Cited by 701Gut microbiota and healthOral microbiology and periodontitis researchMicrobial Community Ecology and Physiology

Gut mucosal microbiome across stages of colorectal carcinogenesis

Open access
Nakatsu, Geicho, Li, Xiangchun, Zhou, Haokui, Sheng, Jianqiu, Wong, Sunny Hei, Wu, William Ka Kai, Ng, Siew Chien, Tsoi, Ho +10 more·2015·Nature Communications

Abstract

Gut microbial dysbiosis contributes to the development of colorectal cancer (CRC). Here we catalogue the microbial communities in human gut mucosae at different stages of colorectal tumorigenesis. We analyse the gut mucosal microbiome of 47 paired samples of adenoma and adenoma-adjacent mucosae, 52 paired samples of carcinoma and carcinoma-adjacent mucosae and 61 healthy controls. Probabilistic partitioning of relative abundance profiles reveals that a metacommunity predominated by members of the oral microbiome is primarily associated with CRC. Analysis of paired samples shows differences in community configurations between lesions and the adjacent mucosae. Correlations of bacterial taxa indicate early signs of dysbiosis in adenoma, and co-exclusive relationships are subsequently more common in cancer. We validate these alterations in CRC-associated microbiome by comparison with two previously published data sets. Our results suggest that a taxonomically defined microbial consortium is implicated in the development of CRC.

Verifying this paper

8 of 9 steps done · this page updates itself — you can leave and come back

  1. Registry recordVerified
  2. Full textRead the full text
  3. Reference list56 references found
  4. Reference checkChecking each cited work — 56 of 56
  5. StatisticsNeeds the full text
  6. ClaimsNeeds the full text
  7. Cited sourcesNeeds claims to check
  8. Self-checkNeeds the full text
  9. VerificationFindings verified

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/ncomms9727

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Specific microbiome and metabolome changes occur across stages of colorectal neoplasia, from adenomatous polyps to early cancer to metastatic disease.

    “Specific changes in the microbiome and metabolome occur during different stages of colorectal neoplasia, from adenomatous polyps to early-stage cancer to metastatic disease, supporting an etiological and diagnostic role for the microbiome.18–20”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Nakatsu, G., Li, X., Zhou, H., Sheng, J., Wong, S. H., Wu, W. K. K., Ng, S. C., Tsoi, H., Dong, Y., Zhang, N., He, Y., Kang, Q., Cao, L., Wang, K., Zhang, J., Liang, Q., Yu, J., & Sung, J. J. Y.
Affiliations
  • Chinese University of Hong Kong (HK)
  • The First Affiliated Hospital, Sun Yat-sen University (CN)
  • The Military General Hospital of Beijing PLA (CN)
Corresponding author
  • Yu, Jun
  • Sung, Joseph J. Y.
Venue
Nature Communications
Published
2015-10-30
Volume
6
Issue
1
Pages
8727-8727
ISSN
2041-1723 (ISSN-L)
OpenAlex
W2262330054
Cited by
701
References
56
Citations by year
2026: 54 · 2025: 62 · 2024: 72 · 2023: 90 · 2022: 90 · 2021: 85 · 2020: 82 · 2019: 60 · 2018: 47 · 2017: 37 · 2016: 22
FWCI
15.33
Type
journal article
Language
en
Open access
Locations
  • Nature Communications (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Funders
  • Croucher Foundation
  • National Natural Science Foundation of China (973 Program, 2012AA02A506, 81272194)
  • Chinese University of Hong Kong
  • Shenzhen Virtual University Park
  • Shenzhen Research Institute, City University of Hong Kong
  • National High-tech Research and Development Program
  • National Key Research and Development Program of China (2013CB531401)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
Keywords
gut microbiota, colorectal cancer, colorectal carcinogenesis, dysbiosis, colorectal adenoma, metacommunity, oral microbiota, bacterial co-occurrence networks, microbial consortia, carcinogenesis
MeSH terms
Gastrointestinal Microbiome, Aged, Bacteria, Female, Humans, Male, Middle Aged, Colorectal Neoplasms, Case-Control Studies, Biodiversity, Carcinogenesis, Dysbiosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review