Cited by 159Pancreatic and Hepatic Oncology ResearchBRCA gene mutations in cancerGenetic factors in colorectal cancer

The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.

Familial pancreatic cancer

Open access

Petersen, Gloria M.·2016·Seminars in Oncology

DOI 10.1053/j.seminoncol.2016.09.002PMC PMC5234085

Open this paper in CoChat — free account

Abstract

Familial pancreatic cancer (FPC) includes those kindreds that contain at least two first-degree relatives with pancreatic ductal adenocarcinoma. At least 12 known hereditary syndromes or genes are associated with increased risk of developing pancreatic cancer, the foremost being BRCA2 and CDKN2A. Research into the identification of mutations in known cancer predisposition genes and through next-generation sequencing has revealed extensive heterogeneity. The development of genetic panel testing has enabled genetic risk assessment and predisposition testing to be routinely offered. Precision oncology has opened the possibility of "incidental" germline mutations that may have implications for family members. However, in both cases, evidence-based recommendations for managing patients and at-risk family members in light of genetic status remain emergent, with current practice based on expert opinion.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1053/j.seminoncol.2016.09.002

Cites

69 of 69 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cancer statistics, 2016
Siegel, R. L., Miller, K. D., & Jemal, A. (2016) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21332 · Cited by 16,003
Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States
Rahib, L., Smith, B. D., Aizenberg, R., Rosenzweig, A. B., Fleshman, J. M., & Matrisian, L. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0155 · Cited by 7,094
ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing
Green, R. C., Berg, J. S., Grody, W. W., Kalia, S. S., Korf, B. R., Martin, C. L., McGuire, A. L., Nussbaum, R. L., O’Daniel, J. M., Ormond, K. E., et al. (2013) · Genetics in Medicine · doi:10.1038/gim.2013.73 · Cited by 2,544
ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes
Syngal, S., Brand, R. E., Church, J. M., Giardiello, F. M., Hampel, H. L., & Burt, R. W. (2015) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.435 · Cited by 1,662
Patients Tested at a Laboratory for Hereditary Cancer Syndromes Show an Overlap for Multiple Syndromes in Their Personal and Familial Cancer Histories
Saam, J. R., Arnell, C., Theisen, A. P., Moyes, K., Marino, I., Roundy, K. M., & WENSTRUP, R. J. (2015) · Oncology · doi:10.1159/000437307 · Cited by 1,533
Very high risk of cancer in familial Peutz–Jeghers syndrome
Giardiello, F. M., Brensinger, J. D., Tersmette, A. C., Goodman, S. N., Petersen, G. M., Booker, S. V., Cruz–Correa, M., & Offerhaus, G. J. A. (2000) · Gastroenterology · doi:10.1053/gast.2000.20228 · Cited by 1,435
Self-citation
Hereditary Pancreatitis and the Risk of Pancreatic Cancer
Lowenfels, A. B., Maisonneuve, P., DiMagno, E. P., Elitsur, Y., Gates, L. K., Perrault, J., Whitcomb, D. C., & International Hereditary Pancreatitis Study Group (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.6.442 · Cited by 988
Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene
Jones, S., Hruban, R. H., Kamiyama, M., Borges, M., Zhang, X., Parsons, D. W., Lin, J. C.-H., Palmisano, E., Brune, K., Jaffee, E. M., et al. (2009) · Science · doi:10.1126/science.1171202 · Cited by 826
International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer
Canto, M. I., Harinck, F., Hruban, R. H., Offerhaus, G. J., Poley, J.-W., Kamel, I., Nio, Y., Schulick, R. S., Bassi, C., Kluijt, I., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303108 · Cited by 784
Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds
Klein, A. P., Brune, K. A., Petersen, G. M., Goggins, M., Tersmette, A. C., Offerhaus, G. J. A., Griffin, C., Cameron, J. L., Yeo, C. J., Kern, S., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3823 · Cited by 678
Self-citation

Show all 69 references

Sorted by citations

Pancreatic cancer: Advances and challenges
Halbrook, C. J., Lyssiotis, C. A., Pasca di Magliano, M., & Maitra, A. (2023) · Cell · doi:10.1016/j.cell.2023.02.014 · Cited by 1,321
Molecular subtypes of pancreatic cancer
Collisson, E. A., Bailey, P., Chang, D. K., & Biankin, A. V. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0109-y · Cited by 892
Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer
Hu, C., Hart, S. N., Polley, E. C., Gnanaolivu, R., Shimelis, H., Lee, K. Y., Lilyquist, J., Na, J., Moore, R., Antwi, S. O., et al. (2018) · JAMA · doi:10.1001/jama.2018.6228 · Cited by 577
Self-citation
NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 1.2020
Daly, M. B., Pilarski, R., Yurgelun, M. B. B., Berry, M. P., Buys, S. S., Dickson, P., Domchek, S. M., Elkhanany, A. M., Friedman, S., Garber, J. E., et al. (2020) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2020.0017 · Cited by 517
Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma
Grossberg, A. J., Chu, L. C. H., Deig, C. R., Fishman, E. K., Hwang, W. L., Maitra, A., Marks, D. L., Mehta, A., Nabavizadeh, N., Simeone, D. M., et al. (2020) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21626 · Cited by 500
PARP inhibitors in pancreatic cancer: molecular mechanisms and clinical applications
Zhu, H., Wei, M., Xu, J., Hua, J., Chen, L., Meng, Q., Zhang, Y., Liu, J., Zhang, B., Yu, X., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01167-9 · Cited by 263
Lead-time trajectory of CA19-9 as an anchor marker for pancreatic cancer early detection
Fahrmann, J. F., Schmidt, C. M., Mao, X., Irajizad, E., Loftus, M., Zhang, J., Patel, N., Vykoukal, J., Dennison, J. B., Long, J. P., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.11.052 · Cited by 208
ASGE guideline on screening for pancreatic cancer in individuals with genetic susceptibility: summary and recommendations
Sawhney, M., Calderwood, A. H., Thosani, N. C., Rebbeck, T. R., Wani, S. B., Canto, M. I., Fishman, D. S., Golan, T., Hidalgo, M. M., Kwon, R. S., et al. (2022) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2021.12.001 · Cited by 158
The Role of BRCA Testing in Hereditary Pancreatic and Prostate Cancer Families
Pilarski, R. (2019) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_238977 · Cited by 115
Curation of the Pancreatic Ductal Adenocarcinoma Subset of the Cancer Genome Atlas Is Essential for Accurate Conclusions about Survival-Related Molecular Mechanisms
Peran, I., Madhavan, S., Byers, S. W., & McCoy, M. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0290 · Cited by 96
DNA damaging agents and DNA repair: From carcinogenesis to cancer therapy
de Almeida, L. C., Calil, F. A., Machado‐Neto, J. A., & Costa-Lotufo, L. V. (2020) · Cancer Genetics · doi:10.1016/j.cancergen.2020.12.002 · Cited by 88
A Transcriptome-Wide Association Study Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer
Zhong, J., Jermusyk, A. A., Wu, L., Hoskins, J. W., Collins, I. J., Mocci, E., Zhang, M., Song, L., Chung, C. C., Zhang, T., et al. (2019) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djz246 · Cited by 79
Self-citation
The intricate relationship between diabetes, obesity and pancreatic cancer
Paternoster, S., & Falasca, M. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.188326 · Cited by 80
BRCA mutated pancreatic cancer: A change is coming
Rosen, M. N., Goodwin, R. A., & Vickers, M. M. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i17.1943 · Cited by 75
Interplays of glucose metabolism and KRAS mutation in pancreatic ductal adenocarcinoma
Liu, Y.-H., Hu, C., Hsu, Y.-S., & Lee, W. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05259-w · Cited by 74
From Machine Learning to Patient Outcomes: A Comprehensive Review of AI in Pancreatic Cancer
Tripathi, S., Tabari, A., Mansur, A., Dabbara, H., Bridge, C. P., & Daye, D. (2024) · Diagnostics · doi:10.3390/diagnostics14020174 · Cited by 70
A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants
Earl, J., Galindo-Pumariño, C., Encinas, J., Barreto, E., Castillo, M. E., Pachón, V., Ferreiro, R., Rodríguez-Garrote, M., González-Martínez, S., y Cajal, T. R., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102675 · Cited by 50
Germline Variants and Risk for Pancreatic Cancer
Zhan, W., Shelton, C. A., Greer, P. J., Brand, R. E., & Whitcomb, D. C. (2018) · Pancreas · doi:10.1097/mpa.0000000000001136 · Cited by 50
Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort
Matejcic, M., Lesueur, F., Biessy, C., Renault, A., Mebirouk, N., Yammine, S. G., Keski‐Rahkonen, P., Li, K., Hémon, B., Weiderpass, E., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.31797 · Cited by 49
Next-Generation Sequencing in Pancreatic Cancer
Shen, G.-Q., Aleassa, E. M., Walsh, R. M., & Morris‐Stiff, G. J. (2019) · Pancreas · doi:10.1097/mpa.0000000000001324 · Cited by 45
A Transcriptome-Wide Association Study Identifies Candidate Susceptibility Genes for Pancreatic Cancer Risk
Liu, D., Zhou, D., Sun, Y., Zhu, J., Ghoneim, D. H., Wu, C., Yao, Q. C., Gamazon, E. R., Cox, N. J., & Wu, L. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-1353 · Cited by 44
A blood-based metabolomic signature predictive of risk for pancreatic cancer
Irajizad, E., Kenney, A., Tang, T. M., Vykoukal, J., Wu, R., Murage, E. N., Dennison, J. B., Sans, M., Long, J. P., Loftus, M., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101194 · Cited by 46
Advances in pancreatic cancer early diagnosis, prevention, and treatment: The past, the present, and the future
Mannucci, A., & Goel, A. (2025) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.70035 · Cited by 54
A pancreatic cancer risk prediction model (Prism) developed and validated on large-scale US clinical data
Jia, K., Kundrot, S., Palchuk, M. B., Warnick, J., Haapala, K., Kaplan, I. D., Rinard, M., & Appelbaum, L. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104888 · Cited by 40
Early detection of pancreatic cancer
Garg, S. K., & Chari, S. T. (2020) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000663 · Cited by 39
Early-onset pancreatic cancer: a review of molecular mechanisms, management, and survival
Ulanja, M. B., Moody, A. E., Beutler, B. D., Antwi‐Amoabeng, D., Rahman, G. A., & Alese, O. B. (2022) · Oncotarget · doi:10.18632/oncotarget.28242 · Cited by 38
BRCA2 gene mutation in cancer
Xie, C., Luo, J., He, Y., Jiang, L., Zhong, L., & Shi, Y. (2022) · Medicine · doi:10.1097/md.0000000000031705 · Cited by 36
Treatment opportunities and future perspectives for pancreatic cancer patients with germline BRCA1-2 pathogenic variants
Macchini, M., Centonze, F., Peretti, U., Orsi, G., Militello, A. M., Valente, M. M., Cascinu, S., & Reni, M. (2021) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2021.102262 · Cited by 34
Epigenetic Landscape in Pancreatic Ductal Adenocarcinoma: On the Way to Overcoming Drug Resistance?
Čierniková, S., Earl, J., García‐Bermejo, L., Števurková, V., Carrato, A., & Smolková, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114091 · Cited by 36
Referral frequency, attrition rate, and outcomes of germline testing in patients with pancreatic adenocarcinoma
Walker, E. J., Carnevale, J. C., Pedley, C., Blanco, A. M., Chan, S. B., Collisson, E. A., Tempero, M. A., & Ko, A. H. (2018) · Familial Cancer · doi:10.1007/s10689-018-0106-2 · Cited by 30
A systematic review of the prevalence of germline pathogenic variants in patients with pancreatic cancer
Astiazarán-Symonds, E., & Goldstein, A. M. (2021) · Journal of Gastroenterology · doi:10.1007/s00535-021-01806-y · Cited by 34
American Society for Gastrointestinal Endoscopy guideline on screening for pancreatic cancer in individuals with genetic susceptibility: methodology and review of evidence
Calderwood, A. H., Sawhney, M., Thosani, N. C., Rebbeck, T. R., Wani, S. B., Canto, M. I., Fishman, D. S., Golan, T., Hidalgo, M. M., Kwon, R. S., et al. (2022) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2021.12.002 · Cited by 30
Pancreas-targeted lipid nanoparticles for relatively non-invasive interleukin-12 mRNA therapy in orthotopic pancreatic ductal adenocarcinoma
Shen, Q., Liu, J., Zeng, L., Ren, Y., Liao, J., Chen, S., Tang, Y., Zhang, Z., Jiang, M., Liao, H., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113588 · Cited by 31
Germinal BRCA1-2 pathogenic variants (gBRCA1-2pv) and pancreatic cancer: epidemiology of an Italian patient cohort
Peretti, U., Cavaliere, A., Niger, M., Tortora, G., Marco, M. D., Rodriquenz, M. G., Centonze, F., Rapposelli, I. G., Giordano, G., Vita, F. D., et al. (2021) · ESMO Open · doi:10.1016/j.esmoop.2020.100032 · Cited by 29
Pancreatic Cancer with Mutation in BRCA1/2, MLH1, and APC Genes: Phenotype Correlation and Detection of a Novel Germline BRCA2 Mutation
Vietri, M. T., D’Elia, G., Caliendo, G., Albanese, L., Signoriello, G., Claudio Napoli, A., & Molinari, A. M. (2022) · Genes · doi:10.3390/genes13020321 · Cited by 29
The Microbiome and Pancreatic Cancer
Archibugi, L., Signoretti, M., & Capurso, G. (2018) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001092 · Cited by 26
Beyond BRCA: The Emerging Significance of DNA Damage Response and Personalized Treatment in Pancreatic and Prostate Cancer Patients
Dalmasso, B., Puccini, A., Catalano, F., Borea, R., Iaia, M. L., Bruno, W., Fornarini, G., Sciallero, S., Rebuzzi, S. E., & Ghiorzo, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094709 · Cited by 25
The Impact of Clinical and Pathological Features on Intraductal Papillary Mucinous Neoplasm Recurrence After Surgical Resection
Pflüger, M. J., Griffin, J. F., Hackeng, W. M., Kawamoto, S., Yu, J., Chianchiano, P. E., Shin, E., Lionheart, G., Tsai, H., Wang, H., et al. (2020) · Annals of Surgery · doi:10.1097/sla.0000000000004427 · Cited by 25
Hereditary and Sporadic Pancreatic Ductal Adenocarcinoma: Current Update on Genetics and Imaging
Morani, A. C., Hanafy, A. K., Ramani, N. S., Katabathina, V. S., Yedururi, S., Dasyam, A. K., & Prasad, S. R. (2020) · Radiology Imaging Cancer · doi:10.1148/rycan.2020190020 · Cited by 24
BRCA testing in a genomic diagnostics referral center during the COVID-19 pandemic
Minucci, A., Scambia, G., Santonocito, C., Concolino, P., & Urbani, A. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05479-3 · Cited by 24
Familial Pancreatic Cancer and Surveillance of High-Risk Individuals
Matsubayashi, H., Takaori, K., Morizane, C., & Kiyozumi, Y. (2019) · Gut and Liver · doi:10.5009/gnl18449 · Cited by 24
Oncology clinic-based germline genetic testing for exocrine pancreatic cancer enables timely return of results and unveils low uptake of cascade testing
Wang, Y., Golesworthy, B., Cuggia, A., Domecq, C., Chaudhury, P. K., Barkun, J. S., Metrakos, P. P., Asselah, J., Bouganim, N., Gao, Z., et al. (2021) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2021-108054 · Cited by 23
Imaging and Screening of Pancreatic Cancer
Burk, K. S., Lo, G. C., Gee, M. S., & Sahani, D. V. (2017) · Radiologic Clinics of North America · doi:10.1016/j.rcl.2017.06.006 · Cited by 23
Germline Aberrations in Pancreatic Cancer: Implications for Clinical Care
Casolino, R., Corbo, V., Beer, P. A., Hwang, C., Paiella, S., Silvestri, V., Ottini, L., & Biankin, A. V. (2022) · Cancers · doi:10.3390/cancers14133239 · Cited by 24
Earlier Diagnosis of Pancreatic Cancer: Is It Possible?
Koltai, T. (2023) · Cancers · doi:10.3390/cancers15184430 · Cited by 22
A Genome-First Approach to Estimate Prevalence of Germline Pathogenic Variants and Risk of Pancreatic Cancer in Select Cancer Susceptibility Genes
Astiazarán-Symonds, E., Kim, J., Haley, J. S., Kim, S. Y., Rao, H. S., Carey, D. J., Stewart, D. R., & Goldstein, A. M. (2022) · Cancers · doi:10.3390/cancers14133257 · Cited by 21
Management of Patients With Pancreatic Cancer Using the “Right Track” Model
Rosenzweig, A., Berlin, J. D., Chari, S. T., Kindler, H. L., Matrisian, L. M., Mayoral, A., Mills, J. B., Nissen, N. N., Picozzi, V. J., Zelada-Arenas, F., et al. (2023) · The Oncologist · doi:10.1093/oncolo/oyad080 · Cited by 20
Clinical interpretation of pathogenic ATM and CHEK2 variants on multigene panel tests: navigating moderate risk
DePersia, A., Blazer, K. R., Stoll, J., Jones, M., Weipert, C. M., Nielsen, S. M., Kupfer, S. S., Weitzel, J. N., & Olopade, O. I. (2018) · Familial Cancer · doi:10.1007/s10689-018-0070-x · Cited by 22
Potential of artificial intelligence in the risk stratification for and early detection of pancreatic cancer
Tovar, D., Rosenthal, M. H., Maitra, A., & Koay, E. J. (2023) · Artificial Intelligence Surgery · doi:10.20517/ais.2022.38 · Cited by 22
Pancreatic Cancer Screening
Das, K. K., & Early, D. S. (2017) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-017-0149-8 · Cited by 19
Genetics, Genomics and Emerging Molecular Therapies of Pancreatic Cancer
Liu, J., Mroczek, M., Mach, A., Stępień, M., Aplas, A., Pronobis‐Szczylik, B., Bukowski, S., Mielczarek, M., Gajewska, E., Topolski, P., et al. (2023) · Cancers · doi:10.3390/cancers15030779 · Cited by 18
Role of bioactive lipofishins in prevention of inflammation and colon cancer
Lombardi, V., Carrera, I., Corzo, L., & Cacabelos, R. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.11.012 · Cited by 18
A region-based gene association study combined with a leave-one-out sensitivity analysis identifies SMG1 as a pancreatic cancer susceptibility gene
Wong, C., Chen, F., Alirezaie, N., Wang, Y., Cuggia, A., Borgida, A., Holter, S., Lenko, T., Domecq, C., Initiative, A. D. N., et al. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008344 · Cited by 19
Self-citation
Proteostasis Dysregulation in Pancreatic Cancer
Arpalahti, L., Haglund, C., & Holmberg, C. I. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-38266-7_4 · Cited by 17
Negative Regulation of Serine Threonine Kinase 11 (STK11) through miR-100 in Head and Neck Cancer
Figueroa‐González, G., Carrillo, J. F., Perez-Rodriguez, I., de León, D. F. C., Campos-Parra, A. D., Martínez-Gutiérrez, A. D., Coronel-Hernández, J., García-Castillo, V., López‐Camarillo, C., Peralta-Zaragoza, Ó., et al. (2020) · Genes · doi:10.3390/genes11091058 · Cited by 16
Attitudes Toward Return of Genetic Research Results to Relatives, Including After Death: Comparison of Cancer Probands, Blood Relatives, and Spouse/Partners
Breitkopf, C. R., Wolf, S. M., Rabe, K. G., Robinson, M., Lindor, N. M., Gordon, D. R., Koenig, B. A., & Petersen, G. M. (2018) · Journal of Empirical Research on Human Research Ethics · doi:10.1177/1556264618769165 · Cited by 15
Self-citation
Building towards Precision Oncology for Pancreatic Cancer: Real-World Challenges and Opportunities
Wang, Y., Lakoma, A., & Zogopoulos, G. (2020) · Genes · doi:10.3390/genes11091098 · Cited by 14
Genetic Signature of Human Pancreatic Cancer and Personalized Targeting
Reshkin, S. J., Cardone, R. A., & Koltai, T. (2024) · Cells · doi:10.3390/cells13070602 · Cited by 14
A rare germline CDKN2A variant (47T>G; p16-L16R) predisposes carriers to pancreatic cancer by reducing cell cycle inhibition
Horn, I. P., Marks, D. L., Koenig, A. N., Hogenson, T. L., Almada, L. L., Goldstein, L. E., Romecín, P. A., Vera, R. E., Vrabel, A. M., Cui, G., et al. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100634 · Cited by 17
Self-citation
CDKN2A founder mutation in pancreatic ductal adenocarcinoma patients without cutaneous features of Familial Atypical Multiple Mole Melanoma (FAMMM) syndrome
Cremin, C., Howard, S. V., Le, L., Karsan, A., Schaeffer, D. F., Renouf, D. J., & Schrader, K. A. (2018) · Hereditary Cancer in Clinical Practice · doi:10.1186/s13053-018-0088-y · Cited by 13
Recommendations, evidence and sustainability of screening for pancreatic cancer in high-risk individuals
Bogdanski, A. M., Acedo, P., Wallace, M. B., van Leerdam, M. E., & Klatte, D. C. F. (2025) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2025.101974 · Cited by 12
Risk of Syndrome-Associated Cancers Among First-Degree Relatives of Patients With Pancreatic Ductal Adenocarcinoma With Pathogenic or Likely Pathogenic Germline Variants
Chen, X., Meyer, M. A., Kemppainen, J. L., Horibe, M., Chandra, S., Majumder, S., Petersen, G. M., & Rabe, K. G. (2023) · JAMA Oncology · doi:10.1001/jamaoncol.2023.0806 · Cited by 14
Self-citation
Splicing alterations in pancreatic ductal adenocarcinoma: a new molecular landscape with translational potential
Alors‐Pérez, E., Pedraza‐Arévalo, S., Blázquez‐Encinas, R., Moreno-Montilla, M. T., García‐Vioque, V., Berbel, I., Luque, R. M., Sáinz, B., Ibáñez‐Costa, A., & Castano, J. P. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02858-z · Cited by 12
Genetic and other risk factors for pancreatic ductal adenocarcinoma (PDAC)
Jacobs, M. F., & Stoffel, E. M. (2024) · Familial Cancer · doi:10.1007/s10689-024-00372-5 · Cited by 15
From classical approaches to artificial intelligence, old and new tools for PDAC risk stratification and prediction
Farinella, R., Felici, A., Peduzzi, G., Testoni, S. G. G., Costello, E., Aretini, P., Blázquez‐Encinas, R., Oz, E., Pastore, A., Tacelli, M., et al. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.03.004 · Cited by 13
Surveillance of Individuals with a Family History of Pancreatic Cancer and Inherited Cancer Syndromes: A Strategy for Detecting Early Pancreatic Cancers
Matsubayashi, H., Kiyozumi, Y., Ishiwatari, H., Uesaka, K., Kikuyama, M., & Ono, H. (2019) · Diagnostics · doi:10.3390/diagnostics9040169 · Cited by 12
Duktales Adenokarzinom des Pankreas
Gallmeier, E., & Gress, T. M. (2018) · Der Internist · doi:10.1007/s00108-018-0460-z · Cited by 12
Small non-coding RNAs and pancreatic ductal adenocarcinoma: Linking diagnosis, pathogenesis, drug resistance, and therapeutic potential
Fuller, R. N., Morcos, A., Bustillos, J. G., Molina, D. C., & Wall, N. R. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189153 · Cited by 11
Murine models for familial pancreatic cancer: Histopathology, latency and drug sensitivity among cancers of Palb2, Brca1 and Brca2 mutant mouse strains
Park, D., Shakya, R., Koivisto, C. S., Pitarresi, J. R., Szabolcs, M. J., Kladney, R. D., Hadjis, A. D., Mace, T. A., & Ludwig, T. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226714 · Cited by 10
McCune Albright syndrome is a genetic predisposition to intraductal papillary and mucinous neoplasms of the pancreas associated pancreatic cancer in relation with GNAS somatic mutation – a case report
Gaujoux, S., Pasmant, É., Silve, C., Mehsen-Cêtre, N., Coriat, R., Rouquette, A., Douset, B., Prat, F., & Leroy, K. (2019) · Medicine · doi:10.1097/md.0000000000018102 · Cited by 10
Design of nano-delivery systems for pancreatic cancer immunotherapy
Fu, S., Gao, C., Yu, Q., Gong, R., Yang, Z., Zang, X., Shan, S., Mombrú, D., Romero, M., Mombrú, Á. W., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.218098 · Cited by 11
Somatic Mutation Profiling in the Liquid Biopsy and Clinical Analysis of Hereditary and Familial Pancreatic Cancer Cases Reveals KRAS Negativity and a Longer Overall Survival
Earl, J., Barreto, E., Castillo, M., Fuentes, R., Rodríguez-Garrote, M., Ferreiro, R., Reguera, P., Muñoz, G., García‐Seisdedos, D., López, J., et al. (2021) · Cancers · doi:10.3390/cancers13071612 · Cited by 10
Implementation of BRCA mutations testing in formalin-fixed paraffin-embedded (FFPE) samples of different cancer types
Zannini, G., Facchini, G., SIO, M. D., Vita, F. D., Ronchi, A., Orditura, M., Vietri, M. T., Ciardiello, F., Franco, R., Accardo, M., et al. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154336 · Cited by 9
Prognostic significance of BRCA1 and BRCA2 methylation status in circulating cell-free DNA of Pancreatic Cancer patients
Koukaki, T., Balgkouranidou, I., Biziota, E., Karayiannakis, A. J., Bolanaki, H., Karamitrousis, E., Zarogoulidis, P., Deftereos, S. P., Charalampidis, C., Ioannidis, A., et al. (2024) · Journal of Cancer · doi:10.7150/jca.93184 · Cited by 9
Genetic landscape of pancreatic cancer: a narrative review
Yakar, D. O., Bozkirli, B. O., & Ceyhan, G. O. (2022) · Chinese Clinical Oncology · doi:10.21037/cco-22-4 · Cited by 11
Is Biannual Surveillance for Pancreatic Cancer Sufficient in Individuals With Genetic Syndromes or Familial Pancreatic Cancer?
Wang, Y., Cuggia, A., Chen, Y., Parent, J., Stanek, A., Denroche, R. E., Zhang, A. X. W., Grant, R. C., Domecq, C., Golesworthy, B., et al. (2022) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2021.7107 · Cited by 9
Life's Essential 8, genetic susceptibility, and risk of incident pancreatic cancer: A prospective cohort study
Wu, Z., Zeng, L., Fang, Z., Yuan, Y., Zhou, Y., & Chen, R. (2024) · International Journal of Cancer · doi:10.1002/ijc.35184 · Cited by 8
Significant detection of new germline pathogenic variants in Australian Pancreatic Cancer Screening Program participants
Murali, K., Dwarte, T. M., Nikfarjam, M., Tucker, K., Vaughan, R., Efthymiou, M., Collins, A., Spigelman, A. D., Salmon, L., Johns, A. L., et al. (2021) · Hereditary Cancer in Clinical Practice · doi:10.1186/s13053-021-00190-1 · Cited by 8
Risk of pancreatic ductal adenocarcinoma associated with carriage of BRCA1 and/or BRCA2 mutation: A systematic review and meta‐analysis
McGarry, J., Creavin, B., Kelly, M. E., & Gallagher, T. K. (2022) · Journal of Surgical Oncology · doi:10.1002/jso.26994 · Cited by 8
The implication of liquid biopsies to predict chemoresistance in pancreatic cancer
Pietri, E., Balsano, R., Corianò, M., Gelsomino, F., Leonardi, F., Bui, S., Gnetti, L., Valle, R. D., & Garajová, I. (2021) · Cancer Drug Resistance · doi:10.20517/cdr.2021.01 · Cited by 7
Depicting the cellular complexity of pancreatic adenocarcinoma by Imaging Mass Cytometry: focus on cancer-associated fibroblasts
Erreni, M., Fumagalli, M. R., D’Anna, R., Sollai, M., Bozzarelli, S., Nappo, G., Zanini, D., Parente, R., Garlanda, C., Rimassa, L., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1472433 · Cited by 7
Hydrogel models of pancreatic adenocarcinoma to study cell mechanosensing
Walker, M., & Morton, J. (2024) · Biophysical Reviews · doi:10.1007/s12551-024-01265-8 · Cited by 10
Hereditäres Magen- und Pankreaskarzinom
Langner, C. (2017) · Der Pathologe · doi:10.1007/s00292-017-0297-6 · Cited by 8
Psychological Impact of Learning CDKN2A Variant Status as a Genetic Research Result
Zhu, X., Leof, E. R., Rabe, K. G., McCormick, J. B., Petersen, G. M., & Breitkopf, C. R. (2018) · Public Health Genomics · doi:10.1159/000496556 · Cited by 7
Self-citation
Pancreatic cancer and melanoma related perceptions and behaviors following disclosure of CDKN2A variant status as a research result
Leof, E. R., Zhu, X., Rabe, K. G., McCormick, J. B., Petersen, G. M., & Breitkopf, C. R. (2019) · Genetics in Medicine · doi:10.1038/s41436-019-0517-y · Cited by 7
Self-citation
The influence of familial pancreatic cancer on postoperative outcome in pancreatic cancer: relevance to adjuvant chemotherapy
Tezuka, K., Okamura, Y., Sugiura, T., Ito, T., Yamamoto, Y., Ashida, R., Ohgi, K., & Uesaka, K. (2020) · Journal of Gastroenterology · doi:10.1007/s00535-020-01730-7 · Cited by 7
Interpreting Sequence Variation in PDAC-Predisposing Genes Using a Multi-Tier Annotation Approach Performed at the Gene, Patient, and Cohort Level
Zimmermann, M. T., Mathison, A., Stodola, T. J., Evans, D. B., Abrudan, J., Demos, W., Tschannen, M., Aldakkak, M., Geurts, J. L., Lomberk, G. A., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.606820 · Cited by 7
Predictive factors of survival in patients with borderline resectable pancreatic cancer who received neoadjuvant therapy
Tezuka, K., Okamura, Y., Sugiura, T., Ito, T., Yamamoto, Y., Ashida, R., Ohgi, K., Otsuka, S., Todaka, A., Fukutomi, A., et al. (2021) · Pancreatology · doi:10.1016/j.pan.2021.08.009 · Cited by 7
Risk of Pancreatic Cancer and Precancerous Lesions in Patients With Chronic Pancreatitis
Wen, A., Pan, S. Y., Dadgar, K., & Yaghoobi, M. (2025) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000002187 · Cited by 6
Gene-Level Associations in Patients With and Without Pathogenic Germline Variants in CDKN2A and Pancreatic Cancer
Astiazarán-Symonds, E., Graham, C., Kim, J., Tucker, M. A., Ingvar, C., Helgadóttir, H., Pastorino, L., van Doorn, R., Sampson, J. N., Zhu, B., et al. (2022) · JCO Precision Oncology · doi:10.1200/po.22.00145 · Cited by 6
Are Aspects of Integrative Concepts Helpful to Improve Pancreatic Cancer Therapy?
Oei, S. L., & Schad, F. (2023) · Cancers · doi:10.3390/cancers15041116 · Cited by 6
Screening for pancreatic cancer: a review for general clinicians
Wiest, N. E., Moktan, V. P., Oman, S. P., & Chirilă, R. M. (2020) · Romanian Journal of Internal Medicine · doi:10.2478/rjim-2020-0009 · Cited by 6
Comprehensive analysis of DNA damage repair genes reveals pathogenic variants beyond BRCA and suggests the need for extensive genetic testing in pancreatic cancer
Rapposelli, I. G., Zampiga, V., Cangini, I., Arcangeli, V., Ravegnani, M., Valgiusti, M., Pini, S., Tamberi, S., Bartolini, G., Passardi, A., et al. (2021) · BMC Cancer · doi:10.1186/s12885-021-08368-5 · Cited by 7
Functional neuroanatomy of arithmetic in monolingual and bilingual adults and children
Brignoni‐Pérez, E., Matejko, A. A., Jamal, N. I., & Eden, G. F. (2021) · Human Brain Mapping · doi:10.1002/hbm.25587 · Cited by 5
Potentially diagnostic and prognostic roles of piRNAs/PIWIs in pancreatic cancer: A review
Liu, Y., Li, C., Cui, X., Li, M., Liu, S., & Wang, Z. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189286 · Cited by 5
Splicing transcriptome-wide association study to identify splicing events for pancreatic cancer risk
Liu, D., Bae, Y. E., Zhu, J., Zhang, Z., Sun, Y., Deng, Y., Wu, C., & Wu, L. (2023) · Carcinogenesis · doi:10.1093/carcin/bgad069 · Cited by 5
Molecular Diagnostics in the Neoplasms of the Pancreas, Liver, Gallbladder, and Extrahepatic Biliary Tract
Zhang, L., Bluth, M. H., & Bhalla, A. (2018) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2018.03.003 · Cited by 5
Epidemiology and geographic distribution of BRCA1-2 and DNA Damage response genes pathogenic variants in pancreatic ductal adenocarcinoma patients
Macchini, M., Centonze, F., Peretti, U., Orsi, G., Militello, A. M., Valente, M. M., Cascinu, S., & Reni, M. (2022) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2022.102357 · Cited by 5
Pancreatic cancer risk to siblings of probands in bilineal cancer settings
Rabe, K. G., Stevens, M. A., Hernández, A. T., Chandra, S., Hubbard, J. M., Kemppainen, J. L., Majumder, S., & Petersen, G. M. (2022) · Genetics in Medicine · doi:10.1016/j.gim.2022.01.016 · Cited by 5
Self-citation
Oxidative stress and pancreatic cancer: a dual role in tumorigenesis and drug toxicity
Limbu, K. R., Chhetri, R. B., Oh, Y. S., Oak, M., Beak, D. J., & Park, E. (2025) · Toxicological Research · doi:10.1007/s43188-025-00301-3 · Cited by 6

Authors: Petersen, G. M.
Affiliations: Mayo Clinic (US)
Corresponding author: Petersen, Gloria M.
ORCID: Petersen, Gloria M.
Venue: Seminars in Oncology
Publisher: Elsevier BV
Published: 2016-10
Volume: 43
Issue: 5
Pages: 548-553
ISSN: 0093-7754 (ISSN-L)
DOI: 10.1053/j.seminoncol.2016.09.002
PMC: PMC5234085
OpenAlex: W2522369252
Cited by: 157
References: 69
Citations by year: 2026: 10 · 2025: 16 · 2024: 21 · 2023: 16 · 2022: 19 · 2021: 21 · 2020: 22 · 2019: 15 · 2018: 12 · 2017: 5
FWCI: 1.07
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Seminars in Oncology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (P50CA102701, R01CA097075)
Topics: Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Keywords: familial pancreatic cancer, pancreatic ductal adenocarcinoma, hereditary cancer, BRCA2, CDKN2A, germline mutations, genetic panel testing, precision oncology, genetic risk prediction
MeSH terms: Fanconi Anemia Complementation Group N Protein, Humans, Nuclear Proteins, Pancreatic Neoplasms, Cyclin-Dependent Kinase Inhibitor p16, Genetic Predisposition to Disease, Genes, BRCA2, Tumor Suppressor Proteins, Cyclin-Dependent Kinase Inhibitor p18, Fanconi Anemia Complementation Group C Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Familial pancreatic cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks