Gut mucosal microbiome across stages of colorectal carcinogenesis
Open accessAbstract
Gut microbial dysbiosis contributes to the development of colorectal cancer (CRC). Here we catalogue the microbial communities in human gut mucosae at different stages of colorectal tumorigenesis. We analyse the gut mucosal microbiome of 47 paired samples of adenoma and adenoma-adjacent mucosae, 52 paired samples of carcinoma and carcinoma-adjacent mucosae and 61 healthy controls. Probabilistic partitioning of relative abundance profiles reveals that a metacommunity predominated by members of the oral microbiome is primarily associated with CRC. Analysis of paired samples shows differences in community configurations between lesions and the adjacent mucosae. Correlations of bacterial taxa indicate early signs of dysbiosis in adenoma, and co-exclusive relationships are subsequently more common in cancer. We validate these alterations in CRC-associated microbiome by comparison with two previously published data sets. Our results suggest that a taxonomically defined microbial consortium is implicated in the development of CRC.
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Specific microbiome and metabolome changes occur across stages of colorectal neoplasia, from adenomatous polyps to early cancer to metastatic disease.
“Specific changes in the microbiome and metabolome occur during different stages of colorectal neoplasia, from adenomatous polyps to early-stage cancer to metastatic disease, supporting an etiological and diagnostic role for the microbiome.18–20”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [19]
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Self-citation
- Authors
- Nakatsu, G., Li, X., Zhou, H., Sheng, J., Wong, S. H., Wu, W. K. K., Ng, S. C., Tsoi, H., Dong, Y., Zhang, N., He, Y., Kang, Q., Cao, L., Wang, K., Zhang, J., Liang, Q., Yu, J., & Sung, J. J. Y.
- Affiliations
- Chinese University of Hong Kong (HK)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- The Military General Hospital of Beijing PLA (CN)
- Corresponding author
- Yu, Jun
- Sung, Joseph J. Y.
- ORCID
- Venue
- Nature Communications
- Published
- 2015-10-30
- Volume
- 6
- Issue
- 1
- Pages
- 8727-8727
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4640069
- OpenAlex
- W2262330054
- Cited by
- 701
- References
- 56
- Citations by year
- 2026: 54 · 2025: 62 · 2024: 72 · 2023: 90 · 2022: 90 · 2021: 85 · 2020: 82 · 2019: 60 · 2018: 47 · 2017: 37 · 2016: 22
- FWCI
- 15.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Croucher Foundation
- National Natural Science Foundation of China (973 Program, 2012AA02A506, 81272194)
- Chinese University of Hong Kong
- Shenzhen Virtual University Park
- Shenzhen Research Institute, City University of Hong Kong
- National High-tech Research and Development Program
- National Key Research and Development Program of China (2013CB531401)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Keywords
- gut microbiota, colorectal cancer, colorectal carcinogenesis, dysbiosis, colorectal adenoma, metacommunity, oral microbiota, bacterial co-occurrence networks, microbial consortia, carcinogenesis
- MeSH terms
- Gastrointestinal Microbiome, Aged, Bacteria, Female, Humans, Male, Middle Aged, Colorectal Neoplasms, Case-Control Studies, Biodiversity, Carcinogenesis, Dysbiosis
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