Pathogenesis and treatment of anaemia of chronic disease

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S. J., Moynihan, J., Paw, B. H., Drejer, A., Barut, B., Zapata, A., et al. (2000) · Nature · doi:10.1038/35001596 · Cited by 1,667

A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation

McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80425-6 · Cited by 1,422

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.

Hentze, M. W., & Kühn, L. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8175 · Cited by 1,292

A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism

Abboud, S., & Haile, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000713200 · Cited by 1,267

Serum Transferrin Receptor and Its Ratio to Serum Ferritin in the Diagnosis of Iron Deficiency

Punnonen, K., Irjala, K., & Rajamäki, A. (1997) · Blood · doi:10.1182/blood.v89.3.1052 · Cited by 859

Deleterious clinical effects of transfusion-associated immunomodulation: fact or fiction?

Vamvakas, E. C., & Blajchman, M. A. (2001) · Blood · doi:10.1182/blood.v97.5.1180 · Cited by 423

Iron regulates nitric oxide synthase activity by controlling nuclear transcription.

Weiss, G., Werner-Felmayer, G., Werner, E. R., Grünewald, K., Wachter, H., & Hentze, M. W. (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.3.969 · Cited by 412

IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex eIF4F.

Muckenthaler, M., Gray, N. K., & Hentze, M. W. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80282-8 · Cited by 297

Nutritional deficiencies and blunted erythropoietin response as causes of the Amemia of critical illness

Rodriguez, R. M., Corwin, H. L., Gettinger, A., Corwin, M. J., Gubler, D., & Pearl, R. G. (2001) · Journal of Critical Care · doi:10.1053/jcrc.2001.21795 · Cited by 282

Effect of Iron Chelation Therapy on Recovery from Deep Coma in Children with Cerebral Malaria

Gordeuk, V., Thuma, P., Brittenham, G., McLaren, C., Parry, D., Backenstose, A., Biemba, G., Msiska, R., Holmes, L., McKinley, E., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199211193272101 · Cited by 210

Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha.

Maciejewski, J. P., Selleri, C., Sato, T., Cho, H. J., Keefer, L. K., Nathan, C. F., & Young, N. S. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118094 · Cited by 209

Functional Requirement of the Hypoxia-responsive Element in the Activation of the Inducible Nitric Oxide Synthase Promoter by the Iron Chelator Desferrioxamine

Melillo, G., Taylor, L. S., Brooks, A., Musso, T., Cox, G. W., & Varesio, L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.18.12236 · Cited by 201

Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis

Cazzola, M., Ponchio, L., de Benedetti, F., Ravelli, A., Rosti, V, Beguin, Y., Invernizzi, R., Barosi, G., & Martini, A. (1996) · Blood · doi:10.1182/blood.v87.11.4824.bloodjournal87114824 · Cited by 197

Regulation of iron metabolism in the acute‐phase response: interferon γ and tumour necrosis factor α induce hypoferraemia, ferritin production and a decrease in circulating transferrin receptors in cancer patients

Feelders, Vreugdenhil, Eggermont, Kuiper‐Kramer, Eijk, V., & Swaak (1998) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1998.00323.x · Cited by 172

Iron Overload Alters Innate and T Helper Cell Responses to Candida albicans in Mice

Mencacci, A., Cenci, E., Boelaert, J. R., Bucci, P., Mosci, P., d'Ostiani, C. F., Bistoni, F., & Romani, L. (1997) · The Journal of Infectious Diseases · doi:10.1086/516481 · Cited by 169

Associations of iron overload in Africa with hepatocellular carcinoma and tuberculosis: Strachan's 1929 thesis revisited

Gordeuk, V., McLaren, C., MacPhail, A., Deichsel, G., & Bothwell, T. (1996) · Blood · doi:10.1182/blood.v87.8.3470.bloodjournal8783470 · Cited by 154

Modulation of iron metabolism in monocyte cell line U937 by inflammatory cytokines: changes in transferrin uptake, iron handling and ferritin mRNA.

Fahmy, M., & Young, S. P. (1993) · Biochemical Journal · doi:10.1042/bj2960175 · Cited by 150

Regulation of transferrin receptor expression and ferritin content in human mononuclear phagocytes. Coordinate upregulation by iron transferrin and downregulation by interferon gamma.

Byrd, T. F., & Horwitz, M. A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116318 · Cited by 149

Understanding the multiple functions of Nramp1

Blackwell, J. M., Searle, S., Goswami, T., & Miller, E. N. (2000) · Microbes and Infection · doi:10.1016/s1286-4579(00)00295-1 · Cited by 136

Differential iron transport into phagosomes isolated from the RAW264.7 macrophage cell lines transfected with Nramp1Gly169 or Nramp1Asp169

Kuhn, D. E., Baker, B. D., Lafuse, W. P., & Zwilling, B. S. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.1.113 · Cited by 113

Role of iron in T cell activation: Th1 clones differ from TH2 clones in their sensitivity to inhibition of DNA synthesis caused by IGG mabs against the transferrin receptor and the iron chelator deferoxamine

Thorson, J. A., Smith, K. M., Gomez, F., Naumann, P. W., & Kemp, J. D. (1991) · Cellular Immunology · doi:10.1016/0008-8749(91)90336-a · Cited by 98

Regulation of iron metabolism in murine J774 macrophages: role of nitric oxide-dependent and -independent pathways following activation with gamma interferon and lipopolysaccharide.

Mulero, V., & Brock, J. H. (1999) · Blood · doi:10.1182/blood.v94.7.2383.419k20_2383_2389 · Cited by 86

Regulatory Interactions between Iron and Nitric Oxide Metabolism for Immune Defense against Plasmodium falciparum Infection

Fritsche, G., Larcher, C., Schennach, H., & Weiss, G. (2001) · The Journal of Infectious Diseases · doi:10.1086/319860 · Cited by 84

Effect of transfusional iron overload on immune response.

Cunningham‐Rundles, S., Giardina, P. J., Grady, R. W., Califano, C., McKenzie, P., & De Sousa, M. (2000) · The Journal of Infectious Diseases · doi:10.1086/315919 · Cited by 71

Anemia of Chronic Disease

Weiss, G., & Goodnough, L. T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041809 · Cited by 3,800

Iron metabolism and toxicity

Papanikolaou, G., & Pantopoulos, K. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.06.021 · Cited by 1,070

Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis

Papanikolaou, G., Samuels, M. E., Ludwig, E. H., MacDonald, M. L. E., Franchini, P. L., Dubé, M.-P., Andres, L., MacFarlane, J., Sakellaropoulos, N., Politou, M., et al. (2004) · Nature Genetics · doi:10.1038/ng1274 · Cited by 974

Ferritin heavy chain upregulation by NF-κB inhibits TNFα-induced apoptosis by suppressing reactive oxygen species

Pham, C. G., Bubici, C., Zazzeroni, F., Papa, S., Jones, J., Alvarez, K., Jayawardena, S., De Smaele, E., Cong, R., Beaumont, C., et al. (2004) · Cell · doi:10.1016/j.cell.2004.10.017 · Cited by 663

Cytokine-mediated regulation of iron transport in human monocytic cells

Ludwiczek, S., Aigner, E., Theurl, I., & Weiss, G. (2003) · Blood · doi:10.1182/blood-2002-08-2459 · Cited by 420