The predictive validity of neonatal MRI for neurodevelopmental outcome in very preterm children
Abstract
Very preterm children are at a high risk for neurodevelopmental impairments, but there is variability in the pattern and severity of outcome. Neonatal magnetic resonance imaging (MRI) enhances the capacity to detect brain injury and altered brain development and assists in the prediction of high-risk children who warrant surveillance and early intervention. This review describes the application of conventional and advanced MRI with very preterm neonates, specifically focusing on the relationship between neonatal MRI findings and later neurodevelopmental outcome. Research demonstrates that conventional MRI is strongly associated with neurodevelopmental outcome in childhood. Further studies are needed to examine the role of advanced MRI techniques in predicting outcome in very preterm children, but early research findings are promising. In conclusion, neonatal MRI is predictive of later neurodevelopment but is dependent on appropriately trained specialists and should be interpreted in conjunction with other clinical and social information.
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Studies of premature infants have generally found that abnormalities of grey-matter and white-matter volume and white-matter diffusivity are associated with poor neurodevelopmental outcomes.
“studies of premature infants have generally found that abnormalities of grey-matter and white-matter volume and of white-matter diffusivity are associated with poor neurodevelopmental outcomes 11, 186.”
From Imaging structural and functional brain development in early childhood (2018) · cites this paper as [11]
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Imaging structural and functional brain development in early childhood
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Self-citation
- Authors
- Anderson, P. J., Cheong, J. L. Y., & Thompson, D. K.
- Affiliations
- The University of Melbourne (AU)
- Royal Women's Hospital (AU)
- Corresponding author
- Anderson, Peter J.
- Venue
- Seminars in Perinatology
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 39
- Issue
- 2
- Pages
- 147-158
- ISSN
- 0146-0005 (ISSN-L)
- OpenAlex
- W2055335542
- Cited by
- 127
- References
- 108
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 8 · 2023: 10 · 2022: 7 · 2021: 17 · 2020: 17 · 2019: 7 · 2018: 17 · 2017: 12 · 2016: 12 · 2015: 1
- FWCI
- 13.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Perinatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- neonatal MRI, very preterm infants, neurodevelopmental outcomes, predictive validity, brain injury, advanced MRI techniques, early intervention, perinatal brain development
- MeSH terms
- Brain, Brain Injuries, Developmental Disabilities, Humans, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Magnetic Resonance Imaging, Predictive Value of Tests, Severity of Illness Index, Intensive Care, Neonatal, Neuroimaging
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