Familial pancreatic adenocarcinoma
Open accessAbstract
Familial pancreatic cancer (FPC) kindreds have at least 2 first-degree relatives with pancreatic ductal adenocarcinoma. Studies of FPC have focused on the discovery of genetic cause and on the management of those at genetically high risk. Research reveals that a half dozen known hereditary syndromes or genes are associated with increased risk of developing pancreatic cancer, the most prominent of which are BRCA2 and CDKN2A. Genetic risk assessment and testing is already available. Owing to limited experience worldwide, guidance is often based on expert opinion, although all agree that research is needed to improve the shaping of options.
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High-risk groups for pancreatic ductal adenocarcinoma include people with inherited predisposition, people with pancreatic cystic lesions, and people older than 50 years with newly diagnosed type 2 diabetes.
“Here, we review groups at high risk for pancreatic ductal adenocarcinoma, including individuals with inherited predisposition and patients with pancreatic cystic lesions.”
From Early detection of pancreatic cancer (2020) · cites this paper as [17]
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- Authors
- Petersen, G. M.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Petersen, Gloria M.
- ORCID
- Petersen, Gloria M.
- Venue
- Hematology/Oncology Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 29
- Issue
- 4
- Pages
- 641-653
- ISSN
- 0889-8588 (ISSN-L)
- PMC
- PMC4522044
- OpenAlex
- W2111337996
- Cited by
- 53
- References
- 57
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 3 · 2015: 1
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hematology/Oncology Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P50CA102701, R01CA097075)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- familial pancreatic cancer, pancreatic ductal adenocarcinoma, hereditary cancer, BRCA2, CDKN2A, genetic risk prediction, genetic testing, high-risk individuals, cancer prevention
- MeSH terms
- Adenocarcinoma, Carcinoma, Genetic Testing, Humans, Pancreatic Neoplasms, Risk Factors, Germ-Line Mutation, Genetic Predisposition to Disease, Precision Medicine
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