Melatonin Supplementation Decreases Hypertrophic Obesity and Inflammation Induced by High-Fat Diet in Mice
Open accessAbstract
Obesity results from critical periods of positive energy balance characterized by caloric intake greater than energy expenditure. This disbalance promotes adipose tissue dysfunction which is related to other comorbidities. Melatonin is a low-cost therapeutic agent and studies indicate that its use may improve obesity-related disorders. To evaluate if the melatonin is efficient in delaying or even blocking the damages caused by excessive ingestion of a high-fat diet (HFD) in mice, as well as improving the inflammatory profile triggered by obesity herein, male C57BL/6 mice of 8 weeks were induced to obesity by a HFD and treated for 10 weeks with melatonin. The results demonstrate that melatonin supplementation attenuated serum triglyceride levels and total and LDL cholesterol and prevented body mass gain through a decreased lipogenesis rate and increased lipolytic capacity in white adipocytes, with a concomitant increment in oxygen consumption and Pgc1a and Prdm16 expression. Altogether, these effects prevented adipocyte hypertrophy caused by HFD and reflected in decreased adiposity. Finally, melatonin supplementation reduced the crown-like-structure (CLS) formation, characteristic of the inflammatory process by macrophage infiltration into white adipose tissue of obese subjects, as well as decreased the gene expression of inflammation-related factors, such as leptin and MCP1. Thus the melatonin can be considered a potential therapeutic agent to attenuate the metabolic and inflammatory disorders triggered by obesity.
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Experimental studies report the lowering properties of melatonin on serum TC concentrations prohibition of the absorption and biosynthesis of cholesterol and also increasing its catabolism.
“Experimental studies report the lowering properties of melatonin on serum TC concentrations prohibition of the absorption and biosynthesis of cholesterol and also increasing its catabolism. 16,32”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [32]
The Results report that melatonin supplementation reduced serum total cholesterol in high-fat-diet-fed mice. The paper does not establish that this reduction occurred through inhibited cholesterol absorption or biosynthesis, or increased cholesterol catabolism; its lipogenesis and lipolysis findings concern adipocyte triglycerides, not cholesterol. (LLM, conf=0.88)
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Melatonin protects against body weight gain induced by sleep deprivation in mice
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Hepatic Encephalopathy and Melatonin
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Impact of Modern Lifestyle on Circadian Health and Its Contribution to Adipogenesis and Cancer Risk
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Meta‐analysis and machine learning reveal the antiobesity effects of melatonin on obese rodents
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Circadian Melatonin Secretion In Obese Adolescents With Or Without Obstructive Sleep Apnea
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“16,32 In agreement with our results, a new systematic review and meta-analysis of RCTs demonstrated the beneficial impacts of melatonin consumption on lipids at doses greater than 8 mg/d and long durations of more than 8 weeks including a notable reduction in TG, TC, and a small reduction in LDL-c…”
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RETRACTED: Astrocyte response to melatonin treatment in rats under high-carbohydrate high-fat diet
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The use of melatonin to mitigate the adverse metabolic side effects of antipsychotics
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Polycystic Ovary Syndrome, Obesity and Melatonin: An Etiological Perspective
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ISSUE 23 (8) ACTUAL ISSUES OF MODERN SCIENCE
(2023) · European Scientific e-Journal · doi:10.47451/col-08-2022-023
Melatonin: A Saga of Health and Longevity
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The role of Melatonin in reducing Obesity and its safety of use: A Review
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Antioxidant effects of melatonin on obese mice
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- Authors
- Farias, T. D. S. M. D., Cruz, M. M., Sa, R. C. D. C. D., Severi, I., Perugini, J., Senzacqua, M., Cerutti, S. M., Giordano, A., Cinti, S., & Alonso-Vale, M. I. C.
- Affiliations
- Universidade Federal de São Paulo (BR)
- Marche Polytechnic University (IT)
- ORCID
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2019-11-05
- Volume
- 10
- Pages
- 750-750
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC6848267
- OpenAlex
- W2983081821
- Semantic Scholar
- d954a3ad44a535a4d7ca95df2f7cb0759053ec35
- Cited by
- 74
- References
- 68
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 13 · 2023: 12 · 2022: 7 · 2021: 15 · 2020: 13 · 2014: 1
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2015/03554-2, 2016/07638-9, 2018/05485-6, 2017/08582-0)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- melatonin, high-fat diet, obesity, adipocyte hypertrophy, adipose tissue inflammation, crown-like structures, macrophage infiltration, lipogenesis, lipolysis, PGC-1α, PRDM16, triglycerides, cholesterol, leptin, MCP-1, white adipose tissue, energy balance
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