Cited by 105Medicinal Plants and NeuroprotectionNatural Products and Biological ResearchPhytochemicals and Medicinal Plants

In vitro and In vivo Antioxidant, Anti-hyperlipidemic Properties and Chemical Characterization of Centella asiatica (L.) Extract

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Kumari, Sima, Deori, Meetali, Elancheran, R., Kotoky, Jibon, Devi, Rajlakshmi·2016·Frontiers in Pharmacology

Abstract

The study aimed to identify the phenolic compounds present in Centella asiatica (L.) (C. asiatica) extract and evaluate the respective antioxidant potential as well as its cholesterol-lowering effects in the experimental animal model. Herein, the antioxidant potential of extracts was assessed by its free radical scavenging activity such as 2, 2-diphenyl -1- picrylhydrazyl as well as reducing capability. The antihyperlipidemic effects of C. asiatica extract (CAE) were evaluated in high cholesterol-fed (HCF) rats for 4 weeks, where different concentrations of extracts (0.25, 0.5 and 1 g/kg/day) were orally administrated daily. Lipid and antioxidant profiles, including total cholesterol (TC), triglyceride (TG), low- density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and superoxide dismutase (SOD), together with the indices of hepatic functions were also examined. C. asiatica revealed excellent free radical scavenging activity as revealed by DPPH assay, with the IC50 values (9.62 ± 0.88 μg/mL). Furthermore, C. asiatica extracts and fenofibrate remarkably lowered the level of TC, TG, LDL-C, and showed elevated levels of HDL-C, SOD. The histopathological observations further demonstrated clear differentiation and structural changes in liver of HCF and CAE treated group. Furthermore, gulonic acid, ferulic acid, kaempferol, chlorogenic acid, and asiatic acid were identified to be the major components which might be responsible for the antioxidant activity of the C. asiatica extract as evidenced from an ultra-high performance liquid chromatography–mass spectrometer (UHPLC-MS/MS). Taken together, these results signifies the excellent antioxidant and antihyperlipidemic properties of C. asiatica leaf extracts, which might be useful for the treatment of oxidative-stress related diseases such as hyperlipidemia.

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Crossref · 10.3389/fphar.2016.00400

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  • Compounds in CA such as ferulic acid and asiatic acid induce Nrf2 and its ARE-regulated targets, exhibiting a neuroprotective effect.

    “Compounds such as the phenolic ferulic acid [89,90] and the triterpene asiatic acid [2,91], induce Nrf2 and its ARE-regulated targets, exhibiting a neuroprotective effect [92,93,94,95].”

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Authors
Kumari, S., Deori, M., Elancheran, R., Kotoky, J., & Devi, R.
Affiliations
Institute of Advanced Study in Science and Technology (IN)
Corresponding author
Devi, Rajlakshmi
Venue
Frontiers in Pharmacology
Published
2016-10-28
Volume
7
Pages
400-400
ISSN
1663-9812 (ISSN-L)
OpenAlex
W2545514195
Cited by
105
References
64
Citations by year
2026: 11 · 2025: 12 · 2024: 16 · 2023: 14 · 2022: 18 · 2021: 10 · 2020: 8 · 2019: 8 · 2018: 6 · 2017: 2
FWCI
10.97
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Pharmacology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Department of Science and Technology, Ministry of Science and Technology
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Surgery › Natural Products and Biological Research
  • Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
Keywords
Centella asiatica, antioxidant activity, hypolipidemic effect, hypercholesterolemia, phenolic compounds, ferulic acid, kaempferol, chlorogenic acid, asiatic acid, free radical scavenging, superoxide dismutase, lipid profile, liver histopathology, fenofibrate, oxidative stress, hyperlipidemia

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