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Familial pancreatic cancer
Open accessAbstract
Familial pancreatic cancer (FPC) includes those kindreds that contain at least two first-degree relatives with pancreatic ductal adenocarcinoma. At least 12 known hereditary syndromes or genes are associated with increased risk of developing pancreatic cancer, the foremost being BRCA2 and CDKN2A. Research into the identification of mutations in known cancer predisposition genes and through next-generation sequencing has revealed extensive heterogeneity. The development of genetic panel testing has enabled genetic risk assessment and predisposition testing to be routinely offered. Precision oncology has opened the possibility of "incidental" germline mutations that may have implications for family members. However, in both cases, evidence-based recommendations for managing patients and at-risk family members in light of genetic status remain emergent, with current practice based on expert opinion.
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“outside of the minority (10–15%) of cases ascribed to germline mutations or known risk factors, such as mucinous cystic lesions and chronic pancreatitis, there is no single attributable risk factor for most patients4.”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [4]
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Cites
Siegel, R. L., Miller, K. D., & Jemal, A. (2016) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21332 · Cited by 16,003
Rahib, L., Smith, B. D., Aizenberg, R., Rosenzweig, A. B., Fleshman, J. M., & Matrisian, L. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0155 · Cited by 7,094
ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing
Green, R. C., Berg, J. S., Grody, W. W., Kalia, S. S., Korf, B. R., Martin, C. L., McGuire, A. L., Nussbaum, R. L., O’Daniel, J. M., Ormond, K. E., et al. (2013) · Genetics in Medicine · doi:10.1038/gim.2013.73 · Cited by 2,544
Syngal, S., Brand, R. E., Church, J. M., Giardiello, F. M., Hampel, H. L., & Burt, R. W. (2015) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.435 · Cited by 1,662
Saam, J. R., Arnell, C., Theisen, A. P., Moyes, K., Marino, I., Roundy, K. M., & WENSTRUP, R. J. (2015) · Oncology · doi:10.1159/000437307 · Cited by 1,533
Very high risk of cancer in familial Peutz–Jeghers syndrome
Giardiello, F. M., Brensinger, J. D., Tersmette, A. C., Goodman, S. N., Petersen, G. M., Booker, S. V., Cruz–Correa, M., & Offerhaus, G. J. A. (2000) · Gastroenterology · doi:10.1053/gast.2000.20228 · Cited by 1,435
Self-citationHereditary Pancreatitis and the Risk of Pancreatic Cancer
Lowenfels, A. B., Maisonneuve, P., DiMagno, E. P., Elitsur, Y., Gates, L. K., Perrault, J., Whitcomb, D. C., & International Hereditary Pancreatitis Study Group (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.6.442 · Cited by 988
Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene
Jones, S., Hruban, R. H., Kamiyama, M., Borges, M., Zhang, X., Parsons, D. W., Lin, J. C.-H., Palmisano, E., Brune, K., Jaffee, E. M., et al. (2009) · Science · doi:10.1126/science.1171202 · Cited by 826
Canto, M. I., Harinck, F., Hruban, R. H., Offerhaus, G. J., Poley, J.-W., Kamel, I., Nio, Y., Schulick, R. S., Bassi, C., Kluijt, I., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303108 · Cited by 784
Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds
Klein, A. P., Brune, K. A., Petersen, G. M., Goggins, M., Tersmette, A. C., Offerhaus, G. J. A., Griffin, C., Cameron, J. L., Yeo, C. J., Kern, S., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3823 · Cited by 678
Self-citationRisk of Pancreatic Cancer in Families With Lynch Syndrome
Kastrinos, F. (2009) · JAMA · doi:10.1001/jama.2009.1529 · Cited by 544
ATM Mutations in Patients with Hereditary Pancreatic Cancer
Roberts, N. J., Jiao, Y., Yu, J., Kopelovich, L., Petersen, G. M., Bondy, M. L., Gallinger, S., Schwartz, A. G., Syngal, S., Cote, M. L., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0194 · Cited by 491
Self-citationBosetti, C., Lucenteforte, E., Silverman, D. T., Petersen, G. M., Bracci, P. M., Ji, B.-T., Negri, E., Li, D., Risch, H. A., Olson, S. H., et al. (2011) · Annals of Oncology · doi:10.1093/annonc/mdr541 · Cited by 446
Self-citationSilverman, D. T., SCHIFFMAN, M. H., Everhart, J., Goldstein, A. M., Lillemoe, K. D., Swanson, G. M., Schwartz, A. G., Brown, L. M., Greenberg, R. S., Schoenberg, J. B., et al. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690607 · Cited by 397
Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer
Roberts, N. J., Norris, A. L., Petersen, G. M., Bondy, M. L., Brand, R., Gallinger, S., Kurtz, R. C., Olson, S. H., Rustgi, A. K., Schwartz, A. G., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0402 · Cited by 361
Self-citationGermline Variants in Targeted Tumor Sequencing Using Matched Normal DNA
Schrader, K. A., Cheng, D. T., Vijai, J., Prasad, M., Walsh, M. F., Zehir, A., Ni, A., Thomas, T., Benayed, R., Ashraf, A. M., et al. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.5208 · Cited by 348
Vasen, H., Ibrahim, I., Ponce, C. G., Slater, E. P., Matthäi, E., Carrato, A., Earl, J., Robbers, K., van Mil, A. M., Potjer, T., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.64.0730 · Cited by 344
Risk Factors for Pancreatic Cancer: Case-Control Study
Hassan, M. M., Bondy, M. L., Wolff, R. A., Abbruzzese, J. L., Vauthey, J., Pisters, P. W. T., Evans, D. B., Khan, R. S., Chou, T.-H., Lenzi, R., et al. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01510.x · Cited by 332
Prevalence of Germline Mutations in Cancer Predisposition Genes in Patients With Pancreatic Cancer
Grant, R. C., Selander, I., Connor, A. A., Selvarajah, S., Borgida, A., Briollais, L., Petersen, G. M., Lerner-Ellis, J., Holter, S., & Gallinger, S. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.11.042 · Cited by 299
Self-citationLIFE-STYLE RISK FACTORS FOR PANCREATIC CANCER IN LOUISIANA: A CASE-CONTROL STUDY
Falk, R. T., Pickle, L. W., Fontham, E. T. H., Correa, P., & Fraumeni, J. F. (1988) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114972 · Cited by 298
BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PACGENE study
Zhen, D. B., Rabe, K. G., Gallinger, S., Syngal, S., Schwartz, A. G., Goggins, M. G., Hruban, R. H., Cote, M. L., McWilliams, R. R., Roberts, N. J., et al. (2015) · Genetics in Medicine · doi:10.1038/gim.2014.153 · Cited by 295
Self-citationRebours, V., Boutron‐Ruault, M., Schnee, M., Férec, C., Maire, F., Hammel, P. R., Ruszniewski, P. B., & Lévy, P. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01597.x · Cited by 264
Fanconi anemia gene mutations in young-onset pancreatic cancer.
van der Heijden, M. S., Yeo, C. J., Hruban, R. H., & Kern, S. E. (2003) · PubMed · Cited by 262
The incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers
T. H. B. C. S. G., Iqbal, J., Ragone, A., Lubinski, J., Lynch, H. T., Moller, P., Ghadirian, P., Foulkes, W. D., Armel, S., Eisen, A., et al. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.483 · Cited by 252
Langer, P., Kann, P. H., Fendrich, V., Habbe, N., Schneider, M., Sina‐Frey, M., Slater, E. P., Heverhagen, J. T., Gress, T. M., Rothmund, Μ., et al. (2009) · Gut · doi:10.1136/gut.2008.171611 · Cited by 249
Genetic susceptibility to pancreatic cancer
Klein, A. P. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.20855 · Cited by 240
Permuth‐Wey, J., & Egan, K. M. (2008) · Familial Cancer · doi:10.1007/s10689-008-9214-8 · Cited by 232
Verna, E. C., Hwang, C., Stevens, P. D., Rotterdam, H., Stavropoulos, S. N., Sy, C. D., Prince, M. A., Chung, W. K., Fine, R. L., Chabot, J. A., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-3209 · Cited by 201
Family history and the risk of liver, gallbladder, and pancreatic cancer.
Fernández, E., Vecchia, C. L., D’Avanzo, B., Negri, E., & Franceschi, S. (1994) · PubMed · Cited by 200
Resta, N., Pierannunzio, D., Lenato, G. M., Stella, A., Capocaccia, R., Bagnulo, R., Lastella, P., Susca, F. C., Bozzao, C., Loconte, D. C., et al. (2013) · Digestive and Liver Disease · doi:10.1016/j.dld.2012.12.018 · Cited by 157
Familial Risk of Pancreatic Cancer
Schenk, M., Schwartz, A. G., O'Neal, E., Kinnard, M. F., Greenson, J. K., Fryzek, J. P., Ying, G., & Garabrant, D. H. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.8.640 · Cited by 157
Jacobs, E. J., Chanock, S. J., Fuchs, C. S., LaCroix, A., McWilliams, R. R., Steplowski, E., Stolzenberg‐Solomon, R. Z., Arslan, A. A., Bueno‐de‐Mesquita, H. B., Gross, M., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.25148 · Cited by 151
Self-citationGerm Line Fanconi Anemia Complementation Group C Mutations and Pancreatic Cancer
Couch, F. J., Johnson, M. R., Rabe, K. G., Boardman, L., McWilliams, R. R., de Andrade, M., & Petersen, G. M. (2005) · Cancer Research · doi:10.1158/0008-5472.383.65.2 · Cited by 146
Self-citationPancreatic Cancer Genetic Epidemiology Consortium
Petersen, G. M., de Andrade, M., Goggins, M., Hruban, R. H., Bondy, M. L., Korczak, J. F., Gallinger, S., Lynch, H. T., Syngal, S., Rabe, K. G., et al. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0734 · Cited by 141
Self-citationPrevalence of pathogenic mutations in cancer predisposition genes among pancreatic cancer patients
Hu, C., Hart, S. N., Bamlet, W. R., Moore, R. M., Nandakumar, K., Eckloff, B. W., Lee, Y. K., Petersen, G. M., McWilliams, R. R., & Couch, F. J. (2016) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-15-0455 · Cited by 137
Self-citationPrevalence of CDKN2A mutations in pancreatic cancer patients: implications for genetic counseling
McWilliams, R. R., Wieben, E. D., Rabe, K. G., Pedersen, K. S., Wu, Y., Sicotte, H., & Petersen, G. M. (2011) · European Journal of Human Genetics · doi:10.1038/ejhg.2010.198 · Cited by 135
Self-citationHruban, R. H., Petersen, G. M., Goggins, M., Tersmette, A. C., Offerhaus, G. J. A., Falatko, F., Yeo, C. J., & Kern, S. E. (1999) · Annals of Oncology · doi:10.1093/annonc/10.suppl_4.s69 · Cited by 134
Self-citationEvidence for a major gene influencing risk of pancreatic cancer
Klein, A. P., Beaty, T. H., Wilson, J., Brune, K. A., Hruban, R. H., & Petersen, G. M. (2002) · Genetic Epidemiology · doi:10.1002/gepi.1102 · Cited by 129
Self-citationKorsse, S. E., Harinck, F., van Lier, M. G., Biermann, K., Offerhaus, G. J. A., Krak, N. C., Looman, C. W. N., van Veelen, W., Kuipers, E. J., Wagner, A., et al. (2012) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2012-101277 · Cited by 118
Inoue, M., Tajima, K., Takezaki, T., Hamajima, N., Hirose, K., Ito, H. M., & Tominaga, S. (2003) · International Journal of Epidemiology · doi:10.1093/ije/dyg062 · Cited by 115
McWilliams, R. R., Petersen, G. M., Rabe, K. G., Holtegaard, L. M., Lynch, P. J., Bishop, M. D., & Highsmith, W. E. (2009) · Cancer · doi:10.1002/cncr.24697 · Cited by 107
Self-citationRaymond, V. M., Gray, S. W., Roychowdhury, S., Joffe, S., Chinnaiyan, A. M., Parsons, D. W., & Plon, S. E. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv351 · Cited by 100
Amundadottir, L. T. (2016) · International Journal of Biological Sciences · doi:10.7150/ijbs.15001 · Cited by 98
Seifert, B. A., O’Daniel, J. M., Amin, K. D., Marchuk, D. S., Patel, N. M., Parker, J. S., Hoyle, A. P., Mose, L. E., Marron, A., Hayward, M. C., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0015 · Cited by 95
Ethical, Legal, and Counseling Challenges Surrounding the Return of Genetic Results in Oncology
Lolkema, M. P., Hooijdonk, C. G. G., Bredenoord, A. L., Kapitein, P., Roach, N., Cuppen, E. P. J. G., Knoers, N. V. A. M., & Voest, E. E. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.45.2789 · Cited by 90
Adenocarcinoma of the Pancreas in Four Siblings
MacDermott, R. P., & Kramer, P. A. (1973) · Gastroenterology · doi:10.1016/s0016-5085(19)33156-7 · Cited by 84
The Genetics ofFANCCandFANCGin Familial Pancreatic Cancer
Rogers, C. D., van der Heijden, M. S., Brune, K. A., Yeo, C. J., Hruban, R. H., Kern, S. E., & Goggins, M. (2004) · Cancer Biology & Therapy · doi:10.4161/cbt.3.2.609 · Cited by 82
Risk of malignancy in first‐degree relatives of patients with pancreatic carcinoma
McWilliams, R. R., Rabe, K. G., Olswold, C., de Andrade, M., & Petersen, G. M. (2005) · Cancer · doi:10.1002/cncr.21166 · Cited by 81
Self-citationProspective risk of cancer in CDKN2A germline mutation carriers
Goldstein, A. M., Struewing, J. P., Fraser, M. C., Smith, M. W., & Tucker, M. A. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2004.019349 · Cited by 81
Tumor genome analysis includes germline genome: Are we ready for surprises?
Catenacci, D. V. T., Amico, A. L., Nielsen, S. M., Geynisman, D. M., Rambo, B., Carey, G. B., Gulden, C., Fackenthal, J., Marsh, R. D., Kindler, H. L., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.29128 · Cited by 78
Risk of pancreatic cancer among individuals with a family history of cancer of the pancreas
Ghadirian, P., Liu, G., Gallinger, S., Schmocker, B., Paradis, A., Lal, G., Brunet, J., Foulkes, W. D., & Narod, S. A. (2001) · International Journal of Cancer · doi:10.1002/ijc.10123 · Cited by 72
Clinical and pathologic features of familial pancreatic cancer
Humphris, J. L., Johns, A. L., Simpson, S. H., Cowley, M. J., Pajic, M., Chang, D. K.-F., Nagrial, A. M., Chin, V. T., Chantrill, L. A., Pinese, M., et al. (2014) · Cancer · doi:10.1002/cncr.28863 · Cited by 65
Smoking, body weight, and early-stage endometrial cancer
Lawrence, C., Tessaro, I. A., Durgerian, S., Caputo, T. A., Richart, R. M., Jacobson, H. I., & Greenwald, P. (1987) · Cancer · doi:10.1002/1097-0142(19870501)59:9 · Cited by 61
Population Attributable Risk for Pancreatic Cancer in Northern Italy
Rosato, V., Polesel, J., Bosetti, C., Serraino, D., Negri, E., & Vecchia, C. L. (2014) · Pancreas · doi:10.1097/mpa.0000000000000251 · Cited by 55
Smith, A. L., Alirezaie, N., Connor, A. A., Chan‐Seng‐Yue, M., Grant, R. C., Selander, I., Bascuñana, C., Borgida, A., Hall, A., Whelan, T., et al. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.10.030 · Cited by 54
Self-citationFamilial pancreatic adenocarcinoma
Petersen, G. M. (2015) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2015.04.007 · Cited by 53
Self-citationRisk Factors for Pancreatic Cancer in China: A Multicenter Case-Control Study
Zheng, Z., Zheng, R., He, Y., Sun, X., Wang, N., Chen, T., & Chen, W. (2015) · Journal of Epidemiology · doi:10.2188/jea.je20140148 · Cited by 50
Potjer, T. P., Kranenburg, H. E., Bergman, W., Cappel, W. H. D. V. T. N., van Monsjou, H. S., Barge‐Schaapveld, D. Q. C. M., & Vasen, H. F. A. (2014) · European Journal of Human Genetics · doi:10.1038/ejhg.2014.187 · Cited by 33
Screening and Surgical Outcomes of Familial Pancreatic Cancer
Templeton, A. W., & Brentnall, T. A. (2013) · Surgical Clinics of North America · doi:10.1016/j.suc.2013.02.002 · Cited by 31
Genetics of the FANCA gene in familial pancreatic cancer
Rogers, C. D., Couch, F. J., Brune, K., Martin, S. T., Philips, J., Murphy, K. M., Petersen, G., Yeo, C. J., Hruban, R. H., & Goggins, M. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2004.024851 · Cited by 26
Self-citation(2013) · Gut · doi:10.1136/gutjnl-2012-303108corr1 · Cited by 25
Familial pancreatic cancer—status quo
Fendrich, V., Langer, P., & Bartsch, D. K. (2013) · International Journal of Colorectal Disease · doi:10.1007/s00384-013-1760-3 · Cited by 24
Cancer of the pancreas in two brothers and one sister
Ghadirian, P., Simard, A., & Baillargeon, J. (1987) · International Journal of Pancreatology · doi:10.1007/bf02788437 · Cited by 23
A Population-Based Description of Familial Clustering of Pancreatic Cancer
Shirts, B. H., Burt, R. W., Mulvihill, S. J., & Cannon‐Albright, L. (2010) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2010.05.012 · Cited by 22
Austin, M. A., Kuo, E., Eeden, S. K. V. D., Mandelson, M. T., Brentnall, T. A., Kamineni, A., & Potter, J. D. (2013) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-13-0518 · Cited by 20
The role of radiation therapy in the treatment of colorectal cancer
Farniok, K. E., & Levitt, S. H. (1994) · Cancer · doi:10.1002/1097-0142(19941001)74:7+ · Cited by 17
Progress in the Earlier Detection of Pancreatic Cancer
Brentnall, T. A. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.66.5265 · Cited by 9
Petersen, G. M., Chaffee, K. G., McWilliams, R. R., Majithia, N., Allen, B. A., Kidd, J., Singh, N., Hartman, A., & Oberg, A. L. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.34.15_suppl.4108 · Cited by 9
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Metadata
- Authors
- Petersen, G. M.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Petersen, Gloria M.
- ORCID
- Petersen, Gloria M.
- Venue
- Seminars in Oncology
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 43
- Issue
- 5
- Pages
- 548-553
- ISSN
- 0093-7754 (ISSN-L)
- PMC
- PMC5234085
- OpenAlex
- W2522369252
- Cited by
- 157
- References
- 69
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 21 · 2023: 16 · 2022: 19 · 2021: 21 · 2020: 22 · 2019: 15 · 2018: 12 · 2017: 5
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Seminars in Oncology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P50CA102701, R01CA097075)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- familial pancreatic cancer, pancreatic ductal adenocarcinoma, hereditary cancer, BRCA2, CDKN2A, germline mutations, genetic panel testing, precision oncology, genetic risk prediction
- MeSH terms
- Fanconi Anemia Complementation Group N Protein, Humans, Nuclear Proteins, Pancreatic Neoplasms, Cyclin-Dependent Kinase Inhibitor p16, Genetic Predisposition to Disease, Genes, BRCA2, Tumor Suppressor Proteins, Cyclin-Dependent Kinase Inhibitor p18, Fanconi Anemia Complementation Group C Protein
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