Melatonin Supplementation Lowers Oxidative Stress and Regulates Adipokines in Obese Patients on a Calorie‐Restricted Diet
Open accessAbstract
Obesity is one of the major global health problems. Melatonin deficiency has been demonstrated to correlate with obesity. The aim of the study was to estimate the effect of melatonin on oxidative stress and adipokine levels in obese patients on a calorie‐restricted diet. Thirty obese patients were supplemented with a daily dose of 10 mg of melatonin (n = 15) or placebo (n = 15) for 30 days with a calorie‐restricted diet. Serum levels of melatonin, 4‐hydroxynonenal (HNE), adiponectin, omentin‐1, leptin, and resistin, as well as erythrocytic malondialdehyde (MDA) concentration and Zn/Cu‐superoxide dismutase, catalase, and glutathione peroxidase (GPx) activities, were measured at baseline and after supplementation. Significant body weight reduction was observed only in the melatonin group. After melatonin supplementation, the adiponectin and omentin‐1 levels and GPx activities statistically increased, whereas the MDA concentrations were reduced. In the placebo group, a significant rise in the HNE and a drop in the melatonin concentrations were found. The results show evidence of increased oxidative stress accompanying calorie restriction. Melatonin supplementation facilitated body weight reduction, improved the antioxidant defense, and regulated adipokine secretion. The findings strongly suggest that melatonin should be considered in obesity management. This trial is registered with CTRI/2017/07/009093.
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Different animal models and clinical studies approved the melatonin's effect on the treatment of circulating adiponectin.
“Different animal models and clinical studies approved the melatonin's effect on the treatment of circulating adiponectin. 19,29,30”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [19]
Investigations about melatonin's effect on obesity in humans are scarce.
“The investigations about melatonin's effect on obesity in humans are scarce. 18-20”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [19]
Melatonin administration decreases the circulating leptin levels in most animal models, however, the results are inconsistent in human studies.
“Melatonin administration decreases the circulating leptin levels in most animal models, 29,30 however, the results are inconsistent in human studies. 19,31”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [19]
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Research works printed but not linked: 1
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Melatonin in type 2 diabetes mellitus and obesity
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Is Melatonin the Cornucopia of the 21st Century?
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Exogenous melatonin decreases circadian misalignment and body weight among early types
Marqueze, E. C., Nogueira, L. F. R., Vetter, C., Skene, D. J., Cipolla‐Neto, J., & Moreno, C. R. C. (2021) · Journal of Pineal Research · doi:10.1111/jpi.12750 · Cited by 42 · see citing works
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Chrononutrition in the context of Ramadan: Potential implications
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- Authors
- Szewczyk-Golec, K., Rajewski, P., Gackowski, M., Mila-Kierzenkowska, C., Wesołowski, R., Sutkowy, P., Pawłowska, M., & Woźniak, A.
- Affiliations
- Wojewódzki Szpital Obserwacyjno-Zakaźny im. Tadeusza Browicza w Bydgoszczy (PL)
- Nicolaus Copernicus University (PL)
- ORCID
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2017-01
- Volume
- 2017
- Issue
- 1
- Pages
- 8494107-8494107
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC5632922
- OpenAlex
- W2757448513
- Cited by
- 92
- References
- 103
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 14 · 2021: 26 · 2020: 14 · 2019: 7 · 2018: 4 · 2014: 1
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- melatonin supplementation, obesity, calorie-restricted diet, oxidative stress, adipokines, adiponectin, omentin-1, leptin, resistin, 4-hydroxynonenal, malondialdehyde, antioxidant enzymes, glutathione peroxidase, weight loss, obesity treatment
- MeSH terms
- Adult, Female, Humans, Male, Melatonin, Obesity, Oxidative Stress, Caloric Restriction, Adipokines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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