Involvement of adrenergic mechanism in hyperglycemia due to SCN stimulation
Abstract
Previously we found that in rats, electrical stimulation of the suprachiasmatic nucleus (SCN) of the hypothalamus elicited hyperglycemia associated with hyperglucagonemia without immediate hyperinsulinemia. To clarify the mechanism of these responses, we examined the effects of blockers of the autonomic nervous system on these responses. Hexamethonium, a ganglion blocker, suppressed the hyperglycemic and hyperglucagonemic responses to electrical stimulation of the SCN. Both bunazosin, an alpha 1-adrenergic blocker, and yohimbin, an alpha 2-adrenergic blocker, increased the level of insulin before stimulation, but only the latter suppressed the hyperglycemic and hyperglucagonemic responses. Propranolol, a beta-adrenergic blocker, partially inhibited the responses. These findings suggest that alpha 2- and beta-adrenergic mechanisms are involved in the hyperglycemic and hyperglucagonemic responses to SCN stimulation.
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Electrical stimulation of the SCN results in hyperglycaemia, an effect that can be prevented by blocking ANS activity with α and β-adrenergic blockers.
“They showed that electrical stimulation of the SCN resulted in hyperglycaemia, an effect that could be prevented by blocking ANS activity by means of (i.p.) administration of α and β-adrenergic blockers [64,65].”
From Circadian control of glucose metabolism (2014) · cites this paper as [64]
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Biological Clock Control of Glucose Metabolism
Ruiter, M., Buijs, R. M., & Kalsbeek, A. (2006) · Springer eBooks · doi:10.1007/0-387-23692-9_5
- Authors
- Fujii, T., Inoue, S., Nagai, K., & Nakagawa, H.
- Affiliations
- Yokohama City University (JP)
- Institute for Protein Research, The University of Osaka (JP)
- ORCID
- Inoue, S.
- Venue
- Hormone and Metabolic Research
- Publisher
- Georg Thieme Verlag KG
- Published
- 1989-12
- Volume
- 21
- Issue
- 12
- Pages
- 643-645
- ISSN
- 0018-5043 (ISSN-L)
- 1439-4286
- OpenAlex
- W2002889115
- Cited by
- 30
- References
- 0
- Citations by year
- 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone and Metabolic Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- suprachiasmatic nucleus, hyperglycemia, hyperglucagonemia, alpha2-adrenoceptors, beta-adrenergic receptors, alpha1-adrenoceptors, autonomic nervous system, hexamethonium, bunazosin, propranolol, hypothalamic electrical stimulation, insulin
- MeSH terms
- Adrenergic alpha-Antagonists, Animals, Autonomic Nervous System, Electric Stimulation, Female, Glucagon, Hexamethonium Compounds, Hyperglycemia, Insulin, Propranolol, Quinazolines, Rats, Inbred Strains, Receptors, Adrenergic, Suprachiasmatic Nucleus, Yohimbine, Hexamethonium, Rats
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