricum</i> MIYAIRI
SEKI, H., SHIOHARA, M., MATSUMURA, T., MIYAGAWA, N., TANAKA, M., KOMIYAMA, A., & KURATA, S. (2003) · Pediatrics International · doi:10.1046/j.1442-200x.2003.01671.x · Cited by 253 · see citing works
Corrêa, N. B. O., Péret Filho, L. A., Penna, F. J., Lima, F. M. L. S., & Nicoli, J. R. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000159217.47419.5b · Cited by 208 · see citing works
Chen, J., & Li, H. (2013) · The Annals of Applied Statistics · doi:10.1214/12-aoas592 · Cited by 191 · cited 1× · see citing works
“To evaluate the statistical power of rank sum metaanalysis method, we simulated microbial composition data following Dirichlet-multinomial distribution [46].”
Shah, M. S., DeSantis, T. Z., Weinmaier, T., McMurdie, P. J., Cope, J. L., Altrichter, A., Yamal, J.-M., & Hollister, E. B. (2018) · Gut · doi:10.1136/gutjnl-2016-313189 · Cited by 180 · see citing works
Safety Assessment of the Oral Cavity Probiotic Streptococcus salivarius K12
Burton, J. P., Wescombe, P. A., Moore, C. J., Chilcott, C. N., & Tagg, J. R. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.4.3050-3053.2006 · Cited by 177 · see citing works
Chen, J., & Li, H. (2011) · Cited by 154 · see citing works
Chang, L., Lin, H., Sibille, E. L., & Tseng, G. C. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-368 · Cited by 135 · see citing works
Diversified pattern of the human colorectal cancer microbiome
Geng, J., Fan, H., Tang, X., Zhai, H., & Zhang, Z. (2013) · Gut Pathogens · doi:10.1186/1757-4749-5-2 · Cited by 126 · see citing works
Li, J., & Tseng, G. C. (2011) · The Annals of Applied Statistics · doi:10.1214/10-aoas393 · Cited by 121 · see citing works
Horz, H., Meinelt, A., Houben, B., & Conrads, G. (2007) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.2007.00334.x · Cited by 120 · see citing works
Probiotics Clostridium Butyricum and Bacillus Subtilis Ameliorate Intestinal Tumorigenesis
Chen, Z., Ai, L., Wang, J., Ren, L.-L., Yu, Y., Xu, J., Chen, H., Yu, J. Q., Li, M., Qin, W., et al. (2015) · Future Microbiology · doi:10.2217/fmb.15.66 · Cited by 113 · see citing works
Comparison study of microarray meta-analysis methods
Campain, A. E., & Yang, J. Y. H. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-408 · Cited by 100 · see citing works
Prideaux, L., Kang, S., Wagner, J., Buckley, M. J., Mahar, J. E., Cruz, P. P. D., Wen, Z., Chen, L., Xia, B., van Langenberg, D. R., et al. (2013) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000435759.05577.12 · Cited by 90 · see citing works
Chong, C. W., Ahmad, A. F., Lim, Y. A. L., Teh, C. S. J., Yap, I. K. S., Lee, S. C., Chin, Y. T., Loke, P., & Chua, K. H. (2015) · Scientific Reports · doi:10.1038/srep13338 · Cited by 81 · see citing works
Molecular Identification of Potentially Probiotic Lactobacilli
Roy, D., Ward, P., Vincent, D., & Mondou, F. (2000) · Current Microbiology · doi:10.1007/s002849910008 · Cited by 73 · see citing works
Rousseau, M., Hsu, R. Y. C., Spicer, J. D., McDonald, B., Chan, C. H. F., Perera, R. M., Giannias, B., Chow, S. C., Rousseau, S., Law, S. Y.-K., et al. (2013) · Surgery · doi:10.1016/j.surg.2013.03.006 · Cited by 44 · see citing works
Kwok, L., Zhang, J., Guo, Z., Gesudu, Q., Zheng, Y., Qiao, J., Huo, D., & Zhang, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093631 · Cited by 41 · see citing works
Zhao, L., Zhang, X., Zuo, T., & Yu, J. Q. (2017) · Engineering · doi:10.1016/j.eng.2017.01.012 · Cited by 33 · see citing works
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Wirbel, J., Pyl, P. T., Kartal, E., Zych, K., Kashani, A., Milanese, A., Fleck, J. S., Voigt, A. Y., Palleja, A., Ponnudurai, R., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0406-6 · Cited by 1,373 · see citing works
Gut microbiota in colorectal cancer: mechanisms of action and clinical applications
Wong, S. H., & Yu, J. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0209-8 · Cited by 1,355 · see citing works
Thomas, A. M., Manghi, P., Asnicar, F., Pasolli, E., Armanini, F., Zolfo, M., Beghini, F., Manara, S., Karcher, N., Pozzi, C., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0405-7 · Cited by 1,030 · see citing works
The future of cystic fibrosis care: a global perspective
Bell, S. C., Mall, M. A., Gutierrez, H., Macek, M., Madge, S. L., Davies, J. C., Burgel, P., Tullis, E., Castaños, C., Castellani, C., et al. (2019) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(19)30337-6 · Cited by 1,042 · see citing works
Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer
Song, M., Chan, A. T., & Sun, J. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.06.048 · Cited by 752 · see citing works
Gut microbiota in colorectal cancer development and therapy
Wong, C. C., & Yu, J. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00766-x · Cited by 751 · see citing works
Wu, Z., Huang, S., Li, T., Li, N., Han, D., Zhang, B., Xu, Z. Z., Zhang, S., Pang, J., Wang, S., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01115-9 · Cited by 700 · see citing works
Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer
Fong, W., Li, Q., & Yu, J. Q. (2020) · Oncogene · doi:10.1038/s41388-020-1341-1 · Cited by 625 · see citing works
High-Fat Diet Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites
Yang, J., Wei, H., Zhou, Y., Szeto, C. H., Li, C., Lin, Y., Coker, O. O., Lau, H. C.-H., Chan, A. W. H., Sung, J. J. �., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.08.041 · Cited by 540 · see citing works
Colorectal Cancer: Epidemiology, Risk Factors, and Prevention
Roshandel, G., Ghasemi‐Kebria, F., & Malekzadeh, R. (2024) · Cancers · doi:10.3390/cancers16081530 · Cited by 476 · see citing works
The role of gut microbiota in cancer treatment: friend or foe?
Cheng, W. Y., Wu, C.-Y., & Yu, J. (2020) · Gut · doi:10.1136/gutjnl-2020-321153 · Cited by 384 · see citing works
Self-citationMicrobiome and colorectal cancer: Roles in carcinogenesis and clinical potential
Saus, E., Iraola‐Guzmán, S., Willis, J. R., Brunet‐Vega, A., & Gabaldón, T. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.05.001 · Cited by 348 · see citing works
Liang, Q., Li, T., Nakatsu, G., Chen, Y., Yau, T. O., Chu, E. S., Wong, S. H., Szeto, C. H., Ng, S. C., Chan, F. K. L., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-318532 · Cited by 344 · see citing works
Liu, N.-N., Jiao, N., Tan, J.-C., Wang, Z., Wu, D., Wang, A.-J., Chen, J., Tao, L., Zhou, C., Fang, W., et al. (2022) · Nature Microbiology · doi:10.1038/s41564-021-01030-7 · Cited by 306 · see citing works
Fong, W., Li, Q., Ji, F., Liang, W., Lau, H. C.-H., Kang, X., Liu, W., To, K. K. W., Zuo, Z., Li, X., et al. (2023) · Gut · doi:10.1136/gutjnl-2023-329543 · Cited by 325 · see citing works
Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer
Qu, R., Zhang, Y., Ma, Y., Zhou, X., Sun, L., Jiang, C., Zhang, Z., & Fu, W. (2023) · Advanced Science · doi:10.1002/advs.202205563 · Cited by 303 · see citing works
Sugimura, N., Li, Q., Chu, E. S., Lau, H. C.-H., Fong, W., Liu, W., Liang, C., Nakatsu, G., Su, A. C. Y., Coker, O. O., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-323951 · Cited by 288 · see citing works
Topçuoğlu, B. D., Lesniak, N. A., Ruffin, M. T., Wiens, J., & Schloss, P. D. (2020) · mBio · doi:10.1128/mbio.00434-20 · Cited by 278 · see citing works
Kong, C., Liang, L., Liu, G., Du, L., Yang, Y., Liu, J., Shi, D., Li, X., & Ma, Y. (2023) · Gut · doi:10.1136/gutjnl-2022-327156 · Cited by 254 · see citing works
Streptococcus thermophilus Inhibits Colorectal Tumorigenesis Through Secreting β-Galactosidase
Li, Q., Hu, W., Liu, W., Zhao, L., Huang, D., Liu, X., Chan, H., Zhang, Y., Zeng, J., Coker, O. O., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.09.003 · Cited by 254 · see citing works
Microbiome in Colorectal Cancer: How to Get from Meta-omics to Mechanism?
Ternes, D., Karta, J., Tsenkova, M., Wilmes, P., Haan, S., & Letellier, E. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2020.01.001 · Cited by 256 · see citing works
Wei, W., Wong, C. C., Jia, Z., Liu, W., Liu, C., Ji, F., Pan, Y., Wang, F., Wang, G., Zhao, L., et al. (2023) · Nature Microbiology · doi:10.1038/s41564-023-01418-7 · Cited by 252 · see citing works
Gupta, A., Dhakan, D. B., Maji, A., Saxena, R., K., V., Mahajan, S., Pulikkan, J., Kurian, J., Gomez, A. M., Scaria, J., et al. (2019) · mSystems · doi:10.1128/msystems.00438-19 · Cited by 229 · see citing works
Hou, Y., Li, J., & Ying, S. (2023) · Metabolites · doi:10.3390/metabo13111166 · Cited by 225 · see citing works
Xia, Y. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.04.003 · Cited by 217 · see citing works
Colorectal Cancer: From Risk Factors to Oncogenesis
Ionescu, V. A., Gheorghe, G., Bacalbaşa, N., Chiotoroiu, A. L., & Diaconu, C. C. (2023) · Medicina · doi:10.3390/medicina59091646 · Cited by 225 · see citing works
On the limits of 16S rRNA gene-based metagenome prediction and functional profiling
Matchado, M. S., Rühlemann, M. C., Reitmeier, S., Kacprowski, T., Frost, F., Haller, D., Baumbach, J., & List, M. (2024) · Microbial Genomics · doi:10.1099/mgen.0.001203 · Cited by 206 · see citing works
Understanding the role of the gut microbiome in gastrointestinal cancer: A review
Ağagündüz, D., Cocozza, E., Cemali, Ö., Bayazıt, A. D., Nanì, M. F., Cerqua, I., Morgillo, F., Saygılı, S. K., Berni Canani, R., Amero, P., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1130562 · Cited by 189 · see citing works
Osman, M. A., Neoh, H., Mutalib, N. A., Chin, S., Mazlan, L., Ali, R. A. R., Zakaria, A. D., Ngiu, C. S., Ang, M. Y., & Jamal, R. (2021) · Scientific Reports · doi:10.1038/s41598-021-82465-0 · Cited by 185 · see citing works
Gut Microbiota Dysbiosis Drives the Development of Colorectal Cancer
Fan, X., Jin, Y., Chen, G., Ma, X., & Zhang, L. (2020) · Digestion · doi:10.1159/000508328 · Cited by 169 · see citing works
Yang, Y., Li, L., Xu, C., Wang, Y., Wang, Z., Chen, M., Zhou, J., Pan, J., Yang, C., Li, X., et al. (2020) · Gut · doi:10.1136/gutjnl-2020-320777 · Cited by 162 · see citing works
Gut Microbiota in Colorectal Cancer: Biological Role and Therapeutic Opportunities
Pandey, H., Tang, D. W. T., Wong, S. H., & Lal, D. (2023) · Cancers · doi:10.3390/cancers15030866 · Cited by 165 · see citing works
Zhao, R., Coker, O. O., Wu, J., Zhou, Y., Zhao, L., Nakatsu, G., Bian, X., Wei, H., Chan, A. W. H., Sung, J. J. �., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.05.004 · Cited by 161 · see citing works
Xia, X., Wu, W. K. K., Wong, S. H., Liu, D., Kwong, T. N. Y., Nakatsu, G., Yan, P. S., Chuang, Y., Chan, M. W. Y., Coker, O. O., et al. (2020) · Microbiome · doi:10.1186/s40168-020-00847-4 · Cited by 153 · see citing works
Tito, R. Y., Verbandt, S., Vázquez, M. A., Lahti, L., Verspecht, C., Lloréns‐Rico, V., Vieira‐Silva, S., Arts, J., Falony, G., Dekker, E., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-02963-2 · Cited by 162 · see citing works
Yang, J., McDowell, A., Kim, E. K., Seo, H., Lee, W. H., Moon, C. M., Kym, S.-M., Lee, D. H., Park, Y. S., Jee, Y., et al. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0313-4 · Cited by 147 · see citing works
The gut microbiome: what the oncologist ought to know
Lee, K. A., Luong, M., Shaw, H. M., Nathan, P., Bataille, V. A., & Spector, T. D. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01467-x · Cited by 151 · see citing works
Lin, Y., Lau, H. C.-H., Liu, Y., Kang, X., Wang, Y., Ting, N. L.-N., Kwong, T. N.-Y., Han, J., Liu, W., Liu, C., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.06.038 · Cited by 142 · see citing works
Self-citationZhao, L., Zhang, X., Zhou, Y., Fu, K., Lau, H. C.-H., Chun, T. W.-Y., Cheung, A. H. K., Coker, O. O., Wei, H., Wu, W. K. K., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02395-7 · Cited by 142 · see citing works
Jian, X., Zhu, Y., Ouyang, J., Wang, Y., Lei, Q., Xia, J., Guan, Y., Zhang, J., Guo, J., He, Y., et al. (2020) · Microbiome · doi:10.1186/s40168-020-00854-5 · Cited by 138 · see citing works
Colorectal cancer and gut microbiota studies in China
Wang, Z., Dan, W., Zhang, N., Fang, J., & Yang, Y. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2236364 · Cited by 145 · see citing works
Gethings-Behncke, C., Coleman, H. G., Jordão, H. W. T., Longley, D. B., Crawford, N., Murray, L., & Kunzmann, A. T. (2020) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-18-1295 · Cited by 137 · see citing works
Lu, K., Dong, S., Wu, X., Jin, R., & Chen, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.638148 · Cited by 133 · see citing works
Li, Q., Chan, H., Liu, W., Liu, C., Zhou, Y., Huang, D., Wang, X., Li, X., Xie, C., Liu, W. Y.-Z., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.06.011 · Cited by 124 · see citing works
Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer
Sun, L., Zhang, Y., Cai, J., Rimal, B., Rocha, E. R., Coleman, J. P., Zhang, C., Nichols, R. G., Luo, Y., Kim, B., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36089-9 · Cited by 122 · see citing works
Montalban‐Arques, A., & Scharl, M. M. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.09.050 · Cited by 118 · see citing works
Integrated approaches for precision oncology in colorectal cancer: The more you know, the better
Andrei, P., Battuello, P., Grasso, G., Rovera, E., Tesio, N., & Bardelli, A. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.04.007 · Cited by 113 · see citing works
Wang, J., Liu, Z., Xu, Y., Wang, Y., Wang, F., Zhang, Q., Ni, C., Yi, Z., Xu, R. C., Liu, Q., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.913815 · Cited by 112 · see citing works
Coker, J. K. C., Moyne, O., Rodionov, D. A., & Zengler, K. (2021) · Gut Microbes · doi:10.1080/19490976.2020.1869502 · Cited by 112 · see citing works
Cueva, C., Silva, M., Pinillos, I., Bartolomé, B., & Moreno-Arribas, M. (2020) · Nutrients · doi:10.3390/nu12030625 · Cited by 99 · see citing works
Avuthu, N., & Guda, C. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.00013-22 · Cited by 112 · see citing works
The gut microbiota associated with high‐Gleason prostate cancer
Matsushita, M., Fujita, K., Motooka, D., Hatano, K., Fukae, S., Kawamura, N., Tomiyama, E., Hayashi, Y., Banno, E., Takao, T., et al. (2021) · Cancer Science · doi:10.1111/cas.14998 · Cited by 103 · see citing works
Mouradov, D., Greenfield, P. A., Li, S., In, E.-J., Storey, C., Sakthianandeswaren, A., Georgeson, P., Buchanan, D. D., Ward, R. L., Hawkins, N. J., et al. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.03.205 · Cited by 105 · see citing works
Clinical applications of gut microbiota in cancer biology
Wong, S. H., Kwong, T. N. Y., Wu, C., & Yu, J. Q. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.05.003 · Cited by 100 · see citing works
Tarallo, S., Ferrero, G., Gallo, G., Francavilla, A., Clerico, G. F., Luc, A. R., Manghi, P., Thomas, A. M., Vineis, P., Segata, N., et al. (2019) · mSystems · doi:10.1128/msystems.00289-19 · Cited by 100 · see citing works
Keung, W.-S., Zhang, W.-H., Luo, H.-Y., Chan, K.-C., Chan, Y.-M., & Xu, J. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.123209 · Cited by 100 · see citing works
Probiotics and postbiotics in colorectal cancer: Prevention and complementary therapy
Kvaková, M., Kamlárová, A., Štofilová, J., Benetinová, V., & Bertková, I. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i27.3370 · Cited by 99 · see citing works
Proteome specialization of anaerobic fungi during ruminal degradation of recalcitrant plant fiber
Hagen, L. H., Brooke, C. G., Shaw, C. A., Norbeck, A. D., Piao, H., Arntzen, M. Ø., Olson, H. M., Copeland, A., Isern, N., Shukla, A. K., et al. (2020) · The ISME Journal · doi:10.1038/s41396-020-00769-x · Cited by 98 · see citing works
Chen, H., Zhang, F., Zhang, J., Zhang, X., Guo, Y., & Yao, Q. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.588079 · Cited by 96 · see citing works
Large-scale microbiome data integration enables robust biomarker identification
Xiao, L., Zhang, F., & Zhao, F. (2022) · Nature Computational Science · doi:10.1038/s43588-022-00247-8 · Cited by 98 · see citing works
Role of Gut Microbiota and Probiotics in Colorectal Cancer: Onset and Progression
Torres-Maravilla, E., Boucard, A.-S., Mohseni, A. H., Taghinezhad‐S, S., Cortes‐Perez, N. G., & Bermúdez‐Humarán, L. G. (2021) · Microorganisms · doi:10.3390/microorganisms9051021 · Cited by 96 · see citing works
The adhesin RadD enhances Fusobacterium nucleatum tumour colonization and colorectal carcinogenesis
Zhang, L., Leng, X.-X., Qi, J., Wang, N., Han, J., Tao, Z., Zhuang, Z.-Y., Ren, Y., Xie, Y., Jiang, S., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01784-w · Cited by 97 · see citing works
Carcinogenic microbiota and its role in colorectal cancer development
Karpiński, T. M. M., Ożarowski, M., & Stasiewicz, M. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.01.004 · Cited by 93 · see citing works
Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma
Jia, W. P., Rajani, C., Xu, H., & Zheng, X. (2020) · Protein & Cell · doi:10.1007/s13238-020-00748-0 · Cited by 88 · see citing works
Microbiome distinctions between the CRC carcinogenic pathways
DeDecker, L. C., Coppedge, B., Avelar‐Barragan, J., Karnes, W. E., & Whiteson, K. (2021) · Gut Microbes · doi:10.1080/19490976.2020.1854641 · Cited by 90 · see citing works
Chang, Y., Huang, Z., Hou, F., Liu, Y., Wang, L., Wang, Z., Sun, Y., Pan, Z., Tan, Y., Ding, L., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02572-2 · Cited by 89 · see citing works
Advances in tests for colorectal cancer screening and diagnosis
Chan, S. C. H., & Liang, Q. (2022) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2022.2065197 · Cited by 85 · see citing works
Lo, C., Wu, D., Jao, S., Wu, C., Lin, C., Chuang, C.-H., Lin, Y.-B., Chen, C.-H., Chen, Y.-T., Chen, J., et al. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00869-0 · Cited by 88 · see citing works
Dalal, N., Jalandra, R., Sharma, M., Prakash, H., Makharia, G. K., Solanki, P. R., Singh, R. K., & Kumar, A. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110648 · Cited by 89 · see citing works
Mucins, gut microbiota, and postbiotics role in colorectal cancer
Pothuraju, R., Chaudhary, S., Rachagani, S., Kaur, S., Roy, H. K., Bouvet, M., & Batra, S. K. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1974795 · Cited by 84 · see citing works
The Role of Microbiota in Gastrointestinal Cancer and Cancer Treatment: Chance or Curse?
Smet, A., Kupčinskas, J., Link, A., Hold, G. L., & Bornschein, J. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.08.013 · Cited by 86 · see citing works
Mechanism and strategies of immunotherapy resistance in colorectal cancer
Shan, J., Han, D. H., Shen, C., Lei, Q., & Zhang, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1016646 · Cited by 82 · see citing works
Liu, Y., Pei, Z., Pan, T., Wang, H., Chen, W., & Lu, W. (2023) · Microbiological Research · doi:10.1016/j.micres.2023.127392 · Cited by 87 · see citing works
Xie, M., Yuan, K., Zhang, Y., Zhang, Y., Zhang, R., Gao, J., Wei, W., Jiang, L., Li, T., Ding, Y., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.07.012 · Cited by 85 · see citing works
The Human Microbiome in Relation to Cancer Risk: A Systematic Review of Epidemiologic Studies
Huybrechts, I., Zouiouich, S., Loobuyck, A., Vandenbulcke, Z., Vogtmann, E., Pisanu, S., Iguacel, I., Scalbert, A., Indave, I., Smelov, V., et al. (2020) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-20-0288 · Cited by 80 · see citing works
Intestinal Microbiota Is Altered in Patients with Gastric Cancer from Shanxi Province, China
Qi, Y.-F., Sun, J., Ren, L., Cao, X.-L., Dong, J.-H., Tao, K. X., Guan, X., Cui, Y.-N., & Su, W. (2018) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-5411-y · Cited by 80 · see citing works
Martin‐Gallausiaux, C., Salesse, L., Garcia-Weber, D., Marinelli, L., Béguet-Crespel, F., Brochard, V., Gléau, C. L., Jamet, A., Dore, J. M., Blottière, H. M., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2295384 · Cited by 84 · see citing works
Li, L., He, S., Liao, B., Wang, M., Lin, H., Hu, B., Lan, X., Shu, Z., Zhang, C., Yu, M., et al. (2024) · Research · doi:10.34133/research.0364 · Cited by 79 · see citing works
Gut microbiome in gastrointestinal cancer: a friend or foe?
Liu, Y., Baba, Y., Ishimoto, T., Gu, X. J., Zhang, J., Nomoto, D., Okadome, K., Baba, H., & Qiu, P. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.69331 · Cited by 80 · see citing works
Burgos-Molina, A. M., Santana, T. T., Redondo, M., & Romero, M. J. B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116188 · Cited by 82 · see citing works
Ding, X. Q., Ting, N. L.-N., Wong, C. C., Huang, P., Бакурадзе, Н., Jiang, L., Liu, C., Lin, Y., Li, S., Liu, Y., et al. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.05.004 · Cited by 81 · see citing works
Yeoh, Y. K., Chen, Z., Wong, M. C. S., Hui, M., Yu, J., Ng, S. C., Sung, J. J. �., Chan, F. K. L., & Chan, P. K. S. (2020) · Gut · doi:10.1136/gutjnl-2019-319635 · Cited by 74 · see citing works
Establishment of the early-life microbiome: a DOHaD perspective
Stinson, L. F. (2019) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174419000588 · Cited by 77 · see citing works
Lactobacillus reuteri in digestive system diseases: focus on clinical trials and mechanisms
Peng, Y., Ma, Y., Luo, Z., Jiang, Y.-F., Xu, Z., & Yu, R. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1254198 · Cited by 77 · see citing works
Yang, J., Li, D., Yang, Z., Dai, W., Feng, X., Liu, Y., Jiang, Y., Li, P., Li, Y., Tang, B., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1712986 · Cited by 73 · see citing works
Véziant, J., Villéger, R., Barnich, N., & Bonnet, M. (2021) · Cancers · doi:10.3390/cancers13092215 · Cited by 72 · see citing works
Su, A. C. Y., Ding, X. Q., Lau, H. C.-H., Kang, X., Li, Q., Wang, X., Liu, Y., Jiang, L., Lu, Y., Liu, W., et al. (2024) · Gut · doi:10.1136/gutjnl-2023-330835 · Cited by 73 · see citing works
Altered gut microbiome composition by appendectomy contributes to colorectal cancer
Shi, F., Liu, G., Lin, Y., Guo, C. L., Han, J. Y., Chu, E. S., Shi, C., Li, Y., Zhang, H., Hu, C., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02569-3 · Cited by 75 · see citing works
Cancer-fighting potentials of algal polysaccharides as nutraceuticals
Ouyang, Y., Qiu, Y., Liu, Y., Zhu, R., Chen, Y., El-Seedi, H. R., Chen, X., & Zhao, C. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110522 · Cited by 71 · see citing works
Bacterial community structure alterations within the colorectal cancer gut microbiome
Loftus, M. G., Hassouneh, S. A.-D., & Yooseph, S. (2021) · BMC Microbiology · doi:10.1186/s12866-021-02153-x · Cited by 69 · see citing works
Microbe-based therapies for colorectal cancer: Advantages and limitations
Saeed, M., Shoaib, A., Kandimalla, R., Javed, S., Almatroudi, A., Gupta, R. C., & Aqil, F. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.018 · Cited by 69 · see citing works
Statistical normalization methods in microbiome data with application to microbiome cancer research
Xia, Y. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2244139 · Cited by 71 · see citing works
Wang, M., Zhou, B., Cong, W., Zhang, M., Li, Z., Li, Y., Liang, S., Chen, K., Yang, D., & Wu, Z. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.797605 · Cited by 71 · see citing works
Modulation of Gut Microbiota to Enhance Effect of Checkpoint Inhibitor Immunotherapy
Wu, J., Wang, S., Zheng, B. J., Qiu, X., Wang, H., & Chen, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.669150 · Cited by 70 · see citing works
Role of gut microbiota in epigenetic regulation of colorectal Cancer
Zhao, Y., Wang, C., & Goel, A. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188490 · Cited by 68 · see citing works
Fernández, J., Ledesma, E., Monte, J., Millán, E., Costa, P., de la Fuente, V. G., García, M. T. F., Martínez‐Camblor, P., Villar, C. J., & Lombó, F. (2019) · Scientific Reports · doi:10.1038/s41598-019-51437-w · Cited by 65 · see citing works
Taylor, J. C., Gao, X., Xu, J., Holder, M., Petrosino, J. F., Kumar, R., Liu, W., Höök, M., Mackenzie, C., Hillhouse, A., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009182 · Cited by 62 · see citing works
Wei, X., Wang, F., Tan, P., Huang, H., Wang, Z., Xie, J., Wang, L., Liu, D., & Hu, Z. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107148 · Cited by 68 · see citing works
de Carvalho, A. C., Pereira, L. D. M., Datorre, J. G., dos Santos, W., Berardinelli, G. N., Matsushita, M. D. M., de Oliveira, M. A., Durães, R. O., Guimarães, D. P., & Reis, R. M. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00813 · Cited by 63 · see citing works
Pu, L. Z. C. T., Yamamoto, K., Honda, T., Nakamura, M., Yamamura, T., Hattori, S., Burt, A. D., Singh, R., Hirooka, Y., & Fujishiro, M. (2019) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.14868 · Cited by 61 · see citing works
- Authors
- Dai, Z., Coker, O. O., Nakatsu, G., Wu, W. K. K., Zhao, L., Chen, Z., Chan, F. K. L., Kristiansen, K., Sung, J. J. Y., Wong, S. H., & Yu, J.
- Affiliations
- Chinese University of Hong Kong (HK)
- BGI Group (China) (CN)
- Corresponding author
- Wong, Sunny Hei
- Yu, Jun
- ORCID
- Venue
- Microbiome
- Published
- 2018-04-11
- Volume
- 6
- Issue
- 1
- Pages
- 70-70
- ISSN
- 2049-2618 (ISSN-L)
- PMC
- PMC5896039
- OpenAlex
- W2796803893
- Cited by
- 545
- References
- 54
- Citations by year
- 2026: 43 · 2025: 70 · 2024: 99 · 2023: 97 · 2022: 67 · 2021: 78 · 2020: 53 · 2019: 29 · 2018: 8
- FWCI
- 14.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Microbiome (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- RGC-GRF (766613, 14106145, 14111216)
- 135 Program Project China (2016YFC1303200)
- 973 Program China (2013CB531401)
- National Key Technology R&D Program (2014BAI09B05)
- Shenzhen Virtual University Park Support Scheme to CUHK Shenzhen Research Institute
- Croucher Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- colorectal cancer, gut microbiota, metagenomics, bacterial markers, Bacteroides fragilis, Fusobacterium nucleatum, Porphyromonas asaccharolytica, Parvimonas micra, Prevotella intermedia, Alistipes finegoldii, dysbiosis, microbial co-occurrence networks, non-invasive cancer diagnosis
- MeSH terms
- Gastrointestinal Microbiome, Aged, Bacteria, Cell Transformation, Neoplastic, Female, Humans, Male, Middle Aged, Colorectal Neoplasms, Computational Biology, Metagenome, Metagenomics, Gene Ontology
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