The sensitivity of different coagulation reagents to the presence of lupus anticoagulants
Abstract
The sensitivity and responsiveness of seven activated partial thromboplastin time reagents to the presence of lupus anticoagulants (LAs) was evaluated with a panel of 50 well-characterized LA plasmas. The results document that some reagents are clearly less responsive and sensitive to LAs; however, there is considerable variability between individual LA samples in these features. In addition, with 16% of these samples, immediate mixing studies showed correction of the activated partial thromboplastin time to the normal range with a 1:1 mixture of normal and LA plasma and 8% to 10% showed either a normal platelet neutralization procedure or a normal tissue thromboplastin inhibition procedure. Together, these findings provide further evidence of the laboratory heterogeneity of these inhibitors. The effect of this variability on the diagnosis of these inhibitors is discussed.
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Sensitivity and specificity of different APTT and dRVVT reagents to LA varies, predominantly due to differences in phospholipid composition and concentration.
“Sensitivity and specificity of different APTT and dRVVT reagents to LA varies, predominantly due to differences in phospholipid composition and concentration.10, 11, 12”
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- Authors
- Triplett, D. A.
- Affiliations
- Ball Memorial Hospital (US)
- Corresponding author
- Douglas A. Triplett
- Venue
- Thrombosis Research
- Publisher
- Elsevier BV
- Published
- 1986-01
- Volume
- 41
- Issue
- 2
- Pages
- 77
- ISSN
- 0049-3848 (ISSN-L)
- OpenAlex
- W2425749970
- Cited by
- 74
- References
- 0
- Citations by year
- 2024: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2014: 2 · 2013: 1 · 2012: 4
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Thrombosis Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Keywords
- lupus anticoagulant, activated partial thromboplastin time, reagent sensitivity, mixing studies
- MeSH terms
- Blood Coagulation Disorders, Blood Coagulation Factors, Evaluation Studies as Topic, Humans, Indicators and Reagents, Partial Thromboplastin Time, Platelet Function Tests, Thromboplastin, Lupus Coagulation Inhibitor
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