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Cited by 993Obstructive Sleep Apnea ResearchNitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 130 of the 134 references it cites were found in a registry or an index.

Obstructive sleep apnoea syndrome – an oxidative stress disorder

Lavie, Lena·2003·Sleep Medicine Reviews
DOI 10.1053/smrv.2002.0261
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Abstract

Obstructive sleep apnoea syndrome (OSA) is associated with increased cardiovascular morbidity and mortality. However, the underlying mechanisms are not entirely understood. This review will summarize the evidence that substantiates the notion that the repeated apnoea-related hypoxic events in OSA, similarly to hypoxia/reperfusion injury, initiate oxidative stress. Thus, affecting energy metabolism, redox-sensitive gene expression, and expression of adhesion molecules. A limited number of studies substantiate this hypothesis directly by demonstrating increased free radical production in OSA leukocytes and increased plasma-lipid peroxidation. A great number of studies, however, support this hypothesis indirectly. Increase in circulating levels of adenosine and urinary uric acid in OSA are implicated with increased production of reactive oxygen species (ROS). Activation of redox-sensitive gene expression is suggested by the increase in some protein products of these genes, including VEGF, erythropoietin, endothelin-1, inflammatory cytokines and adhesion molecules. These implicate the participation of redox-sensitive transcription factors as HIF-1 AP-1 and NFkappaB. Finally, adhesion molecule-dependent increased avidity of OSA monocytes to endothelial cells, combined with diminished NO bioavailability, lead to exaggerated endothelial cell damage and dysfunction. Cumulatively, these processes may exacerbate atherogenic sequelae in OSA.

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Crossref · 10.1053/smrv.2002.0261

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4 of the 134 references couldn’t be matched to a known paper.

Research works printed but not linked: 4

  1. Yuan, 2001, Activation of HIF-2a by intermittent hypoxia requires CaMKII (Abstract), FASEB J, 15, A154
  2. Lavie, 1998, Production of heat shock protein 70 by peripheral blood monocytes from patients with sleep apnea syndrome, J Sleep Res, 7, 150
  3. Ghandour, 1999, Expression of heat shock proteins in obstructive sleep apnea syndrome, Sleep, 22, S331
  4. Carlson, 1997, Increased plasma concentration of ADMA a naturally occurring nitric oxide synthesis inhibitor in OSA patients, Am J Respir Crit Care Med, 155, A869

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Metadata

Authors
Lavie, L.
Affiliations
Technion – Israel Institute of Technology (IL)
Corresponding author
Lavie, Lena
Venue
Sleep Medicine Reviews
Publisher
Elsevier BV
Published
2003-02
Volume
7
Issue
1
Pages
35-51
ISSN
1087-0792 (ISSN-L)
DOI
10.1053/smrv.2002.0261
OpenAlex
W1988114644
Cited by
993
References
134
Citations by year
2026: 17 · 2025: 44 · 2024: 28 · 2023: 30 · 2022: 33 · 2021: 43 · 2020: 42 · 2019: 31 · 2018: 38 · 2017: 37 · 2016: 44 · 2015: 51 · 2014: 58 · 2013: 48 · 2012: 51
FWCI
4.50
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Sleep Medicine Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministry of Health, State of Israel
Topics
  • Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords
obstructive sleep apnea, oxidative stress, hypoxia/reoxygenation injury, reactive oxygen species, lipoprotein oxidation, adhesion molecules, adenosine, uric acid, HIF-1, NF-κB, AP-1, endothelial dysfunction, monocyte adhesion, nitric oxide bioavailability, atherosclerosis, cardiovascular risk
MeSH terms
Cardiovascular Diseases, Free Radicals, Humans, Leukocytes, Lymphokines, Nitric Oxide, Lipid Peroxidation, Endothelial Growth Factors, Oxidative Stress, Hyperhomocysteinemia, Sleep Apnea, Obstructive, Intercellular Signaling Peptides and Proteins, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A

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