Enhanced Skin-Protective Effects of a Novel Centella asiatica Variety (BT-Care) Cultivated for 75 Days via Modulation of Antioxidant Defense, Collagen Synthesis, and Skin Barrier Function

Antioxidant activity applying an improved ABTS radical cation decolorization assay

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Use of a Free Radical Method to Evaluate Antioxidant Activity

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The skin: an indispensable barrier

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Hyaluronic acid: A key molecule in skin aging

Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012) · Dermato-Endocrinology · doi:10.4161/derm.21923 · Cited by 1,031 · see citing works

Pharmacological review on Centella asiatica: A potential herbal cure-all

Gohil, K., Patel, J. A., & Gajjar, A. (2010) · Indian Journal of Pharmaceutical Sciences · doi:10.4103/0250-474x.78519 · Cited by 666 · see citing works

TNF-α stimulates activation of pro-MMP2 in human skin through NF-κB mediated induction of MT1-MMP

Han, Y.-P., Tuan, T., Wu, H., Hughes, M. W., & Garner, W. L. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.1.131 · Cited by 412 · see citing works

Pentacyclic Triterpenoids from the Medicinal Herb, Centella asiatica (L.) Urban

James, J. T., & Dubery, I. A. (2009) · Molecules · doi:10.3390/molecules14103922 · Cited by 399 · see citing works

Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

Sun, B., Wu, L., Wu, Y., Zhang, C., Qin, L., Hayashi, M., Kudo, M., Gao, M., & Liu, T. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.568032 · Cited by 353 · see citing works

Solar UV radiation reduces the barrier function of human skin

Biniek, K., Levi, K., & Dauskardt, R. H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206851109 · Cited by 324 · see citing works

Centella asiatica: Phytochemistry and mechanisms of neuroprotection and cognitive enhancement

Gray, N. E., Alcazar Magana, A., Lak, P., Wright, K. M., Quinn, J., Stevens, J. F., Maier, C. S., & Soumyanath, A. (2018) · Phytochemistry Reviews · doi:10.1007/s11101-017-9528-y · Cited by 299 · see citing works

Review on plants with CNS-effects used in traditional South African medicine against mental diseases

Stafford, G. I., Pedersen, M. E., van Staden, J., & Jäger, A. K. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.08.010 · Cited by 256 · see citing works

Centella asiatica in Dermatology: An Overview

Bylka, W., Znajdek-Awiżeń, P., Studzińska-Sroka, E., Dańczak‐Pazdrowska, A., & Brzezińska, M. (2014) · Phytotherapy Research · doi:10.1002/ptr.5110 · Cited by 225 · see citing works

Modulation of Melanogenesis by Aloesin: A Competitive Inhibitor of Tyrosinase

Jones, K., Hughes, J. L., Hong, M., Jia, Q., & Orndorff, S. (2002) · Pigment Cell Research · doi:10.1034/j.1600-0749.2002.02014.x · Cited by 212 · see citing works

Bioavailability, Distribution, and Antioxidative Effects of Selected Triterpenes in Mice

Yin, M., Lin, M., Mong, M., & Lin, C.-Y. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf302529x · Cited by 179 · see citing works

Inhibition of collagenase and metalloproteinases by aloins and aloe gel

Barrantes, E., & Guinea, M. T. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02308-1 · Cited by 145 · see citing works

Filaggrin and Skin Barrier Function

Kežić, S., & Jakaša, I. (2016) · Current problems in dermatology · doi:10.1159/000441539 · Cited by 128 · see citing works

Insights into antioxidant activities and anti-skin-aging potential of callus extract from Centella asiatica (L.)

Buranasudja, V., Rani, D., Malla, A., Kobtrakul, K., & Vimolmangkang, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-92958-7 · Cited by 112 · see citing works

Identification of Major Active Ingredients Responsible for Burn Wound Healing of<i>Centella asiatica</i>Herbs

Wu, F., Bian, D., Xia, Y., Gong, Z., Tan, Q., Chen, J., & Dai, Y. (2012) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2012/848093 · Cited by 105 · see citing works

Nuclear DNA damage-triggered NLRP3 inflammasome activation promotes UVB-induced inflammatory responses in human keratinocytes

Hasegawa, T., Nakashima, M., & Suzuki, Y. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.06.106 · Cited by 101 · see citing works

Ultraviolet Irradiation Induces Smad7 via Induction of Transcription Factor AP-1 in Human Skin Fibroblasts

Quan, T., He, T., Voorhees, J. J., & Fisher, G. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409647200 · Cited by 97 · see citing works

Cardiovascular Protective Effects of Centella asiatica and Its Triterpenes: A Review

Razali, N. N. M., Ng, C. T., & Fong, L. Y. (2019) · Planta Medica · doi:10.1055/a-1008-6138 · Cited by 95 · see citing works

Oral Intake of Collagen Peptide Attenuates Ultraviolet B Irradiation-Induced Skin Dehydration In Vivo by Regulating Hyaluronic Acid Synthesis

Kang, M. C., Yumnam, S., & Kim, S. Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113551 · Cited by 91 · see citing works

Asiaticoside nitric oxide gel accelerates diabetic cutaneous ulcers healing by activating Wnt/β-catenin signaling pathway

Nie, X., Zhang, H., Shi, X., Zhao, J., Chen, Y., Wu, F., Yang, J., & Li, X. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.106109 · Cited by 81 · see citing works

Protein Contents, Amino Acid Compositions and Nitrogen-to-Protein Conversion Factors for Cassava Roots

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Factors affecting the content of pentacyclic triterpenes inCentella asiaticaraw materials

Puttarak, P., & Panichayupakaranant, P. (2012) · Pharmaceutical Biology · doi:10.3109/13880209.2012.685946 · Cited by 71 · see citing works

p38 MAP kinase plays a functional role in UVB‐Induced mouse skin carcinogenesis

Dickinson, S. E., Olson, E. R., Zhang, J. Y., Cooper, S. J., Melton, T., Criswell, P. J., Casanova, A., Dong, Z., Hu, C., Saboda, K., et al. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.20734 · Cited by 65 · see citing works

Genome-Wide Transcriptional Profiling of Skin and Dorsal Root Ganglia after Ultraviolet-B-Induced Inflammation

Dawes, J. M., Antunes‐Martins, A., Perkins, J. R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093338 · Cited by 65 · see citing works

Pharmacokinetics of a Standardized Extract of Centella asiatica ECa 233 in Rats

Anukunwithaya, T., Tantisira, M. H., Tantisira, B., & Khemawoot, P. (2016) · Planta Medica · doi:10.1055/s-0042-122344 · Cited by 60 · see citing works

Centella asiatica alleviates psoriasis through JAK/STAT3-mediated inflammation: An in vitro and in vivo study

Lin, P., Shi, H., Lu, Y., & Lin, J. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116746 · Cited by 60 · see citing works

In vivo disposition and metabolism of madecassoside, a major bioactive constituent in Centella asiatica (L.) Urb.

Dan-dan, L., Han, W., Rui, Y., Dai, Y., & Xia, Y. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.09.004 · Cited by 54 · see citing works

<i>Propionibacterium acnes</i> related anti-inflammation and skin hydration activities of madecassoside, a pentacyclic triterpene saponin from <i>Centella asiatica</i>

Shen, X., Guo, M., Yu, H., Liu, D., Lu, Z., & Lu, Y. (2019) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2018.1547627 · Cited by 54 · see citing works

Phytochemical Analysis and Antioxidant Activity of Centella Asiatica Extracts: An Experimental and Theoretical Investigation of Flavonoids

Anbazhakan, K., Aruchamy, K., Praveena, R., Varadhaiyan, D., Gowri, C., Oh, T. H., Ramasundaram, S., & Balasankar, A. (2023) · Plants · doi:10.3390/plants12203547 · Cited by 45 · see citing works

Human stratum corneum proteomics reveals cross‐linking of a broad spectrum of proteins in cornified envelopes

Karim, N., Phinney, B. S., Salemi, M., Wu, P., Naeem, M., & Rice, R. H. (2019) · Experimental Dermatology · doi:10.1111/exd.13925 · Cited by 44 · see citing works

Stellera chamaejasme and its constituents induce cutaneous wound healing and anti-inflammatory activities

Kim, M., Lee, H. J., Randy, A., Yun, J. H., Oh, S., & Nho, C. W. (2017) · Scientific Reports · doi:10.1038/srep42490 · Cited by 41 · see citing works

Preparation, Development, and Scale-Up of Standardized Pentacyclic Triterpenoid-Rich Extract from Centella asiatica (L.) Urb. and Study of Its Wound Healing Activity

Rachpirom, M., Pichayakorn, W., & Puttarak, P. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17807 · Cited by 26 · see citing works

Effects of Asiaticoside Treatment on the Survival of Random Skin Flaps in Rats

Feng, X., Huang, D., Lin, D., Zhu, L., Zhang, M., Chen, Y., & Wu, F. (2021) · Journal of Investigative Surgery · doi:10.1080/08941939.2019.1584255 · Cited by 23 · see citing works

Decoupling of Plant Growth and Accumulation of Biologically Active Compounds in Leaves, Roots, and Root Exudates of Hypericum perforatum L. by the Combination of Jasmonate and Far-Red Lighting

Paponov, M., Antonyan, M., Slimestad, R., et al. (2021) · Biomolecules · doi:10.3390/biom11091283 · Cited by 23 · see citing works

Identification of potential cultivation areas for centelloside-specific elite chemotypes of Centella asiatica (L.) using ecological niche modeling

Singh, S. P., Misra, A., Kumar, B., et al. (2022) · Industrial Crops and Products · doi:10.1016/j.indcrop.2022.115657 · Cited by 23 · see citing works

Reinvestigation of Herniaria glabra L. saponins and their biological activity

Kozachok, S., Pecio, Ł., Orhan, İ. E., et al. (2019) · Phytochemistry · doi:10.1016/j.phytochem.2019.112162 · Cited by 22 · see citing works

Variations in the leaf metabolite profile between hydroponic and field grown Moringa oleifera Lam. genotypes

Managa, L. R., du Toit, E. S., & Prinsloo, G. (2021) · Biochemical Systematics and Ecology · doi:10.1016/j.bse.2021.104302 · Cited by 14 · see citing works

Ultraviolet B irradiation induces the expression of hornerin in xenotransplanted human skin

Makino, T., Yamakoshi, T., Mizawa, M., & Shimizu, T. (2013) · Acta Histochemica · doi:10.1016/j.acthis.2013.05.001 · Cited by 10 · see citing works

Centella asiatica transfersomes and Bergamot essential oil nanoemulsion combined in gel exhibited anti-photoaging effects on UVB-radiated BALB/c mice

Retnaningtyas, E., Susatia, B., Khotimah, H., Rudijanto, A., Abousouh, A. A. A., & Setiawan, A. (2024) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2024.103207 · Cited by 8 · see citing works

Global prospects for cultivating Centella asiatica: An ecological niche modeling approach under current and future climatic scenarios

Lin, P.-C., Chiang, T., Chen, M., Hsu, T., Gean, P., Cheng, S.-T., & Hsu, Y. (2024) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2024.101380 · Cited by 7 · see citing works

Anti-Photoaging and Anti-Melanogenic Effects of a Novel <i>Lactiplantibacillus plantarum</i> RKBP Isolated from Giant <i>Centella asiatica</i>

Seo, J., Sung, E. J., Son, D. Y., Yoo, D. S., Seo, D. B., Kim, M., & Yoo, C. (2026) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2603.03011

A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women.

Hur, N., Seo, Y., Bae, J., Kim, Y. J., Kim, E. J., & Choi, Y. J. (2026) · Nutrients · doi:10.3390/nu18101505

Triterpene Composition and Bioactivities of Centella asiatica

Hashim, P., Sidek, H., Helan, M. H. M., Sabery, A., Palanisamy, U. D., & Ilham, M. (2011) · Molecules · doi:10.3390/molecules16021310 · Cited by 266 · see citing works

Pegaga (Centella asiatica)

Taher, M., & Darnis, D. S. (2016)

EFFECT OF 50% ETHANOLIC EXTRACT OF PEGAGAN HERB (Centella asiatica (L.) Urban) ON CELL PROLIFERATION OF LYMPHOCYTES IN Balb/c MALE MICE INDUCED BY HEPATITIS B VACCINE PENGARUH EKSTRAK ETANOLIK 50% HERBA PEGAGAN (Centella asiatica (L.) Urban) TERHADAP PENINGKATAN PROLIFERASI SEL LIMFOSIT MENCIT JANTAN GALUR Balb/c YANG DIINDUKSI VAKSIN HEPATITIS B

Pramono, S., & Sasmito, E. (2015)

In vitro studies on Centella asiatica L urban an ayurvedic medicinal herb

Alagumanian, S. (2001) · Shodhganga

AKTIVITAS HEPATOPROTEKTOR KOMBINASI EKSTRAK AIR PEGAGAN (Centella asiatica L. Urban) DAN EKSTRAK ETANOL KUNYIT (Curcuma longa Linn) TERHADAP TIKUS PUTIH JANTAN SPRAGUE DAWLEY

Firman, G. T. A., Rahminiwati, M., & Wiendarlina, I. Y. (2017) · FITOFARMAKA Jurnal Ilmiah Farmasi · doi:10.33751/jf.v7i1.797