The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Interleukin-6 Stimulates Coagulation, not Fibrinolysis, in Humans
Abstract
Summary: The role of IL-6 as a mediator of haemostatic changes during severe inflammation is controversial. To assess the effect of IL-6 on haemostasis we conducted a controlled cross-over study in eight patients with metastatic renal cell cancer. In all subjects coagulation and fibrinolysis were monitored during and after a 4-h infusion of either 150 μg recombinant human (rh) IL-6, or during infusion of saline (control study). Mean maximum IL-6 concentrations were 1418.0 ± 755.8 pg/ml. Compared to the control study, rhIL-6 induced activation of coagulation as reflected by a 190 ± 55% increase in the plasma levels of thrombin-antithrombin III complexes (p <0.001) and by a 24 ± 11% increase in the plasma levels of in the prothrombin activation fragment F1 + 2 (p <0.001). In contrast, fibrinolysis was not affected. We conclude that in severe inflammation IL-6 may contribute to the activation of coagulation, whereas other factors mediate changes in fibrinolysis.
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Metadata
- Authors
- Stouthard, J. M. L., Levi, M., Hack, C. E., Veenhof, C. H. N., Romijn, H. A., Sauerwein, H. P., & Poll, T. V. D.
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 1996
- Volume
- 76
- Issue
- 05
- Pages
- 738-742
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W191300012
- Cited by
- 279
- References
- 23
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- closed
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