In vitro and In vivo Antioxidant, Anti-hyperlipidemic Properties and Chemical Characterization of Centella asiatica (L.) Extract
Open accessAbstract
The study aimed to identify the phenolic compounds present in Centella asiatica (L.) (C. asiatica) extract and evaluate the respective antioxidant potential as well as its cholesterol-lowering effects in the experimental animal model. Herein, the antioxidant potential of extracts was assessed by its free radical scavenging activity such as 2, 2-diphenyl -1- picrylhydrazyl as well as reducing capability. The antihyperlipidemic effects of C. asiatica extract (CAE) were evaluated in high cholesterol-fed (HCF) rats for 4 weeks, where different concentrations of extracts (0.25, 0.5 and 1 g/kg/day) were orally administrated daily. Lipid and antioxidant profiles, including total cholesterol (TC), triglyceride (TG), low- density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and superoxide dismutase (SOD), together with the indices of hepatic functions were also examined. C. asiatica revealed excellent free radical scavenging activity as revealed by DPPH assay, with the IC50 values (9.62 ± 0.88 μg/mL). Furthermore, C. asiatica extracts and fenofibrate remarkably lowered the level of TC, TG, LDL-C, and showed elevated levels of HDL-C, SOD. The histopathological observations further demonstrated clear differentiation and structural changes in liver of HCF and CAE treated group. Furthermore, gulonic acid, ferulic acid, kaempferol, chlorogenic acid, and asiatic acid were identified to be the major components which might be responsible for the antioxidant activity of the C. asiatica extract as evidenced from an ultra-high performance liquid chromatography–mass spectrometer (UHPLC-MS/MS). Taken together, these results signifies the excellent antioxidant and antihyperlipidemic properties of C. asiatica leaf extracts, which might be useful for the treatment of oxidative-stress related diseases such as hyperlipidemia.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Compounds in CA such as ferulic acid and asiatic acid induce Nrf2 and its ARE-regulated targets, exhibiting a neuroprotective effect.
“Compounds such as the phenolic ferulic acid [89,90] and the triterpene asiatic acid [2,91], induce Nrf2 and its ARE-regulated targets, exhibiting a neuroprotective effect [92,93,94,95].”
From Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice (2019) · cites this paper as [89]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423 · see citing works
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,460 · see citing works
Ellman, G. L. (1959) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(59)90090-6 · Cited by 26,383 · see citing works
Antioxidant activity applying an improved ABTS radical cation decolorization assay
Re, R., Pellegrini, N., Proteggente, A. R., Pannala, A. S., Yang, M. H., & Rice-Evans, C. A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00315-3 · Cited by 26,298 · see citing works
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525 · see citing works
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,089 · see citing works
Marklund, S. L., & MARKLUND, G. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03714.x · Cited by 10,382 · see citing works
Cholesterol Treatment Trialists' (CTT) Collaboration (2010) · The Lancet · doi:10.1016/s0140-6736(10)61350-5 · Cited by 6,550 · see citing works
Antihyperlipidemic and Biochemical Activities of Mcy Protein in Streptozotocin Induced Diabetic Rats
Marella, S., Maddirela, D. R., Badri, K. R., Kumar, M. V. J., & Chippada, A. R. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373954 · Cited by 5,938 · see citing works
Cellular defenses against damage from reactive oxygen species
Yu, B. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.1.139 · Cited by 2,378 · see citing works
Comparison of ABTS/DPPH assays to measure antioxidant capacity in popular antioxidant-rich US foods
Floegel, A., Kim, D., Chung, S., Koo, S. I., & Chun, O. K. (2011) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2011.01.008 · Cited by 1,818 · see citing works
Role of oxidative stress in atherosclerosis
Harrison, D., Griendling, K. K., Landmesser, U., Hornig, B., & Drexler, H. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)03144-2 · Cited by 1,275 · see citing works
Lifetime risks of cardiovascular disease
Berry, J. D., Dyer, A., Cai, X., Garside, D. B., Ning, H., Thomas, A., Greenland, P., Van Horn, L., Tracy, R. P., & Lloyd-Jones, D. M. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1012848 · Cited by 945 · see citing works
The comet assay with 8 mouse organs: results with 39 currently used food additives
Sasaki, Y. F., Kawaguchi, S., Kamaya, A., Ohshita, M., Kabasawa, K., Iwama, K., TANIGUCHI, K., & Tsuda, S. (2002) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(02)00128-6 · Cited by 724 · see citing works
Pharmacological review on Centella asiatica: A potential herbal cure-all
Gohil, K., Patel, J. A., & Gajjar, A. (2010) · Indian Journal of Pharmaceutical Sciences · doi:10.4103/0250-474x.78519 · Cited by 666 · see citing works
Antioxidative Phenolic Compounds from Sage (Salvia officinalis)
Wang, M., Li, J., Rangarajan, M., Shao, Y., LaVoie, E. J., Huang, T., & Ho, C. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980614b · Cited by 622 · see citing works
Dietary antioxidants in preventing atherogenesis
Kaliora, A. C., Dedoussis, G. V., & Schmidt, H. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.11.001 · Cited by 417 · see citing works
Antioxidant activity of Smilax excelsa L. leaf extracts
Özsoy, N., Can, A., Yanardağ, R., & Akev, N. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.02.037 · Cited by 406 · see citing works
In vitro and in vivo antioxidant activity of aqueous extract from Choerospondias axillaris fruit
Wang, H., Gao, X., Zhou, G., Cai, L., & Yao, W. B. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.05.068 · Cited by 358 · see citing works
Beyond Low-Density Lipoprotein Cholesterol
Arsenault, B. J., Rana, J. S., Stroes, E. S. G., Després, J.-P., Shah, P. K., Kastelein, J. J. P., Wareham, N. J., Boekholdt, S. M., & Khaw, K.-T. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.07.057 · Cited by 342 · see citing works
Atheroprotective mechanisms of HDL
Stein, O., & Stein, Y. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00065-9 · Cited by 318 · see citing works
Antioxidant capacity and phenol content of selected Algerian medicinal plants
Atmani-Kilani, D., Chaher, N., Berboucha, M., Ayouni, K., Lounis, H., Boudaoud, H., Debbache-Benaida, N., & Atmani, D. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.05.077 · Cited by 285 · see citing works
The biology and chemistry of hyperlipidemia
Jain, K. S., Kathiravan, M. K., Somani, R. S., & Shishoo, C. J. (2007) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2007.04.031 · Cited by 266 · see citing works
Liao, D., Jin, Z., Baas, A. S., Daum, G., Gygi, S. P., Aebersold, R. H., & Berk, B. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.189 · Cited by 262 · see citing works
Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats
Khanna, A., Rizvi, F., & Chander, R. (2002) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(02)00136-8 · Cited by 247 · see citing works
Antioxidant and cytotoxic activities of Centella asiatica (L) Urb
Pittella, F., Dutra, R. C., Junior, D. D., Lopes, M. T. P., & Barbosa, N. R. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10093713 · Cited by 244 · see citing works
Orhan, I. E. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/946259 · Cited by 238 · see citing works
Somboonwong, J., Kankaisre, M., Tantisira, B., & Tantisira, M. H. (2012) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-12-103 · Cited by 232 · see citing works
The role of phytochemicals in inhibition of cancer and inflammation: New directions and perspectives
Issa, A., Volate, S. R., & Wargovich, M. J. (2006) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2006.02.009 · Cited by 169 · see citing works
Minhajuddin, M., Beg, Z. H., & Iqbal, J. (2005) · Food and Chemical Toxicology · doi:10.1016/j.fct.2005.01.015 · Cited by 166 · see citing works
Antimicrobial activity of flavonoids in medicinal plants from Tafı del Valle (Tucumán, Argentina)
Hernández, N., Tereschuk, M. L., & Abdala, L. R. (2000) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(00)00295-6 · Cited by 152 · see citing works
Triglycerides and Cardiovascular Risk
Harchaoui, K. E., Visser, M., Kastelein, J. J. P., Stroes, E. S. G., & Dallinga‐Thie, G. M. (2009) · Current Cardiology Reviews · doi:10.2174/157340309788970315 · Cited by 139 · see citing works
Devi, R., & Sharma, D. K. (2003) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2003.09.022 · Cited by 123 · see citing works
Self-citationChang, Y., Chou, C., Chiu, C., Yang, K., Lin, Y., Weng, W.-L., & Chen, Y. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf103167u · Cited by 118 · see citing works
Fki, I., Bouaziz, M. A., Sahnoun, Z., & Sayadi, S. (2005) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2005.05.036 · Cited by 116 · see citing works
Ma, Y., Wang, W., Zhang, J., Lu, Y., Wu, W., Yan, H., & Wang, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035835 · Cited by 113 · see citing works
Biochemical Targets of Plant Bioactive Compounds
Polya, G. M. (2003) · CRC Press eBooks · doi:10.1201/9780203013717 · Cited by 93 · see citing works
Jiang, C., Wang, Q., Wei, Z., Yao, N., Wu, Z.-F., Ma, Y., Lin, Z. L., Zhao, M., Che, C., Yao, X., et al. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.10.006 · Cited by 91 · see citing works
FUNCTIONAL PROPERTIES OF CENTELLA ASIATICA (L.): A REVIEW
S.Vasantharuba, P. B., Premalatha, S., & Arumugam, T. (2012) · Cited by 88 · see citing works
Beneficial effects of noni (Morinda citrifolia L.) juice on livers of high-fat dietary hamsters
Lin, Y., Chang, Y., Yang, D., Tzang, B., & Chen, Y. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.02.035 · Cited by 85 · see citing works
Bajpai, V. K., Sharma, A., Kang, S. C., & Baek, K.-H. (2014) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(13)60183-2 · Cited by 85 · see citing works
Maruthanila, V. L., Jayakumar, P., & Mirunalini, S. (2014) · Advances in Pharmacological Sciences · doi:10.1155/2014/832161 · Cited by 69 · see citing works
Inhibitory effects of constituents of Morinda citrifolia seeds on elastase and tyrosinase
Masuda, M., Murata, K., Fukuhama, A., Naruto, S., Fujita, T., Uwaya, A., Isami, F., & Matsuda, H. (2009) · Journal of Natural Medicines · doi:10.1007/s11418-009-0328-6 · Cited by 68 · see citing works
Kumari, S., Elancheran, R., Kotoky, J., & Devi, R. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.02.101 · Cited by 67 · see citing works
Self-citationFeng, J., Fitz, Y., Li, Y., Fernandez, M., Puch, I. C., Wang, D., Pazniokas, S., Bucher, B., Cui, X., & Solomon, S. B. (2015) · Journal of Visualized Experiments · doi:10.3791/51881 · Cited by 65 · see citing works
Lee, M., Bok, S., Jeong, T., Moon, S., Lee, S.-E., Park, Y. B., & Choi, M. (2002) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(02)00059-7 · Cited by 54 · see citing works
Kumthekar, M. M., & Katyare, S. S. (1992) · PubMed · Cited by 53 · see citing works
Yang, D., Chang, Y., Hsu, C., Liu, C., Wang, Y., & Chen, Y. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.09.027 · Cited by 52 · see citing works
Antioxidant and antigenotoxic effects of pupae of the muga silkworm Antheraea assamensis
Deori, M., Boruah, D. C., Devi, D., & Devi, R. (2014) · Food Bioscience · doi:10.1016/j.fbio.2013.12.001 · Cited by 51 · see citing works
Self-citationGorinstein, S., Yamamoto, K., Katrich, E., Hanna Leontowicz, A., Lojek, A., Maria Leontowicz, A., Čı́ž, M., Goshev, I., SHALEV, U., & Trakhtenberg, S. (2003) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.67.907 · Cited by 49 · see citing works
Ahmed, S. A., Hanif, S., & Iftkhar, T. (2013) · Open Journal of Medical Microbiology · doi:10.4236/ojmm.2013.33025 · Cited by 49 · see citing works
Sarma, R., Kumari, S., Elancheran, R., Deori, M., & Devi, R. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00294 · Cited by 48 · see citing works
Self-citationAntibacterial Activity of 2-(2’,4’-Dibromophenoxy)-4,6-dibromophenol from Dysidea granulosa
Shridhar, D. M., Mahajan, G., Kamat, V. P., Naik, C. G., Parab, R., Thakur, N. R., & Mishra, P. D. (2009) · Marine Drugs · doi:10.3390/md7030464 · Cited by 40 · see citing works
Lesser known ethnomedicinal plants of Mizoram, North East India: an Indo-Burma hotspot region.
Kumar, P., & Lalramnghinglova, H. (2010) · Journal of Medicinal Plants Research · doi:10.5897/jmpr09.480 · Cited by 39 · see citing works
Apichartsrangkoon, A., Wongfhun, P., & Gordon, M. H. (2009) · Journal of Food Science · doi:10.1111/j.1750-3841.2009.01358.x · Cited by 37 · see citing works
Drugs from nature: past achievements, future prospects
Cragg, G. M. L., & Newman, D. J. (2002) · Advances in phytomedicine · doi:10.1016/s1572-557x(02)80010-1 · Cited by 36 · see citing works
Choi, W. H., Gwon, S. Y., Ahn, J., Jung, C. H., & Ha, T. Y. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.04.006 · Cited by 35 · see citing works
Cardiovascular protection of deep-seawater drinking water in high-fat/cholesterol fed hamsters
Hsu, C., Chang, Y., Chiu, C., Yang, K., Wang, Y., Fu, S., & Chen, Y. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.01.116 · Cited by 35 · see citing works
Flavour characterisation of fresh and processed pennywort (Centella asiatica L.) juices
Wongfhun, P., Gordon, M. H., & Apichartsrangkoon, A. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.05.072 · Cited by 35 · see citing works
Taurine alleviates dyslipidemia and liver damage induced by a high-fat/cholesterol-dietary habit
Yang, S., Tzang, B., Yang, K., Hsiao, Y.-C., Chang, Y., Chan, C., Fu, S., & Chen, Y. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.10.001 · Cited by 33 · see citing works
In vitro evaluation of free radical scavenging activity of Codariocalyx motorius root extract
Chidambaram, U., Vanitha, P., Suganya, N., Bhakkiyalakshmi, E., Suriyanarayanan, & Ramkumar, K. M. (2013) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(13)60021-8 · Cited by 32 · see citing works
Chaturvedi, P. (2013) · International Journal of Pharma and Bio Sciences · Cited by 23 · see citing works
Liu, C.-W., Yang, D., Chang, Y., Hsu, C., Tseng, J., Chang, M.-H., Wang, M., & Chen, Y. (2011) · Food Research International · doi:10.1016/j.foodres.2011.11.007 · Cited by 22 · see citing works
The Folk Medicinal Plants of the Mao Naga in Manipur, North East India
Lokho, A. (2012) · Cited by 22 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review
Sun, B., Wu, L., Wu, Y., Zhang, C., Qin, L., Hayashi, M., Kudo, M., Gao, M., & Liu, T. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.568032 · Cited by 353 · see citing works
Innate-adaptive immunity interplay and redox regulation in immune response
Sun, L., Wang, X., Saredy, J., Yuan, Z., Yang, X., & Wang, H. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101759 · Cited by 343 · see citing works
Centella asiatica: Phytochemistry and mechanisms of neuroprotection and cognitive enhancement
Gray, N. E., Alcazar Magana, A., Lak, P., Wright, K. M., Quinn, J., Stevens, J. F., Maier, C. S., & Soumyanath, A. (2018) · Phytochemistry Reviews · doi:10.1007/s11101-017-9528-y · Cited by 299 · see citing works
Buranasudja, V., Rani, D., Malla, A., Kobtrakul, K., & Vimolmangkang, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-92958-7 · Cited by 112 · see citing works
Idris, F. N., & Nadzir, M. M. (2021) · Antibiotics · doi:10.3390/antibiotics10040457 · Cited by 124 · see citing works
Cardiovascular Protective Effects of Centella asiatica and Its Triterpenes: A Review
Razali, N. N. M., Ng, C. T., & Fong, L. Y. (2019) · Planta Medica · doi:10.1055/a-1008-6138 · Cited by 95 · see citing works
Saleem, M., Durani, A. I., Asari, A., Ahmed, M., Ahmad, M., Yousaf, N., & Muddassar, M. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15433 · Cited by 94 · see citing works
Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice
Matthews, D. G., Caruso, M., Murchison, C. F., Zhu, J. Y., Wright, K. M., Harris, C. J., Gray, N. E., Quinn, J. F., & Soumyanath, A. (2019) · Antioxidants · doi:10.3390/antiox8120630 · Cited by 86 · see citing works
Vijayakumar, N., Kumari, B. V., Ayyadurai, G. K., Rajendran, J., Gopinath, K., Nicoletti, M., Alarifi, S. A., & Govindarajan, M. (2021) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.11.065 · Cited by 66 · see citing works
Kumari, S., Elancheran, R., & Devi, R. (2018) · Indian Journal of Pharmacology · doi:10.4103/ijp.ijp_77_18 · Cited by 49 · see citing works
Self-citationHiranpradith, V., Therdthai, N., Soontrunnarudrungsri, A., & Rungsuriyawiboon, O. (2025) · Foods · doi:10.3390/foods14020291 · Cited by 48 · see citing works
Abedi, F., Ramezani, M., Dehghan, R., Amiri, M. S., Moghadam, A. T., Shakour, N., Elyasi, S., Sahebkar, A., & Emami, S. A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-64872-5_25 · Cited by 48 · see citing works
Khursheed, T., Khalil, A. A., Akhtar, M. N., Khalid, A., Tariq, M. R., Alsulami, T. S., Mugabi, R., & Nayik, G. A. (2024) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2024.107091 · Cited by 47 · see citing works
Bao, Y.-T., Qu, Y., Li, J., Li, Y., Ren, X., Maffucci, K. G., Li, R., Wang, Z., & Zeng, R. (2018) · Molecules · doi:10.3390/molecules23020392 · Cited by 47 · see citing works
Hawthorn fruit acid consumption attenuates hyperlipidemia-associated oxidative damage in rats
Feng, Y., Gao, S., Zhu, T., Sun, G., Zhang, P., Huang, Y., Qu, S., Du, X., & Mou, D. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.936229 · Cited by 44 · see citing works
Saipraba, S., Subban, M., Ragavendran, C., Kamaraj, C., Nakouti, I., El‐Sheikh, M. A., & Shaik, J. P. (2023) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2023.110787 · Cited by 43 · see citing works
Sung, Y.-Y., Kim, D.-S., Kim, S., & Kim, H. K. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2152-6 · Cited by 43 · see citing works
Kalemba, M. R. K., Makhuvele, R., & Njobeh, P. B. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24435 · Cited by 41 · see citing works
Khanal, P., & Patil, B. M. (2020) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2020.02.004 · Cited by 39 · see citing works
Manye, S. J., Saleh, J. S., Ishaya, H. B., Chiroma, S. M., Attah, M. O. O., & Dibal, N. I. (2023) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2023.100291 · Cited by 38 · see citing works
Kumari, S., Katare, P. B., Elancheran, R., Nizami, H. L., Bugga, P., Arava, S. K., Sarma, P. P., Kumar, R., Mahajan, D., Kumar, Y., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/7147498 · Cited by 34 · see citing works
Self-citationLei-gong-gen formula granule attenuates hyperlipidemia in rats via cGMP-PKG signaling pathway
Lan, T., Li, Q., Chang, M., Yin, C., Zhu, D., Wu, Z., Li, X., Zhang, W., Yue, B., Shi, J., et al. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112989 · Cited by 28 · see citing works
Asiatic acid and its derivatives: Pharmacological insights and applications
Liang, C., Ma, Y., Ding, M., Gao, F., Yu, K., Wang, S., Qu, Y., Hu, X., & Li, D. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117429 · Cited by 29 · see citing works
Cruz, J. N., Muzammil, S., Ashraf, A., Ijaz, M. U., Siddique, M. H., Abbas, R., Sadia, M., Saba, Hayat, S., & Lima, R. R. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e29500 · Cited by 24 · see citing works
Eze, F. N., Leelawatwattana, L., & Prapunpoj, P. (2019) · Biomolecules · doi:10.3390/biom9040128 · Cited by 24 · see citing works
Non-Dairy Fermented Beverages Produced with Functional Lactic Acid Bacteria
Zamfir, M., Angelescu, I.-R., Voaideṣ, C., Cornea, C. P., Boiu-Sicuia, O.-A., & Grosu‐Tudor, S. (2022) · Microorganisms · doi:10.3390/microorganisms10122314 · Cited by 24 · see citing works
Rajamanickam, G., & Manju, S. L. (2023) · Macromolecular Research · doi:10.1007/s13233-023-00114-z · Cited by 22 · see citing works
Rochmah, M. A., Harini, I. M., Septyaningtrias, D. E., Sari, D. C. R., & Susilowati, R. (2019) · BioMed Research International · doi:10.1155/2019/2649281 · Cited by 22 · see citing works
Ranjith, G. P., Jisha, S. P., Hemanthakumar, A. S., Saji, C. V., Shenoi, R. A., & Sabu, K. K. (2021) · Phytochemistry · doi:10.1016/j.phytochem.2021.112735 · Cited by 20 · see citing works
Wahyuni, D. K., Wacharasindhu, S., Bankeeree, W., Punnapayak, H., & Prasongsuk, S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13644 · Cited by 19 · see citing works
Nazir, A., Zahid, S., Mahmood, Z., Kanwal, F., Latif, S., Imran, M., Hassan, F., & Iqbal, M. (2022) · Zeitschrift für Physikalische Chemie · doi:10.1515/zpch-2022-0014 · Cited by 18 · see citing works
Verma, P., Tripathi, S., Yadav, S., & Chandra, R. (2022) · Archives of Microbiology · doi:10.1007/s00203-022-03236-7 · Cited by 18 · see citing works
Bunaim, M. K., Kamisah, Y., Mustazil, M. N. M., Zuhair, J. S. F., Juliana, A. H., & Muhammad, N. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.742562 · Cited by 15 · see citing works
Liu, Y.-Q., Zhang, D., Deng, J., Liu, Y., Li, W., & Nie, X. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/1419146 · Cited by 14 · see citing works
Khan, W., Wei, X., Ali, H. H., Zulfiqar, F., Chen, J., Iqbal, R., Zaheer, M. S., Ali, B., Ghafoor, S., Rabiya, U. E., et al. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.958978 · Cited by 13 · see citing works
Toussé, R. K., Bossi, D. S. D., Saah, M. B. D., Kouam, E. M. F., Njapndounké, B., Téné, S. T., Kaktcham, P. M., & Ngoufack, F. Z. (2024) · Journal of Food Biochemistry · doi:10.1155/2024/1445355 · Cited by 12 · see citing works
Hassan, A., Rijo, P. M., Abu-Amara, T. M. M., Lashin, L. S., Kamar, S. A., Bangay, G., Al-Sawahli, M. M., Fouad, M. K., Zoair, M. A., Abdalrhman, T. I., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12020279 · Cited by 12 · see citing works
Identification of annotated metabolites in the extract of Centella asiatica
Komal, R. P., Mitali, T., Singh, A., Vairamani, S., Shanmugam, A., Manoj, P., & Srinivasan, A. (2019) · Journal of Medicinal Plants Research · doi:10.5897/jmpr2018.6711 · Cited by 11 · see citing works
Chang, Y. B., Ahn, Y., Seo, D.-B., Bae, S., Suh, H. J., Hong, Y. H., & Jung, E. Y. (2023) · Applied Biological Chemistry · doi:10.1186/s13765-023-00846-7 · Cited by 10 · see citing works
Kuamsub, S., Singthong, P., Chanthasri, W., Chobngam, N., Sangkaew, W., Hemdecho, S., Kaewmanee, T., & Chusri, S. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/2687173 · Cited by 10 · see citing works
Tran, T. T. L., Ly, H. T., Le, T. K. O., & Le, V. M. (2024) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2024.100428 · Cited by 9 · see citing works
Singh, L. S., & Singh, W. S. (2024) · Discover Plants. · doi:10.1007/s44372-024-00070-7 · Cited by 9 · see citing works
Rosli, S. Z., Adzahan, N. M., Radu, S., Karim, R., Adzahan, N. M., Aadil, R. M., & Koh, P. C. (2021) · Journal of Food Science and Technology · doi:10.1007/s13197-021-05131-3 · Cited by 9 · see citing works
Traditional herbs and spices: bioactive properties and potential food applications
Aggarwal, D., Sachdev, B., Agarwal, A., Nigam, S., Raizada, P., & Siddhu, A. (2025) · Discover Food · doi:10.1007/s44187-025-00546-9 · Cited by 8 · see citing works
Saipraba, S., Meena, R., Ragavendran, C., Gatasheh, M. K., Ahmed, A., & Murugesan, S. (2025) · Next Materials · doi:10.1016/j.nxmate.2025.101030 · Cited by 7 · see citing works
Krishnamoorthy, R., Yehia, H. M., Abdulhameed, M. M., Periasamy, V. S., Alshuniaber, M. A., Alzahrani, A. A., & Alshatwi, A. A. (2022) · Green Processing and Synthesis · doi:10.1515/gps-2022-0083 · Cited by 7 · see citing works
Mushtaq, F., Akhtar, M. F., Saleem, A., Sharif, A., Akhtar, B., Askary, A. E., Abdel‐Daim, M. M., Javaid, Z., Sohail, K., & Anwar, F. (2022) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530322666220429125241 · Cited by 7 · see citing works
Barua, C. C., Saikia, B., Ren, X., Elancheran, R., Pathak, D., Tamuli, S., & Barua, A. (2018) · Pharmacognosy Magazine · doi:10.4103/pm.pm_606_17 · Cited by 7 · see citing works
Borges, A. L. S., Bittar, V. P., Justino, A. B., Carrillo, M. S. P., Duarte, R. F. M., Silva, N. B. S., Gonçalves, D. S., Prado, D. G., Araújo, I. A. C., Martins, M. M., et al. (2024) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2024.116143 · Cited by 6 · see citing works
Mango Anthracnose: Global Status and the Way Forward for Disease Management
Iqbal, S., Khan, M. A., Atiq, M., Rajput, N. A., Usman, M., Nawaz, A. A., Kachelo, G. A., Akram, A., & Ahmad, H. (2022) · Journal of Innovative Sciences · doi:10.17582/journal.jis/2022/8.2.222.235 · Cited by 6 · see citing works
Sharma, S., Sharma, S., Chourasia, R., Pandey, A., Rai, A. K., & Sahoo, D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819212-2.00044-x · Cited by 6 · see citing works
Saxena, A., Prabhudesai, K. S., Damle, A., Ramakrishnan, S., Durairaj, P., Kalankariyan, S., Vijayalakshmi, A. B., & Venkatesh, K. V. (2024) · Scientific Reports · doi:10.1038/s41598-024-60112-8 · Cited by 6 · see citing works
Galla, R., Ferrari, S., Miletto, I., Mulè, S., & Uberti, F. (2025) · Foods · doi:10.3390/foods14152678 · Cited by 6 · see citing works
A herb mixture to ameliorate non-alcoholic fatty liver in rats fed a high-fat diet
Ha, S. K., Lee, J.-A., Kim, D., Yoo, G., & Choi, I.-W. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18889 · Cited by 5 · see citing works
Pinto, P., Alva, P. D., Chinnarasu, S., Sadasivam, M., & Louis Cojandaraj, A. (2024) · BIO Web of Conferences · doi:10.1051/bioconf/20248601055 · Cited by 5 · see citing works
Vishnumukkala, T., Gopalakrishna, P. K., Karikalan, B., Thomas, W., Jagadeesan, S., Chiroma, S. M., Nor, N. H. M., & Moklas, M. A. M. (2024) · Bioinformation · doi:10.6026/973206300200508 · Cited by 5 · see citing works
Shin, H. Y., Kim, Y. S., Joung, M. Y., Kim, W. J., Shin, K., & Yu, K. (2025) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.14213 · Cited by 5 · see citing works
Buranasudja, V., Rani, D., Malla, A., Kobtrakul, K., & Vimolmangkang, S. (2021) · Research Square · doi:10.21203/rs.3.rs-218867/v1 · Cited by 5 · see citing works
Barlian, A., Cho, Y., Rahmah, Y., Zahra, A. N. A., Maulidisya, H. A., Vanawati, N., & Nursatya, S. M. (2026) · Future Science OA · doi:10.1080/20565623.2026.2654777 · Cited by 4 · see citing works
EFFECT OF BANANA (Musa Balbisiana) FRUITS AND ITS PEELS ON ACUTE HEPATOTOXICITY WITH DIABETIC RATS
(2020) · Egyptian Journal of Applied Science · doi:10.21608/ejas.2020.136412 · Cited by 4 · see citing works
Hoang, T. X., Dang, N. M., Bae, K. G., & Kim, J. Y. (2025) · Pharmaceuticals · doi:10.3390/ph18091270 · Cited by 3 · see citing works
Sensitivity of phenolic compounds evaluated by a new approach of analytical methods
Berton, S. B. R., Bonafé, E. G., de Jesus, G. A. M., da Silveira, R., Visentainer, J. V., Martins, A. F., & Matsushita, M. (2021) · Chemical Papers · doi:10.1007/s11696-021-01698-5 · Cited by 3 · see citing works
Sarma, H., Rabha, D., Khound, P., Gurumayum, N., Sarma, P. P., Dutta, P. P., Choudhury, P., Saikia, K., Pait, S., Borah, J. C., et al. (2022) · Vegetos · doi:10.1007/s42535-022-00494-0 · Cited by 3 · see citing works
Self-citationKrishnamoorthy, R., Adisa, A. R., Periasamy, V. S., Ahamed, A., Alshuniaber, M. A., & Alshatwi, A. A. (2022) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2022.101976 · Cited by 3 · see citing works
Idris, F. N., Shukor, S. R. A., & Nadzir, M. M. (2022) · ASEAN Engineering Journal · doi:10.11113/aej.v12.17950 · Cited by 3 · see citing works
Odinga, T.-B., Sammer Yousuf, B., Choudhary, M. I., Ndukwe, G. I., Obinna, P. C., Otobo, M. B., & Nwokogba, C. C. (2023) · International Journal of Medicinal Plants and Natural Products · doi:10.20431/2454-7999.0901002 · Cited by 3 · see citing works
Bhat, M. A., Mishra, A. K., Magray, F. A., Jan, S., Rehman, M. T., Alajmi, M. F., Rahman, S., Wani, S. A., & Jan, A. T. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202500610 · Cited by 2 · see citing works
Maruthiyodan, S., Munegowda, G., Thomas, M., Gangadharan, G., Joshi, M. B., Mumbrekar, K. D., Goyal, A., Mahadevan, A., Anandan, E. M., Sankaran, M. T., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120633 · Cited by 2 · see citing works
Yang, J., Zhu, H., Zhang, Q., Dai, Y., Yao, Q., & Nie, X. (2026) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-026-00747-y · Cited by 2 · see citing works
Centella asiatica (L.) Urban (Apiaceae/Umbelliferae)
Akbar, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-16807-0_61 · Cited by 2 · see citing works
Sub-Acute Toxicity Profile of Aqueous Leaf Extract of Pavetta crassipes (K. Schum) in Rats
Patrick, E. B., Otimenyin, S. O., & Bukar, B. B. (2023) · Tropical Journal of Natural Product Research · doi:10.26538/tjnpr/v7i5.25 · Cited by 2 · see citing works
Zain, M. M., Shamsuddin, N., & Noorden, M. S. A. (2021) · ASM Science Journal · doi:10.32802/asmscj.2021.907 · Cited by 2 · see citing works
Sameena, V. P., & Thoppil, J. E. (2023) · Vegetos · doi:10.1007/s42535-023-00700-7 · Cited by 3 · see citing works
Akrom, A., Hidayati, T., Kurniawan, N. U., & Saputri, G. Z. (2022) · International Journal of Public Health Science (IJPHS) · doi:10.11591/ijphs.v11i3.21683 · Cited by 1 · see citing works
Elbeltagy, M. G., Alazemi, M. J., Badawi, M. F., & badr, A. E.-S. (2024) · The Journal of Contemporary Dental Practice · doi:10.5005/jp-journals-10024-3636 · Cited by 1 · see citing works
Shewale, S., Undale, V., Bhalchim, V. M., Kuchekar, M., Warude, B., & Mali, M. (2024) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-024-00740-z · Cited by 1 · see citing works
Sharker, M. R., Naeem, M. J., Roy, P., Datta, P., Alam, M. A., Haque, N., & Choi, S. (2025) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2025.102534 · Cited by 1 · see citing works
Jin, X., Zang, J., Li, A., Yao, Y., Dai, Z., Feng, X., & Qiu, F. (2026) · Chemistry & Biodiversity · doi:10.1002/cbdv.202501872 · Cited by 1 · see citing works
Review on Vinca : Catharanthus Roseus
Bangar Prathamesh, K., Gawade Kiran, L., Kale Hrushikesh, R., Dhumal Prathmesh, K., & Datkhile, P. S. V. (2022) · International Journal of Advanced Research in Science Communication and Technology · doi:10.48175/ijarsct-5006 · Cited by 1 · see citing works
Patonah, P., Sulaeman, A., & Pambudi, D. R. (2022) · Jurnal Ilmiah Manuntung · doi:10.51352/jim.v8i1.488 · Cited by 1 · see citing works
Maity, S., Padhy, G. K., Kanthal, L. K., & Pattanayak, S. (2023) · Asian Journal of Chemistry · doi:10.14233/ajchem.2024.28337 · Cited by 1 · see citing works
Rao, B. V., Heggade, R. H. B., & Jagannath, H. H. (2024) · Indian Journal of Pharmaceutical Education and Research · doi:10.5530/ijper.58.1s.29 · Cited by 1 · see citing works
The black cumin seeds oil with Curcuma xanthorrhiza extract preparation increases IFN-γ expression
Hidayati, T., Sun, H. S., & Akrom, A. (2023) · Bali Medical Journal · doi:10.15562/bmj.v12i3.3781 · Cited by 1 · see citing works
Japranata, V. V., Purwaningsih, E. H., Hakim, R. W., Dwijayanti, A., & Krisnamurti, D. G. B. (2019) · AIP conference proceedings · doi:10.1063/1.5096717 · Cited by 1 · see citing works
Ragupathi, S., Gunasekar, A., Chathalingath, N., & Mohan, T. P. (2022) · South African Journal of Botany · doi:10.1016/j.sajb.2022.04.052 · Cited by 1 · see citing works
Naik, R., Borkar, S. D., Bhat, S., & Acharya, R. (2018) · Journal of Drug Research in Ayurvedic Sciences · doi:10.5005/jp-journals-10059-0052
Determinação dos compostos fenólicos em extratos de plantas medicinais
Nascimento, G. M., Kavamoto, I. M., Júnior, C. A. D. C., & Melo, F. R. (2019) · Programa de Iniciação Científica - PIC/UniCEUB - Relatórios de Pesquisa · doi:10.5102/pic.n1.2018.6372
Caracterização da atividade antioxidante e antibiótica de extratos de plantas medicinais
Tondolo, A. S., & Júnior, C. A. D. C. (2019) · Programa de Iniciação Científica - PIC/UniCEUB - Relatórios de Pesquisa · doi:10.5102/pic.n1.2018.6407
Verma, P., Tripathi, S., Yadav, S., Chandra, R., & Ram, C. (2022) · Research Square · doi:10.21203/rs.3.rs-1839514/v1
Studies on Ficus racemosa Fruit Extract: A Potent Antioxidant and Antibacterial Agent
Rajesh, D., Saravanan, R., & Sonia, K. (2022) · International Journal of Zoological Investigations · doi:10.33745/ijzi.2022.v08i02.079
Sari, D. C. R., Setyaningsih, W. A. W., Mainichi, R. N., Dara, G. M., Kemalasari, R., Romi, M. M., Rochmah, M. A., & Arfian, N. (2023) · African Journal of Traditional Complementary and Alternative Medicines · doi:10.21010/ajtcamv17i2.1
Hartanti, & Sariyanto, I. (2023) · GSC Biological and Pharmaceutical Sciences · doi:10.30574/gscbps.2023.25.3.0525
Dash, S., Sahoo, N., Pattnaik, G., Das, C., Pattanaik, S., Ghosh, G., Rath, G., & Kar, B. (2024) · Current Bioactive Compounds · doi:10.2174/0115734072294929240206060527
Techno-economical analysis of crossbreed cattle milk production in Western Himalayas of India
Khalandar, S., Shrama, R., Sharif, M., Bashist, R., & Ramu, M. S. (2024) · International Journal of Research in Agronomy · doi:10.33545/2618060x.2024.v7.i3sb.437
Alshammari, A. N., & Abdulbaqi, A. A. (2025) · Research Square · doi:10.21203/rs.3.rs-6315244/v1
Zhang, Y. J., Qiu, C., Li, X., Peng, Y., Liu, J., & Zhu, P. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2026.1754817
Raja, S., Mohapatra, S., Amitkumar, K., Natarajan, K., Rani, J., Devasagayam, A., & Rahman, F. (2026) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/3368
Recent applications of Traditional Chinese Medicine in cosmetology: a Review
Zheng, H., Wu, S., Wang, S., Winkeljann, B., Liao, L., & Song, J. (2026) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(26)61176-4
Dobriyal, P., Singh, V., Goel, F., & Garg, V. K. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02309-z
Shen, Y., Yao, Y., Liu, Z., Li, Y., Cao, S., & Feng, X. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48070663
- Authors
- Kumari, S., Deori, M., Elancheran, R., Kotoky, J., & Devi, R.
- Affiliations
- Institute of Advanced Study in Science and Technology (IN)
- Corresponding author
- Devi, Rajlakshmi
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2016-10-28
- Volume
- 7
- Pages
- 400-400
- ISSN
- 1663-9812 (ISSN-L)
- PMC
- PMC5083837
- OpenAlex
- W2545514195
- Cited by
- 105
- References
- 64
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 16 · 2023: 14 · 2022: 18 · 2021: 10 · 2020: 8 · 2019: 8 · 2018: 6 · 2017: 2
- FWCI
- 10.97
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Pharmacology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Department of Science and Technology, Ministry of Science and Technology
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Keywords
- Centella asiatica, antioxidant activity, hypolipidemic effect, hypercholesterolemia, phenolic compounds, ferulic acid, kaempferol, chlorogenic acid, asiatic acid, free radical scavenging, superoxide dismutase, lipid profile, liver histopathology, fenofibrate, oxidative stress, hyperlipidemia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review