The effect of melatonin on treatment of patients with non-alcoholic fatty liver disease: a randomized double blind clinical trial
Abstract
Objectives Many factors implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) are including oxidative stress, insulin resistance and abnormal production of adipokines. The aim of this clinical trial was to evaluate the effect of melatonin supplement on some important biochemical markers and signs related to NAFLD.Design A randomized double-blind, placebo-controlled, clinical trial.Setting Twenty-four participants in the melatonin group and 21 participants in the placebo group completed the study.Intervention Participants received 6 mg melatonin or placebo daily, 1 h before bedtime. The intervention period was 12 weeks.Main outcome measures Anthropometric measurements, systolic and diastolic blood pressure, liver enzymes, high sensitive C‑reactive protein (hs-CRP), fatty liver grade, also leptin and adiponectin serum levels, were measured at the baseline and the end of intervention.Results A significant improvement was observed in weight (p = 0.043), waist circumference (p = 0.027), abdominal circumference (p = 0.043), systolic (p = 0.039), and diastolic (p = 0.015) blood pressure, leptin serum levels (p = 0.032), hs-CRP (p = 0.024), alanine aminotransferase (p = 0.011), aspartate aminotransferase (p = 0.034), also the grade of fatty liver (p = 0.020) in melatonin treated group compared with the placebo.Conclusions Administration of 6 mg/day melatonin had improvement effect on many factors related to NAFLD such as liver enzymes, hs-CRP, anthropometric measurements, blood pressure, leptin serum levels and the grade of fatty liver.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Clinical evidence reveals melatonin supplements did not have striking effects on weight and the results of various doses and times on weight are inconsistent.
“However, the clinical evidence reveals melatonin supplements did not have striking effects on weight and the results of various doses and times on weight are inconsistent. 39-42”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [39]
Cites
Younossi, Z. M., Koenig, A. B., Abdelatif, D., Fazel, Y., Henry, L., & Wymer, M. (2016) · Hepatology · doi:10.1002/hep.28431 · Cited by 10,781 · see citing works
Chalasani, N., Younossi, Z., Lavine, J. E., Charlton, M., Cusi, K., Rinella, M., Harrison, S. A., Brunt, E. M., & Sanyal, A. J. (2018) · Hepatology · doi:10.1002/hep.29367 · Cited by 7,239 · see citing works
AASLD guidelines for treatment of chronic hepatitis B
Terrault, N. A., Bzowej, N. H., Chang, K., Hwang, J. P., Jonas, M. M., & Murad, M. H. (2015) · Hepatology · doi:10.1002/hep.28156 · Cited by 2,002 · see citing works
Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
Promrat, K., Kleiner, D. E., Niemeier, H. M., Jackvony, E., Kearns, M., Wands, J. R., Fava, J. L., & Wing, R. R. (2010) · Hepatology · doi:10.1002/hep.23276 · Cited by 1,330 · see citing works
Buscemi, N., Vandermeer, B., Hooton, N., Pandya, R., Tjosvold, L., Hartling, L., Vohra, S., Klassen, T. P., & Baker, G. (2006) · BMJ · doi:10.1136/bmj.38731.532766.f6 · Cited by 454 · see citing works
Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension
Scheer, F. A. J. L., Van Montfrans, G. A., van Someren, E. J. W., Mairuhu, G., & Buijs, R. M. (2004) · Hypertension · doi:10.1161/01.hyp.0000113293.15186.3b · Cited by 451 · see citing works
Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease
Nobili, V., Manco, M., Vito, R. D., Ciommo, V. M. D., Comparcola, D., Sartorelli, M. R., Piemonte, F., Marcellini, M., & Angulo, P. (2008) · Hepatology · doi:10.1002/hep.22336 · Cited by 412 · see citing works
Wolden‐Hanson, T., Mitton, D. R., McCants, R. L., Yellon, S. M., Wilkinson, C. W., Matsumoto, A. M., & Rasmussen, D. D. (2000) · Endocrinology · doi:10.1210/endo.141.2.7311 · Cited by 390 · see citing works
Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice
Yin, J., Li, Y., Han, H. L., Chen, S., Gao, J., Liu, G., Wu, X., Deng, J., Yu, Q., Huang, X., et al. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12524 · Cited by 384 · see citing works
Farzanegi, P., Dana, A., Ebrahimpoor, Z., Asadi, M., & Azarbayjani, M. A. (2019) · European Journal of Sport Science · doi:10.1080/17461391.2019.1571114 · Cited by 382 · see citing works
Dietary Sources and Bioactivities of Melatonin
Meng, X., Li, Y., Li, S., Zhou, Y., Gan, R.-Y., Xu, D.-P., & Li, H.-B. (2017) · Nutrients · doi:10.3390/nu9040367 · Cited by 362 · see citing works
Koziróg, M., Poliwczak, A. R., Duchnowicz, P., Koter-Michalak, M., Sikora, J., & Broncel, M. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00835.x · Cited by 299 · see citing works
Melatonin prevents obesity through modulation of gut microbiota in mice
Xu, P., Wang, J., Hong, F., Wang, S., Jin, X., Xue, T., Jia, L., & Zhai, Y. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12399 · Cited by 281 · see citing works
Melatonin reduces night blood pressure in patients with nocturnal hypertension
Grossman, E., Laudon, M., Yalcin, R., Zengil, H., Peleg, E., Sharabi, Y., Kamari, Y., Shen-Orr, Z., & Zisapel, N. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.02.002 · Cited by 168 · see citing works
Effects of Melatonin on Liver Injuries and Diseases
Zhang, J., Meng, X., Li, Y., Zhou, Y., Xu, D.-P., Li, S., & Li, H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040673 · Cited by 144 · see citing works
Nduhirabandi, F., Toit, E. F. D., & Lochner, A. (2012) · Acta Physiologica · doi:10.1111/j.1748-1716.2012.02410.x · Cited by 116 · see citing works
Celiński, K., Konturek, P. C., Słomka, M., Cichoz-Lach, H., Brzozowski, T., Konturek, S. J., & Korolczuk, A. (2014) · PubMed · Cited by 114 · see citing works
Role of melatonin in blood pressure regulation: An adjunct anti‐hypertensive agent
Baker, J. R., & Kimpinski, K. (2018) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12942 · Cited by 111 · see citing works
The multiple functions of melatonin in regenerative medicine
Majidinia, M., Reiter, R. J., Shakouri, S. K., Mohebbi, I., Rastegar, M., Kaviani, M., Darband, S. G., Jahanban‐Esfahlan, R., Nabavi, S. M., & Yousefi, B. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.04.003 · Cited by 100 · see citing works
Mesri Alamdari, N., Mahdavi, R., Roshanravan, N., Lotfi Yaghin, N., Ostadrahimi, A., & Faramarzi, E. (2014) · Hormone and Metabolic Research · doi:10.1055/s-0034-1384587 · Cited by 93 · see citing works
Szewczyk-Golec, K., Rajewski, P., Gackowski, M., Mila-Kierzenkowska, C., Wesołowski, R., Sutkowy, P., Pawłowska, M., & Woźniak, A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8494107 · Cited by 92 · see citing works
Amstrup, A. K., Sikjær, T., Pedersen, S. B., Heickendorff, L., Mosekilde, L., & Rejnmark, L. (2015) · Clinical Endocrinology · doi:10.1111/cen.12942 · Cited by 87 · see citing works
Gonciarz, M., Gonciarz, Z., Bielański, W., Mularczyk, A., Konturek, P. C., Brzozowski, T., & Konturek, S. J. (2012) · PubMed · Cited by 82 · see citing works
Melatonin supplementation to treat the metabolic syndrome: a randomized controlled trial
Goyal, A., Terry, P., Superak, H. M., Nell‐Dybdahl, C., Chowdhury, R., Phillips, L. S., & Kutner, M. H. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-124 · Cited by 74 · see citing works
Promising Antineoplastic Actions of Melatonin
Favero, G., Moretti, E., Bonomini, F., Reiter, R. J., Rodella, L. F., & Rezzani, R. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01086 · Cited by 70 · see citing works
Pakravan, H., Ahmadian, M., Fani, A., Aghaee, D., Brumanad, S., & Pakzad, B. (2017) · Advanced Biomedical Research · doi:10.4103/2277-9175.204593 · Cited by 67 · see citing works
Fatty Liver Disease and Gut Microbiota: A Comprehensive Update
Campo, L., Eiseler, S., Apfel, T., & Pyrsopoulos, N. (2018) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2018.00008 · Cited by 67 · see citing works
Melatonin attenuates high fat diet-induced fatty liver disease in rats
Hatzis, G. S., Ziakas, P. D., Kavantzas, N., Triantafyllou, A., Sigalas, P., Andreadou, I., Ioannidis, K., Chatzis, S., Filis, K., Papalampros, A., et al. (2013) · World Journal of Hepatology · doi:10.4254/wjh.v5.i4.160 · Cited by 66 · see citing works
Cichoż‐Lach, H., Celiński, K., Konturek, P. C., Konturek, S. J., & Słomka, M. (2010) · PubMed · Cited by 62 · see citing works
Gonciarz, M., Gonciarz, Z., Bielański, W., Mularczyk, A., Konturek, P. C., Brzozowski, T., & Konturek, S. J. (2010) · PubMed · Cited by 57 · see citing works
Stacchiotti, A., Favero, G., Lavazza, A., Golić, I., Aleksic, M., Korać, A., Rodella, L. F., & Rezzani, R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148115 · Cited by 57 · see citing works
Gonciarz, M., Bielański, W., Partyka, R., Brzozowski, T., Konturek, P. C., Eszyk, J., Celiński, K., Reiter, R. J., & Konturek, S. J. (2013) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2012.01023.x · Cited by 56 · see citing works
Daneshi‐Maskooni, M., Keshavarz, S. A., Qorbani, M., Mansouri, S., Alavian, S. M., Badri-Fariman, M., Jazayeri-Tehrani, S. A., & Sotoudeh, G. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0297-4 · Cited by 56 · see citing works
Chojnacki, C. J., Walecka‐Kapica, E., Klupińska, G., Pawłowicz, M., Błońska, A., & Chojnacki, J. (2015) · PubMed · Cited by 51 · see citing works
Increased Orocecal Transit Time in Patients with Nonalcoholic Fatty Liver Disease
Soza, A., Riquelme, A. J., Gonzalez, R. G., Alvarez, M. G., Pérez‐Ayuso, R. M., Glasinovic, J. C., & Arrese, M. A. (2005) · Digestive Diseases and Sciences · doi:10.1007/s10620-005-2720-8 · Cited by 50 · see citing works
Raffaele, M., Bellner, L., Singh, S. P., Favero, G., Rezzani, R., Rodella, L. F., Falck, J. R., Abraham, N. G., & Vanella, L. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.04.029 · Cited by 49 · see citing works
Demirtas, C. Y., Paşaoğlu, Ö. T., Bircan, F. S., Kantar, Ş., & Türközkan, N. (2015) · PubMed · Cited by 24 · see citing works
The role of melatonin supplement in metabolic syndrome
Bahrami, M., Cheraghpour, M., Jafarirad, S., Alavinejad, P., & Cheraghian, B. (2019) · Nutrition & Food Science · doi:10.1108/nfs-01-2019-0018 · Cited by 24 · see citing works
Self-citationMelatonin role preventing steatohepatitis and improving liver transplantation results
Zubero, E. E., García‐Gil, F. A., López‐Pingarrón, L., Alatorre-Jiménez, M. A., Rodríguez, J. M. ́., Tan, D., García, J. J., & Reiter, R. J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2185-2 · Cited by 21 · see citing works
Kutner, M., Terry, P., Goyal, Superak, H. M., & Phillips, L. S. (2013) · Open Access Journal of Clinical Trials · doi:10.2147/oajct.s39551 · Cited by 8 · see citing works
Mohammadi, S., Shakerhosseini, R., Rastmanesh, R., Jafarian, K., Amiri, Z., & Jahangir, F. (2015) · qums (Qazvin University of Medical Sciences) · Cited by 4 · see citing works
Terry, P. D., Goyal, A., Phillips, L. S., Superak, H. M., & Kutner, M. H. (2013) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 3 · see citing works
Flagged first, then by citations
2 of the 44 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Mechanisms of Melatonin in Obesity: A Review
Guan, Q., Wang, Z., Cao, J., Dong, Y., & Chen, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010218 · Cited by 142 · see citing works
Evidence for the Benefits of Melatonin in Cardiovascular Disease
Tobeiha, M., Jafari, A., Fadaei, S., Mirazimi, S. M. A., Dashti, F., Amiri, A., Khan, H. Z., Asemi, Z., Reiter, R. J., Hamblin, M. R., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.888319 · Cited by 126 · see citing works
Genário, R., Cipolla‐Neto, J., Bueno, A. A., & Santos, H. O. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105254 · Cited by 68 · see citing works
Delpino, F. M., Figueiredo, L. M., & Nunes, B. P. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.06.007 · Cited by 56 · see citing works
Protective Effects of Melatonin against Obesity‐Induced by Leptin Resistance
Suriyagandhi, V., & Nachiappan, V. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113598 · Cited by 44 · see citing works
Melatonin: Potential avenue for treating iron overload disorders
Yang, J., Tang, Q., & Zeng, Y. H. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101717 · Cited by 41 · see citing works
Phytochemicals: Targeting Mitophagy to Treat Metabolic Disorders
Su, Z., Guo, Y., Huang, X., Feng, B. C., Tang, L., Zheng, G., & Zhu, Y. J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.686820 · Cited by 40 · see citing works
Delpino, F. M., & Figueiredo, L. M. (2021) · Nutrition · doi:10.1016/j.nut.2021.111399 · Cited by 36 · see citing works
What’s New in the Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD)
Kosmalski, M., Frankowski, R., Ziółkowska, S., Różycka-Kosmalska, M., & Pietras, T. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12051852 · Cited by 37 · see citing works
Csoma, B., & Bikov, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814145 · Cited by 33 · see citing works
The Emerging Factors and Treatment Options for NAFLD-Related Hepatocellular Carcinoma
Zhang, C., & Yang, M. J. (2021) · Cancers · doi:10.3390/cancers13153740 · Cited by 34 · see citing works
Lauritzen, E. S., Kampmann, U., Smedegaard, S. B., & Støy, J. (2021) · Clinical Endocrinology · doi:10.1111/cen.14576 · Cited by 28 · see citing works
Melatonin alleviates alcoholic liver disease via EGFR–BRG1–TERT axis regulation
Che, Z., Song, Y., Xu, C., Li, W., Dong, Z., Wang, C., Ren, Y., So, K., Tipoe, G. L., Wang, F., et al. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.06.015 · Cited by 27 · see citing works
Ziamanesh, F., Mohammadi, M., Ebrahimpour, S., Tabatabaei‐Malazy, O., Mosallanejad, A., & Larijani, B. A. (2023) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-023-01293-3 · Cited by 28 · see citing works
Self-citationIntestinal Dysbiosis, the Tryptophan Pathway and Nonalcoholic Steatohepatitis
Chen, J., Vitetta, L., Henson, J. D., & Hall, S. (2022) · International Journal of Tryptophan Research · doi:10.1177/11786469211070533 · Cited by 27 · see citing works
Mehrzadi, S., Sheibani, M., Koosha, F., Alinaghian, N., Pourhanifeh, M. H., Tabaeian, S. P., Reiter, R. J., & Hosseinzadeh, A. (2023) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2023.2267439 · Cited by 19 · see citing works
Hepatic Encephalopathy and Melatonin
Arjunan, A., Sah, D. K., Jung, Y. D., & Song, J. (2022) · Antioxidants · doi:10.3390/antiox11050837 · Cited by 19 · see citing works
Impact of Modern Lifestyle on Circadian Health and Its Contribution to Adipogenesis and Cancer Risk
Dobrovinskaya, O. R., Alamilla, J., & Olivas-Aguirre, M. (2024) · Cancers · doi:10.3390/cancers16213706 · Cited by 20 · see citing works
Gut microbiota in non-alcoholic fatty liver disease: Pathophysiology, diagnosis, and therapeutics
Pandey, H., Goel, P., Srinivasan, V. M., Tang, D. W. T., Wong, S. H., & Lal, D. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i6.106849 · Cited by 17 · see citing works
Circadian rhythms and inflammatory diseases of the liver and gut
Ferrell, J. M. (2023) · Liver Research · doi:10.1016/j.livres.2023.08.004 · Cited by 15 · see citing works
Revealing Melatonin’s Mysteries: Receptors, Signaling Pathways, and Therapeutics Applications
Kulsoom, K., Ali, W., Saba, Z., Hussain, S., Yasin, M., Zahra, S., Irshad, M., & Ramzan, M. (2023) · Hormone and Metabolic Research · doi:10.1055/a-2226-3971 · Cited by 15 · see citing works
Experimental Data on the Role of Melatonin in the Pathogenesis of Nonalcoholic Fatty Liver Disease
Terziev, D., & Terzieva, D. D. (2023) · Biomedicines · doi:10.3390/biomedicines11061722 · Cited by 15 · see citing works
Melatonin as a Repairing Agent in Cadmium- and Free Fatty Acid-Induced Lipotoxicity
Migni, A., Mancuso, F., Baroni, T., Sante, G. D., Rende, M., Galli, F., & Bartolini, D. (2023) · Biomolecules · doi:10.3390/biom13121758 · Cited by 12 · see citing works
Leelaviwat, N., Mekraksakit, P., Cross, K. M., Landis, D. M., McLain, M., Sehgal, L., & Payne, J. D. (2022) · Clinical Therapeutics · doi:10.1016/j.clinthera.2022.03.008 · Cited by 12 · see citing works
Melatonin's paradox: From therapeutic benefits to toxicity warnings
Amrollahi‐Sharifabadi, M., Oladejo, T. O., Ibrahim, A. S., Shakoor, B., Mehrpour, O., Hashjin, G. S., & Gonçalves, S. D. (2025) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2025.111556 · Cited by 11 · see citing works
Chronic obstructive pulmonary disease and emerging ER stress-related therapeutic targets
Yeap, J. W., Ali, I. A. H., Ibrahim, B., & Tan, M. (2023) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2023.102218 · Cited by 10 · see citing works
Benefits and Risks of Melatonin in Hepatic and Pancreatic Disorders; A Review of Clinical Evidences.
Abdi, S., Abbasinazari, M., Ataei, S., Khanzadeh-Moghaddam, N., & Keshvari, N. (2021) · PubMed Central · doi:10.22037/ijpr.2020.114477.14872 · Cited by 9 · see citing works
Nutritional supplementation for nonalcohol-related fatty liver disease: a network meta-analysis
Komolafe, O., Buzzetti, E., Linden, A., Best, L. M., Madden, A. M., Roberts, D., Chase, T. J., Fritche, D., Freeman, S. C., Cooper, N. J., et al. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013157.pub2 · Cited by 21 · see citing works
Dietary melatonin and liver cancer incidence in Japan: From the Takayama study
Wada, K., Hattori, A., Maruyama, Y., Mori, T., Sugino, M., Nakashima, Y., Yamakawa, M., Yamamoto, M. P., Hori, A., Seishima, M., et al. (2024) · Cancer Science · doi:10.1111/cas.16103 · Cited by 7 · see citing works
Shi, R., Chai, K., Wang, H., Zhou, J., Yang, S., Li, J., Qiao, C., Sheng, X., Zhang, X., & Wu, J. (2025) · Journal of Evidence-Based Medicine · doi:10.1111/jebm.70002 · Cited by 9 · see citing works
Melatonin Alleviates Liver Mitochondrial Dysfunction in Leptin-Deficient Mice
de Luxán‐Delgado, B., Potes, Y., Rubio‐González, A., Solano, J. J., Boga, J. A., Antuña, E., Cachán-Vega, C., Bermejo-Millo, J. C., Menéndez-Coto, N., García-González, C., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168677 · Cited by 7 · see citing works
Laurindo, L. F., Simili, O. A. G., Araújo, A. C., Guiguer, É. L., Direito, R., Valenti, V. E., de Oliveira, V., de Oliveira, J. S., Yanaguizawa, J. L., Dias, J. A., et al. (2025) · Biology · doi:10.3390/biology14020143 · Cited by 7 · see citing works
Immunotherapy for NAFLD and NAFLD-related hepatocellular carcinoma
Jeong, S., Shin, W.-Y., & Oh, Y. H. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1150360 · Cited by 7 · see citing works
Bondy, S. C. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-26576-1_13 · Cited by 7 · see citing works
Li, S., Rao, P., Yu, W., Tang, Y., Jiang, X., & Liu, J. (2025) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2025.037 · Cited by 6 · see citing works
Sedhom, S. S., Wakeel, L. M. E., Barakat, E., Shousha, H. I., Shamkh, M. A., Salama, S. H., Zaky, D. Z., & Kholy, A. A. E. (2025) · Therapeutic Advances in Chronic Disease · doi:10.1177/20406223251358659 · Cited by 6 · see citing works
Mohammadi, S., Ashtary‐Larky, D., Erfanian-Salim, M., Alaghemand, N., Yousefi, M., Pirayvatlou, P. S., Mirkarimi, M., Mavi, S. A., Alavi, I., Ettehad, Y., et al. (2025) · Nutrients · doi:10.3390/nu18010134 · Cited by 9 · see citing works
Tuned by time: the role of circadian rhythms in metabolic energy sensing and chronotherapy
Rajakumar, A. T., & Muthukaliannan, G. K. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2596548 · Cited by 5 · see citing works
Gonciarz, M., Wiatrak, B., Lombard, I., Konecki, Ł., & Sarbinowska, J. (2025) · Journal of Pineal Research · doi:10.1111/jpi.70101 · Cited by 5 · see citing works
Xu, L., Li, H., Zhang, O., Zhang, F., Song, M., Ma, M., Zhao, Y., Ding, R., Li, D., Dong, Z., et al. (2022) · Journal of Molecular Endocrinology · doi:10.1530/jme-22-0075 · Cited by 5 · see citing works
Mesri Alamdari, N., Namazi Shabestari, A., Najafipour, F., & Mirmazhari, A. (2024) · Biomedicine Advances · doi:10.34172/bma.05 · Cited by 4 · see citing works
Movahedian, M., Tabibi, H., Atabak, S., Hedayati, M., Najafi, I., Seyrafian, S., & Rouhani, M. H. (2025) · Scientific Reports · doi:10.1038/s41598-025-20792-2 · Cited by 2 · see citing works
Hadi, S., Hadi, V., Mohammadzadeh, M., & Jahangirfard, B. (2026) · Nutrition & Metabolism · doi:10.1186/s12986-025-01061-5 · Cited by 2 · see citing works
Sun, D., Ma, Y., Bai, Y., Bai, X., Liu, W., Du, L., Wang, P., Liang, X., Liang, H., & Zhang, H. (2025) · Nutrients · doi:10.3390/nu17233641 · Cited by 2 · see citing works
Altaf-Ul-Amin, M., Nasution, A. K., Rumman, M. I., Gao, P., Ono, N., & Kanaya, S. (2025) · Metabolites · doi:10.3390/metabo15040255 · Cited by 1 · see citing works
Yang, Y., He, X., Cai, J., Qu, X., Tan, S., You, J., He, Y., Yao, Z., & Yang, H. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1682688 · Cited by 1 · see citing works
Las mil y una noches de la melatonina
Saavedra-López, H. F., García-Pérez, M. J., & Arteaga-Díaz, J. M. (2022) · Revista Colombiana de Endocrinología Diabetes & Metabolismo · doi:10.53853/encr.8.4.725 · Cited by 1 · see citing works
New perspectives on the use of melatonin in menopausal metabolic syndrome
Danilova, M. V., & Usoltseva, E. N. (2023) · Ural Medical Journal · doi:10.52420/2071-5943-2023-22-5-131-139 · Cited by 1 · see citing works
Laurindo, L. F., Zanuso, B. D. O., Guiguer, É. L., de Carvalho, G. M., & Barbalho, S. M. (2023) · Reference series in phytochemistry · doi:10.1007/978-3-031-30037-0_3-1
Laurindo, L. F., Zanuso, B. D. O., Guiguer, É. L., de Carvalho, G. M., & Barbalho, S. M. (2025) · Reference series in phytochemistry · doi:10.1007/978-3-031-51158-5_3
Melatonin for blood pressure control in adults
Haq, M. Z. U., Mansoor, J., Santos, C. C. L. D., Ramos, A. A. P., Cueva, E. P., & Harzand, A. (2025) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd016159
hasannia, F., Keshavarz, S. A., & Shadnoush, M. (2025) · Journal of Nutrition Sciences and Food Technology · doi:10.61882/nsft.20.3.21
Melatonin in the pathogenesis and treatment of metabolic liver diseases
Ovanesov, K. B., & Бакулина, Н. В. (2025) · Reviews on Clinical Pharmacology and Drug Therapy · doi:10.17816/rcf683407
Naderi, M., Khosravi, S., Hemmati, P., Ghasemi, S., & Rasaee, Z. (2025) · Advances in Skin, Wound and Tissue Repair · doi:10.61882/aswtr.22.2.10
Ma, Y., Sun, D., Bai, Y., Liu, W., Bai, X., Liu, Z., Kong, T., Wang, P., Liang, X., Zhang, Z., et al. (2025) · Nutrients · doi:10.3390/nu18010068
Liver clock: Malalignment and entrainment therapeutics
Sharma, S., Pandey, S., & Mishra, A. K. (2026) · World Journal of Gastrointestinal Pharmacology and Therapeutics · doi:10.4292/wjgpt.v17.i1.112588
Muniraj, A., Elango, S. V., Iyer, M., Rani, M. R., Vinayagam, S., Gnanasekaran, L., Yadav, M. K., Rao, K. R. S. S., Vellingiri, B., Mukherjee, A. G., et al. (2026) · Comprehensive physiology · doi:10.1002/cph4.70220 · Cited by 1 · see citing works
Rahman, M. A., Sim, D., Bhajan, S. K., Bishwas, A. K., Jalouli, M., Choi, J., Aktary, N., Park, S., Yoo, I., Rani, A., et al. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1931181
Zhao, R., Zheng, J.-L., Wang, Y., Lu, B., Zhang, Y., & Deng, B.-C. (2026) · World Journal of Hepatology · doi:10.4254/wjh.124748
Pan, B., Lv, X., Guo, X., & Liu, J. (2026) · Biomolecules · doi:10.3390/biom16091357
- Authors
- Bahrami, M., Cheraghpour, M., Jafarirad, S., Alavinejad, P., Asadi, F., Hekmatdoost, A., Mohammadi, M., & Yari, Z.
- Affiliations
- Ahvaz Jundishapur University of Medical Sciences (IR)
- National Nutrition and Food Technology Research Institute (IR)
- Corresponding author
- Jafarirad, Sima
- Venue
- Complementary Therapies in Medicine
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 52
- Pages
- 102452
- ISSN
- 0965-2299 (ISSN-L)
- OpenAlex
- W3028100062
- Cited by
- 60
- References
- 44
- Citations by year
- 2026: 7 · 2025: 18 · 2024: 4 · 2023: 13 · 2022: 8 · 2021: 9 · 2020: 1
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Complementary Therapies in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ahvaz Jundishapur University of Medical Sciences
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- melatonin, non-alcoholic fatty liver disease, leptin, adiponectin, C-reactive protein, liver enzymes, alanine aminotransferase, aspartate aminotransferase, blood pressure, anthropometry, oxidative stress, insulin resistance, adipokines
- MeSH terms
- Adult, Antioxidants, Blood Pressure, Body Weights and Measures, Double-Blind Method, Female, Humans, Male, Melatonin, Middle Aged, Biomarkers, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
