The DOI matches its Crossref record; 130 of the 134 references it cites were found in a registry or an index.
Obstructive sleep apnoea syndrome – an oxidative stress disorder
Abstract
Obstructive sleep apnoea syndrome (OSA) is associated with increased cardiovascular morbidity and mortality. However, the underlying mechanisms are not entirely understood. This review will summarize the evidence that substantiates the notion that the repeated apnoea-related hypoxic events in OSA, similarly to hypoxia/reperfusion injury, initiate oxidative stress. Thus, affecting energy metabolism, redox-sensitive gene expression, and expression of adhesion molecules. A limited number of studies substantiate this hypothesis directly by demonstrating increased free radical production in OSA leukocytes and increased plasma-lipid peroxidation. A great number of studies, however, support this hypothesis indirectly. Increase in circulating levels of adenosine and urinary uric acid in OSA are implicated with increased production of reactive oxygen species (ROS). Activation of redox-sensitive gene expression is suggested by the increase in some protein products of these genes, including VEGF, erythropoietin, endothelin-1, inflammatory cytokines and adhesion molecules. These implicate the participation of redox-sensitive transcription factors as HIF-1 AP-1 and NFkappaB. Finally, adhesion molecule-dependent increased avidity of OSA monocytes to endothelial cells, combined with diminished NO bioavailability, lead to exaggerated endothelial cell damage and dysfunction. Cumulatively, these processes may exacerbate atherogenic sequelae in OSA.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Long-term chronic hypoxia caused by OSA can lead to several physiological and biochemical modifications, such as changes in the NLR, PLR, and levels of C-reactive proteins and markers of serum inflammation [33–37].”
From Airway morphology, hyoid position, and serum inflammatory markers of obstructive sleep apnea in children treated with modified twin-block appliances (2025) · cites this paper as [33]
Citations
Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513
Oxygen-Derived Free Radicals in Postischemic Tissue Injury
Epstein, F. H., & McCord, J. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120305 · Cited by 5,399
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Prospective Study of the Association between Sleep-Disordered Breathing and Hypertension
Peppard, P. E., Young, T., Palta, M., & Skatrud, J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005113421901 · Cited by 4,973
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992) · The Lancet · doi:10.1016/0140-6736(92)93147-f · Cited by 4,742
A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease
Boushey, C. J. (1995) · JAMA · doi:10.1001/jama.1995.03530130055028 · Cited by 3,708
Nieto, F. J. (2000) · JAMA · doi:10.1001/jama.283.14.1829 · Cited by 3,369
Sleep-disordered Breathing and Cardiovascular Disease
SHAHAR, E., WHITNEY, C. W., REDLINE, S., LEE, E. T., NEWMAN, A. B., JAVIER NIETO, F., O'CONNOR, G. T., BOLAND, L. L., SCHWARTZ, J. E., & SAMET, J. M. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.1.2001008 · Cited by 2,901
Research works printed but not linked: 4
- Yuan, 2001, Activation of HIF-2a by intermittent hypoxia requires CaMKII (Abstract), FASEB J, 15, A154
- Lavie, 1998, Production of heat shock protein 70 by peripheral blood monocytes from patients with sleep apnea syndrome, J Sleep Res, 7, 150
- Ghandour, 1999, Expression of heat shock proteins in obstructive sleep apnea syndrome, Sleep, 22, S331
- Carlson, 1997, Increased plasma concentration of ADMA a naturally occurring nitric oxide synthesis inhibitor in OSA patients, Am J Respir Crit Care Med, 155, A869
Cited by
Sorted by citations
Sleep Apnea and Cardiovascular Disease
Somers, V. K., White, D. P., Amin, R. S., Abraham, W. T., Costa, F., Culebras, A., Daniels, S. R., Floras, J. S., Hunt, C. E., Olson, L. J., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.05.002 · Cited by 1,530
“Some studies have reported increased levels of thiobarbituric acid reactive substances, isoprostanes, and oxidized low-density lipoprotein in OSA (100), although these changes have not been confirmed in other studies (101).”
ResultGoldberger, J. J., Cain, M. E., Hohnloser, S. H., Kadish, A. H., Knight, B. P., Lauer, M. S., Maron, B. J., Page, R. L., Passman, R. S., Siscovick, D., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.189375 · Cited by 1,450
Sleep Apnea and Cardiovascular Disease
Somers, V. K., White, D. P., Amin, R. S., Abraham, W. T., Costa, F., Culebras, A., Daniels, S. R., Floras, J. S., Hunt, C. E., Olson, L. J., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.189420 · Cited by 1,347
Obstructive sleep apnoea syndrome
Lévy, P., Kohler, M., McNicholas, W. T., Barbé, F., McEvoy, R. D., Somers, V. K., Lavie, L., & Pépin, J.-L. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.15 · Cited by 1,235
Self-citationRegulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1
Semenza, G. L. (2009) · Physiology · doi:10.1152/physiol.00045.2008 · Cited by 926
McNicholas, W. T., Bonsignore, M. R., & the Management Committee of EU COST ACTION B26 (2007) · European Respiratory Journal · doi:10.1183/09031936.00027406 · Cited by 911
Lavie, L. (2014) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.07.003 · Cited by 732
Self-citationObstructive Sleep Apnea and Cardiovascular Disease
Parish, J. M., & Somers, V. K. (2004) · Mayo Clinic Proceedings · doi:10.4065/79.8.1036 · Cited by 627
Endothelial Function in Obstructive Sleep Apnea and Response to Treatment
Ip, M. S. M., Tse, H.-F., Lam, B., Tsang, K. W. T., & Lam, W.-K. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200306-767oc · Cited by 615
“Other mechanisms for impaired nitric oxide–mediated endothelial function, including increased oxidant load, enhanced oxidation of low density lipoprotein, insulin resistance, and increased sympathetic activity (46, 47), have been demonstrated to be present in OSA ( 10 , 33, 48, 49).”
BackgroundInfluentialObstructive sleep apnoea and cardiovascular disease
Sánchez‐de‐la‐Torre, M., Campos‐Rodríguez, F., & Barbé, F. (2012) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(12)70051-6 · Cited by 512
Doherty, L. S., Kiely, J. L., Swan, V., & McNicholas, W. T. (2005) · Chest · doi:10.1378/chest.127.6.2076 · Cited by 485
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
Lv, R., Liu, X., Zhang, Y., Dong, N., Wang, X., He, Y., Yue, H., & Yin, Q. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01496-3 · Cited by 555
Therapeutic potential of intermittent hypoxia: a matter of dose
Navarrete-Opazo, A. A., & Mitchell, G. S. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00208.2014 · Cited by 495
“For instance, IH consisting of hypercapnic hypoxia (6 min of 8% O2, 7% CO2; 6 min normoxic/normocapnic intervals, 90 min) does not increase TNF- or CRP in male piglets (227).”
BackgroundMethodInfluentialNeurocognitive Impairment in Obstructive Sleep Apnea
Lal, C., Strange, C., & Bachman, D. (2012) · Chest · doi:10.1378/chest.11-2214 · Cited by 406
Cardiovascular Morbidity in Obstructive Sleep Apnea
Gozal, D., & Gozal, D. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200608-1190pp · Cited by 408
Campos-Rodriguez, F., Martinez-Garcia, M. A., Martinez, M., Duran-Cantolla, J., Peña, M. D. L., Masdeu, M. J., Gonzalez, M., Campo, F. D., Gallego, I., Marin, J. M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201209-1671oc · Cited by 386
Xu, W., Chi, L., Row, B. W., Xu, R., Ke, Y., Xu, B., Luo, C., Kheirandish, L., Gozal, D., & Liu, R. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.03.055 · Cited by 377
Obstructive Sleep Apnea and Type 2 Diabetes
Tasali, E., Mokhlesi, B., & Van Cauter, E. (2008) · Chest · doi:10.1378/chest.07-0828 · Cited by 371
Molecular mechanisms of cardiovascular disease in OSAHS: the oxidative stress link
Lavie, L., & Lavie, P. (2009) · European Respiratory Journal · doi:10.1183/09031936.00086608 · Cited by 380
Self-citationObstructive sleep apnea and type 2 diabetes
Rasche, K., Keller, T., Tautz, B., Hader, C., Hergenç, G., Antosiewicz, J., Giulio, C. D., & Pokorski, M. (2010) · European journal of medical research · doi:10.1186/2047-783x-15-s2-152 · Cited by 367
Obstructive Sleep Apnea and Metabolic Syndrome: Alterations in Glucose Metabolism and Inflammation
Tasali, E., & Ip, M. S. M. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200708-139mg · Cited by 365
Predictors of Elevated Nuclear Factor-κB–dependent Genes in Obstructive Sleep Apnea Syndrome
Ryan, S., Taylor, C. T., & McNicholas, W. T. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200601-066oc · Cited by 354
“There is growing evidence that sustained and intermittent hypoxia lead to significantly different molecular responses and different patterns of transcription factor activation (11, 28 , 29).”
BackgroundMolecular Signatures of Obstructive Sleep Apnea in Adults: A Review and Perspective
Arnardóttir, E. S., Mackiewicz, M., Gíslason, Þ., Teff, K. L., & Pack, A. I. (2009) · SLEEP · doi:10.1093/sleep/32.4.447 · Cited by 355
Ryan, S., Taylor, C. T., & McNicholas, W. T. (2009) · Postgraduate Medical Journal · doi:10.1136/thx.2008.105577 · Cited by 343
Sleep, sleep-disordered breathing and metabolic consequences
Levy, P. A., Bonsignore, M. R., & Eckel, J. (2009) · European Respiratory Journal · doi:10.1183/09031936.00166808 · Cited by 345
Kerner, N. A., & Roose, S. P. (2016) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.01.134 · Cited by 338
Sleep and Cardiovascular Disease
Wolk, R. A., Gami, A. S., García‐Touchard, A., & Somers, V. K. (2005) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2005.07.002 · Cited by 340
Hypoxia and brain aging: Neurodegeneration or neuroprotection?
Burtscher, J., Mallet, R. T., Burtscher, M., & Millet, G. P. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101343 · Cited by 359
“resultant oxidative damage of biomolecules (Lavie, 2003), mitochondrial dysfunction (Duranteau et al.”
BackgroundBuchner, N. J., Sanner, B. M., Borgel, J., & Rump, L. C. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200611-1588oc · Cited by 317
All-cause mortality in males with sleep apnoea syndrome: declining mortality rates with age
Lavie, P., Lavie, L., & Herer, P. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00051504 · Cited by 320
Self-citationJean‐Louis, G., Zizi, F., Clark, L. T., Brown, C. D., & McFarlane, S. I. (2008) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27191 · Cited by 313
Sleep-disordered breathing and type 2 diabetes
Shaw, J. E., Punjabi, N. M., Wilding, J. P. H., Alberti, K. G. M. M., & Zimmet, P. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.04.025 · Cited by 299
“leukin-6, tumour necrosis factor, C-reactive protein, and platelet activation and coagulation factors have been described in OSA [87,89–100].”
BackgroundCrossing the apnoeic threshold: causes and consequences
Dempsey, J. A. (2004) · Experimental Physiology · doi:10.1113/expphysiol.2004.028985 · Cited by 282
“These effects are likely to be mediated through intermittent hypoxia causing oxidative stress and endothelial dysfunction and increased sympathetic nerve activity, leading eventually to daytime hypertension (Fletcher, 2003; Lavie, 2003).”
BackgroundMechanisms of cardiac dysfunction in obstructive sleep apnea
Baguet, J.-P., Barone‐Rochette, G., Tamisier, R., Levy, P. A., & Pépin, J. (2012) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2012.141 · Cited by 285
Redline, S., Sotres-Alvarez, D., Loredo, J., Hall, M., Patel, S. R., Ramos, A., Shah, N., Ries, A., Arens, R., Barnhart, J., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201309-1735oc · Cited by 270
Association of obstructive sleep apnea with hypertension: A systematic review and meta-analysis
Hou, H., Zhao, Y., Yu, W., Dong, H., Xue, X., Ding, J., Xing, W., & Wang, W. (2018) · Journal of Global Health · doi:10.7189/jogh.08.010405 · Cited by 346
Oxidative Stress—A Unifying Paradigm in Obstructive Sleep Apnea and Comorbidities
Lavie, L. (2008) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2008.08.003 · Cited by 274
Self-citationHeavy Snoring as a Cause of Carotid Artery Atherosclerosis
Lee, S. A., Amis, T. C., Byth, K., Larcos, G., Kairaitis, K., Robinson, T. D., & Wheatley, J. R. (2008) · SLEEP · doi:10.5665/sleep/31.9.1207 · Cited by 261
Obstructive Sleep Apnea, Hypoxia, and Nonalcoholic Fatty Liver Disease
Mesarwi, O. A., Loomba, R. S., & Malhotra, A. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201806-1109tr · Cited by 275
Chronic intermittent hypoxia predisposes to liver injury†
Savransky, V., Nanayakkara, A., Vivero, A., Li, J., Bevans‐Fonti, S., Smith, P. L., Torbenson, M. S., & Polotsky, V. Y. (2007) · Hepatology · doi:10.1002/hep.21593 · Cited by 262
Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea
McNicholas, W. T. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200903-0347pp · Cited by 249
Suzuki, Y., Jain, V., Park, A.-M., & Day, R. M. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.01.008 · Cited by 245
“This reoxygenation/reperfusion phase is thought to result in the production of reactive oxygen species (ROS) and the promotion of oxidative stress [15-17].”
BackgroundZhang, R., Wu, Y., Zhao, M. L., Liu, C., Zhou, L., Shen, S.-M., Liao, S., Yang, K., Li, Q. Y., & Wan, H. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90415.2008 · Cited by 236
“Hypoxia is a complex physiological phenomenon, and many transcriptional regulators are activated during hypoxia (16, 37).”
BackgroundOxidative Stress and Left Ventricular Function with Chronic Intermittent Hypoxia in Rats
Chen, L., Einbinder, E., Zhang, Q., Hasday, J. D., Balke, C. W., & Scharf, S. M. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200504-560oc · Cited by 237
Craig, S. E., Kohler, M., Nicoll, D., Bratton, D. J., Nunn, A., Davies, R., & Stradling, J. (2012) · Thorax · doi:10.1136/thoraxjnl-2012-202178 · Cited by 228
Obstructive Sleep Apnea and Cardiovascular Disease
Pack, A. I., & Gislason, T. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2009.01.002 · Cited by 228
The Severity of Oxygen Desaturation Is Predictive of Carotid Wall Thickening and Plaque Occurrence
Baguet, J.-P., Hammer, L., Leívy, P., Pierre, H., Launois, S. H., Mallion, J.-M., & Pépin, J. (2005) · CHEST Journal · doi:10.1378/chest.128.5.3407 · Cited by 239
The Relationship between Obstructive Sleep Apnea and Alzheimer’s Disease
Andrade, A. G., Bubu, O. M., Varga, A. W., & Osorio, R. S. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179936 · Cited by 216
“Mounting evidence suggests that repetitive cycles of intermittent hypoxia followed by reoxygenation, characteristicofOSA,promoteROSproduction[137, 138]andreducebloodantioxidantcapacity[165].”
Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives
Levy, P. A., Pépin, J., Arnaud, C., Tamisier, R., Borel, J., Demattéis, M., Godin‐Ribuot, D., & Ribuot, C. (2008) · European Respiratory Journal · doi:10.1183/09031936.00013308 · Cited by 216
Endothelial Dysfunction in Obstructive Sleep Apnea
Budhiraja, R., Parthasarathy, S., & Quan, S. F. (2007) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26864 · Cited by 208
Sleep apnea: epidemiology, pathophysiology, and relation to cardiovascular risk
Parati, G., Lombardi, C., & Narkiewicz, K. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00400.2007 · Cited by 205
“preferential activation of inflammatory pathways may be a consequence of the intermittent reoxygenation that is characteristic of intermittent hypoxia and thus represents a variant of reperfusion injury (72).”
BackgroundBarceló, A., Barbé, F., de la Peña, M., Vila, M., Pérez, G., Piérola, J., Duran, J., & Agustí, A. G. N. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00067605 · Cited by 201
Sleep-Disordered Breathing and Cardiovascular Risk
Caples, S. M., García‐Touchard, A., & Somers, V. K. (2007) · SLEEP · doi:10.1093/sleep/30.3.291 · Cited by 201
Obesity, obstructive sleep apnoea and metabolic syndrome
LAM, J. C. M., MAK, J. C. W., & IP, M. S. M. (2012) · Respirology · doi:10.1111/j.1440-1843.2011.02081.x · Cited by 198
HDL dysfunction in obstructive sleep apnea
Tan, K. C. B., Chow, W.-S., Lam, J., LAM, B. K., Wong, W.-K., Tam, S., & Ip, M. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.04.024 · Cited by 200
Htoo, A. K., Greenberg, H. E., Tongia, S., Chen, G., Henderson, T., Wilson, D., & Liu, S. F. (2006) · Sleep And Breathing · doi:10.1007/s11325-005-0046-6 · Cited by 201
“When cells are stimulated by various signals, including ROS, I-κB is rapidly phosphorylated by I-κB kinase.”
BackgroundInfluentialCarotid body chemoreceptors: physiology, pathology, and implications for health and disease
Iturriaga, R., Alcayaga, J., Chapleau, M. W., & Somers, V. K. (2021) · Physiological Reviews · doi:10.1152/physrev.00039.2019 · Cited by 206
Antioxidant defense responses to sleep loss and sleep recovery
Everson, C. A., Laatsch, C. D., & Hogg, N. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00565.2004 · Cited by 192
“injury, and in this way contributes to cardiovascular complications and inflammatory processes [e.g., (7, 39 , 55)].”
BackgroundJullian‐Desayes, I., Joyeux‐Faure, M., Tamisier, R., Launois, S. H., Borel, A., Levy, P. A., & Pépin, J. (2014) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.07.004 · Cited by 205
Advances in Sleep-disordered Breathing
Pack, A. I. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200509-1478oe · Cited by 192
Relationship of Metabolic Syndrome and Obstructive Sleep Apnea
Parish, J. M., Adam, T. J., & Facchiano, L. (2007) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26910 · Cited by 190
“(15-89) (31-90) (15-75) (31-83) (29-51) (25-85) (29-80) (25-85)”
López-Jiménez, F. A., Kuniyoshi, F. H. S., Gami, A. S., & Somers, V. K. (2008) · CHEST Journal · doi:10.1378/chest.07-0800 · Cited by 187
Unexpected survival advantage in elderly people with moderate sleep apnoea
Lavie, P., & Lavie, L. (2009) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2009.00754.x · Cited by 185
“Although ischaemic preconditioning is elicited largely by exposure to up to five sublethal ischaemic events, chronic intermittent hypoxia resembling sleep apnoea also confers cardioprotection; furthermore, oxidative stress that is associated closely with sleep apnoea (Lavie, 2003) was implicated specifically in these…”
BackgroundSelf-citationChronic intermittent hypoxia and obstructive sleep apnea: an experimental and clinical approach
Sforza, E. A., & Roche, F. (2016) · Hypoxia · doi:10.2147/hp.s103091 · Cited by 195
Sleep-Disordered Breathing in Down Syndrome
Lal, C., White, D. R., Joseph, J. E., van Bakergem, K., & LaRosa, A. (2015) · CHEST Journal · doi:10.1378/chest.14-0266 · Cited by 186
Intermittent hypoxia and vascular function: implications for obstructive sleep apnoea
Foster, G. E., Poulin, M. J., & Hanly, P. J. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2006.035204 · Cited by 179
“Although the mechanism by which intermittent hypoxia leads to vascular disease in OSA is unknown, it has been proposed that sympathetic nervous system overactivity (Fletcher, 2001), oxidative stress (Lavie, 2003) and endothelial dysfunction (Lavie, 2003) contribute to it.”
BackgroundInfluentialSahebkar, A., Kotani, K., Șerban, M.-C., Ursoniu, S., Mikhailidis, D. P., Jones, S. R., Ray, K. K., Blaha, M. J., Rysz, J., Toth, P. P., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.05.022 · Cited by 182
Palombi, K., Renard, E., Levy, P. A., Chiquet, C., Deschaux, C., Romanet, J. P., & Pépin, J. (2006) · British Journal of Ophthalmology · doi:10.1136/bjo.2005.087452 · Cited by 176
Effects of different acute hypoxic regimens on tissue oxygen profiles and metabolic outcomes
Reinke, C., Bevans‐Fonti, S., Drager, L. F., Shin, M., & Polotsky, V. Y. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00492.2011 · Cited by 179
“There was a general assumption that the pathogenesis of intermittent hypoxia and sleep apnea is similar to ischemiareperfusion injury (22, 23, 31).”
BackgroundItzhaki, S., Dorchin, H., Clark, G., Lavie, L., Lavie, P., & Pillar, G. (2007) · Chest · doi:10.1378/chest.06-0965 · Cited by 172
Self-citationObstructive Sleep Apnea and Inflammation
McNicholas, W. T. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2008.10.005 · Cited by 174
Belaïdi, E., Joyeux‐Faure, M., Ribuot, C., Launois, S. H., Levy, P. A., & Godin‐Ribuot, D. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.12.050 · Cited by 185
Intermittent Hypoxia: Cause of or Therapy for Systemic Hypertension?
Serebrovskaya, T. V., Manukhina, E. B., Smith, M. L., Downey, H. F., & Mallet, R. T. (2008) · Experimental Biology and Medicine · doi:10.3181/0710-mr-267 · Cited by 175
“The pro-inflammatory factors NF-jB (228, 230, 264, 265) and iNOS (233, 234) are activated in the OSA setting in response to ROS.”
BackgroundObstructive sleep apnea and the metabolic syndrome in community-based Chinese adults in Hong Kong
Lam, J., LAM, B. K., Lam, C.-L., Fong, D., Wang, J. K. L., Tse, H., Lam, K. S. L., & Ip, M. (2005) · Respiratory Medicine · doi:10.1016/j.rmed.2005.10.003 · Cited by 170
Hypoxia, energy balance and obesity: from pathophysiological mechanisms to new treatment strategies
Kayser, B., & Vergès, S. (2013) · Obesity Reviews · doi:10.1111/obr.12034 · Cited by 165
“The desaturation-reoxygenation sequence typical of OSA leads to oxidative stress, with production of reactive oxygen species (95), contributing to the development of systemic inflammation (96).”
BackgroundLavie, L., & Lavie, P. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2005.10.033 · Cited by 164
Self-citationEffect of sleep apnea on cognition and mood
El-Ad, B., & Lavie, P. (2005) · International Review of Psychiatry · doi:10.1080/09540260500104508 · Cited by 166
“Sleep apnea has been linked to development of hypertension, increased cardiovascular morbidity, and, on cellular and molecular levels, to an increased oxidative stress leading to endothelial damage by activation of cytokines and a decrease in plasma levels of nitric oxide (Lavie, 2003).”
BackgroundLiu, L., Cao, Q., Guo, Z., & Dai, Q. (2016) · The Journal of Clinical Hypertension · doi:10.1111/jch.12639 · Cited by 160
Inflammation, Oxidative Stress, and the Vascular Endothelium in Obstructive Sleep Apnea
Jelić, S., & Jemtel, T. H. L. (2008) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2008.11.008 · Cited by 167
Cardiovascular Drugs and Serum Uric Acid
Reyes, A. J. (2003) · Cardiovascular Drugs and Therapy · doi:10.1023/b:card.0000015855.02485.e3 · Cited by 163
“Oxidative stress could also mediate part of the increase in cardiovascular risk caused by sleep apnoea [217].”
BackgroundPack, A. I. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2401008 · Cited by 163
Obstructive sleep apnea and cardiovascular disease
Butt, M., Dwivedi, G., Khair, O. A., & Lip, G. Y. H. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.05.021 · Cited by 167
Chronic Intermittent Hypoxia/Reoxygenation Facilitate Amyloid-β Generation in Mice
Shiota, S., Takekawa, H., Matsumoto, S., Takeda, K., Nurwidya, F., Yoshioka, Y., Takahashi, F., Hattori, N., Tabira, T., Mochizuki, H., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130419 · Cited by 155
“A numbers of studies have produced supportive evidence for the presence of oxidative stress in OSA patients [41] [42] [43] [44] [45]; some studies went on to show reversible oxidative stress after treatment of continuous positive airway pressure therapy [41] [42] [44] [45].”
BackgroundPhenotypic and Functional Characterization of Blood γδ T Cells in Sleep Apnea
Dyugovskaya, L., Lavie, P., & Lavie, L. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200210-1226oc · Cited by 157
“Sleep apnea–related oxidative stress and a state of inflammatory cell activation resulting in endothelial cell injury have been proposed as one of the underlying mechanisms responsible for atherogenesis in this syndrome (4, 5 ).”
BackgroundInfluentialSelf-citationObstructive sleep apnoea and stroke
Yaggi, H. K., & Mohsenin, V. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00766-5 · Cited by 158
Hypoxia: The Force that Drives Chronic Kidney Disease
Fu, Q., Colgan, S. P., & Shelley, C. S. (2016) · Clinical Medicine & Research · doi:10.3121/cmr.2015.1282 · Cited by 156
Cardiovascular Consequences of Sleep Apnea
Selim, B. J., Won, C. H. J., & Yaggi, H. K. (2010) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2010.02.010 · Cited by 153
Obstructive sleep apnea and cognitive impairment: Addressing the blood–brain barrier
Lim, D. C., & Pack, A. I. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.12.003 · Cited by 158
Sleep and Cardiovascular Disease: An Overview
Malhotra, A., & Loscalzo, J. (2008) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2008.10.004 · Cited by 154
Mechanisms and Clinical Consequences of Untreated Central Sleep Apnea in Heart Failure
Costanzo, M. R., Khayat, R., Ponikowski, P. P., Augostini, R. S., Stellbrink, C., Mianulli, M. J., & Abraham, W. T. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.10.025 · Cited by 153
Endothelial Cell Apoptosis in Obstructive Sleep Apnea
Solh, A. A. E., Akinnusi, M. E., Baddoura, F. H., & Mankowski, C. R. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200611-1598oc · Cited by 151
“These mechanisms include the phenomenon of hypoxia reoxygenation (30), oxidative stress ( 31 ), and release of proinflammatory markers (32), all of which have been described to cause endothelial cell apopto-”
BackgroundObstructive Sleep Apnea, Cardiovascular Disease, and Pulmonary Hypertension
Golbin, J. M., Somers, V. K., & Caples, S. M. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200708-143mg · Cited by 146
“Each acute oxyhemoglobin desaturation is coupled to an episode of reoxygenation, a process thought to promote oxidative stress through formation of reactive oxygen species (6, 7 ), a cascade that may be associated with heightened inflammation (8, 9) and mitochondrial dysfunction (10).”
BackgroundInteractions of Obstructive Sleep Apnea With the Pathophysiology of Cardiovascular Disease, Part 1
Javaheri, S., Javaheri, S., Somers, V. K., Gozal, D., Mokhlesi, B., Mehra, R., McNicholas, W. T., Zee, P. C., Campos‐Rodríguez, F., Martínez‐García, M. Á., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.02.059 · Cited by 173
Does obstructive sleep apnea cause endothelial dysfunction? A critical review of the literature
Hoyos, C. M., Melehan, K. L., Liu, P. Y., Grunstein, R. R., & Phillips, C. L. (2015) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.06.003 · Cited by 142
Tennessen, J. M., Bertagnolli, N. M., Evans, J. M., Sieber, M., Cox, J. E., & Thummel, C. S. (2014) · G3 Genes Genomes Genetics · doi:10.1534/g3.114.010652 · Cited by 141
“…acid production in humans is commonly associated with disorders in which oxidative metabolism is disrupted, such as cardiac failure, acute stroke, sleep apnea, and the onset of type 2 diabetes (Fessel 1980; Leyva et al. 1998; Fang and Alderman 2000; Lavie 2003; Weir et al. 2003; Bhole et al. 2010).”
Chen, H.-Y., Cheng, I.-C., Pan, Y.-J., Chiu, Y.-L., Hsu, S.-P., Pai, M.-F., Yang, J.-Y., Peng, Y.-S., Tsai, T.-J., & Wu, K.-D. (2011) · Kidney International · doi:10.1038/ki.2011.151 · Cited by 140
Obstructive sleep apnea, pain, and opioids
Lam, K. K., Kunder, S., Wong, J., Doufas, A. G., & Chung, F. F. (2015) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000265 · Cited by 141
Oxidative stress inflammation and endothelial dysfunction in obstructive sleep apnea
Lavie, L. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e469 · Cited by 142
Self-citationHypoxic Conditioning as a New Therapeutic Modality
Vergès, S., Chacaroun, S., Godin‐Ribuot, D., & Baillieul, S. (2015) · Frontiers in Pediatrics · doi:10.3389/fped.2015.00058 · Cited by 134
“Desaturation–reoxygenation sequences lead to oxidative stress and the production of reactive oxygen species (ROS) (1).”
BackgroundInfluentialKuvat, N., Tanrıverdi, H., & Armutçu, F. (2020) · The Clinical Respiratory Journal · doi:10.1111/crj.13175 · Cited by 145
Metadata
- Authors
- Lavie, L.
- Affiliations
- Technion – Israel Institute of Technology (IL)
- Corresponding author
- Lavie, Lena
- Venue
- Sleep Medicine Reviews
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 7
- Issue
- 1
- Pages
- 35-51
- ISSN
- 1087-0792 (ISSN-L)
- OpenAlex
- W1988114644
- Cited by
- 993
- References
- 134
- Citations by year
- 2026: 17 · 2025: 44 · 2024: 28 · 2023: 30 · 2022: 33 · 2021: 43 · 2020: 42 · 2019: 31 · 2018: 38 · 2017: 37 · 2016: 44 · 2015: 51 · 2014: 58 · 2013: 48 · 2012: 51
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sleep Medicine Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Health, State of Israel
- Topics
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- obstructive sleep apnea, oxidative stress, hypoxia/reoxygenation injury, reactive oxygen species, lipoprotein oxidation, adhesion molecules, adenosine, uric acid, HIF-1, NF-κB, AP-1, endothelial dysfunction, monocyte adhesion, nitric oxide bioavailability, atherosclerosis, cardiovascular risk
- MeSH terms
- Cardiovascular Diseases, Free Radicals, Humans, Leukocytes, Lymphokines, Nitric Oxide, Lipid Peroxidation, Endothelial Growth Factors, Oxidative Stress, Hyperhomocysteinemia, Sleep Apnea, Obstructive, Intercellular Signaling Peptides and Proteins, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
